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The map label for this gene is uvrC [H]

Identifier: 108812419

GI number: 108812419

Start: 2537676

End: 2539529

Strand: Reverse

Name: uvrC [H]

Synonym: YPN_2258

Alternate gene names: 108812419

Gene position: 2539529-2537676 (Counterclockwise)

Preceding gene: 108812420

Following gene: 108812418

Centisome position: 56.0

GC content: 44.77

Gene sequence:

>1854_bases
ATGCGGAGACGTTATCAAATAGTGACTGATCTTTTTGATTATAAAGAATTTTTGAAAACTGTTACCAGTCAGCCTGGTGT
TTATCGGATGTACGATACTGCAGGAACAGTTATTTATGTCGGTAAAGCAAAAGATCTCAAAAAGCGTCTGACGAGCTATT
TTCGTGCTCAGGTCGCCAACCGAAAAACTGAAACGTTAGTTAAAAATATTGCTCAAATTGATGTCACCGTTACGCATACT
GAAACGGAAGCATTGTTGCTTGAGCACAATTACATCAAGCTTTATCAGCCACGTTACAATGTGTTGCTACGTGATGATAA
GTCATATCCGCTTATTTTCTTGAGTGCGGATGAGCACCCGCGCCTTGCTGTGCACCGTGGCGCAAAACATGAGAAAGGGG
AGTATTTTGGGCCGTTTCCAAACTCCTATGCAGTGCGTGAAACGTTGGCATTATTACAGAAGCTTTTTCCAGTAAGGCAA
TGTGAGAATAGTGTTTACCGCAATCGCTCACGGCCTTGCCTACAATATCAGATTGGGCGTTGTTCCGGGCCTTGTGTGGA
GGGGTTGGTAAGTGAAGAGGAGTATCAGCGCCAAGTTGATTACGTTCGCTTGTTCCTCTCAGGTAAAGATCAGCAAGTCT
TGACGCAGCTAATCACCCGTATGGAGGAGGCTAGCCAGCAACTGCATTTTGAAGATGCAGCACGGATTCGCGATCAAATC
CAAGCTGTGCGTCGAGTAACGGAACAACAGTTTGTTTCTGGCGACAGTGAAGATCTTGATGTTATCGGTGTGGCATTTGA
TGCGGGGCTCGCTTGTGTCCATGTACTGTTTATCAGATTAGGGAAAGTATTAGGTAGCCGGAGTTATTTCCCTAAAGTTC
CCGCGGGTACTGAGTTGAGCGAAGTCGTTCAGACTTTTGTTGGGCAGTTTTATTTGCAAGGAAGCCAAGGGCGTACATTG
CCTGGTGAAATTTTACTGGATTTTACCCTCACAGAAAAAGACCTGTTGGCATCTTCTCTTTCTGAACTGGCTGGGCGAAA
AATTCAGATACAAAGCCGCCCCCGAGGAGATCGTGCGCGTTATCTCAAGTTAGCACGTACCAATGCTTCAACCGCATTGA
TAACCCGCTTATCTCAGCAATCGACTATTCATCAACGCATGAAGGAATTAGCCAAGGTCCTTAAGCTTGATGAAATTAAT
CGTATGGAATGTTTTGATATCAGCCATACGATGGGGGAACAGACCGTAGCCTCTTGTGTCGTATTTGATGCGAATGGTCC
TGTACGATCTGAATATCGGCGCTACAATATTAGTGGTATCACGCCGGGTGATGATTATGCAGCGATGGCTCAAGTACTAA
AACGTCGATATGGGAAAGCATTAGACGATCAAAAAATTCCTGATGTCATATTTATTGACGGTGGGAAGGGGCAGTTGTCA
CAGGCCTTTGATGTTTTTGCCTCGTTGAATGTTCCGTGGGATAAGCAAAAGCCATTGCTAGTCGGTGTAGCGAAAGGTAG
TGATCGCAAAGCGGGTTTAGAAACATTATTCTTGGCATCAGAAGGTGAGGGCTTTTCTTTACCCCCAGATTCACCAGCAT
TACATCTGATCCAGCATATTCGTGATGATTCTCATAATCATGCGATAACCGGGCACCGGCAGCGGCGATCTAAAGTAAAA
AATACCAGTGCGTTAGAAATGATAGAAGGTGTTGGCCCCAAACGACGGCAAGTTTTGTTGAAATATATGGGTGGACTACA
ACCTTTGTTTAACGCAAGCGTCGAGGAAATTGCAAAAGTGCCGGGTATTTCACAAGCATTGGCAGAAAAAATCCACAATG
CATTGAAACACTGA

Upstream 100 bases:

>100_bases
CCGAAAACGGTTAATAGTTACCGCTACCGTATGTTCAGTAAACTCAATATTAGTGGTGACGTTGAATTAACCCATTTGGC
TATTCGCCACGGTTTATTTA

Downstream 100 bases:

>100_bases
AGCTAATGTTGCACCATACTCATAGTGTCCACACCAGCCAGATAGTTATCGTAGCATTATGCAATTGAATATACCGACTT
GGCTTACCTTGTTCCGTGTT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 617; Mature: 617

Protein sequence:

>617_residues
MRRRYQIVTDLFDYKEFLKTVTSQPGVYRMYDTAGTVIYVGKAKDLKKRLTSYFRAQVANRKTETLVKNIAQIDVTVTHT
ETEALLLEHNYIKLYQPRYNVLLRDDKSYPLIFLSADEHPRLAVHRGAKHEKGEYFGPFPNSYAVRETLALLQKLFPVRQ
CENSVYRNRSRPCLQYQIGRCSGPCVEGLVSEEEYQRQVDYVRLFLSGKDQQVLTQLITRMEEASQQLHFEDAARIRDQI
QAVRRVTEQQFVSGDSEDLDVIGVAFDAGLACVHVLFIRLGKVLGSRSYFPKVPAGTELSEVVQTFVGQFYLQGSQGRTL
PGEILLDFTLTEKDLLASSLSELAGRKIQIQSRPRGDRARYLKLARTNASTALITRLSQQSTIHQRMKELAKVLKLDEIN
RMECFDISHTMGEQTVASCVVFDANGPVRSEYRRYNISGITPGDDYAAMAQVLKRRYGKALDDQKIPDVIFIDGGKGQLS
QAFDVFASLNVPWDKQKPLLVGVAKGSDRKAGLETLFLASEGEGFSLPPDSPALHLIQHIRDDSHNHAITGHRQRRSKVK
NTSALEMIEGVGPKRRQVLLKYMGGLQPLFNASVEEIAKVPGISQALAEKIHNALKH

Sequences:

>Translated_617_residues
MRRRYQIVTDLFDYKEFLKTVTSQPGVYRMYDTAGTVIYVGKAKDLKKRLTSYFRAQVANRKTETLVKNIAQIDVTVTHT
ETEALLLEHNYIKLYQPRYNVLLRDDKSYPLIFLSADEHPRLAVHRGAKHEKGEYFGPFPNSYAVRETLALLQKLFPVRQ
CENSVYRNRSRPCLQYQIGRCSGPCVEGLVSEEEYQRQVDYVRLFLSGKDQQVLTQLITRMEEASQQLHFEDAARIRDQI
QAVRRVTEQQFVSGDSEDLDVIGVAFDAGLACVHVLFIRLGKVLGSRSYFPKVPAGTELSEVVQTFVGQFYLQGSQGRTL
PGEILLDFTLTEKDLLASSLSELAGRKIQIQSRPRGDRARYLKLARTNASTALITRLSQQSTIHQRMKELAKVLKLDEIN
RMECFDISHTMGEQTVASCVVFDANGPVRSEYRRYNISGITPGDDYAAMAQVLKRRYGKALDDQKIPDVIFIDGGKGQLS
QAFDVFASLNVPWDKQKPLLVGVAKGSDRKAGLETLFLASEGEGFSLPPDSPALHLIQHIRDDSHNHAITGHRQRRSKVK
NTSALEMIEGVGPKRRQVLLKYMGGLQPLFNASVEEIAKVPGISQALAEKIHNALKH
>Mature_617_residues
MRRRYQIVTDLFDYKEFLKTVTSQPGVYRMYDTAGTVIYVGKAKDLKKRLTSYFRAQVANRKTETLVKNIAQIDVTVTHT
ETEALLLEHNYIKLYQPRYNVLLRDDKSYPLIFLSADEHPRLAVHRGAKHEKGEYFGPFPNSYAVRETLALLQKLFPVRQ
CENSVYRNRSRPCLQYQIGRCSGPCVEGLVSEEEYQRQVDYVRLFLSGKDQQVLTQLITRMEEASQQLHFEDAARIRDQI
QAVRRVTEQQFVSGDSEDLDVIGVAFDAGLACVHVLFIRLGKVLGSRSYFPKVPAGTELSEVVQTFVGQFYLQGSQGRTL
PGEILLDFTLTEKDLLASSLSELAGRKIQIQSRPRGDRARYLKLARTNASTALITRLSQQSTIHQRMKELAKVLKLDEIN
RMECFDISHTMGEQTVASCVVFDANGPVRSEYRRYNISGITPGDDYAAMAQVLKRRYGKALDDQKIPDVIFIDGGKGQLS
QAFDVFASLNVPWDKQKPLLVGVAKGSDRKAGLETLFLASEGEGFSLPPDSPALHLIQHIRDDSHNHAITGHRQRRSKVK
NTSALEMIEGVGPKRRQVLLKYMGGLQPLFNASVEEIAKVPGISQALAEKIHNALKH

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=610, Percent_Identity=83.2786885245902, Blast_Score=1069, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 69666; Mature: 69666

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRRYQIVTDLFDYKEFLKTVTSQPGVYRMYDTAGTVIYVGKAKDLKKRLTSYFRAQVAN
CCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHC
RKTETLVKNIAQIDVTVTHTETEALLLEHNYIKLYQPRYNVLLRDDKSYPLIFLSADEHP
CHHHHHHHHHHHEEEEEEECCCEEEEEECCEEEEECCCCCEEEECCCCCCEEEEECCCCC
RLAVHRGAKHEKGEYFGPFPNSYAVRETLALLQKLFPVRQCENSVYRNRSRPCLQYQIGR
CCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEECCC
CSGPCVEGLVSEEEYQRQVDYVRLFLSGKDQQVLTQLITRMEEASQQLHFEDAARIRDQI
CCCHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QAVRRVTEQQFVSGDSEDLDVIGVAFDAGLACVHVLFIRLGKVLGSRSYFPKVPAGTELS
HHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHH
EVVQTFVGQFYLQGSQGRTLPGEILLDFTLTEKDLLASSLSELAGRKIQIQSRPRGDRAR
HHHHHHHHHHEEECCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCEEEECCCCCCCHHH
YLKLARTNASTALITRLSQQSTIHQRMKELAKVLKLDEINRMECFDISHTMGEQTVASCV
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHCHHHHHEEE
VFDANGPVRSEYRRYNISGITPGDDYAAMAQVLKRRYGKALDDQKIPDVIFIDGGKGQLS
EECCCCCHHHHHHEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCHHH
QAFDVFASLNVPWDKQKPLLVGVAKGSDRKAGLETLFLASEGEGFSLPPDSPALHLIQHI
HHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHH
RDDSHNHAITGHRQRRSKVKNTSALEMIEGVGPKRRQVLLKYMGGLQPLFNASVEEIAKV
HCCCCCCCCCCCHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHCCHHHHHHC
PGISQALAEKIHNALKH
CCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRRRYQIVTDLFDYKEFLKTVTSQPGVYRMYDTAGTVIYVGKAKDLKKRLTSYFRAQVAN
CCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHC
RKTETLVKNIAQIDVTVTHTETEALLLEHNYIKLYQPRYNVLLRDDKSYPLIFLSADEHP
CHHHHHHHHHHHEEEEEEECCCEEEEEECCEEEEECCCCCEEEECCCCCCEEEEECCCCC
RLAVHRGAKHEKGEYFGPFPNSYAVRETLALLQKLFPVRQCENSVYRNRSRPCLQYQIGR
CCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEECCC
CSGPCVEGLVSEEEYQRQVDYVRLFLSGKDQQVLTQLITRMEEASQQLHFEDAARIRDQI
CCCHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QAVRRVTEQQFVSGDSEDLDVIGVAFDAGLACVHVLFIRLGKVLGSRSYFPKVPAGTELS
HHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHH
EVVQTFVGQFYLQGSQGRTLPGEILLDFTLTEKDLLASSLSELAGRKIQIQSRPRGDRAR
HHHHHHHHHHEEECCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCEEEECCCCCCCHHH
YLKLARTNASTALITRLSQQSTIHQRMKELAKVLKLDEINRMECFDISHTMGEQTVASCV
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHCHHHHHEEE
VFDANGPVRSEYRRYNISGITPGDDYAAMAQVLKRRYGKALDDQKIPDVIFIDGGKGQLS
EECCCCCHHHHHHEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCHHH
QAFDVFASLNVPWDKQKPLLVGVAKGSDRKAGLETLFLASEGEGFSLPPDSPALHLIQHI
HHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHH
RDDSHNHAITGHRQRRSKVKNTSALEMIEGVGPKRRQVLLKYMGGLQPLFNASVEEIAKV
HCCCCCCCCCCCHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHCCHHHHHHC
PGISQALAEKIHNALKH
CCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA