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The map label for this gene is nanM

Identifier: 108812426

GI number: 108812426

Start: 2545351

End: 2546529

Strand: Reverse

Name: nanM

Synonym: YPN_2265

Alternate gene names: 108812426

Gene position: 2546529-2545351 (Counterclockwise)

Preceding gene: 108812428

Following gene: 108812424

Centisome position: 56.16

GC content: 50.72

Gene sequence:

>1179_bases
ATGACCCAGTTATACCCACAATATAAGAAACAATTGACGACAAAAATAGTGCTGTTTAGTGCGTTATCTCTATTGATGAT
GGCATCGCTACCTAATACCTATGCGGAACAATATCCTGACGTTCCGGTACCATTTAAAAACGGTACGGGTGGCAAAGTGG
AGAACAGCTTATATGTGGGGCTGGGGAGCGCCGGTGTGTCGTGGTTCCGTCTGGATACAGATAAAACCGGTGCTGGGTGG
CAGAAAGTGGCTAATTTCCCAGGCCAGCCTCGTGAACAGGCTGTGACGGTGGTATTGGCAGGGAAACTGTACGTGTTCGG
TGGGGTGGGGAAAACGAACGCCAACGATACCCAAGTACGGGCACTGGATGATGCGTATCGTTTTGATCCACAAACTAATC
AATGGCAGCAACTGGCTACCCGCGCTCCCCGAGGTCTGGTGGGGACCGTGGCCACGACACTGGACGGCTCCCAGGCGGTG
CTGTTAGGCGGTGTAAATAAAGCGATTTTTGACGGTTATTTTACTGATCTTGCGTCAGCCGGAAGTGATGAAGTACGCAA
GAGTGCGGTAATAAACGCCTATTTTAATCAGGCTCCGGCTGATTATTTCTACAACCGTGATGTCCTTATCTATGATCCGC
AAAAAAATCAGTGGAAAAGCGGCGGTTTGCTGCCATTTTTAGGGACAGCCGGGTCAGCCATCAGCCGCATGGATAATCGC
TTGATATTAATCAATGGCGAAATTAAACCTGGTTTACGCACAGCGGCTGTATGGCAGGGGCTAATGCAAGGGAATGTACT
GGAGTGGCAGCCACAACCGGACTTAATCGGAGCTGAAACGGGATCCGCACAGGAAGGATTGGCTGGCGCATTTTCCGGTA
TCAGTCATAAAACAGTCTTAGTCGCCGGAGGCGCTAATTTCCCTGGTGCCTGGAAGCAATTTAATCGCGGTCACCTATAT
GCTCACCAAGGGCTGGAAAAACAGTGGCACCAGCAGGTGTATGCGTTGGTCGATAATCAGTGGAGAATCGCCGGGAAGTT
GCCTCAACCGCTGGGTTATGGCGTCTCTATTCAGGGGCCAGATAAGGTCATTTTGATTGGCGGCGAAACCACCGGAGGTA
CGGCCACTTCAGCGGTCACACAGCTATCTTGGCAGGGAGGAAAACTGCATATTGAGTAA

Upstream 100 bases:

>100_bases
TGACTCCATAATTAAATTGTTAATGGAGTTTTGCTCTCCTTGGGAGCCATACTGCTAACATTATGGTTCCACCACGATGA
ATTAATGAGGAACACTGCTG

Downstream 100 bases:

>100_bases
ATTGAGGTTGAAATGAATGAAAGAACCTTATTCAGTAGCGGGTTGTCGGCGTTATGGAATAAGTGATTAGAGGGGGAAAT
AAAACGGTACCAGAACACCT

Product: N-acetylneuraminic acid mutarotase

Products: NA

Alternate protein names: N-acetylneuraminate mutarotase; Neu5Ac mutarotase; Sialic acid epimerase

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MTQLYPQYKKQLTTKIVLFSALSLLMMASLPNTYAEQYPDVPVPFKNGTGGKVENSLYVGLGSAGVSWFRLDTDKTGAGW
QKVANFPGQPREQAVTVVLAGKLYVFGGVGKTNANDTQVRALDDAYRFDPQTNQWQQLATRAPRGLVGTVATTLDGSQAV
LLGGVNKAIFDGYFTDLASAGSDEVRKSAVINAYFNQAPADYFYNRDVLIYDPQKNQWKSGGLLPFLGTAGSAISRMDNR
LILINGEIKPGLRTAAVWQGLMQGNVLEWQPQPDLIGAETGSAQEGLAGAFSGISHKTVLVAGGANFPGAWKQFNRGHLY
AHQGLEKQWHQQVYALVDNQWRIAGKLPQPLGYGVSIQGPDKVILIGGETTGGTATSAVTQLSWQGGKLHIE

Sequences:

>Translated_392_residues
MTQLYPQYKKQLTTKIVLFSALSLLMMASLPNTYAEQYPDVPVPFKNGTGGKVENSLYVGLGSAGVSWFRLDTDKTGAGW
QKVANFPGQPREQAVTVVLAGKLYVFGGVGKTNANDTQVRALDDAYRFDPQTNQWQQLATRAPRGLVGTVATTLDGSQAV
LLGGVNKAIFDGYFTDLASAGSDEVRKSAVINAYFNQAPADYFYNRDVLIYDPQKNQWKSGGLLPFLGTAGSAISRMDNR
LILINGEIKPGLRTAAVWQGLMQGNVLEWQPQPDLIGAETGSAQEGLAGAFSGISHKTVLVAGGANFPGAWKQFNRGHLY
AHQGLEKQWHQQVYALVDNQWRIAGKLPQPLGYGVSIQGPDKVILIGGETTGGTATSAVTQLSWQGGKLHIE
>Mature_391_residues
TQLYPQYKKQLTTKIVLFSALSLLMMASLPNTYAEQYPDVPVPFKNGTGGKVENSLYVGLGSAGVSWFRLDTDKTGAGWQ
KVANFPGQPREQAVTVVLAGKLYVFGGVGKTNANDTQVRALDDAYRFDPQTNQWQQLATRAPRGLVGTVATTLDGSQAVL
LGGVNKAIFDGYFTDLASAGSDEVRKSAVINAYFNQAPADYFYNRDVLIYDPQKNQWKSGGLLPFLGTAGSAISRMDNRL
ILINGEIKPGLRTAAVWQGLMQGNVLEWQPQPDLIGAETGSAQEGLAGAFSGISHKTVLVAGGANFPGAWKQFNRGHLYA
HQGLEKQWHQQVYALVDNQWRIAGKLPQPLGYGVSIQGPDKVILIGGETTGGTATSAVTQLSWQGGKLHIE

Specific function: Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, whic

COG id: COG3055

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Periplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 7 Kelch repeats

Homologues:

Organism=Escherichia coli, GI87082419, Length=373, Percent_Identity=39.142091152815, Blast_Score=283, Evalue=1e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NANM_YERP3 (A7FJ01)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001401229.1
- ProteinModelPortal:   A7FJ01
- STRING:   A7FJ01
- GeneID:   5384284
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_2260
- eggNOG:   COG3055
- HOGENOM:   HBG365569
- OMA:   FTTAEII
- ProtClustDB:   PRK14131
- BioCyc:   YPSE349747:YPSIP31758_2260-MONOMER
- HAMAP:   MF_01195
- InterPro:   IPR013089
- InterPro:   IPR015915
- InterPro:   IPR006652
- InterPro:   IPR019936
- Gene3D:   G3DSA:2.120.10.80
- PANTHER:   PTHR23230
- TIGRFAMs:   TIGR03547

Pfam domain/function: PF01344 Kelch_1

EC number: NA

Molecular weight: Translated: 42294; Mature: 42163

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: NA

Important sites: ACT_SITE 247-247

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQLYPQYKKQLTTKIVLFSALSLLMMASLPNTYAEQYPDVPVPFKNGTGGKVENSLYVG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCEEEEE
LGSAGVSWFRLDTDKTGAGWQKVANFPGQPREQAVTVVLAGKLYVFGGVGKTNANDTQVR
ECCCCCEEEEEECCCCCCCHHHHHCCCCCCHHHEEEEEEECEEEEEECCCCCCCCCCEEE
ALDDAYRFDPQTNQWQQLATRAPRGLVGTVATTLDGSQAVLLGGVNKAIFDGYFTDLASA
EEHHHHHCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEEECCCHHHHHHHHHHHHCC
GSDEVRKSAVINAYFNQAPADYFYNRDVLIYDPQKNQWKSGGLLPFLGTAGSAISRMDNR
CHHHHHHHHHHHHHHCCCCHHHEECCCEEEECCCCCCCCCCCCCEECCCCCHHHHHCCCE
LILINGEIKPGLRTAAVWQGLMQGNVLEWQPQPDLIGAETGSAQEGLAGAFSGISHKTVL
EEEEECCCCCCCHHHHHHHHHHCCCEEEECCCCCEEECCCCCCHHCHHHHHCCCCCEEEE
VAGGANFPGAWKQFNRGHLYAHQGLEKQWHQQVYALVDNQWRIAGKLPQPLGYGVSIQGP
EECCCCCCHHHHHCCCCEEEECCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCEEECCC
DKVILIGGETTGGTATSAVTQLSWQGGKLHIE
CEEEEEECCCCCCCHHHHHHEEECCCCEEEEC
>Mature Secondary Structure 
TQLYPQYKKQLTTKIVLFSALSLLMMASLPNTYAEQYPDVPVPFKNGTGGKVENSLYVG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCEEEEE
LGSAGVSWFRLDTDKTGAGWQKVANFPGQPREQAVTVVLAGKLYVFGGVGKTNANDTQVR
ECCCCCEEEEEECCCCCCCHHHHHCCCCCCHHHEEEEEEECEEEEEECCCCCCCCCCEEE
ALDDAYRFDPQTNQWQQLATRAPRGLVGTVATTLDGSQAVLLGGVNKAIFDGYFTDLASA
EEHHHHHCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEEECCCHHHHHHHHHHHHCC
GSDEVRKSAVINAYFNQAPADYFYNRDVLIYDPQKNQWKSGGLLPFLGTAGSAISRMDNR
CHHHHHHHHHHHHHHCCCCHHHEECCCEEEECCCCCCCCCCCCCEECCCCCHHHHHCCCE
LILINGEIKPGLRTAAVWQGLMQGNVLEWQPQPDLIGAETGSAQEGLAGAFSGISHKTVL
EEEEECCCCCCCHHHHHHHHHHCCCEEEECCCCCEEECCCCCCHHCHHHHHCCCCCEEEE
VAGGANFPGAWKQFNRGHLYAHQGLEKQWHQQVYALVDNQWRIAGKLPQPLGYGVSIQGP
EECCCCCCHHHHHCCCCEEEECCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCEEECCC
DKVILIGGETTGGTATSAVTQLSWQGGKLHIE
CEEEEEECCCCCCCHHHHHHEEECCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA