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The map label for this gene is bfmBAA [H]

Identifier: 108760073

GI number: 108760073

Start: 5696942

End: 5697952

Strand: Direct

Name: bfmBAA [H]

Synonym: MXAN_4564

Alternate gene names: 108760073

Gene position: 5696942-5697952 (Clockwise)

Preceding gene: 108761536

Following gene: 108757679

Centisome position: 62.33

GC content: 66.57

Gene sequence:

>1011_bases
GTGTCTCGTCCCCGACTCATCAAAGAATCCTCAGAAGCGTCCGCGCCGCTCGAGCGGGAGCTGCTGGTCCGCATCCATGA
CCTCATGGTGAAGACGCGCGTCCTCGAGGAGCGCCTCATCCAGATGTACAAGCAAGGCCACGGATACTTCTGGATTGGCG
GCCCCGGCGAGGAGGCGTTCAACGTCTCCCTGGGCCTGCTCATGAAGAAGGGCCAGGGCCCCGACTTCGACTATCTGCAT
GCGCACTACCGGCAGTCCGGCACCCTGCTCGCGCTGGGTGAGGAGCCCATCGGCTCCCTGCGGCAGATGAAGAACACGGC
CACGGACCCGTATTCGGGCGGCCGCAACTTCGCGGGCCACTACTCCGCCCGGAAGTACAACGTGGCGCCGGTGTCCTCGC
CCATCGAGGTCCAGTACGCCATCGCCCCGGGCACGGCCATGGTGCAGAAGCGCCACGGCGGTGACGGCATCACCATCGTC
ACCGGTGGCGACGCCGGCACGGCCGAGGGCGATTTCGCCTCGTGCCTGGTGTGGAGCAGCCGCCCCGCCAACCCGCTGCC
CATCCTCATCATCGTCACCAACAACAAGTGGGGCATCTCCACGGCGGCGGAGGGCCAGCACGGCGAGCAGCGCATCAGCG
ACCGCGGCAAGGCCTTTGGCATCCGCAGCAAGACCATCAACGGCAACGACGCCGTGGAGGCCTACACCGAGCTGCGCGAG
GCCATGGCCTACGTGCGCACGGAGCGCAAGCCCTTCCTCCTGGAGGCCAACGTGTCGCGCCTGTACGGCCACTCGTCCGC
CTCCGGAGCCAACTACGTGAGCAACGAAGTCGACTGCCTCACGGACTTCGAGGCGAAGCTGGAGAAGGACGGCGTCCTGA
CGCGAGAGCAGATGGACGCGCTGCGCAACAGCTACACCGAGGAGATGGCCGCCGCCGCCCGACAGGTGCGCGACGAGCCA
CAGCCCGACCCCGAATCCATCTGGAAGCACATCTACGCGGAGGACAAGTAA

Upstream 100 bases:

>100_bases
TCTCCGCCTGACGTCCGGCAGGCGGCCCATCAACTGCCTTGAGCGGGAGGCACGTATCCGGGTTATAGGGGCGTCCCCTC
CAGCCAGAGGAAGGTCGCGC

Downstream 100 bases:

>100_bases
CCCATGGCGAACATGGCACAGGCCATCCGCATGGCCCTGCACTACGCCGAGGAGCACCTGGGCGTCACCGACATCTTCGG
CGAGGACGTGGGCGCCCCCC

Product: 2-oxoisovalerate dehydrogenase complex, E1 component subunit alpha

Products: NA

Alternate protein names: Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDH E1-alpha [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MSRPRLIKESSEASAPLERELLVRIHDLMVKTRVLEERLIQMYKQGHGYFWIGGPGEEAFNVSLGLLMKKGQGPDFDYLH
AHYRQSGTLLALGEEPIGSLRQMKNTATDPYSGGRNFAGHYSARKYNVAPVSSPIEVQYAIAPGTAMVQKRHGGDGITIV
TGGDAGTAEGDFASCLVWSSRPANPLPILIIVTNNKWGISTAAEGQHGEQRISDRGKAFGIRSKTINGNDAVEAYTELRE
AMAYVRTERKPFLLEANVSRLYGHSSASGANYVSNEVDCLTDFEAKLEKDGVLTREQMDALRNSYTEEMAAAARQVRDEP
QPDPESIWKHIYAEDK

Sequences:

>Translated_336_residues
MSRPRLIKESSEASAPLERELLVRIHDLMVKTRVLEERLIQMYKQGHGYFWIGGPGEEAFNVSLGLLMKKGQGPDFDYLH
AHYRQSGTLLALGEEPIGSLRQMKNTATDPYSGGRNFAGHYSARKYNVAPVSSPIEVQYAIAPGTAMVQKRHGGDGITIV
TGGDAGTAEGDFASCLVWSSRPANPLPILIIVTNNKWGISTAAEGQHGEQRISDRGKAFGIRSKTINGNDAVEAYTELRE
AMAYVRTERKPFLLEANVSRLYGHSSASGANYVSNEVDCLTDFEAKLEKDGVLTREQMDALRNSYTEEMAAAARQVRDEP
QPDPESIWKHIYAEDK
>Mature_335_residues
SRPRLIKESSEASAPLERELLVRIHDLMVKTRVLEERLIQMYKQGHGYFWIGGPGEEAFNVSLGLLMKKGQGPDFDYLHA
HYRQSGTLLALGEEPIGSLRQMKNTATDPYSGGRNFAGHYSARKYNVAPVSSPIEVQYAIAPGTAMVQKRHGGDGITIVT
GGDAGTAEGDFASCLVWSSRPANPLPILIIVTNNKWGISTAAEGQHGEQRISDRGKAFGIRSKTINGNDAVEAYTELREA
MAYVRTERKPFLLEANVSRLYGHSSASGANYVSNEVDCLTDFEAKLEKDGVLTREQMDALRNSYTEEMAAAARQVRDEPQ
PDPESIWKHIYAEDK

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltran

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BCKDHA family [H]

Homologues:

Organism=Homo sapiens, GI11386135, Length=333, Percent_Identity=24.9249249249249, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI258645172, Length=333, Percent_Identity=24.9249249249249, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI4885543, Length=346, Percent_Identity=23.6994219653179, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI291084742, Length=341, Percent_Identity=23.4604105571848, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI4505685, Length=341, Percent_Identity=23.4604105571848, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI291084744, Length=347, Percent_Identity=23.0547550432277, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI86563357, Length=282, Percent_Identity=27.3049645390071, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI86563355, Length=282, Percent_Identity=27.3049645390071, Blast_Score=98, Evalue=5e-21,
Organism=Drosophila melanogaster, GI21355903, Length=335, Percent_Identity=24.4776119402985, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24639744, Length=347, Percent_Identity=21.3256484149856, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI28571106, Length=347, Percent_Identity=21.3256484149856, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24639740, Length=347, Percent_Identity=21.3256484149856, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.4 [H]

Molecular weight: Translated: 37106; Mature: 36975

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRPRLIKESSEASAPLERELLVRIHDLMVKTRVLEERLIQMYKQGHGYFWIGGPGEEAF
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHH
NVSLGLLMKKGQGPDFDYLHAHYRQSGTLLALGEEPIGSLRQMKNTATDPYSGGRNFAGH
EEEEEEEEECCCCCCHHHHHHHHCCCCCEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCC
YSARKYNVAPVSSPIEVQYAIAPGTAMVQKRHGGDGITIVTGGDAGTAEGDFASCLVWSS
CCCCEEECCCCCCCCEEEEEECCCHHHHHHCCCCCEEEEEECCCCCCCCCCCEEEEEECC
RPANPLPILIIVTNNKWGISTAAEGQHGEQRISDRGKAFGIRSKTINGNDAVEAYTELRE
CCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHH
AMAYVRTERKPFLLEANVSRLYGHSSASGANYVSNEVDCLTDFEAKLEKDGVLTREQMDA
HHHHHHCCCCCEEEECCHHHHHCCCCCCCCCHHCCCHHHHHHHHHHHHHCCCCCHHHHHH
LRNSYTEEMAAAARQVRDEPQPDPESIWKHIYAEDK
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure 
SRPRLIKESSEASAPLERELLVRIHDLMVKTRVLEERLIQMYKQGHGYFWIGGPGEEAF
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHH
NVSLGLLMKKGQGPDFDYLHAHYRQSGTLLALGEEPIGSLRQMKNTATDPYSGGRNFAGH
EEEEEEEEECCCCCCHHHHHHHHCCCCCEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCC
YSARKYNVAPVSSPIEVQYAIAPGTAMVQKRHGGDGITIVTGGDAGTAEGDFASCLVWSS
CCCCEEECCCCCCCCEEEEEECCCHHHHHHCCCCCEEEEEECCCCCCCCCCCEEEEEECC
RPANPLPILIIVTNNKWGISTAAEGQHGEQRISDRGKAFGIRSKTINGNDAVEAYTELRE
CCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHH
AMAYVRTERKPFLLEANVSRLYGHSSASGANYVSNEVDCLTDFEAKLEKDGVLTREQMDA
HHHHHHCCCCCEEEECCHHHHHCCCCCCCCCHHCCCHHHHHHHHHHHHHCCCCCHHHHHH
LRNSYTEEMAAAARQVRDEPQPDPESIWKHIYAEDK
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8504804; 8969508; 9384377 [H]