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The map label for this gene is bkdA2 [H]

Identifier: 108757679

GI number: 108757679

Start: 5697956

End: 5699014

Strand: Direct

Name: bkdA2 [H]

Synonym: MXAN_4565

Alternate gene names: 108757679

Gene position: 5697956-5699014 (Clockwise)

Preceding gene: 108760073

Following gene: 108758448

Centisome position: 62.34

GC content: 68.74

Gene sequence:

>1059_bases
ATGGCGAACATGGCACAGGCCATCCGCATGGCCCTGCACTACGCCGAGGAGCACCTGGGCGTCACCGACATCTTCGGCGA
GGACGTGGGCGCCCCCCTGGGCGGCGTCTTCACCTGCACGCAGGGCCTGAAGACGACGTGGAACTCTCCCCTGGACGAGC
GCGGCATCATCGGCGCGGCCATGGGCATCGCCATGGCCGGCGGACGGCCGGTGGCGGAGATCCAGTTCTGCGACTACGTC
TACAACACCATCGACCTGCTGAAGCTGGCGGGCAACACCAGCTGGTCCACCTTCGGTGACTGGAACCTGCCCATGGTGGT
GCGCACGCCGGTGGGCAGCGGCATCCGCGGGTCCATCTACCACTCGCACTCGTTCGACGCGACGATGACCCACATCGCCG
GGTGGAAGGTGGTCATGCCCTCCACGCCGCTGGACGCGTACGGGCTGCTCATCACCGCGTGCCAGGAGAAGAACCCCGTC
ATGTTCCTGGAGCCCAAGGCGCTCCTGCGCGTGAAGGGCGAGGAGCGGATTCCGGGCGAGCCGGAGGATGACCGCGCGCT
GTCGAAGCTCATCGACGCGCCGCTGGGAGACCGCTCCCAGTGGAAGCCGCAGTGGCCCACGGGCCTGGAGGCGTACGCGG
TGCCCTTCGGCAAGGGCAAGATCGTGCGCGAGGGCACGCAGCTCACCGTGGTGAGCTACGGCCGCACCCTGCCCCTGTGC
ACGAAGGCCGCGGAGACGCTGGCCGCGGACGGAATCAGCGCGGAGGTCATCGACCTGCGCTCGCTGTGGCCGTACGACTG
GGAGCTCATCAAGGCCTCCGTCCAGAAGACGGGCCGCGTCCTCTTCGTCAACGAGGACACCGAAGTGACGAACTTCGGCG
AGCACCTGGTGCGCCGCACGGTGGAGGAGCTGTTCTACTCGCTGCTGGCCCCGCCGCGGCTGCTGGCCGGCAAGTTCCTG
CCGGGCATCGGCCTGGCGGACGCGCTGGAGATGGCGTCGGTGCCGCAACTGGGTGACATCACCACCGCCATCCGGTCGCT
CGCGGGCGAGCAGCCGTAA

Upstream 100 bases:

>100_bases
CACCGAGGAGATGGCCGCCGCCGCCCGACAGGTGCGCGACGAGCCACAGCCCGACCCCGAATCCATCTGGAAGCACATCT
ACGCGGAGGACAAGTAACCC

Downstream 100 bases:

>100_bases
GAGCGGCACCCACAATCCCCTGCTCGTGAGCCCCTTGTCTCACGGGAGAAGCACCCCGGGCCGCCATTCCTCTTTGAAGG
GATGGCGGCCCATTCGTTAG

Product: 2-oxoisovalerate dehydrogenase complex, E1 component subunit beta

Products: NA

Alternate protein names: Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDH E1-beta [H]

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MANMAQAIRMALHYAEEHLGVTDIFGEDVGAPLGGVFTCTQGLKTTWNSPLDERGIIGAAMGIAMAGGRPVAEIQFCDYV
YNTIDLLKLAGNTSWSTFGDWNLPMVVRTPVGSGIRGSIYHSHSFDATMTHIAGWKVVMPSTPLDAYGLLITACQEKNPV
MFLEPKALLRVKGEERIPGEPEDDRALSKLIDAPLGDRSQWKPQWPTGLEAYAVPFGKGKIVREGTQLTVVSYGRTLPLC
TKAAETLAADGISAEVIDLRSLWPYDWELIKASVQKTGRVLFVNEDTEVTNFGEHLVRRTVEELFYSLLAPPRLLAGKFL
PGIGLADALEMASVPQLGDITTAIRSLAGEQP

Sequences:

>Translated_352_residues
MANMAQAIRMALHYAEEHLGVTDIFGEDVGAPLGGVFTCTQGLKTTWNSPLDERGIIGAAMGIAMAGGRPVAEIQFCDYV
YNTIDLLKLAGNTSWSTFGDWNLPMVVRTPVGSGIRGSIYHSHSFDATMTHIAGWKVVMPSTPLDAYGLLITACQEKNPV
MFLEPKALLRVKGEERIPGEPEDDRALSKLIDAPLGDRSQWKPQWPTGLEAYAVPFGKGKIVREGTQLTVVSYGRTLPLC
TKAAETLAADGISAEVIDLRSLWPYDWELIKASVQKTGRVLFVNEDTEVTNFGEHLVRRTVEELFYSLLAPPRLLAGKFL
PGIGLADALEMASVPQLGDITTAIRSLAGEQP
>Mature_351_residues
ANMAQAIRMALHYAEEHLGVTDIFGEDVGAPLGGVFTCTQGLKTTWNSPLDERGIIGAAMGIAMAGGRPVAEIQFCDYVY
NTIDLLKLAGNTSWSTFGDWNLPMVVRTPVGSGIRGSIYHSHSFDATMTHIAGWKVVMPSTPLDAYGLLITACQEKNPVM
FLEPKALLRVKGEERIPGEPEDDRALSKLIDAPLGDRSQWKPQWPTGLEAYAVPFGKGKIVREGTQLTVVSYGRTLPLCT
KAAETLAADGISAEVIDLRSLWPYDWELIKASVQKTGRVLFVNEDTEVTNFGEHLVRRTVEELFYSLLAPPRLLAGKFLP
GIGLADALEMASVPQLGDITTAIRSLAGEQP

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltran

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=329, Percent_Identity=33.434650455927, Blast_Score=172, Evalue=6e-43,
Organism=Homo sapiens, GI34101272, Length=329, Percent_Identity=33.434650455927, Blast_Score=172, Evalue=6e-43,
Organism=Homo sapiens, GI156564403, Length=331, Percent_Identity=31.7220543806647, Blast_Score=141, Evalue=9e-34,
Organism=Homo sapiens, GI291084858, Length=330, Percent_Identity=30.3030303030303, Blast_Score=125, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI17506935, Length=347, Percent_Identity=31.9884726224784, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17538422, Length=350, Percent_Identity=32.2857142857143, Blast_Score=145, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6319698, Length=353, Percent_Identity=31.4447592067989, Blast_Score=123, Evalue=4e-29,
Organism=Drosophila melanogaster, GI160714832, Length=324, Percent_Identity=32.4074074074074, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI160714828, Length=324, Percent_Identity=32.4074074074074, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI21358145, Length=361, Percent_Identity=31.5789473684211, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24650940, Length=361, Percent_Identity=31.5789473684211, Blast_Score=135, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.4 [H]

Molecular weight: Translated: 38271; Mature: 38140

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANMAQAIRMALHYAEEHLGVTDIFGEDVGAPLGGVFTCTQGLKTTWNSPLDERGIIGAA
CCHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCHHHHHHHCHHHHCCCCCCCCCCHHHH
MGIAMAGGRPVAEIQFCDYVYNTIDLLKLAGNTSWSTFGDWNLPMVVRTPVGSGIRGSIY
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCCCEE
HSHSFDATMTHIAGWKVVMPSTPLDAYGLLITACQEKNPVMFLEPKALLRVKGEERIPGE
ECCCCCHHHHHHCCCEEEECCCCCHHHHHHEEEECCCCCEEEECCHHEEEECCCCCCCCC
PEDDRALSKLIDAPLGDRSQWKPQWPTGLEAYAVPFGKGKIVREGTQLTVVSYGRTLPLC
CCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEECCCEEEEEECCCCCCHH
TKAAETLAADGISAEVIDLRSLWPYDWELIKASVQKTGRVLFVNEDTEVTNFGEHLVRRT
HHHHHHHHHCCCCEEEEEHHHCCCCHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHH
VEELFYSLLAPPRLLAGKFLPGIGLADALEMASVPQLGDITTAIRSLAGEQP
HHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
ANMAQAIRMALHYAEEHLGVTDIFGEDVGAPLGGVFTCTQGLKTTWNSPLDERGIIGAA
CHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCHHHHHHHCHHHHCCCCCCCCCCHHHH
MGIAMAGGRPVAEIQFCDYVYNTIDLLKLAGNTSWSTFGDWNLPMVVRTPVGSGIRGSIY
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCCCEE
HSHSFDATMTHIAGWKVVMPSTPLDAYGLLITACQEKNPVMFLEPKALLRVKGEERIPGE
ECCCCCHHHHHHCCCEEEECCCCCHHHHHHEEEECCCCCEEEECCHHEEEECCCCCCCCC
PEDDRALSKLIDAPLGDRSQWKPQWPTGLEAYAVPFGKGKIVREGTQLTVVSYGRTLPLC
CCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEECCCEEEEEECCCCCCHH
TKAAETLAADGISAEVIDLRSLWPYDWELIKASVQKTGRVLFVNEDTEVTNFGEHLVRRT
HHHHHHHHHCCCCEEEEEHHHCCCCHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHH
VEELFYSLLAPPRLLAGKFLPGIGLADALEMASVPQLGDITTAIRSLAGEQP
HHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]