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The map label for this gene is pgi [H]

Identifier: 108563530

GI number: 108563530

Start: 1161539

End: 1163176

Strand: Direct

Name: pgi [H]

Synonym: HPAG1_1105

Alternate gene names: 108563530

Gene position: 1161539-1163176 (Clockwise)

Preceding gene: 108563528

Following gene: 108563531

Centisome position: 72.76

GC content: 40.66

Gene sequence:

>1638_bases
ATGCTAACCCAATTAAAAACTTATCCAAAATTACTCAAACATTATGAAGAAATCAAAGAAGCGCATATGCGCGATTGGTT
TTCCAAAGACAAAGAGCGAGCGAGCCGCTATTTCGTGCAATTTGAAAGCTTGAGTTTGGATTATTCCAAAAACCGCCTGA
ACGATACCACTTTAAAGCTTCTTTTTGAATTAGCGAATGACTGCTCTTTAAAAGAAAAGATTGAAGCGATGTTTAAGGGC
GAAAAGATCAACACCACCGAAAAAAGGGCCGTTTTACACACCGCTTTAAGAAGCTTGAATGACACTGAAATTTTACTAGA
CAACATGGAAGTGTTAAAAAGCGTGAGAAGCGTTTTAAAACGCATGCGAGCCTTTAGCGATAGCGTGAGGAGCGGTAAAA
GATTGGGCTATACCAATCAAGTGATCACTGATATTGTCAATATCGGTATTGGGGGGTCAGATTTGGGCGCTTTAATGGTT
TGCACCGCCTTAAAACGCTACGGCCACCCGAGATTAAAAATGCATTTTGTGTCTAATGTGGATGGCACACAGATTTTAGA
CGTTTTGGAAAAACTCAATCCAGCCAGCACGCTTTTTATCGTGGCTTCTAAGACTTTTTCCACTCAAGAAACCTTAACCA
ACGCCCTAACCGCTAGAAAATGGTTTGTAGAAAGAAGCGGCGATGAAAAGCATATCGCTAAGCACTTTGTAGCGGTATCC
ACCAATAAAGAAGCCGTGCAACAATTTGGCATTGATGAGCATAACATGTTTGAATTTTGGGATTTTGTAGGGGGGCGTTA
TAGCTTGTGGTCGGCTATTGGCTTATCCATTATGATCTATTTGGGGAAGAAAAATTTTAACGCTCTTTTGAAAGGGGCGT
ATTTGATGGATGAGCATTTTAGAAACGCCCCTTTTGAAAGCAATTTACCCGTTTTAATGGGGCTAATTGGCGTGTGGTAT
ATCAATTTTTTCCAATCCAAAAGCCATTTAATCGCTCCTTACGATCAGTATTTAAGGCATTTCCCTAAATTCATTCAGCA
ATTGGATATGGAAAGTAATGGCAAACGCATCAGCAAAAAAGGCGAAACCATCCCCTATGACACATGCCCTGTTGTTTGGG
GCGATATGGGCATTAACGCTCAGCATGCCTTTTTCCAACTCTTGCATCAAGGCACGCATTTAATCCCCATTGATTTTATC
GCTTCTTTAGATAAAAAACCTAACGCTAAAGGCCATCATGAGATTTTATTCAGCAATGTCTTAGCGCAAGCGCAAGCCTT
CATGAAAGGCAAGAGTTATGAAGAAGCGCTTGGGGAATTGCTCTTTAAAGGATTAGACAAAGATGAAGCCAAAGATTTAG
CCCACCATAGGGTGTTTTTTGGCAACCGCCCCTCTAATATCCTTTTATTAGAAAAGATTTCACCAAGCAATATTGGGGCG
TTAGTGGCTCTTTATGAGCATAAGGTTTTTGTGCAAGGGGTCATTTGGGATATTAACAGCTTTGATCAATGGGGCGTGGA
GCTTGGGAAAGAACTGGCCGTGCCGATTTTACAAGAATTAGAAGGGCATAAAAGCAACGCTTATTTTGACAGCTCCACTA
AGCACTTAATAGAATTGTATAAGAATTACAACCAATAG

Upstream 100 bases:

>100_bases
TCGCCCCATAGTAAGCTAAAATGTTTTTTCTTAACATTTGAAAATTATAATTAAAACTAGCTTATAATACAGCGTTATAT
CTTTTCATTAAGGGGTATTG

Downstream 100 bases:

>100_bases
GCTTTATCTTACAACAAGATAAAACCTAAAAACAATGAAGCGAAGCTTAACCCCATTCTCAAGCACTCCATTCAAAATGA
TCCGTCAATCATAACGGATT

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI [H]

Number of amino acids: Translated: 545; Mature: 545

Protein sequence:

>545_residues
MLTQLKTYPKLLKHYEEIKEAHMRDWFSKDKERASRYFVQFESLSLDYSKNRLNDTTLKLLFELANDCSLKEKIEAMFKG
EKINTTEKRAVLHTALRSLNDTEILLDNMEVLKSVRSVLKRMRAFSDSVRSGKRLGYTNQVITDIVNIGIGGSDLGALMV
CTALKRYGHPRLKMHFVSNVDGTQILDVLEKLNPASTLFIVASKTFSTQETLTNALTARKWFVERSGDEKHIAKHFVAVS
TNKEAVQQFGIDEHNMFEFWDFVGGRYSLWSAIGLSIMIYLGKKNFNALLKGAYLMDEHFRNAPFESNLPVLMGLIGVWY
INFFQSKSHLIAPYDQYLRHFPKFIQQLDMESNGKRISKKGETIPYDTCPVVWGDMGINAQHAFFQLLHQGTHLIPIDFI
ASLDKKPNAKGHHEILFSNVLAQAQAFMKGKSYEEALGELLFKGLDKDEAKDLAHHRVFFGNRPSNILLLEKISPSNIGA
LVALYEHKVFVQGVIWDINSFDQWGVELGKELAVPILQELEGHKSNAYFDSSTKHLIELYKNYNQ

Sequences:

>Translated_545_residues
MLTQLKTYPKLLKHYEEIKEAHMRDWFSKDKERASRYFVQFESLSLDYSKNRLNDTTLKLLFELANDCSLKEKIEAMFKG
EKINTTEKRAVLHTALRSLNDTEILLDNMEVLKSVRSVLKRMRAFSDSVRSGKRLGYTNQVITDIVNIGIGGSDLGALMV
CTALKRYGHPRLKMHFVSNVDGTQILDVLEKLNPASTLFIVASKTFSTQETLTNALTARKWFVERSGDEKHIAKHFVAVS
TNKEAVQQFGIDEHNMFEFWDFVGGRYSLWSAIGLSIMIYLGKKNFNALLKGAYLMDEHFRNAPFESNLPVLMGLIGVWY
INFFQSKSHLIAPYDQYLRHFPKFIQQLDMESNGKRISKKGETIPYDTCPVVWGDMGINAQHAFFQLLHQGTHLIPIDFI
ASLDKKPNAKGHHEILFSNVLAQAQAFMKGKSYEEALGELLFKGLDKDEAKDLAHHRVFFGNRPSNILLLEKISPSNIGA
LVALYEHKVFVQGVIWDINSFDQWGVELGKELAVPILQELEGHKSNAYFDSSTKHLIELYKNYNQ
>Mature_545_residues
MLTQLKTYPKLLKHYEEIKEAHMRDWFSKDKERASRYFVQFESLSLDYSKNRLNDTTLKLLFELANDCSLKEKIEAMFKG
EKINTTEKRAVLHTALRSLNDTEILLDNMEVLKSVRSVLKRMRAFSDSVRSGKRLGYTNQVITDIVNIGIGGSDLGALMV
CTALKRYGHPRLKMHFVSNVDGTQILDVLEKLNPASTLFIVASKTFSTQETLTNALTARKWFVERSGDEKHIAKHFVAVS
TNKEAVQQFGIDEHNMFEFWDFVGGRYSLWSAIGLSIMIYLGKKNFNALLKGAYLMDEHFRNAPFESNLPVLMGLIGVWY
INFFQSKSHLIAPYDQYLRHFPKFIQQLDMESNGKRISKKGETIPYDTCPVVWGDMGINAQHAFFQLLHQGTHLIPIDFI
ASLDKKPNAKGHHEILFSNVLAQAQAFMKGKSYEEALGELLFKGLDKDEAKDLAHHRVFFGNRPSNILLLEKISPSNIGA
LVALYEHKVFVQGVIWDINSFDQWGVELGKELAVPILQELEGHKSNAYFDSSTKHLIELYKNYNQ

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family [H]

Homologues:

Organism=Homo sapiens, GI18201905, Length=547, Percent_Identity=51.5539305301645, Blast_Score=570, Evalue=1e-163,
Organism=Homo sapiens, GI296080693, Length=547, Percent_Identity=48.0804387568556, Blast_Score=517, Evalue=1e-147,
Organism=Escherichia coli, GI1790457, Length=542, Percent_Identity=53.1365313653137, Blast_Score=586, Evalue=1e-168,
Organism=Caenorhabditis elegans, GI71996703, Length=548, Percent_Identity=49.8175182481752, Blast_Score=550, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI71996708, Length=548, Percent_Identity=49.8175182481752, Blast_Score=550, Evalue=1e-157,
Organism=Saccharomyces cerevisiae, GI6319673, Length=552, Percent_Identity=49.0942028985507, Blast_Score=521, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24651916, Length=548, Percent_Identity=53.8321167883212, Blast_Score=582, Evalue=1e-166,
Organism=Drosophila melanogaster, GI24651914, Length=548, Percent_Identity=53.8321167883212, Blast_Score=582, Evalue=1e-166,
Organism=Drosophila melanogaster, GI17737445, Length=548, Percent_Identity=53.8321167883212, Blast_Score=582, Evalue=1e-166,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189 [H]

Pfam domain/function: PF00342 PGI [H]

EC number: =5.3.1.9 [H]

Molecular weight: Translated: 62345; Mature: 62345

Theoretical pI: Translated: 8.83; Mature: 8.83

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1 ; PS00174 P_GLUCOSE_ISOMERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTQLKTYPKLLKHYEEIKEAHMRDWFSKDKERASRYFVQFESLSLDYSKNRLNDTTLKL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
LFELANDCSLKEKIEAMFKGEKINTTEKRAVLHTALRSLNDTEILLDNMEVLKSVRSVLK
HHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
RMRAFSDSVRSGKRLGYTNQVITDIVNIGIGGSDLGALMVCTALKRYGHPRLKMHFVSNV
HHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCC
DGTQILDVLEKLNPASTLFIVASKTFSTQETLTNALTARKWFVERSGDEKHIAKHFVAVS
CHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
TNKEAVQQFGIDEHNMFEFWDFVGGRYSLWSAIGLSIMIYLGKKNFNALLKGAYLMDEHF
CCHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHH
RNAPFESNLPVLMGLIGVWYINFFQSKSHLIAPYDQYLRHFPKFIQQLDMESNGKRISKK
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHCCCCCCCCHHCC
GETIPYDTCPVVWGDMGINAQHAFFQLLHQGTHLIPIDFIASLDKKPNAKGHHEILFSNV
CCCCCCCCCCCEECCCCCCHHHHHHHHHHCCCCEEEHHHHHHCCCCCCCCCHHHHHHHHH
LAQAQAFMKGKSYEEALGELLFKGLDKDEAKDLAHHRVFFGNRPSNILLLEKISPSNIGA
HHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHEECCCCCCEEEEEECCCCCHHH
LVALYEHKVFVQGVIWDINSFDQWGVELGKELAVPILQELEGHKSNAYFDSSTKHLIELY
HHHHHHHHHEEHEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
KNYNQ
HCCCC
>Mature Secondary Structure
MLTQLKTYPKLLKHYEEIKEAHMRDWFSKDKERASRYFVQFESLSLDYSKNRLNDTTLKL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
LFELANDCSLKEKIEAMFKGEKINTTEKRAVLHTALRSLNDTEILLDNMEVLKSVRSVLK
HHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
RMRAFSDSVRSGKRLGYTNQVITDIVNIGIGGSDLGALMVCTALKRYGHPRLKMHFVSNV
HHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCC
DGTQILDVLEKLNPASTLFIVASKTFSTQETLTNALTARKWFVERSGDEKHIAKHFVAVS
CHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
TNKEAVQQFGIDEHNMFEFWDFVGGRYSLWSAIGLSIMIYLGKKNFNALLKGAYLMDEHF
CCHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHH
RNAPFESNLPVLMGLIGVWYINFFQSKSHLIAPYDQYLRHFPKFIQQLDMESNGKRISKK
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHCCCCCCCCHHCC
GETIPYDTCPVVWGDMGINAQHAFFQLLHQGTHLIPIDFIASLDKKPNAKGHHEILFSNV
CCCCCCCCCCCEECCCCCCHHHHHHHHHHCCCCEEEHHHHHHCCCCCCCCCHHHHHHHHH
LAQAQAFMKGKSYEEALGELLFKGLDKDEAKDLAHHRVFFGNRPSNILLLEKISPSNIGA
HHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHEECCCCCCEEEEEECCCCCHHH
LVALYEHKVFVQGVIWDINSFDQWGVELGKELAVPILQELEGHKSNAYFDSSTKHLIELY
HHHHHHHHHEEHEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
KNYNQ
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA