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The map label for this gene is map [H]

Identifier: 108798021

GI number: 108798021

Start: 1146509

End: 1147312

Strand: Direct

Name: map [H]

Synonym: Mmcs_1048

Alternate gene names: 108798021

Gene position: 1146509-1147312 (Clockwise)

Preceding gene: 108798020

Following gene: 108798022

Centisome position: 20.09

GC content: 72.39

Gene sequence:

>804_bases
GTGGCCGGGCTGAGGCTGCGCAAGGAGAAGGTCGTCGCGCAACGCACCACCGCGGAGCTCGACGCGATGGCCGCCGCCGG
CGCGCTGGTCGCAGCGGCGCTGACCGCGGTGCGCGAAGCGGCCGTACCCGGCGTGAGCACCAAAGAACTCGACGCGATCG
CCGAAGCCGTCATCCGCGACGGCGGCGGCATCCCGTCGTTCCTCGGCTACCACGGTTTTCCCGCCAGCATCTGCTCCTCG
GTCAACGACCGGGTCGTCCACGGCATCCCGTCGGCCACCGAGACGCTGGCCTCCGGTGACCTGGTGTCCATCGACTGCGG
CGCCATCCTCGACGGCTGGCACGGCGACTCGGCGATCACCTTCGGGGTCGGCCCGCTCATCCCGGTCGACGAGGCGCTCT
CCGCGGCCACCCGCGAGTCCATGGAGGCGGGTATCGCCGCGATGGTGCCCGGTAACCGGCTGACCGACGTCTCCCACGCC
ATCGAGAAGGGCACCCGCGCCGCCGAGGCGCGCTACCAGCGGGGCTTCGGCATCGTCGACGGCTACGGCGGCCACGGCAT
CGGCAGGCAGATGCACATGGACCCGTTCCTGCCCAACGAGGGCGCCCCCGGCCGCGGTCCGCGCCTGGCCCCCGGTTCCG
TGCTGGCGATCGAGCCCATGCTCACGCTCGGCACCACGAAGACCAAGGTGCTCGACGACGAGTGGACGGTCGTCACCTCC
GACGGCTCCCGCGCGGCACACTGGGAGCACACCGTGGCGGTCACCGAGGACGGGCCCCGCATCCTCACGCTGCCCGCGGA
CTGA

Upstream 100 bases:

>100_bases
ACTCAAGACGGTCGACGCCGTCGGGTCTCTGGACGAGGTGTTCGCCCGGGCGCTGCAGGCGCTGGGTCGGTGAACCGACA
ATCAGGCAGGCGCAGATAAC

Downstream 100 bases:

>100_bases
ACCAAACCGCAGCCGGCGTCGTGTACCTGACGGAGGTTGGGGATGGACGATCCGGAAGCCACGATGATGCGCGTGCTCTA
CGACGAGCACGCCGATGCAT

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MAGLRLRKEKVVAQRTTAELDAMAAAGALVAAALTAVREAAVPGVSTKELDAIAEAVIRDGGGIPSFLGYHGFPASICSS
VNDRVVHGIPSATETLASGDLVSIDCGAILDGWHGDSAITFGVGPLIPVDEALSAATRESMEAGIAAMVPGNRLTDVSHA
IEKGTRAAEARYQRGFGIVDGYGGHGIGRQMHMDPFLPNEGAPGRGPRLAPGSVLAIEPMLTLGTTKTKVLDDEWTVVTS
DGSRAAHWEHTVAVTEDGPRILTLPAD

Sequences:

>Translated_267_residues
MAGLRLRKEKVVAQRTTAELDAMAAAGALVAAALTAVREAAVPGVSTKELDAIAEAVIRDGGGIPSFLGYHGFPASICSS
VNDRVVHGIPSATETLASGDLVSIDCGAILDGWHGDSAITFGVGPLIPVDEALSAATRESMEAGIAAMVPGNRLTDVSHA
IEKGTRAAEARYQRGFGIVDGYGGHGIGRQMHMDPFLPNEGAPGRGPRLAPGSVLAIEPMLTLGTTKTKVLDDEWTVVTS
DGSRAAHWEHTVAVTEDGPRILTLPAD
>Mature_266_residues
AGLRLRKEKVVAQRTTAELDAMAAAGALVAAALTAVREAAVPGVSTKELDAIAEAVIRDGGGIPSFLGYHGFPASICSSV
NDRVVHGIPSATETLASGDLVSIDCGAILDGWHGDSAITFGVGPLIPVDEALSAATRESMEAGIAAMVPGNRLTDVSHAI
EKGTRAAEARYQRGFGIVDGYGGHGIGRQMHMDPFLPNEGAPGRGPRLAPGSVLAIEPMLTLGTTKTKVLDDEWTVVTSD
GSRAAHWEHTVAVTEDGPRILTLPAD

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=252, Percent_Identity=33.7301587301587, Blast_Score=141, Evalue=5e-34,
Organism=Homo sapiens, GI40385867, Length=254, Percent_Identity=33.4645669291339, Blast_Score=140, Evalue=1e-33,
Organism=Escherichia coli, GI1786364, Length=257, Percent_Identity=37.7431906614786, Blast_Score=182, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI71996291, Length=260, Percent_Identity=35.7692307692308, Blast_Score=156, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6323273, Length=224, Percent_Identity=38.8392857142857, Blast_Score=147, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24583427, Length=254, Percent_Identity=35.8267716535433, Blast_Score=151, Evalue=4e-37,
Organism=Drosophila melanogaster, GI21355531, Length=245, Percent_Identity=35.5102040816327, Blast_Score=151, Evalue=5e-37,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 27578; Mature: 27446

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGLRLRKEKVVAQRTTAELDAMAAAGALVAAALTAVREAAVPGVSTKELDAIAEAVIRD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHC
GGGIPSFLGYHGFPASICSSVNDRVVHGIPSATETLASGDLVSIDCGAILDGWHGDSAIT
CCCCCHHHHCCCCHHHHHCCCCCCEEECCCHHHHHHCCCCEEEEECCCEEECCCCCCEEE
FGVGPLIPVDEALSAATRESMEAGIAAMVPGNRLTDVSHAIEKGTRAAEARYQRGFGIVD
ECCCCCCCHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHCCHHHHHHHHCCCCCEE
GYGGHGIGRQMHMDPFLPNEGAPGRGPRLAPGSVLAIEPMLTLGTTKTKVLDDEWTVVTS
CCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCEEEECCCEEECCCCCEEECCCEEEEEC
DGSRAAHWEHTVAVTEDGPRILTLPAD
CCCCCCCCEEEEEEECCCCEEEEECCC
>Mature Secondary Structure 
AGLRLRKEKVVAQRTTAELDAMAAAGALVAAALTAVREAAVPGVSTKELDAIAEAVIRD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHC
GGGIPSFLGYHGFPASICSSVNDRVVHGIPSATETLASGDLVSIDCGAILDGWHGDSAIT
CCCCCHHHHCCCCHHHHHCCCCCCEEECCCHHHHHHCCCCEEEEECCCEEECCCCCCEEE
FGVGPLIPVDEALSAATRESMEAGIAAMVPGNRLTDVSHAIEKGTRAAEARYQRGFGIVD
ECCCCCCCHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHCCHHHHHHHHCCCCCEE
GYGGHGIGRQMHMDPFLPNEGAPGRGPRLAPGSVLAIEPMLTLGTTKTKVLDDEWTVVTS
CCCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCEEEECCCEEECCCCCEEECCCEEEEEC
DGSRAAHWEHTVAVTEDGPRILTLPAD
CCCCCCCCEEEEEEECCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]