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The map label for this gene is uvrY [H]

Identifier: 108812420

GI number: 108812420

Start: 2539501

End: 2540157

Strand: Reverse

Name: uvrY [H]

Synonym: YPN_2259

Alternate gene names: 108812420

Gene position: 2540157-2539501 (Counterclockwise)

Preceding gene: 108812423

Following gene: 108812419

Centisome position: 56.02

GC content: 45.51

Gene sequence:

>657_bases
TTGATCAGCGTTCTTCTTGTTGATGACCACGAATTGGTGCGCGCAGGGATACGACGCATTCTTGACGACATCAAAGGTAT
CAAAGTCGCGGGTGAGATGCAGTGTGGTGAAGATGCGGTCAAATGGTGCCGTAGCCATGTTGTAGATATCGTCCTGATGG
ATATGAATATGCCCGGTATTGGCGGGTTGGAAGCAACACGTAAAATTTTACGTTTTTCGCCGGATACTAAAGTTATAATG
CTAACCATTCATACGGAGAATCCATTACCGGCAAAGGTCATGCAAGCGGGAGCGGGGGGGTATCTCAGTAAAGGAGCTGC
TCCGCAGGATGTTATAACCGCCATCCGTATGGTACATGCTGGGCAACGTTACATAGCTTCTGATATTGCACAACAAATGG
CACTGAGCCAGCTTGAGCCTCCAGCAGAAACACCTTTTAGCTGTTTGTCGGAGCGTGAGTTGCAAATAATGATAATGATA
ACGAAAGGCCAAAAGGTGAATGAGATCTCAGAACAGCTTCATCTGAGTCCGAAAACGGTTAATAGTTACCGCTACCGTAT
GTTCAGTAAACTCAATATTAGTGGTGACGTTGAATTAACCCATTTGGCTATTCGCCACGGTTTATTTAATGCGGAGACGT
TATCAAATAGTGACTGA

Upstream 100 bases:

>100_bases
TTGCAATTATTCTGTATTCATTCTTTGGTCGAAAACAAGTAATATCATTACGGTAAACAAAGCATGGTTAGTCTACTCCC
TTATTTCTGGAGAAATTTCT

Downstream 100 bases:

>100_bases
TCTTTTTGATTATAAAGAATTTTTGAAAACTGTTACCAGTCAGCCTGGTGTTTATCGGATGTACGATACTGCAGGAACAG
TTATTTATGTCGGTAAAGCA

Product: response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MISVLLVDDHELVRAGIRRILDDIKGIKVAGEMQCGEDAVKWCRSHVVDIVLMDMNMPGIGGLEATRKILRFSPDTKVIM
LTIHTENPLPAKVMQAGAGGYLSKGAAPQDVITAIRMVHAGQRYIASDIAQQMALSQLEPPAETPFSCLSERELQIMIMI
TKGQKVNEISEQLHLSPKTVNSYRYRMFSKLNISGDVELTHLAIRHGLFNAETLSNSD

Sequences:

>Translated_218_residues
MISVLLVDDHELVRAGIRRILDDIKGIKVAGEMQCGEDAVKWCRSHVVDIVLMDMNMPGIGGLEATRKILRFSPDTKVIM
LTIHTENPLPAKVMQAGAGGYLSKGAAPQDVITAIRMVHAGQRYIASDIAQQMALSQLEPPAETPFSCLSERELQIMIMI
TKGQKVNEISEQLHLSPKTVNSYRYRMFSKLNISGDVELTHLAIRHGLFNAETLSNSD
>Mature_218_residues
MISVLLVDDHELVRAGIRRILDDIKGIKVAGEMQCGEDAVKWCRSHVVDIVLMDMNMPGIGGLEATRKILRFSPDTKVIM
LTIHTENPLPAKVMQAGAGGYLSKGAAPQDVITAIRMVHAGQRYIASDIAQQMALSQLEPPAETPFSCLSERELQIMIMI
TKGQKVNEISEQLHLSPKTVNSYRYRMFSKLNISGDVELTHLAIRHGLFNAETLSNSD

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=217, Percent_Identity=83.4101382488479, Blast_Score=380, Evalue=1e-107,
Organism=Escherichia coli, GI1790102, Length=200, Percent_Identity=34.5, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI1788521, Length=205, Percent_Identity=29.7560975609756, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI1786747, Length=201, Percent_Identity=26.3681592039801, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1788712, Length=216, Percent_Identity=26.3888888888889, Blast_Score=84, Evalue=6e-18,
Organism=Escherichia coli, GI1787473, Length=183, Percent_Identity=27.8688524590164, Blast_Score=78, Evalue=4e-16,
Organism=Escherichia coli, GI1788546, Length=205, Percent_Identity=24.390243902439, Blast_Score=72, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 24095; Mature: 24095

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISVLLVDDHELVRAGIRRILDDIKGIKVAGEMQCGEDAVKWCRSHVVDIVLMDMNMPGI
CEEEEEECCHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHEEEEEECCCCCC
GGLEATRKILRFSPDTKVIMLTIHTENPLPAKVMQAGAGGYLSKGAAPQDVITAIRMVHA
CCHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHC
GQRYIASDIAQQMALSQLEPPAETPFSCLSERELQIMIMITKGQKVNEISEQLHLSPKTV
CHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCEEEEEEEECCCCHHHHHHHHCCCCCHH
NSYRYRMFSKLNISGDVELTHLAIRHGLFNAETLSNSD
HHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MISVLLVDDHELVRAGIRRILDDIKGIKVAGEMQCGEDAVKWCRSHVVDIVLMDMNMPGI
CEEEEEECCHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHEEEEEECCCCCC
GGLEATRKILRFSPDTKVIMLTIHTENPLPAKVMQAGAGGYLSKGAAPQDVITAIRMVHA
CCHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHC
GQRYIASDIAQQMALSQLEPPAETPFSCLSERELQIMIMITKGQKVNEISEQLHLSPKTV
CHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCEEEEEEEECCCCHHHHHHHHCCCCCHH
NSYRYRMFSKLNISGDVELTHLAIRHGLFNAETLSNSD
HHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]