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The map label for this gene is guaC [H]

Identifier: 108563263

GI number: 108563263

Start: 874492

End: 875469

Strand: Direct

Name: guaC [H]

Synonym: HPAG1_0838

Alternate gene names: 108563263

Gene position: 874492-875469 (Clockwise)

Preceding gene: 108563259

Following gene: 108563280

Centisome position: 54.78

GC content: 41.92

Gene sequence:

>978_bases
TTGAAAGTATTTGATTACGAAGATGTCCAACTCATTCCTAATAAATGCATCGTGAATAGCCGTTCAGAATGCGATACGAC
TGTTATTCTAGGCAAACATGCGTTTAAAATGCCTATAGTCCCAGCCAACATGCAGACAATCATCAACGAACCGATCGCAG
AATTTCTAGCAGAAAATGGCTATTTCTACATCATGCACCGCTTTAATGGATCGACAAGAATCCCGTTTGTCAAAAAAATG
AAAGAACGCCAATGGATCAGCTCAATCAGCGTGGGGGTGAAAAAGGAAGAATATCTTTTGATAGAAGAGTTAGCCAAACA
AGGATTAACGCCAGACTATATCACAATCGATATTGCGCATGGTCATTCAAATTCTGTCATTGAAATGATCCAACGCATCA
AAACGCGTTTGCCAGAAACTTTTGTGATTGCCGGGAATGTTGGCACGCCAGAAGCAGTCCGTGAATTAGAGAACGCCGGT
GCTGACGCTACGAAAGTTGGCATCGGACCTGGGAAAGTGTGTATCACTAAAATCAAAACAGGCTTTGGTACAGGTGGTTG
GCAACTAGCGGCTCTTAGGTGGTGCGCTAAAGCAGCAAGAAAGCCCATTATTGCAGATGGCGGTATTCGCACGCATGGGG
ATATTGCAAAATCAATACGCTTTGGCGCGACAATGGTAATGATTGGCTCGCTTTTTGCAGGGCATGAAGAATCATCTGGA
GAAACAAAAATAGAAAATGGTGTCGCATATAAAGAATATTTCGGTTCGGCATCAGAGTTCCAAAAAGGTGAAAAGAAAAA
TGTTGAAGGCAAGAAAATTTGGATCCAGCATAAAGGATCATTAAAAGACACGCTGGTTGAAATGCAACAAGATTTGCAAT
CTTCCATCTCCTATGCTGGCGGGAGAGACCTTGAAGCGATTCGAAAAGTGGATTATGTCATTGTGAAAAATTCAATTTTC
AATGGGGACACAATCTAA

Upstream 100 bases:

>100_bases
TTTGACGCCCAAAATTTGATCGAGCCTATATCATTTCCTCTTGATTTTTTATTCAATTTAAGGTAAAAATAATGTTTTAA
AGCAAAAAAGGATCAAGTCA

Downstream 100 bases:

>100_bases
AAAGATTGATAAAACGAAAGCAAAAGACAGAAAAAAGGGTTTTCAACCTCTTTTTCAAGCGATTTGCTTTGACTTGGGTT
TTTGTTGTTTTTTGATCCTT

Product: guanosine 5'-monophosphate oxidoreductase

Products: NA

Alternate protein names: Guanosine 5'-monophosphate oxidoreductase; Guanosine monophosphate reductase [H]

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MKVFDYEDVQLIPNKCIVNSRSECDTTVILGKHAFKMPIVPANMQTIINEPIAEFLAENGYFYIMHRFNGSTRIPFVKKM
KERQWISSISVGVKKEEYLLIEELAKQGLTPDYITIDIAHGHSNSVIEMIQRIKTRLPETFVIAGNVGTPEAVRELENAG
ADATKVGIGPGKVCITKIKTGFGTGGWQLAALRWCAKAARKPIIADGGIRTHGDIAKSIRFGATMVMIGSLFAGHEESSG
ETKIENGVAYKEYFGSASEFQKGEKKNVEGKKIWIQHKGSLKDTLVEMQQDLQSSISYAGGRDLEAIRKVDYVIVKNSIF
NGDTI

Sequences:

>Translated_325_residues
MKVFDYEDVQLIPNKCIVNSRSECDTTVILGKHAFKMPIVPANMQTIINEPIAEFLAENGYFYIMHRFNGSTRIPFVKKM
KERQWISSISVGVKKEEYLLIEELAKQGLTPDYITIDIAHGHSNSVIEMIQRIKTRLPETFVIAGNVGTPEAVRELENAG
ADATKVGIGPGKVCITKIKTGFGTGGWQLAALRWCAKAARKPIIADGGIRTHGDIAKSIRFGATMVMIGSLFAGHEESSG
ETKIENGVAYKEYFGSASEFQKGEKKNVEGKKIWIQHKGSLKDTLVEMQQDLQSSISYAGGRDLEAIRKVDYVIVKNSIF
NGDTI
>Mature_325_residues
MKVFDYEDVQLIPNKCIVNSRSECDTTVILGKHAFKMPIVPANMQTIINEPIAEFLAENGYFYIMHRFNGSTRIPFVKKM
KERQWISSISVGVKKEEYLLIEELAKQGLTPDYITIDIAHGHSNSVIEMIQRIKTRLPETFVIAGNVGTPEAVRELENAG
ADATKVGIGPGKVCITKIKTGFGTGGWQLAALRWCAKAARKPIIADGGIRTHGDIAKSIRFGATMVMIGSLFAGHEESSG
ETKIENGVAYKEYFGSASEFQKGEKKNVEGKKIWIQHKGSLKDTLVEMQQDLQSSISYAGGRDLEAIRKVDYVIVKNSIF
NGDTI

Specific function: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides [H]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI50541954, Length=338, Percent_Identity=32.8402366863905, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI50541952, Length=338, Percent_Identity=32.8402366863905, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI50541948, Length=338, Percent_Identity=32.8402366863905, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI50541956, Length=338, Percent_Identity=32.8402366863905, Blast_Score=165, Evalue=4e-41,
Organism=Homo sapiens, GI156104880, Length=338, Percent_Identity=31.0650887573964, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI217035148, Length=255, Percent_Identity=32.9411764705882, Blast_Score=121, Evalue=7e-28,
Organism=Homo sapiens, GI217035146, Length=255, Percent_Identity=33.3333333333333, Blast_Score=121, Evalue=7e-28,
Organism=Homo sapiens, GI217035150, Length=255, Percent_Identity=33.3333333333333, Blast_Score=121, Evalue=8e-28,
Organism=Homo sapiens, GI217035152, Length=255, Percent_Identity=33.3333333333333, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI34328930, Length=255, Percent_Identity=33.3333333333333, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI156616279, Length=255, Percent_Identity=33.3333333333333, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI34328928, Length=255, Percent_Identity=33.3333333333333, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI66933016, Length=255, Percent_Identity=31.7647058823529, Blast_Score=119, Evalue=5e-27,
Organism=Escherichia coli, GI1786293, Length=344, Percent_Identity=30.2325581395349, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1788855, Length=220, Percent_Identity=38.1818181818182, Blast_Score=113, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17560440, Length=323, Percent_Identity=31.8885448916409, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71994385, Length=262, Percent_Identity=30.5343511450382, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI71994389, Length=188, Percent_Identity=34.5744680851064, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6322012, Length=252, Percent_Identity=30.1587301587302, Blast_Score=96, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6323585, Length=253, Percent_Identity=29.2490118577075, Blast_Score=96, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6323464, Length=253, Percent_Identity=29.2490118577075, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319352, Length=138, Percent_Identity=32.6086956521739, Blast_Score=66, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24641071, Length=259, Percent_Identity=32.046332046332, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24641073, Length=259, Percent_Identity=32.046332046332, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI28571163, Length=259, Percent_Identity=32.046332046332, Blast_Score=116, Evalue=2e-26,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005994
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00478 IMPDH [H]

EC number: =1.7.1.7 [H]

Molecular weight: Translated: 35949; Mature: 35949

Theoretical pI: Translated: 8.81; Mature: 8.81

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVFDYEDVQLIPNKCIVNSRSECDTTVILGKHAFKMPIVPANMQTIINEPIAEFLAENG
CCCCCCCCCEECCCHHCCCCCCCCCEEEEECCCCEECCCCCCHHHHHHHHHHHHHHHCCC
YFYIMHRFNGSTRIPFVKKMKERQWISSISVGVKKEEYLLIEELAKQGLTPDYITIDIAH
EEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEEEEC
GHSNSVIEMIQRIKTRLPETFVIAGNVGTPEAVRELENAGADATKVGIGPGKVCITKIKT
CCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCEEECCCCCCEEEEEECC
GFGTGGWQLAALRWCAKAARKPIIADGGIRTHGDIAKSIRFGATMVMIGSLFAGHEESSG
CCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
ETKIENGVAYKEYFGSASEFQKGEKKNVEGKKIWIQHKGSLKDTLVEMQQDLQSSISYAG
CCHHHCCCCHHHHCCCHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCC
GRDLEAIRKVDYVIVKNSIFNGDTI
CCCHHHHHHHCEEEEECCCCCCCCC
>Mature Secondary Structure
MKVFDYEDVQLIPNKCIVNSRSECDTTVILGKHAFKMPIVPANMQTIINEPIAEFLAENG
CCCCCCCCCEECCCHHCCCCCCCCCEEEEECCCCEECCCCCCHHHHHHHHHHHHHHHCCC
YFYIMHRFNGSTRIPFVKKMKERQWISSISVGVKKEEYLLIEELAKQGLTPDYITIDIAH
EEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEEEEC
GHSNSVIEMIQRIKTRLPETFVIAGNVGTPEAVRELENAGADATKVGIGPGKVCITKIKT
CCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCCEEECCCCCCEEEEEECC
GFGTGGWQLAALRWCAKAARKPIIADGGIRTHGDIAKSIRFGATMVMIGSLFAGHEESSG
CCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
ETKIENGVAYKEYFGSASEFQKGEKKNVEGKKIWIQHKGSLKDTLVEMQQDLQSSISYAG
CCHHHCCCCHHHHCCCHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCC
GRDLEAIRKVDYVIVKNSIFNGDTI
CCCHHHHHHHCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9252185 [H]