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The map label for this gene is hom [H]

Identifier: 108563233

GI number: 108563233

Start: 843239

End: 844504

Strand: Direct

Name: hom [H]

Synonym: HPAG1_0808

Alternate gene names: 108563233

Gene position: 843239-844504 (Clockwise)

Preceding gene: 108563232

Following gene: 108563234

Centisome position: 52.82

GC content: 41.07

Gene sequence:

>1266_bases
ATGAAAAAGAGATTGAATATAGGGCTTGTGGGTTTAGGGTGTGTGGGGAGCGCGGTCGCTAAAATCTTACAAGAAAATCA
AGAAATCATTAAAGACAGAGCCGGTGTGGGAATTGTGATTAAAAAAGCGGTGGTGCGAGACGTGAAAAAACACAAAGGCT
ATGCTTTTGAAATCAGTAATGATTTAGAAAGCCTGATAGAAGATGAAGAAATTGATATTGTCGTGGAGCTTATGGGTGGG
GTGGAAGCGCCTTATCTTTTAGCTAAAAAAACTTTAGCCAAACAAAAAGCCTTCGTTACAGCCAATAAAGCCATGTTAGC
GTACCACCGCTATGAATTAGAACAAACCGCTAAAAACACCCCCATAGGCTTTGAAGCGAGCGTGTGTGGGGGTATCCCTA
TTATCAAGGCTTTAAAAGACGGCTTGAGCGCTAATCACATCCTTTCTTTTAAAGGGATTTTAAACGGCACGAGCAATTAC
ATTTTAAGCCAGATGTTTAAAAATCAAGCGAGCTTTAAGGACGCTTTGAAAGACGCGCAACATTTAGGCTATGCGGAATT
GAACCCTGAATTTGACATTAAGGGCATTGATGCGGCGCACAAATTATTGATTTTAGCGTCTTTAGCGTATGGCATTGACG
CGAAATTAGAAGAAATTTTAATTGAAGGCATTGAAAAAATAGAGCCAGACGACATGGAGTTTGCTAAAGAATTTGGTTAT
AGCATCAAACTTTTAGGCATCGCTAAAAAACACCCAGATTGCATTGAACTAAGGGTGCATCCAAGCATGATCAAAAACGA
ATGCATGCTCTCTAAAGTGGATGGGGTGATGAACGCTATCAGCGTTATAGGGGATAAGGTGGGCGAGACTTTGTATTATG
GGGCTGGGGCTGGGGGAGAGCCTACCGCAAGCGCGGTCATTAGCGATATTATAGAAATCGCAAGGAAAAAAAGCTCTTTA
ATGCTGGGCTTTGAAACCCCTCAAAAACTCCCCCTAAAACCCAAAGAAGAAATCCAATGCGCTTATTATGCGCGTTTATT
AGTGAGCGATGAAAAAGGGGTTTTTTCTCAAATTAGCGCGATTTTAGCCCAAAATGATATTTCGCTCAACAATGTCTTAC
AAAAAGAAATCCCGCATTCCAACAAGGCCAAAATCTTATTTTCCACACACACCACCAACGAAAAATCTATGCTGAACGCC
CTTAAAGAGCTTGAAAATTTACAAAGCGTGTTGGATACCCCTAAAATGATCCGTTTGGAACATTGA

Upstream 100 bases:

>100_bases
AAAAAATTATTGGATTATTTTGGGAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAGGAAAAAAACGCTGTTTTAAAAAA
ACGAATTTAAAGGAAAAAAC

Downstream 100 bases:

>100_bases
TGCGCTTTTTGAATAACAAACACAGGGCAAAGGGTTTGAAGGCTGAAGAAGAAGCTTGCGAATTTTTAAAAACGCTGGGT
TTTGAAATGGTGGAGAGGAA

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MKKRLNIGLVGLGCVGSAVAKILQENQEIIKDRAGVGIVIKKAVVRDVKKHKGYAFEISNDLESLIEDEEIDIVVELMGG
VEAPYLLAKKTLAKQKAFVTANKAMLAYHRYELEQTAKNTPIGFEASVCGGIPIIKALKDGLSANHILSFKGILNGTSNY
ILSQMFKNQASFKDALKDAQHLGYAELNPEFDIKGIDAAHKLLILASLAYGIDAKLEEILIEGIEKIEPDDMEFAKEFGY
SIKLLGIAKKHPDCIELRVHPSMIKNECMLSKVDGVMNAISVIGDKVGETLYYGAGAGGEPTASAVISDIIEIARKKSSL
MLGFETPQKLPLKPKEEIQCAYYARLLVSDEKGVFSQISAILAQNDISLNNVLQKEIPHSNKAKILFSTHTTNEKSMLNA
LKELENLQSVLDTPKMIRLEH

Sequences:

>Translated_421_residues
MKKRLNIGLVGLGCVGSAVAKILQENQEIIKDRAGVGIVIKKAVVRDVKKHKGYAFEISNDLESLIEDEEIDIVVELMGG
VEAPYLLAKKTLAKQKAFVTANKAMLAYHRYELEQTAKNTPIGFEASVCGGIPIIKALKDGLSANHILSFKGILNGTSNY
ILSQMFKNQASFKDALKDAQHLGYAELNPEFDIKGIDAAHKLLILASLAYGIDAKLEEILIEGIEKIEPDDMEFAKEFGY
SIKLLGIAKKHPDCIELRVHPSMIKNECMLSKVDGVMNAISVIGDKVGETLYYGAGAGGEPTASAVISDIIEIARKKSSL
MLGFETPQKLPLKPKEEIQCAYYARLLVSDEKGVFSQISAILAQNDISLNNVLQKEIPHSNKAKILFSTHTTNEKSMLNA
LKELENLQSVLDTPKMIRLEH
>Mature_421_residues
MKKRLNIGLVGLGCVGSAVAKILQENQEIIKDRAGVGIVIKKAVVRDVKKHKGYAFEISNDLESLIEDEEIDIVVELMGG
VEAPYLLAKKTLAKQKAFVTANKAMLAYHRYELEQTAKNTPIGFEASVCGGIPIIKALKDGLSANHILSFKGILNGTSNY
ILSQMFKNQASFKDALKDAQHLGYAELNPEFDIKGIDAAHKLLILASLAYGIDAKLEEILIEGIEKIEPDDMEFAKEFGY
SIKLLGIAKKHPDCIELRVHPSMIKNECMLSKVDGVMNAISVIGDKVGETLYYGAGAGGEPTASAVISDIIEIARKKSSL
MLGFETPQKLPLKPKEEIQCAYYARLLVSDEKGVFSQISAILAQNDISLNNVLQKEIPHSNKAKILFSTHTTNEKSMLNA
LKELENLQSVLDTPKMIRLEH

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=134, Percent_Identity=35.0746268656716, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46191; Mature: 46191

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS01042 HOMOSER_DHGENASE ; PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKRLNIGLVGLGCVGSAVAKILQENQEIIKDRAGVGIVIKKAVVRDVKKHKGYAFEISN
CCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCEEEEECH
DLESLIEDEEIDIVVELMGGVEAPYLLAKKTLAKQKAFVTANKAMLAYHRYELEQTAKNT
HHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PIGFEASVCGGIPIIKALKDGLSANHILSFKGILNGTSNYILSQMFKNQASFKDALKDAQ
CCCCCCHHHCCHHHHHHHHCCCCCCCEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
HLGYAELNPEFDIKGIDAAHKLLILASLAYGIDAKLEEILIEGIEKIEPDDMEFAKEFGY
HCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHCCC
SIKLLGIAKKHPDCIELRVHPSMIKNECMLSKVDGVMNAISVIGDKVGETLYYGAGAGGE
EEEEEEEECCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCC
PTASAVISDIIEIARKKSSLMLGFETPQKLPLKPKEEIQCAYYARLLVSDEKGVFSQISA
HHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHH
ILAQNDISLNNVLQKEIPHSNKAKILFSTHTTNEKSMLNALKELENLQSVLDTPKMIRLE
HHHHCCCCHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEC
H
C
>Mature Secondary Structure
MKKRLNIGLVGLGCVGSAVAKILQENQEIIKDRAGVGIVIKKAVVRDVKKHKGYAFEISN
CCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCEEEEECH
DLESLIEDEEIDIVVELMGGVEAPYLLAKKTLAKQKAFVTANKAMLAYHRYELEQTAKNT
HHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PIGFEASVCGGIPIIKALKDGLSANHILSFKGILNGTSNYILSQMFKNQASFKDALKDAQ
CCCCCCHHHCCHHHHHHHHCCCCCCCEEEEHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
HLGYAELNPEFDIKGIDAAHKLLILASLAYGIDAKLEEILIEGIEKIEPDDMEFAKEFGY
HCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHCCC
SIKLLGIAKKHPDCIELRVHPSMIKNECMLSKVDGVMNAISVIGDKVGETLYYGAGAGGE
EEEEEEEECCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCC
PTASAVISDIIEIARKKSSLMLGFETPQKLPLKPKEEIQCAYYARLLVSDEKGVFSQISA
HHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHH
ILAQNDISLNNVLQKEIPHSNKAKILFSTHTTNEKSMLNALKELENLQSVLDTPKMIRLE
HHHHCCCCHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEC
H
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]