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The map label for this gene is fabG [C]

Identifier: 108797576

GI number: 108797576

Start: 656181

End: 657101

Strand: Reverse

Name: fabG [C]

Synonym: Mmcs_0596

Alternate gene names: 108797576

Gene position: 657101-656181 (Counterclockwise)

Preceding gene: 108797581

Following gene: 108797575

Centisome position: 11.52

GC content: 69.16

Gene sequence:

>921_bases
ATGAGCGCGAACACCAAATGGACTGCGGCGGACGTGCCCGACCAGGAAGGCCGTGTCGCCGTCATCACCGGCGCCAACAC
GGGTATCGGTTACGAGGCGGCGGCGGTGCTGGCCGCCAAGGGCGCCCACGTGGTGCTCGCGGTGCGCAACACCGACAAGG
GCGGCGCCGCGGCCGAGCGCATCCGTTCTGCGCTGCCGCATGCGGACGTGACCGTGCGCGAACTCGACCTGACGTCGCTG
GACAGCATCCGCGAGGCCGCGGACGGGCTGCGCGCCGACTATCCGCGGATCGACCTGCTGATCAACAACGCGGGCGTGAT
GATGACCGAGAAGGGCGCTACCAAGGACGGTTTCGAGCTCCAGCTCGGCACCAACCACCTCGGCCACTTCGCGCTCACCG
GCCAACTGCTCGACAACCTGCTCCCCGTCGAGGGGTCGCGGGTGGTGACCGTCAGCAGCAACGCCCACCGGTGGGGCCGC
GTGAACTTCGACGATCTGCAGTCCGAGCGCAGCTACAACCGGGTCACCGCCTACGGGCAGAGCAAGCTGGCCAACCTGCT
GTTCACCTATGAGCTCAACCGCCGACTGTCGGCGAAGGGTGCGCCGACCATCGCCGTCGCCGCCCATCCCGGGACATCGA
GTACCGAGCTGACCCGCAACCTGTGGCCGGTGGCCCGCCGGCCCGTCGAACTCGTCTGGGGACTTGTCGCGCAGACACCG
GAGATGGGTGCGTTGCCGACACTGCGGGCAGCCACCGACCCGGACGTGCGCGGCGGGCAGTACTACGGCCCCGACGGCAT
CGGGGAACAACGCGGCCACCCGAAGCTCGTGCAGTCCAACGCCCGCTCGTACGACGAGGCCGCACAGCGCCGGTTGTGGA
GCGTGTCCGAGGAACTCACCGGCGTCACGTTCCCCGTCTGA

Upstream 100 bases:

>100_bases
TCGGCCGGTGCTCGGGATCTGCCAGAACGAGGGGCGCGTACTCCATGGTCCGAGCATGGCTCATCGGGGGCCGACGGCGG
GAGGCCAGTAGGGTTTCCCC

Downstream 100 bases:

>100_bases
ACATGCGGACTGTCGAAGAGCACCAGCGCGTCGTCGCCGGGCTGATCGAGCGGCGTCCACCCGTCCGTCTGCCGATCGCC
GCCACGCTCGGTCTCACATT

Product: short chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MSANTKWTAADVPDQEGRVAVITGANTGIGYEAAAVLAAKGAHVVLAVRNTDKGGAAAERIRSALPHADVTVRELDLTSL
DSIREAADGLRADYPRIDLLINNAGVMMTEKGATKDGFELQLGTNHLGHFALTGQLLDNLLPVEGSRVVTVSSNAHRWGR
VNFDDLQSERSYNRVTAYGQSKLANLLFTYELNRRLSAKGAPTIAVAAHPGTSSTELTRNLWPVARRPVELVWGLVAQTP
EMGALPTLRAATDPDVRGGQYYGPDGIGEQRGHPKLVQSNARSYDEAAQRRLWSVSEELTGVTFPV

Sequences:

>Translated_306_residues
MSANTKWTAADVPDQEGRVAVITGANTGIGYEAAAVLAAKGAHVVLAVRNTDKGGAAAERIRSALPHADVTVRELDLTSL
DSIREAADGLRADYPRIDLLINNAGVMMTEKGATKDGFELQLGTNHLGHFALTGQLLDNLLPVEGSRVVTVSSNAHRWGR
VNFDDLQSERSYNRVTAYGQSKLANLLFTYELNRRLSAKGAPTIAVAAHPGTSSTELTRNLWPVARRPVELVWGLVAQTP
EMGALPTLRAATDPDVRGGQYYGPDGIGEQRGHPKLVQSNARSYDEAAQRRLWSVSEELTGVTFPV
>Mature_305_residues
SANTKWTAADVPDQEGRVAVITGANTGIGYEAAAVLAAKGAHVVLAVRNTDKGGAAAERIRSALPHADVTVRELDLTSLD
SIREAADGLRADYPRIDLLINNAGVMMTEKGATKDGFELQLGTNHLGHFALTGQLLDNLLPVEGSRVVTVSSNAHRWGRV
NFDDLQSERSYNRVTAYGQSKLANLLFTYELNRRLSAKGAPTIAVAAHPGTSSTELTRNLWPVARRPVELVWGLVAQTPE
MGALPTLRAATDPDVRGGQYYGPDGIGEQRGHPKLVQSNARSYDEAAQRRLWSVSEELTGVTFPV

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI166795268, Length=288, Percent_Identity=43.4027777777778, Blast_Score=201, Evalue=5e-52,
Organism=Homo sapiens, GI186928839, Length=291, Percent_Identity=43.6426116838488, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI10190746, Length=303, Percent_Identity=39.9339933993399, Blast_Score=189, Evalue=2e-48,
Organism=Homo sapiens, GI225579078, Length=296, Percent_Identity=41.2162162162162, Blast_Score=188, Evalue=7e-48,
Organism=Homo sapiens, GI193804850, Length=296, Percent_Identity=37.8378378378378, Blast_Score=176, Evalue=2e-44,
Organism=Homo sapiens, GI19923931, Length=261, Percent_Identity=40.6130268199234, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI7706523, Length=300, Percent_Identity=34.6666666666667, Blast_Score=148, Evalue=7e-36,
Organism=Homo sapiens, GI146231950, Length=292, Percent_Identity=39.3835616438356, Blast_Score=145, Evalue=3e-35,
Organism=Homo sapiens, GI13375997, Length=174, Percent_Identity=29.3103448275862, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI72534732, Length=166, Percent_Identity=29.5180722891566, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17558006, Length=296, Percent_Identity=32.0945945945946, Blast_Score=133, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI17532805, Length=303, Percent_Identity=33.003300330033, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI193207620, Length=311, Percent_Identity=30.8681672025724, Blast_Score=118, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17532791, Length=298, Percent_Identity=30.8724832214765, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71992402, Length=299, Percent_Identity=33.4448160535117, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI72001364, Length=299, Percent_Identity=32.7759197324415, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17505416, Length=246, Percent_Identity=30.4878048780488, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17535059, Length=299, Percent_Identity=31.438127090301, Blast_Score=97, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI32565532, Length=211, Percent_Identity=33.6492890995261, Blast_Score=91, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI115533174, Length=294, Percent_Identity=26.530612244898, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI115533172, Length=294, Percent_Identity=26.530612244898, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71997402, Length=143, Percent_Identity=35.6643356643357, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324820, Length=331, Percent_Identity=27.4924471299094, Blast_Score=106, Evalue=6e-24,
Organism=Drosophila melanogaster, GI22024069, Length=297, Percent_Identity=43.7710437710438, Blast_Score=206, Evalue=1e-53,
Organism=Drosophila melanogaster, GI28573296, Length=296, Percent_Identity=43.5810810810811, Blast_Score=201, Evalue=4e-52,
Organism=Drosophila melanogaster, GI19921754, Length=296, Percent_Identity=42.5675675675676, Blast_Score=199, Evalue=1e-51,
Organism=Drosophila melanogaster, GI161076371, Length=256, Percent_Identity=43.359375, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24586328, Length=294, Percent_Identity=40.1360544217687, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI45554248, Length=252, Percent_Identity=43.2539682539683, Blast_Score=168, Evalue=5e-42,
Organism=Drosophila melanogaster, GI24640117, Length=252, Percent_Identity=43.2539682539683, Blast_Score=168, Evalue=5e-42,
Organism=Drosophila melanogaster, GI45553409, Length=293, Percent_Identity=33.1058020477816, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24647948, Length=293, Percent_Identity=33.1058020477816, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24647946, Length=293, Percent_Identity=33.1058020477816, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI20129347, Length=300, Percent_Identity=33.3333333333333, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24656154, Length=261, Percent_Identity=36.3984674329502, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI19922628, Length=261, Percent_Identity=36.3984674329502, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24647931, Length=273, Percent_Identity=34.0659340659341, Blast_Score=111, Evalue=6e-25,
Organism=Drosophila melanogaster, GI21358495, Length=212, Percent_Identity=30.188679245283, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI21357041, Length=214, Percent_Identity=30.3738317757009, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 32918; Mature: 32787

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSANTKWTAADVPDQEGRVAVITGANTGIGYEAAAVLAAKGAHVVLAVRNTDKGGAAAER
CCCCCCEEECCCCCCCCCEEEEECCCCCCCHHHHHHEEECCCEEEEEEECCCCCCHHHHH
IRSALPHADVTVRELDLTSLDSIREAADGLRADYPRIDLLINNAGVMMTEKGATKDGFEL
HHHHCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEECCCCCCCCEEE
QLGTNHLGHFALTGQLLDNLLPVEGSRVVTVSSNAHRWGRVNFDDLQSERSYNRVTAYGQ
EECCCCCCHHEEHHHHHHCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHCCCHHHHHCH
SKLANLLFTYELNRRLSAKGAPTIAVAAHPGTSSTELTRNLWPVARRPVELVWGLVAQTP
HHHHHEEEEEEECCEECCCCCCEEEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCC
EMGALPTLRAATDPDVRGGQYYGPDGIGEQRGHPKLVQSNARSYDEAAQRRLWSVSEELT
CCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHC
GVTFPV
CCCCCC
>Mature Secondary Structure 
SANTKWTAADVPDQEGRVAVITGANTGIGYEAAAVLAAKGAHVVLAVRNTDKGGAAAER
CCCCCEEECCCCCCCCCEEEEECCCCCCCHHHHHHEEECCCEEEEEEECCCCCCHHHHH
IRSALPHADVTVRELDLTSLDSIREAADGLRADYPRIDLLINNAGVMMTEKGATKDGFEL
HHHHCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEECCCCCCCCEEE
QLGTNHLGHFALTGQLLDNLLPVEGSRVVTVSSNAHRWGRVNFDDLQSERSYNRVTAYGQ
EECCCCCCHHEEHHHHHHCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHCCCHHHHHCH
SKLANLLFTYELNRRLSAKGAPTIAVAAHPGTSSTELTRNLWPVARRPVELVWGLVAQTP
HHHHHEEEEEEECCEECCCCCCEEEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCC
EMGALPTLRAATDPDVRGGQYYGPDGIGEQRGHPKLVQSNARSYDEAAQRRLWSVSEELT
CCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHC
GVTFPV
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8383668 [H]