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The map label for this gene is moaE2 [H]

Identifier: 108797575

GI number: 108797575

Start: 654982

End: 656178

Strand: Reverse

Name: moaE2 [H]

Synonym: Mmcs_0595

Alternate gene names: 108797575

Gene position: 656178-654982 (Counterclockwise)

Preceding gene: 108797576

Following gene: 108797574

Centisome position: 11.5

GC content: 72.18

Gene sequence:

>1197_bases
ATGCGGACTGTCGAAGAGCACCAGCGCGTCGTCGCCGGGCTGATCGAGCGGCGTCCACCCGTCCGTCTGCCGATCGCCGC
CACGCTCGGTCTCACATTGGCCGAGGACATCGTCGCGCCGTTGTCGCTGCCGGGGTTCGACAACTCCGCGATGGACGGGT
ACGCCGTCGTCGCCGAGGACGTCGCGGACGCGACCGAGGACCGGCCGGTGTATCTGCCGGTCGCCGAGGACATCCCCGCC
GGGCGCACCGATCCGCTGGTGCTGCAACCGGGTACGGCGCACCGCATCATGACCGGCGCACCGCTGCCGCGCGGGGCGAC
CGCGGTGGTCCCGGTCGAGGCGACGAACGCCGCCACCGACACCGTCGCGATCCGGTCCGCGGCCAAGGCCGGCCAGCACG
TCCGTACCGCCGGTGAGGACGTCACCGCGGGTACCACGGTCCTGCGGGCCGGGGTCGCGCTCACCCCGGCGGCCCTGGGT
CTGGCGGCCGCGCTCGGCCTCGGCGAGTTGTCGGTCATCGCTCCGCAGCGGGTGCTGGTCATGTCGACGGGGACCGAACT
GGTCGCGCCGGGCATCCCGCTGCTGCCGGGTCAGATCTACGAGTCCAACGCCGTCATGCTCGCCGCCGCCGTCCGGGAGG
CGGGCGGTGAGGTGGTCGCCTCGACGATGACCGGTGACGACGTGGACGCCTTCCGGGCGACGCTGGACCGGTACGCCGGA
CAGGCGGATCTGATTGTCACCACCGGCGGCGTCAGCGCGGGCGCGTACGAGGTCGTCAAGGACACGCTTGGTTCCAGCGA
GGTCGAGTTCGCCAAGGTCGCCATGCAGCCCGGTATGCCGCAGGGCGCGGGCCGGGTCGGGGAGACACCCGTCATCACCC
TGCCGGGCAATCCGGTCAGCGCGCTGGTCTCGTTCGAGGTGTTCCTACGGGCGCCGCTGCGCGCGGCGATGGGGGCGGAC
CGGCCCGAACGTCCGCGCCGCAGCGCGGTGCTGACCGAGGATCTGACGTCGCCGCGCGGTAAACGCCAGTTCCGGCGCGG
GGTGTTCGACCAGCACACCGGCGAGGTCACGAGCTACGGTCCCCCGGCGTCACACCACCTGCGCTGGCTGGCGTCGGCCA
ACTGCCTCCTCGAGATCCCCGAAGACGTCAGCGAGCTACCCGCCGGATCGCGGGTAGAAGTATGGGACCTGAGCTAG

Upstream 100 bases:

>100_bases
AGCTCGTGCAGTCCAACGCCCGCTCGTACGACGAGGCCGCACAGCGCCGGTTGTGGAGCGTGTCCGAGGAACTCACCGGC
GTCACGTTCCCCGTCTGAAC

Downstream 100 bases:

>100_bases
CCTGCCCGACACCCCACGCACGTAGAATCCAGCCGATGGCCAGACGCCCCAGCACCGATGACCTGAGATCCGGCCCAGAG
CGGTTCATGGCGCTGGTGAA

Product: molybdopterin molybdochelatase

Products: NA

Alternate protein names: MPT Mo-transferase 2 [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MRTVEEHQRVVAGLIERRPPVRLPIAATLGLTLAEDIVAPLSLPGFDNSAMDGYAVVAEDVADATEDRPVYLPVAEDIPA
GRTDPLVLQPGTAHRIMTGAPLPRGATAVVPVEATNAATDTVAIRSAAKAGQHVRTAGEDVTAGTTVLRAGVALTPAALG
LAAALGLGELSVIAPQRVLVMSTGTELVAPGIPLLPGQIYESNAVMLAAAVREAGGEVVASTMTGDDVDAFRATLDRYAG
QADLIVTTGGVSAGAYEVVKDTLGSSEVEFAKVAMQPGMPQGAGRVGETPVITLPGNPVSALVSFEVFLRAPLRAAMGAD
RPERPRRSAVLTEDLTSPRGKRQFRRGVFDQHTGEVTSYGPPASHHLRWLASANCLLEIPEDVSELPAGSRVEVWDLS

Sequences:

>Translated_398_residues
MRTVEEHQRVVAGLIERRPPVRLPIAATLGLTLAEDIVAPLSLPGFDNSAMDGYAVVAEDVADATEDRPVYLPVAEDIPA
GRTDPLVLQPGTAHRIMTGAPLPRGATAVVPVEATNAATDTVAIRSAAKAGQHVRTAGEDVTAGTTVLRAGVALTPAALG
LAAALGLGELSVIAPQRVLVMSTGTELVAPGIPLLPGQIYESNAVMLAAAVREAGGEVVASTMTGDDVDAFRATLDRYAG
QADLIVTTGGVSAGAYEVVKDTLGSSEVEFAKVAMQPGMPQGAGRVGETPVITLPGNPVSALVSFEVFLRAPLRAAMGAD
RPERPRRSAVLTEDLTSPRGKRQFRRGVFDQHTGEVTSYGPPASHHLRWLASANCLLEIPEDVSELPAGSRVEVWDLS
>Mature_398_residues
MRTVEEHQRVVAGLIERRPPVRLPIAATLGLTLAEDIVAPLSLPGFDNSAMDGYAVVAEDVADATEDRPVYLPVAEDIPA
GRTDPLVLQPGTAHRIMTGAPLPRGATAVVPVEATNAATDTVAIRSAAKAGQHVRTAGEDVTAGTTVLRAGVALTPAALG
LAAALGLGELSVIAPQRVLVMSTGTELVAPGIPLLPGQIYESNAVMLAAAVREAGGEVVASTMTGDDVDAFRATLDRYAG
QADLIVTTGGVSAGAYEVVKDTLGSSEVEFAKVAMQPGMPQGAGRVGETPVITLPGNPVSALVSFEVFLRAPLRAAMGAD
RPERPRRSAVLTEDLTSPRGKRQFRRGVFDQHTGEVTSYGPPASHHLRWLASANCLLEIPEDVSELPAGSRVEVWDLS

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=389, Percent_Identity=34.9614395886889, Blast_Score=171, Evalue=8e-43,
Organism=Homo sapiens, GI10880983, Length=389, Percent_Identity=34.9614395886889, Blast_Score=171, Evalue=9e-43,
Organism=Escherichia coli, GI1787049, Length=365, Percent_Identity=38.3561643835616, Blast_Score=218, Evalue=7e-58,
Organism=Caenorhabditis elegans, GI25147659, Length=374, Percent_Identity=28.8770053475936, Blast_Score=128, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17562606, Length=322, Percent_Identity=25.4658385093168, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17136978, Length=391, Percent_Identity=28.3887468030691, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24638841, Length=391, Percent_Identity=28.3887468030691, Blast_Score=127, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 41384; Mature: 41384

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTVEEHQRVVAGLIERRPPVRLPIAATLGLTLAEDIVAPLSLPGFDNSAMDGYAVVAED
CCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEHH
VADATEDRPVYLPVAEDIPAGRTDPLVLQPGTAHRIMTGAPLPRGATAVVPVEATNAATD
HHCCCCCCEEEEEECCCCCCCCCCCEEECCCCCCEEEECCCCCCCCEEEEEEECCCCCCH
TVAIRSAAKAGQHVRTAGEDVTAGTTVLRAGVALTPAALGLAAALGLGELSVIAPQRVLV
HHHHHHHHHCCHHHHHCCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCCCEEEECCCEEEE
MSTGTELVAPGIPLLPGQIYESNAVMLAAAVREAGGEVVASTMTGDDVDAFRATLDRYAG
EECCCHHHCCCCCCCCCCEECCCCEEEEHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCC
QADLIVTTGGVSAGAYEVVKDTLGSSEVEFAKVAMQPGMPQGAGRVGETPVITLPGNPVS
CCEEEEEECCCCCCHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCHH
ALVSFEVFLRAPLRAAMGADRPERPRRSAVLTEDLTSPRGKRQFRRGVFDQHTGEVTSYG
HHHHHHHHHHHHHHHHHCCCCCCCCCHHEEHHHHHCCCHHHHHHHHCCCCCCCCCCCCCC
PPASHHLRWLASANCLLEIPEDVSELPAGSRVEVWDLS
CCHHHHHHHHHCCCEEEECCHHHHHCCCCCEEEEEECC
>Mature Secondary Structure
MRTVEEHQRVVAGLIERRPPVRLPIAATLGLTLAEDIVAPLSLPGFDNSAMDGYAVVAED
CCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEHH
VADATEDRPVYLPVAEDIPAGRTDPLVLQPGTAHRIMTGAPLPRGATAVVPVEATNAATD
HHCCCCCCEEEEEECCCCCCCCCCCEEECCCCCCEEEECCCCCCCCEEEEEEECCCCCCH
TVAIRSAAKAGQHVRTAGEDVTAGTTVLRAGVALTPAALGLAAALGLGELSVIAPQRVLV
HHHHHHHHHCCHHHHHCCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCCCEEEECCCEEEE
MSTGTELVAPGIPLLPGQIYESNAVMLAAAVREAGGEVVASTMTGDDVDAFRATLDRYAG
EECCCHHHCCCCCCCCCCEECCCCEEEEHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCC
QADLIVTTGGVSAGAYEVVKDTLGSSEVEFAKVAMQPGMPQGAGRVGETPVITLPGNPVS
CCEEEEEECCCCCCHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCHH
ALVSFEVFLRAPLRAAMGADRPERPRRSAVLTEDLTSPRGKRQFRRGVFDQHTGEVTSYG
HHHHHHHHHHHHHHHHHCCCCCCCCCHHEEHHHHHCCCHHHHHHHHCCCCCCCCCCCCCC
PPASHHLRWLASANCLLEIPEDVSELPAGSRVEVWDLS
CCHHHHHHHHHCCCEEEECCHHHHHCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]