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The map label for this gene is adk

Identifier: 108798020

GI number: 108798020

Start: 1145936

End: 1146481

Strand: Direct

Name: adk

Synonym: Mmcs_1047

Alternate gene names: 108798020

Gene position: 1145936-1146481 (Clockwise)

Preceding gene: 108798019

Following gene: 108798021

Centisome position: 20.08

GC content: 67.95

Gene sequence:

>546_bases
TTGAGAATCGTTCTACTCGGACCGCCGGGTGCGGGCAAGGGCACGCAGGCGGCGAAGCTGGCCGACAAGCTGGGCGTCCC
GCACATCTCCACCGGCGATCTGTTCCGCGACAACATCACCAACGAGACCGAACTCGGGGTGGAGGCCAAGCGCTACCTCG
ACGCCGGTGACCTCGTCCCGAGCTCCCTCACCAACGCGCTGGTCGAGGACCGCATCGACCAGGACGACGCGAAGAACGGC
TTCATCCTCGACGGCTACCCCCGCTCGGTCGAACAGGCCGAGGCGCTCGGCGACATGCTCGCGGCCCGCAACCTGTCGCT
CGACGCGGTGATCGAATTCCGCGTCTCCGAGGACGAGCTGCTCTCCCGGCTCAAGGGCCGCGGTCGCGCCGACGACACCG
AAGAGGTCATCCTCAACCGGATGAAGGTCTACCGCGACGAGACGGCGCCGCTGCTCGACCACTACCGCGCCGAACTCAAG
ACGGTCGACGCCGTCGGGTCTCTGGACGAGGTGTTCGCCCGGGCGCTGCAGGCGCTGGGTCGGTGA

Upstream 100 bases:

>100_bases
ATCATGATCGGCGTGGGTCTGGACACCGTGAAACAGATCGAAAGCCAGCTCATGCAGCGCAACTACGAGGGCTTTTTGAA
GTGAGAGAGGGTTCGGTAAG

Downstream 100 bases:

>100_bases
ACCGACAATCAGGCAGGCGCAGATAACGTGGCCGGGCTGAGGCTGCGCAAGGAGAAGGTCGTCGCGCAACGCACCACCGC
GGAGCTCGACGCGATGGCCG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 181; Mature: 181

Protein sequence:

>181_residues
MRIVLLGPPGAGKGTQAAKLADKLGVPHISTGDLFRDNITNETELGVEAKRYLDAGDLVPSSLTNALVEDRIDQDDAKNG
FILDGYPRSVEQAEALGDMLAARNLSLDAVIEFRVSEDELLSRLKGRGRADDTEEVILNRMKVYRDETAPLLDHYRAELK
TVDAVGSLDEVFARALQALGR

Sequences:

>Translated_181_residues
MRIVLLGPPGAGKGTQAAKLADKLGVPHISTGDLFRDNITNETELGVEAKRYLDAGDLVPSSLTNALVEDRIDQDDAKNG
FILDGYPRSVEQAEALGDMLAARNLSLDAVIEFRVSEDELLSRLKGRGRADDTEEVILNRMKVYRDETAPLLDHYRAELK
TVDAVGSLDEVFARALQALGR
>Mature_181_residues
MRIVLLGPPGAGKGTQAAKLADKLGVPHISTGDLFRDNITNETELGVEAKRYLDAGDLVPSSLTNALVEDRIDQDDAKNG
FILDGYPRSVEQAEALGDMLAARNLSLDAVIEFRVSEDELLSRLKGRGRADDTEEVILNRMKVYRDETAPLLDHYRAELK
TVDAVGSLDEVFARALQALGR

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=214, Percent_Identity=36.9158878504673, Blast_Score=142, Evalue=2e-34,
Organism=Homo sapiens, GI4502013, Length=214, Percent_Identity=36.9158878504673, Blast_Score=142, Evalue=2e-34,
Organism=Homo sapiens, GI7706497, Length=188, Percent_Identity=32.9787234042553, Blast_Score=108, Evalue=2e-24,
Organism=Homo sapiens, GI4502011, Length=180, Percent_Identity=33.8888888888889, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI28144897, Length=184, Percent_Identity=34.2391304347826, Blast_Score=105, Evalue=1e-23,
Organism=Homo sapiens, GI28144899, Length=184, Percent_Identity=34.2391304347826, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI19923437, Length=189, Percent_Identity=30.6878306878307, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI310110345, Length=184, Percent_Identity=30.4347826086957, Blast_Score=94, Evalue=7e-20,
Organism=Homo sapiens, GI53832003, Length=184, Percent_Identity=30.4347826086957, Blast_Score=94, Evalue=7e-20,
Organism=Homo sapiens, GI8051579, Length=184, Percent_Identity=30.4347826086957, Blast_Score=94, Evalue=7e-20,
Organism=Homo sapiens, GI53832001, Length=184, Percent_Identity=30.4347826086957, Blast_Score=94, Evalue=7e-20,
Organism=Homo sapiens, GI22749187, Length=127, Percent_Identity=31.496062992126, Blast_Score=68, Evalue=4e-12,
Organism=Escherichia coli, GI1786680, Length=189, Percent_Identity=39.1534391534392, Blast_Score=134, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17552384, Length=217, Percent_Identity=34.1013824884793, Blast_Score=134, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17567503, Length=177, Percent_Identity=35.0282485875706, Blast_Score=108, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17533833, Length=176, Percent_Identity=29.5454545454545, Blast_Score=95, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17550688, Length=156, Percent_Identity=30.1282051282051, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17537943, Length=215, Percent_Identity=27.4418604651163, Blast_Score=73, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI25147457, Length=187, Percent_Identity=26.2032085561497, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320432, Length=215, Percent_Identity=34.4186046511628, Blast_Score=130, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6321018, Length=185, Percent_Identity=31.3513513513514, Blast_Score=91, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6322828, Length=168, Percent_Identity=32.1428571428571, Blast_Score=86, Evalue=3e-18,
Organism=Drosophila melanogaster, GI22026816, Length=211, Percent_Identity=36.4928909952607, Blast_Score=139, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24663208, Length=184, Percent_Identity=32.6086956521739, Blast_Score=104, Evalue=3e-23,
Organism=Drosophila melanogaster, GI17647141, Length=184, Percent_Identity=32.6086956521739, Blast_Score=104, Evalue=4e-23,
Organism=Drosophila melanogaster, GI17737899, Length=186, Percent_Identity=33.3333333333333, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24645822, Length=186, Percent_Identity=33.3333333333333, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI221459597, Length=179, Percent_Identity=29.608938547486, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI21356893, Length=179, Percent_Identity=29.608938547486, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24582962, Length=156, Percent_Identity=33.974358974359, Blast_Score=71, Evalue=4e-13,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_MYCSJ (A3PVF5)

Other databases:

- EMBL:   CP000580
- RefSeq:   YP_001069373.1
- ProteinModelPortal:   A3PVF5
- SMR:   A3PVF5
- STRING:   A3PVF5
- EnsemblBacteria:   EBMYCT00000050936
- GeneID:   4876815
- GenomeReviews:   CP000580_GR
- KEGG:   mjl:Mjls_1075
- eggNOG:   COG0563
- GeneTree:   EBGT00050000015504
- HOGENOM:   HBG630208
- OMA:   CGEGYHD
- ProtClustDB:   PRK00279
- BioCyc:   MSP164757:MJLS_1075-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK

EC number: =2.7.4.3

Molecular weight: Translated: 19763; Mature: 19763

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIVLLGPPGAGKGTQAAKLADKLGVPHISTGDLFRDNITNETELGVEAKRYLDAGDLVP
CEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHCHHHHHHCCCCCCCH
SSLTNALVEDRIDQDDAKNGFILDGYPRSVEQAEALGDMLAARNLSLDAVIEFRVSEDEL
HHHHHHHHHHHCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHCCCCHHHEEEEECCHHHH
LSRLKGRGRADDTEEVILNRMKVYRDETAPLLDHYRAELKTVDAVGSLDEVFARALQALG
HHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHC
R
C
>Mature Secondary Structure
MRIVLLGPPGAGKGTQAAKLADKLGVPHISTGDLFRDNITNETELGVEAKRYLDAGDLVP
CEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHCHHHHHHCCCCCCCH
SSLTNALVEDRIDQDDAKNGFILDGYPRSVEQAEALGDMLAARNLSLDAVIEFRVSEDEL
HHHHHHHHHHHCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHCCCCHHHEEEEECCHHHH
LSRLKGRGRADDTEEVILNRMKVYRDETAPLLDHYRAELKTVDAVGSLDEVFARALQALG
HHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHC
R
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA