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The map label for this gene is zwf [H]

Identifier: 108563464

GI number: 108563464

Start: 1094115

End: 1095392

Strand: Direct

Name: zwf [H]

Synonym: HPAG1_1039

Alternate gene names: 108563464

Gene position: 1094115-1095392 (Clockwise)

Preceding gene: 108563460

Following gene: 108563465

Centisome position: 68.54

GC content: 37.17

Gene sequence:

>1278_bases
ATGTTGGATTTTGATTTGGTTCTTTTTGGTGCGACTGGGGATTTAGCCATGCGAAAGCTCTTTGTTTCGCTCTATGAAAT
TTATACCCATTATGGTTTTAAAAAAGATTCTAAAATTATCGCATCGGGGCGTAAGGAACTATCCAATGAAGAATTTTTAG
TGCTCCTTTGTGAAAAAACGCAGTTGCATTCAAGAGAAAAGGGTGAGGAATTTTTAGCCCATATCAGTTATTTTTGCGTC
CGTTTGGATAACCCTAAAGACTTTGAAGAACTGAGTAAAATCGCTACAAAAAATAAGCCCTTGATTTTCTACTTTTCTAT
CTCGCCTAGTTTTTTTGCAACGACCGCCCAACATTTAGCCCAAAACGCGCTCAATCACGCTAATACGCGCTTGATTTTAG
AAAAGCCTTTAGGGCATGATTTAAAGACTTGTAAAGAGATTTTCCAAAGCATTAGTGCTTTTTTTAAAGAAGAACAAATC
TTTAGAATCGATCATTATTTAGGGAAAAAGGGCGTTCAAAATATCCTTGAATTGCGCTTAAATAACCCTATCTTAAACAT
TTTATGGGATCAAATCAGTGCAGTTGAAATCTGCGTGTATGAGACTTTAGGGGTGGAAGAAAGGGGCGAATTTTACGATA
AAATCGGGGCTTTAAGGGATATGGTTCAAAACCATCTCTTGCAAGTTTTATCCCTTATCGCTACAGATTTACCCAACGAT
TTAAAGGATTTGAGGAAAGAAAAAATCAAAGTTTTAAAAACCTTACAACCCCCCAAAGATTTCAAAAAACAAGTTATTCG
GGCCCAGTATCAAGGCTATAGAGATGAAAATAAGGTTAATAAAGAGAGCCAGACAGAAACTTTTGTCGCTATTAAGGCCT
TTTTGGATACGCCCAAATTTAAAGGCGTGCCTTTCTATCTCAAGCACGCTAAAAAAATGCCCCACAACCAAGCGAGCGTG
AAAATCCATTTTAATGCAGTCAATACGCTAGAATTTTTTCTCTCTCAAGATAAAATCACCCTCACCCTAAAAGACAATCA
AAACCCCCTTATTTTAGAAACCCATAACAAACAAGAATTTTTACAGCCCTACGCTAAATTGCTCTATGATGCGATAGGAA
ATAACCACAATAATTTCGCCCACCAGCTGGAACTAGAAGCGTCATGGGTTTTTATTGACACGCTTATAGAGGGCTTTATG
AATAACGCCACGCCCTTACATTCCTATGAAAGCCATAATCTCAACGAATCCGAATTTTTAAAACCACTCTATCAATAA

Upstream 100 bases:

>100_bases
TTTTCTTTGATTTGTTCTAAAGAATGCTTAGGCATGAACACCCCTTCAATTAAGATTTAATATATAATAATAACTTAAAA
ACACTCTAAAAGGGTTATTG

Downstream 100 bases:

>100_bases
AAGGGATTTCATGGGTTATCAATTGTTTGAATTTGAAAATTTGAAAGATTGCCACAAGGCTTTAATAGAGCGTTTTAAAG
AATTTTTTAACACCGCCTTA

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MLDFDLVLFGATGDLAMRKLFVSLYEIYTHYGFKKDSKIIASGRKELSNEEFLVLLCEKTQLHSREKGEEFLAHISYFCV
RLDNPKDFEELSKIATKNKPLIFYFSISPSFFATTAQHLAQNALNHANTRLILEKPLGHDLKTCKEIFQSISAFFKEEQI
FRIDHYLGKKGVQNILELRLNNPILNILWDQISAVEICVYETLGVEERGEFYDKIGALRDMVQNHLLQVLSLIATDLPND
LKDLRKEKIKVLKTLQPPKDFKKQVIRAQYQGYRDENKVNKESQTETFVAIKAFLDTPKFKGVPFYLKHAKKMPHNQASV
KIHFNAVNTLEFFLSQDKITLTLKDNQNPLILETHNKQEFLQPYAKLLYDAIGNNHNNFAHQLELEASWVFIDTLIEGFM
NNATPLHSYESHNLNESEFLKPLYQ

Sequences:

>Translated_425_residues
MLDFDLVLFGATGDLAMRKLFVSLYEIYTHYGFKKDSKIIASGRKELSNEEFLVLLCEKTQLHSREKGEEFLAHISYFCV
RLDNPKDFEELSKIATKNKPLIFYFSISPSFFATTAQHLAQNALNHANTRLILEKPLGHDLKTCKEIFQSISAFFKEEQI
FRIDHYLGKKGVQNILELRLNNPILNILWDQISAVEICVYETLGVEERGEFYDKIGALRDMVQNHLLQVLSLIATDLPND
LKDLRKEKIKVLKTLQPPKDFKKQVIRAQYQGYRDENKVNKESQTETFVAIKAFLDTPKFKGVPFYLKHAKKMPHNQASV
KIHFNAVNTLEFFLSQDKITLTLKDNQNPLILETHNKQEFLQPYAKLLYDAIGNNHNNFAHQLELEASWVFIDTLIEGFM
NNATPLHSYESHNLNESEFLKPLYQ
>Mature_425_residues
MLDFDLVLFGATGDLAMRKLFVSLYEIYTHYGFKKDSKIIASGRKELSNEEFLVLLCEKTQLHSREKGEEFLAHISYFCV
RLDNPKDFEELSKIATKNKPLIFYFSISPSFFATTAQHLAQNALNHANTRLILEKPLGHDLKTCKEIFQSISAFFKEEQI
FRIDHYLGKKGVQNILELRLNNPILNILWDQISAVEICVYETLGVEERGEFYDKIGALRDMVQNHLLQVLSLIATDLPND
LKDLRKEKIKVLKTLQPPKDFKKQVIRAQYQGYRDENKVNKESQTETFVAIKAFLDTPKFKGVPFYLKHAKKMPHNQASV
KIHFNAVNTLEFFLSQDKITLTLKDNQNPLILETHNKQEFLQPYAKLLYDAIGNNHNNFAHQLELEASWVFIDTLIEGFM
NNATPLHSYESHNLNESEFLKPLYQ

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=444, Percent_Identity=27.2522522522523, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI109389365, Length=444, Percent_Identity=27.2522522522523, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI52145310, Length=353, Percent_Identity=29.7450424929178, Blast_Score=155, Evalue=6e-38,
Organism=Escherichia coli, GI1788158, Length=454, Percent_Identity=33.7004405286344, Blast_Score=248, Evalue=5e-67,
Organism=Caenorhabditis elegans, GI17538218, Length=445, Percent_Identity=29.438202247191, Blast_Score=196, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6324088, Length=445, Percent_Identity=31.9101123595506, Blast_Score=209, Evalue=7e-55,
Organism=Drosophila melanogaster, GI24643352, Length=434, Percent_Identity=29.9539170506912, Blast_Score=187, Evalue=8e-48,
Organism=Drosophila melanogaster, GI24643350, Length=434, Percent_Identity=29.9539170506912, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI221513548, Length=361, Percent_Identity=26.5927977839335, Blast_Score=136, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 49311; Mature: 49311

Theoretical pI: Translated: 7.28; Mature: 7.28

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDFDLVLFGATGDLAMRKLFVSLYEIYTHYGFKKDSKIIASGRKELSNEEFLVLLCEKT
CCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEEECCH
QLHSREKGEEFLAHISYFCVRLDNPKDFEELSKIATKNKPLIFYFSISPSFFATTAQHLA
HHCCHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHH
QNALNHANTRLILEKPLGHDLKTCKEIFQSISAFFKEEQIFRIDHYLGKKGVQNILELRL
HHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHC
NNPILNILWDQISAVEICVYETLGVEERGEFYDKIGALRDMVQNHLLQVLSLIATDLPND
CCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
LKDLRKEKIKVLKTLQPPKDFKKQVIRAQYQGYRDENKVNKESQTETFVAIKAFLDTPKF
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHCCCCHHHHHHHHHHHHHCCCCC
KGVPFYLKHAKKMPHNQASVKIHFNAVNTLEFFLSQDKITLTLKDNQNPLILETHNKQEF
CCCCHHHHHHHHCCCCCCEEEEEEEHHHHHHHHHCCCEEEEEEECCCCCEEEEECCHHHH
LQPYAKLLYDAIGNNHNNFAHQLELEASWVFIDTLIEGFMNNATPLHSYESHNLNESEFL
HHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
KPLYQ
HHHCC
>Mature Secondary Structure
MLDFDLVLFGATGDLAMRKLFVSLYEIYTHYGFKKDSKIIASGRKELSNEEFLVLLCEKT
CCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEEECCH
QLHSREKGEEFLAHISYFCVRLDNPKDFEELSKIATKNKPLIFYFSISPSFFATTAQHLA
HHCCHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHH
QNALNHANTRLILEKPLGHDLKTCKEIFQSISAFFKEEQIFRIDHYLGKKGVQNILELRL
HHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHC
NNPILNILWDQISAVEICVYETLGVEERGEFYDKIGALRDMVQNHLLQVLSLIATDLPND
CCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
LKDLRKEKIKVLKTLQPPKDFKKQVIRAQYQGYRDENKVNKESQTETFVAIKAFLDTPKF
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHCCCCHHHHHHHHHHHHHCCCCC
KGVPFYLKHAKKMPHNQASVKIHFNAVNTLEFFLSQDKITLTLKDNQNPLILETHNKQEF
CCCCHHHHHHHHCCCCCCEEEEEEEHHHHHHHHHCCCEEEEEEECCCCCEEEEECCHHHH
LQPYAKLLYDAIGNNHNNFAHQLELEASWVFIDTLIEGFMNNATPLHSYESHNLNESEFL
HHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
KPLYQ
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]