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The map label for this gene is uvrC [H]

Identifier: 108563232

GI number: 108563232

Start: 841444

End: 843228

Strand: Direct

Name: uvrC [H]

Synonym: HPAG1_0807

Alternate gene names: 108563232

Gene position: 841444-843228 (Clockwise)

Preceding gene: 108563231

Following gene: 108563233

Centisome position: 52.71

GC content: 37.87

Gene sequence:

>1785_bases
ATGGCTGATTTATTGTCCAGTTTGAAAAACCTTTCTCATAGCAGTGGGGTGTATCAATATTTTGATAAAAACCGCCAATT
ACTCTATATCGGTAAGGCGAAAAATTTAAAAAAGCGCATCAAAAGCTATTTTTCTATCCATAACAATGAAATCACGCCCA
ACCATCGCGCAAGCTTACGCATCCAAATGATGGTCAAACAAATCGCTTTTTTAGAAACCATTTTAGTGGAAAACGAGCAA
GACGCTTTGATTTTGGAAAATTCTTTAATCAAGCAGCTCAAGCCCAAATACAACATTCTTTTAAGAGACGATAAAACTTA
CCCTTATATTTACATGGATTTTTCCACTGATTTCCCTATCCCTTTAATCACACGAAAAATTTTAAAACAGCCTGGCGTTA
AATATTTTGGCCCTTTTACGAGCGGGGCTAAGGATATTTTGGACAGCTTGTATGAATTGCTCCCATTAGTTCAAAAGAAA
AATTGCATCAAGGATAAAAAGGCATGCATGTTTTATCAAATAGAGCGTTGTAAAGCCCCATGCGAGAATAAAATCACCAA
AGAAGAGTATTCAAAAATCGCTAAAGAATGTTTAGAAATGATTGAAAATAGAGACAAGCTCATCAAGGAGCTTGAATTAA
AAATGGAGCGCCTTTCTAATAACTTGCGTTTTGAAGAAGCCCTAATTTACAGGGACAGGATTGCAAAAATCCAAAAAATC
GCCCCTTTCACTTGCATGGATTTAGCCAAACTCTATGATTTGGACATTTTTGCTTTTTATGGCGCAAGCAATAAGGCGGT
GTTGGTGAAAATGTTTATGCGTGGGGGTAAAATCATTTCTTCAGCGTTTGAAAAAATCCACTCCCTTAATGGGTTTGACA
CTGATGAAGCGATGAAACAAGCCATTATCAATCATTACCAATCGCATTTACCTTTGATGCCTGAACAGATCTTGTTGAGC
GCTTGCTCTAATGAAGCGCTTAAAGAATTGCAAGAATTTATCTCTCATCAATATTCTAAAAAAATCGCTCTTAGCATTCC
TAAAAAAGGCGATAAGCTCGCTTTAATAGAAATCGCTATGAAAAACGCTCAAGAGATTTTTAGCCAAGAAAAAACCTCTG
ATGAAGATCTGATTTTAGAAGAGGTGCGATCGCTCTTTAATTTAGAGTGCGTGCCTTATAGGGTAGAAATCTTTGACACA
AGCCACCATTCAAACAGCCAATGCGTGGGGGGAATGGTCGTGTATGAAAACAATGCATTTCAAAAAAACTCTTACCGGCG
CTACCATTTAAAAGGCTCTAACGAATACGATCAAATGAGCGAATTGCTCACCAGAAGGGCTTTAGACTTTGCTAAAGAGC
CACCGCCTAATTTGTGGGTGATTGATGGAGGGAGGGCACAATTAAACATCGCTTTAGAAATTTTAAAAAGCAGCGGGAGT
TTTGTAGAAGTGATCGCTATTTCTAAAGAAAAAAGGGATTCTAAAGCTTATCGCTCTAAAGGGGGCGCTAAAGACATCAT
CCATACGCCTAGCGATACTTTTAAATTGCTCCCTAGCGACAAACGCTTGCAATGGGTGCAAAAATTGCGCGATGAAAGCC
ACCGGTATGCGATAAACTTCCACAGATCCACTAAACTTAAAAACATGAAACAAATCGCTCTTTTAAAAGAAAAGGGCATA
GGAGAAGCCAGCGTGAAAAAATTATTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAGGAAAAAAA
CGCTGTTTTAAAAAAACGAATTTAA

Upstream 100 bases:

>100_bases
AGGGTTGTTCCATAACCCCATTAAAGACGCTCGTTTGCATGAATGTTTTGAAAAAGCGCGTTCTTTGATCCGCTACCAAC
GAAGTTTTTTTGAGGAATGA

Downstream 100 bases:

>100_bases
AGGAAAAAACATGAAAAAGAGATTGAATATAGGGCTTGTGGGTTTAGGGTGTGTGGGGAGCGCGGTCGCTAAAATCTTAC
AAGAAAATCAAGAAATCATT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 594; Mature: 593

Protein sequence:

>594_residues
MADLLSSLKNLSHSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSIHNNEITPNHRASLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCENKITKEEYSKIAKECLEMIENRDKLIKELELKMERLSNNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYGASNKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQSHLPLMPEQILLS
ACSNEALKELQEFISHQYSKKIALSIPKKGDKLALIEIAMKNAQEIFSQEKTSDEDLILEEVRSLFNLECVPYRVEIFDT
SHHSNSQCVGGMVVYENNAFQKNSYRRYHLKGSNEYDQMSELLTRRALDFAKEPPPNLWVIDGGRAQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTPSDTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRI

Sequences:

>Translated_594_residues
MADLLSSLKNLSHSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSIHNNEITPNHRASLRIQMMVKQIAFLETILVENEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACMFYQIERCKAPCENKITKEEYSKIAKECLEMIENRDKLIKELELKMERLSNNLRFEEALIYRDRIAKIQKI
APFTCMDLAKLYDLDIFAFYGASNKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQSHLPLMPEQILLS
ACSNEALKELQEFISHQYSKKIALSIPKKGDKLALIEIAMKNAQEIFSQEKTSDEDLILEEVRSLFNLECVPYRVEIFDT
SHHSNSQCVGGMVVYENNAFQKNSYRRYHLKGSNEYDQMSELLTRRALDFAKEPPPNLWVIDGGRAQLNIALEILKSSGS
FVEVIAISKEKRDSKAYRSKGGAKDIIHTPSDTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGI
GEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRI
>Mature_593_residues
ADLLSSLKNLSHSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSIHNNEITPNHRASLRIQMMVKQIAFLETILVENEQD
ALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPIPLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKKN
CIKDKKACMFYQIERCKAPCENKITKEEYSKIAKECLEMIENRDKLIKELELKMERLSNNLRFEEALIYRDRIAKIQKIA
PFTCMDLAKLYDLDIFAFYGASNKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQAIINHYQSHLPLMPEQILLSA
CSNEALKELQEFISHQYSKKIALSIPKKGDKLALIEIAMKNAQEIFSQEKTSDEDLILEEVRSLFNLECVPYRVEIFDTS
HHSNSQCVGGMVVYENNAFQKNSYRRYHLKGSNEYDQMSELLTRRALDFAKEPPPNLWVIDGGRAQLNIALEILKSSGSF
VEVIAISKEKRDSKAYRSKGGAKDIIHTPSDTFKLLPSDKRLQWVQKLRDESHRYAINFHRSTKLKNMKQIALLKEKGIG
EASVKKLLDYFGSFEAIEKASEQEKNAVLKKRI

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=609, Percent_Identity=30.0492610837438, Blast_Score=248, Evalue=8e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 68633; Mature: 68501

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADLLSSLKNLSHSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSIHNNEITPNHRASLR
CHHHHHHHHHCCCCCCHHHHHCCCCCEEEEECHHHHHHHHHHHHHHCCCCCCCCCCHHHH
IQMMVKQIAFLETILVENEQDALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPI
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCEEEEECCCCCCH
PLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKKNCIKDKKACMFYQIERCKAP
HHHHHHHHHCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
CENKITKEEYSKIAKECLEMIENRDKLIKELELKMERLSNNLRFEEALIYRDRIAKIQKI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
APFTCMDLAKLYDLDIFAFYGASNKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQ
CCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHH
AIINHYQSHLPLMPEQILLSACSNEALKELQEFISHQYSKKIALSIPKKGDKLALIEIAM
HHHHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHCCEEEEECCCCCCCEEEHHHHH
KNAQEIFSQEKTSDEDLILEEVRSLFNLECVPYRVEIFDTSHHSNSQCVGGMVVYENNAF
HHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCEEEEECCCC
QKNSYRRYHLKGSNEYDQMSELLTRRALDFAKEPPPNLWVIDGGRAQLNIALEILKSSGS
CCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEHHHHHHHHCCCC
FVEVIAISKEKRDSKAYRSKGGAKDIIHTPSDTFKLLPSDKRLQWVQKLRDESHRYAINF
EEEEEEECCHHHHHHHHHHCCCCCCCEECCCHHEEECCCCHHHHHHHHHHCCCCEEEEEE
HRSTKLKNMKQIALLKEKGIGEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRI
ECHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ADLLSSLKNLSHSSGVYQYFDKNRQLLYIGKAKNLKKRIKSYFSIHNNEITPNHRASLR
HHHHHHHHHCCCCCCHHHHHCCCCCEEEEECHHHHHHHHHHHHHHCCCCCCCCCCHHHH
IQMMVKQIAFLETILVENEQDALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSTDFPI
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCEEEEECCCCCCH
PLITRKILKQPGVKYFGPFTSGAKDILDSLYELLPLVQKKNCIKDKKACMFYQIERCKAP
HHHHHHHHHCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
CENKITKEEYSKIAKECLEMIENRDKLIKELELKMERLSNNLRFEEALIYRDRIAKIQKI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
APFTCMDLAKLYDLDIFAFYGASNKAVLVKMFMRGGKIISSAFEKIHSLNGFDTDEAMKQ
CCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHH
AIINHYQSHLPLMPEQILLSACSNEALKELQEFISHQYSKKIALSIPKKGDKLALIEIAM
HHHHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHCCEEEEECCCCCCCEEEHHHHH
KNAQEIFSQEKTSDEDLILEEVRSLFNLECVPYRVEIFDTSHHSNSQCVGGMVVYENNAF
HHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCEEEEECCCC
QKNSYRRYHLKGSNEYDQMSELLTRRALDFAKEPPPNLWVIDGGRAQLNIALEILKSSGS
CCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEHHHHHHHHCCCC
FVEVIAISKEKRDSKAYRSKGGAKDIIHTPSDTFKLLPSDKRLQWVQKLRDESHRYAINF
EEEEEEECCHHHHHHHHHHCCCCCCCEECCCHHEEECCCCHHHHHHHHHHCCCCEEEEEE
HRSTKLKNMKQIALLKEKGIGEASVKKLLDYFGSFEAIEKASEQEKNAVLKKRI
ECHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA