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The map label for this gene is menB [H]

Identifier: 108812282

GI number: 108812282

Start: 2396051

End: 2396908

Strand: Reverse

Name: menB [H]

Synonym: YPN_2120

Alternate gene names: 108812282

Gene position: 2396908-2396051 (Counterclockwise)

Preceding gene: 108812283

Following gene: 108812281

Centisome position: 52.86

GC content: 51.98

Gene sequence:

>858_bases
ATGCTTTATCCGAGCGAAGAACAATTGTACGCCGCCATCGACTGGCTGGATTGCTCCGCCGGATTTGAAGATATTCGTTA
TCACAAATCCAACGATGGTATTGCCAAGATCACCATTAACCGCCCACATGTGCGTAATGCGTTCCGCCCATTAACCGTTA
AAGAGATGATCCAGGCGTTGGCCGATGCCCGTTATGACGACAATATCGGTGTGATTATTTTGACGGGGGAAGGCGATAAA
GCCTTCTGTTCCGGCGGTGATCAGAAAGTGCGTGGCGATTACGGCGGCTATCAGGATAACAGTGGTGTTCATCACCTGAA
CGTACTGGATTTCCAACGTCAGATCCGCACCTGTCCAAAACCGGTGGTCGCGATGGTGGCCGGCTATTCTATTGGCGGCG
GGCATGTCTTGCATATGATGTGTGATTTAACTGTTGCGGCAGATAATGCCATTTTTGGTCAGACGGGACCGAAAGTCGGT
TCATTCGACGGCGGTTGGGGTGCGGCGTATATGGCGCGGATTGTCGGCCAGAAAAAAGCGCGGGAAATTTGGTTCCTGTG
CCGCCAATATGATGCCAAACAAGCTTTGGATATGGGGCTGGTCAATACCGTGGTCCCCCTGGCAGATCTCGAAAAAGAAA
CTGTGCGTTGGTGCCGTGAAATGCTGCAAAACAGCCCGATGGCGCTGCGTTGTCTGAAAGCAGCGCTGAATGCGGATTGC
GATGGTCAGGCGGGTTTGCAGGAGTTAGCCGGTAACGCCACCATGCTGTTCTATATGACCGATGAAGGGCAGGAGGGGCG
TAACGCATTCAATGAAAAACGCCAACCGGACTTCAGCAAATTCAAGCGTAATCCGTAA

Upstream 100 bases:

>100_bases
CGGGCGAATCCCGGTGCTTTTGCTGCACAGGTGCTGGCATTTTTGTCACAGTCATCATGCTTACCACCGTCATCATTATC
TCGTTAAAGGAATGTTTACT

Downstream 100 bases:

>100_bases
TGCGCACGGCTACCCTTTACCGCTACAGTGTACCGATGGAAGCGGGGGTGATACTGCGCCATCAGCGGCTGAAAAGTCGC
GATGGGTTGCTGGTCAAATT

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MLYPSEEQLYAAIDWLDCSAGFEDIRYHKSNDGIAKITINRPHVRNAFRPLTVKEMIQALADARYDDNIGVIILTGEGDK
AFCSGGDQKVRGDYGGYQDNSGVHHLNVLDFQRQIRTCPKPVVAMVAGYSIGGGHVLHMMCDLTVAADNAIFGQTGPKVG
SFDGGWGAAYMARIVGQKKAREIWFLCRQYDAKQALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADC
DGQAGLQELAGNATMLFYMTDEGQEGRNAFNEKRQPDFSKFKRNP

Sequences:

>Translated_285_residues
MLYPSEEQLYAAIDWLDCSAGFEDIRYHKSNDGIAKITINRPHVRNAFRPLTVKEMIQALADARYDDNIGVIILTGEGDK
AFCSGGDQKVRGDYGGYQDNSGVHHLNVLDFQRQIRTCPKPVVAMVAGYSIGGGHVLHMMCDLTVAADNAIFGQTGPKVG
SFDGGWGAAYMARIVGQKKAREIWFLCRQYDAKQALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADC
DGQAGLQELAGNATMLFYMTDEGQEGRNAFNEKRQPDFSKFKRNP
>Mature_285_residues
MLYPSEEQLYAAIDWLDCSAGFEDIRYHKSNDGIAKITINRPHVRNAFRPLTVKEMIQALADARYDDNIGVIILTGEGDK
AFCSGGDQKVRGDYGGYQDNSGVHHLNVLDFQRQIRTCPKPVVAMVAGYSIGGGHVLHMMCDLTVAADNAIFGQTGPKVG
SFDGGWGAAYMARIVGQKKAREIWFLCRQYDAKQALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADC
DGQAGLQELAGNATMLFYMTDEGQEGRNAFNEKRQPDFSKFKRNP

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=264, Percent_Identity=34.0909090909091, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI31542718, Length=258, Percent_Identity=31.0077519379845, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI45643119, Length=220, Percent_Identity=30.4545454545455, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI260275230, Length=220, Percent_Identity=30.4545454545455, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI260274832, Length=220, Percent_Identity=30.4545454545455, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI4502327, Length=259, Percent_Identity=29.3436293436293, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI213417737, Length=225, Percent_Identity=24.8888888888889, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI157694516, Length=225, Percent_Identity=24.8888888888889, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI4757966, Length=240, Percent_Identity=25, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI51538581, Length=240, Percent_Identity=25, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI25453481, Length=254, Percent_Identity=24.4094488188976, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI51538573, Length=254, Percent_Identity=24.4094488188976, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI37594469, Length=142, Percent_Identity=28.8732394366197, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI37594471, Length=142, Percent_Identity=28.8732394366197, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1788597, Length=285, Percent_Identity=93.3333333333333, Blast_Score=564, Evalue=1e-162,
Organism=Escherichia coli, GI1787659, Length=245, Percent_Identity=31.4285714285714, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI87082183, Length=255, Percent_Identity=27.0588235294118, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI221142681, Length=251, Percent_Identity=29.0836653386454, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1787660, Length=257, Percent_Identity=28.4046692607004, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1788682, Length=230, Percent_Identity=26.5217391304348, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI25145438, Length=253, Percent_Identity=32.0158102766798, Blast_Score=117, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17554946, Length=261, Percent_Identity=30.2681992337165, Blast_Score=109, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17540714, Length=212, Percent_Identity=29.7169811320755, Blast_Score=107, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17535521, Length=232, Percent_Identity=25.4310344827586, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17534483, Length=271, Percent_Identity=28.0442804428044, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17549921, Length=197, Percent_Identity=24.8730964467005, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17536985, Length=220, Percent_Identity=25.4545454545455, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17560910, Length=190, Percent_Identity=28.9473684210526, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI20129971, Length=264, Percent_Identity=32.9545454545455, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24653477, Length=264, Percent_Identity=32.9545454545455, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24653139, Length=261, Percent_Identity=27.9693486590038, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI21357171, Length=183, Percent_Identity=32.2404371584699, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24654903, Length=183, Percent_Identity=25.6830601092896, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24650670, Length=173, Percent_Identity=30.635838150289, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI19922422, Length=199, Percent_Identity=28.1407035175879, Blast_Score=67, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 31596; Mature: 31596

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYPSEEQLYAAIDWLDCSAGFEDIRYHKSNDGIAKITINRPHVRNAFRPLTVKEMIQAL
CCCCCHHHHEEEEEHHCCCCCHHHHEEECCCCCEEEEEECCCHHHHCCCCCCHHHHHHHH
ADARYDDNIGVIILTGEGDKAFCSGGDQKVRGDYGGYQDNSGVHHLNVLDFQRQIRTCPK
HCCCCCCCCEEEEEECCCCCHHHCCCCCEECCCCCCCCCCCCCEEEHHHHHHHHHHCCCH
PVVAMVAGYSIGGGHVLHMMCDLTVAADNAIFGQTGPKVGSFDGGWGAAYMARIVGQKKA
HHHHHHHCCCCCCHHHHHHHHHHHEECCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHH
REIWFLCRQYDAKQALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
DGQAGLQELAGNATMLFYMTDEGQEGRNAFNEKRQPDFSKFKRNP
CCCHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCCCHHHHCCCC
>Mature Secondary Structure
MLYPSEEQLYAAIDWLDCSAGFEDIRYHKSNDGIAKITINRPHVRNAFRPLTVKEMIQAL
CCCCCHHHHEEEEEHHCCCCCHHHHEEECCCCCEEEEEECCCHHHHCCCCCCHHHHHHHH
ADARYDDNIGVIILTGEGDKAFCSGGDQKVRGDYGGYQDNSGVHHLNVLDFQRQIRTCPK
HCCCCCCCCEEEEEECCCCCHHHCCCCCEECCCCCCCCCCCCCEEEHHHHHHHHHHCCCH
PVVAMVAGYSIGGGHVLHMMCDLTVAADNAIFGQTGPKVGSFDGGWGAAYMARIVGQKKA
HHHHHHHCCCCCCHHHHHHHHHHHEECCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHH
REIWFLCRQYDAKQALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
DGQAGLQELAGNATMLFYMTDEGQEGRNAFNEKRQPDFSKFKRNP
CCCHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]