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The map label for this gene is hslU [H]

Identifier: 108562915

GI number: 108562915

Start: 508542

End: 509873

Strand: Direct

Name: hslU [H]

Synonym: HPAG1_0490

Alternate gene names: 108562915

Gene position: 508542-509873 (Clockwise)

Preceding gene: 108562914

Following gene: 108562916

Centisome position: 31.86

GC content: 38.74

Gene sequence:

>1332_bases
ATGTCTAAATTGAATATGACCCCAAGAGAAATTGTCGCTTATTTAGATGAATATATCATTGGGCAAAAGGAAGCTAAAAA
GTCTATCGCTATCGCTTTTAGGAATCGTTACAGGCGTTTGCAACTGGAAAAATCCTTACAAGAAGAAATCACGCCTAAAA
ACATTTTAATGATTGGCTCTACTGGCGTGGGTAAAACGGAAATCGCAAGAAGAATAGCAAAAATCATGGAACTCCCCTTT
GTGAAAGTGGAGGCGAGCAAGTACACAGAAGTGGGTTTTGTGGGGCGTGATGTGGAGTCTATGGTGAGGGATTTGGTTAA
TAACAGCGTGCTTTTAGTGGAAAATGAGCATAAAGAAAAATTAAAAGACAAGATTGAAGAGGCGGTTGTAGAAAAAATCG
CTAAAAAACTCCTACCCCCTTTGCCTAATGGCGTGAGCGAAGAAAAAAAACAAGAATACGCTAACAGCCTTTTAAAGATG
CAACAAAGAATCGTGCAAGGCGAGTTGGATAGTAGAGAAATTGAAATTGAAGTGCGTAAAAAAAGCATAGAGATTGATTC
CAATGTGCCGCCTGAAATTTTAAGGGTTCAAGAAAACTTGATTAAGGTTTTCCATAAAGAACAGGATAAAGTCAAAAAAA
CTTTAAGCGTTAAAGAGGCTAAAGAAGCCTTAAAAGCAGAAATTAGCGACACGCTTTTAGACAGCGAAGCCATTAAAATG
GAAGGCTTGAAGCGCGCGGAAAGTTCAGGGGTGATTTTTATTGATGAAATTGATAAGATCGCTGTCAGCTCTAAAGAAGG
AAGCCGTCAAGATCCCAGTAAAGAGGGGGTTCAAAGGGATTTGTTGCCGATTGTAGAGGGGAGTGTGGTGAATACGAAGT
ATGGCTCTATTAAAACAGAGCATATTCTATTCATTGCAGCCGGGGCTTTTCATCTTTCTAAGCCAAGCGATCTCATTCCT
GAATTGCAAGGCCGTTTCCCTTTAAGGGTGGAGTTAGAAAATTTAACCGAAGAAATCATGTATATGATTTTAACCCAAAC
TAAAACTTCTATCATTAAACAATACCAAGCCCTTTTACAAGTGGAAGGCGTAGGAATTGCGTTTGAAGACGATGCGATCA
AAGAGTTAGCCAAACTTTCTTATAACGCCAATCAAAAAAGCGAAGATATAGGCGCTAGAAGGTTGCACACCACCATTGAA
AAAGTGCTAGAAGACATTAGTTTTGAAGCGGAGGATTATTTGGGGCAAAAGGTTACTATCACTAAAGAATTGGTTCAATC
AAAGCTAGAGGATTTAGTGGCTGATGAAAATTTAGTGAAGTATATTTTATAA

Upstream 100 bases:

>100_bases
TCGCTCATTTAGAGCCTAGAAAACTTGTAGAAGAGTCCTTAAAAATCGCAGGGGATCTTTGCATTTACACCAACACAAAT
ATTAAAATTTTGGAGCTTTA

Downstream 100 bases:

>100_bases
TGAAAAATAAGGCGGGCTTTGTAGCTCTTATAGGCAAACCAAACGCTGGAAAAAGCACTCTTTTAAACACTTTATTAAAC
GCTCATTTAGCCCTTGTTTC

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU [H]

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MSKLNMTPREIVAYLDEYIIGQKEAKKSIAIAFRNRYRRLQLEKSLQEEITPKNILMIGSTGVGKTEIARRIAKIMELPF
VKVEASKYTEVGFVGRDVESMVRDLVNNSVLLVENEHKEKLKDKIEEAVVEKIAKKLLPPLPNGVSEEKKQEYANSLLKM
QQRIVQGELDSREIEIEVRKKSIEIDSNVPPEILRVQENLIKVFHKEQDKVKKTLSVKEAKEALKAEISDTLLDSEAIKM
EGLKRAESSGVIFIDEIDKIAVSSKEGSRQDPSKEGVQRDLLPIVEGSVVNTKYGSIKTEHILFIAAGAFHLSKPSDLIP
ELQGRFPLRVELENLTEEIMYMILTQTKTSIIKQYQALLQVEGVGIAFEDDAIKELAKLSYNANQKSEDIGARRLHTTIE
KVLEDISFEAEDYLGQKVTITKELVQSKLEDLVADENLVKYIL

Sequences:

>Translated_443_residues
MSKLNMTPREIVAYLDEYIIGQKEAKKSIAIAFRNRYRRLQLEKSLQEEITPKNILMIGSTGVGKTEIARRIAKIMELPF
VKVEASKYTEVGFVGRDVESMVRDLVNNSVLLVENEHKEKLKDKIEEAVVEKIAKKLLPPLPNGVSEEKKQEYANSLLKM
QQRIVQGELDSREIEIEVRKKSIEIDSNVPPEILRVQENLIKVFHKEQDKVKKTLSVKEAKEALKAEISDTLLDSEAIKM
EGLKRAESSGVIFIDEIDKIAVSSKEGSRQDPSKEGVQRDLLPIVEGSVVNTKYGSIKTEHILFIAAGAFHLSKPSDLIP
ELQGRFPLRVELENLTEEIMYMILTQTKTSIIKQYQALLQVEGVGIAFEDDAIKELAKLSYNANQKSEDIGARRLHTTIE
KVLEDISFEAEDYLGQKVTITKELVQSKLEDLVADENLVKYIL
>Mature_442_residues
SKLNMTPREIVAYLDEYIIGQKEAKKSIAIAFRNRYRRLQLEKSLQEEITPKNILMIGSTGVGKTEIARRIAKIMELPFV
KVEASKYTEVGFVGRDVESMVRDLVNNSVLLVENEHKEKLKDKIEEAVVEKIAKKLLPPLPNGVSEEKKQEYANSLLKMQ
QRIVQGELDSREIEIEVRKKSIEIDSNVPPEILRVQENLIKVFHKEQDKVKKTLSVKEAKEALKAEISDTLLDSEAIKME
GLKRAESSGVIFIDEIDKIAVSSKEGSRQDPSKEGVQRDLLPIVEGSVVNTKYGSIKTEHILFIAAGAFHLSKPSDLIPE
LQGRFPLRVELENLTEEIMYMILTQTKTSIIKQYQALLQVEGVGIAFEDDAIKELAKLSYNANQKSEDIGARRLHTTIEK
VLEDISFEAEDYLGQKVTITKELVQSKLEDLVADENLVKYIL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790366, Length=441, Percent_Identity=47.8458049886621, Blast_Score=414, Evalue=1e-117,
Organism=Escherichia coli, GI1786642, Length=104, Percent_Identity=43.2692307692308, Blast_Score=96, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 50174; Mature: 50043

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKLNMTPREIVAYLDEYIIGQKEAKKSIAIAFRNRYRRLQLEKSLQEEITPKNILMIGS
CCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEC
TGVGKTEIARRIAKIMELPFVKVEASKYTEVGFVGRDVESMVRDLVNNSVLLVENEHKEK
CCCCHHHHHHHHHHHHHCCCEEEECCCCCHHCCCCCCHHHHHHHHHCCCEEEEECCHHHH
LKDKIEEAVVEKIAKKLLPPLPNGVSEEKKQEYANSLLKMQQRIVQGELDSREIEIEVRK
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEE
KSIEIDSNVPPEILRVQENLIKVFHKEQDKVKKTLSVKEAKEALKAEISDTLLDSEAIKM
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHH
EGLKRAESSGVIFIDEIDKIAVSSKEGSRQDPSKEGVQRDLLPIVEGSVVNTKYGSIKTE
HHHHHCCCCCEEEEECCCHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCEEEC
HILFIAAGAFHLSKPSDLIPELQGRFPLRVELENLTEEIMYMILTQTKTSIIKQYQALLQ
EEEEEEECCCCCCCCHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VEGVGIAFEDDAIKELAKLSYNANQKSEDIGARRLHTTIEKVLEDISFEAEDYLGQKVTI
HCCCCEEECHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCEEHH
TKELVQSKLEDLVADENLVKYIL
HHHHHHHHHHHHHCCCHHHHHCC
>Mature Secondary Structure 
SKLNMTPREIVAYLDEYIIGQKEAKKSIAIAFRNRYRRLQLEKSLQEEITPKNILMIGS
CCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEC
TGVGKTEIARRIAKIMELPFVKVEASKYTEVGFVGRDVESMVRDLVNNSVLLVENEHKEK
CCCCHHHHHHHHHHHHHCCCEEEECCCCCHHCCCCCCHHHHHHHHHCCCEEEEECCHHHH
LKDKIEEAVVEKIAKKLLPPLPNGVSEEKKQEYANSLLKMQQRIVQGELDSREIEIEVRK
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEE
KSIEIDSNVPPEILRVQENLIKVFHKEQDKVKKTLSVKEAKEALKAEISDTLLDSEAIKM
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHH
EGLKRAESSGVIFIDEIDKIAVSSKEGSRQDPSKEGVQRDLLPIVEGSVVNTKYGSIKTE
HHHHHCCCCCEEEEECCCHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCEEEC
HILFIAAGAFHLSKPSDLIPELQGRFPLRVELENLTEEIMYMILTQTKTSIIKQYQALLQ
EEEEEEECCCCCCCCHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VEGVGIAFEDDAIKELAKLSYNANQKSEDIGARRLHTTIEKVLEDISFEAEDYLGQKVTI
HCCCCEEECHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCEEHH
TKELVQSKLEDLVADENLVKYIL
HHHHHHHHHHHHHCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA