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The map label for this gene is gyrB [H]

Identifier: 108562902

GI number: 108562902

Start: 493399

End: 495720

Strand: Direct

Name: gyrB [H]

Synonym: HPAG1_0477

Alternate gene names: 108562902

Gene position: 493399-495720 (Clockwise)

Preceding gene: 108562901

Following gene: 108562903

Centisome position: 30.91

GC content: 40.57

Gene sequence:

>2322_bases
ATGCAAAATTACCAGAGCCATAGTATTAAGGTTTTAAAAGGCTTAGAGGGGGTTAGGAAACGCCCTGGAATGTATATTGG
CGATACCAATATAGGCGGGTTGCACCACATGGTGTATGAAGTCGTGGATAACGCTGTAGATGAGAGCATGGCGGGTTTTT
GTGATACAATTAATATCACTTTGACTAGTGAGGGGTCATGCATTGTAGAAGATAACGGGCGAGGCATTCCTGTAGATATC
CACCCCACGGAAAAAATCCCCGCTTGCACCGTGGTTTTAACGATTTTGCATGCGGGGGGCAAGTTTGATAATGATACTTA
TAAAGTTTCAGGCGGTTTGCATGGCGTGGGCGTTTCGGTTGTGAACGCTTTGAGCAAACGCTTGATTATGACCATTAAAA
AAGAGGGTCAAATCTACCGCCAAGAGTTTGAAAAGGGTATCCCCATTAGCGAGCTTGAAATCATTGGCAAAACCAAAAGC
GCTAAAGAAAGCGGCACGACTATTGAATTTTTCCCTGATGAAAGCGTGATGGAAGTCGTTGAATTTCAAGCGGGTATTTT
GCAAAAACGCTTCAAAGAAATGGCGTATCTTAACGACGGCTTAAAAATTTCTTTCAAAGAAGAAAAAACCCAACTGCAAG
AGACTTATTTTTATAAAGACGGCTTGAAACAATTCGTTAAAGACAGCGCTAAAAAAGAATTGCTCACCCCCGTTATTGCG
TTTAAAAGCATGGATGAAGAAACGCGCACTTCTATAGAAGTCGCTTTAGCGTATGCTGATGATTACAATGAAAACACTTT
AAGCTTTGTGAATAACATTAAAACTTCTGAGGGCGGCACGCATGAGGCGGGCTTTAAAATGGGCTTGTCTAAGGCGATTT
TGCAATACATTGACAATAATATTAAAACTAAAGAGTCGCGCCCCATCTCTGAAGACATTAAAGAGGGGTTGATCGCTGTT
GTGAGCTTGAAAATGAGCGAGCCTTTGTTTGAAGGGCAGACTAAATCCAAGCTCGGCAGTTCGTATGCACGCGCGTTAGT
TTCAAAATTAGTCTATGATAAAATCCATCAGTTTTTAGAAGAAAACCCTAACGAAGCCAAAATCATTGCCAATAAAGCCC
TACTAGCTGCAAAAGCCAGAGAAGCCAGTAAGAAAGCCAGAGAGCTTACAAGGAAAAAAGATAATTTGAGTGTTGGCACT
TTGCCTGGAAAATTAGCCGATTGCCAGAGTAAAGACCCCTTAGAGAGTGAAATCTTTTTAGTGGAGGGCGATAGTGCGGG
CGGGAGCGCTAAACAAGGGCGCGATAGGGTTTTCCAAGCGATCTTGCCCTTAAAAGGTAAGATTTTAAATGTGGAAAAAA
GCCATTTGTCAAAAATCCTGAAATCAGAAGAAATTAAAAACATGATTACGGCTTTTGGGTGCGGCATTCAAGAGAGTTTT
GATATAGAAAGATTGCGCTATCATAAAATCATTATCATGACCGATGCTGATGTGGATGGGAGCCATATCCAAACCTTGCT
GATGACTTTTTTCTATCGTTATTTACGCCCGCTGATTGAACAAGGGCATGTTTATATCGCTCAAGCCCCTCTTTACAAAT
ACAAGAAAGGCAAGACAGAAATCTATCTTAAAGACAGCGTCGCTTTGGATCATTTTTTAATTGAGCATGGCATCAATTCG
GTGGATATTGAAGGGATTGGCAAGAACGATTTGATGAATTTGTTAAAAGTGGCGCGCCATTACCGCTACGCGCTTTTGGA
ATTAGAAAAACGCTACAATTTGCTAGAAATTTTACGCTTTTTGATTGAAACTAAGGACGCCTTAAGCCTTGATATGAAAG
TTTTAGAAAAAAGCATTTTAGAAAAATTAGAGGGCTTGAATTATCAGATCTTACGCTCTTTTGCTACTGAAGAAAGCTTG
CATTTGCACGCGCAAACCCCTAAGGGCTTGGTGGAATTTAACCTAGATGACAACCTCTTTAAAGAAGTGTTGTTTGAAGA
AGCGCATTACACTTACCAAAAGCTTATGGAATATAATTTAGATTTCTTAGAAAATAAGGATATTTTGGCGTTTTTAGAAG
AAGTGGAAAATCACGCTAAAAAGGGAGCGAATATCCAGCGCTATAAGGGGCTAGGCGAGATGAACCCTAATGATTTGTGG
GAAACGACCATGCATAAAGAAAACCGCAGCTTGATCAAACTTAAAATTGAAGATTTAGAAAAAACCGATGCAGTCTTTTC
GCTTTGCATGGGCGATGAAGTAGAGCCTAGAAGAGCCTTTATCCAAGCGCATGCTAAAGACGTGAAACAACTAGATGTGT
AA

Upstream 100 bases:

>100_bases
GCCTTTTTTGATCCAAGAGTCTCTTGATGAAAAGCAAAGCCACTTGAGCGCTAAAATTTCCACTTTGATGATGCCAATCA
CATTATAAAGGCTTGATTGA

Downstream 100 bases:

>100_bases
GGGATTTTAATCGCCACTCCCAAACATTTAAATCAGCGAGAGAGCGTGAATTTAGGGGCTTATTACACGCCCCCTTATTT
AGTGGATTGCGCTTACAAGC

Product: DNA gyrase subunit B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 773; Mature: 773

Protein sequence:

>773_residues
MQNYQSHSIKVLKGLEGVRKRPGMYIGDTNIGGLHHMVYEVVDNAVDESMAGFCDTINITLTSEGSCIVEDNGRGIPVDI
HPTEKIPACTVVLTILHAGGKFDNDTYKVSGGLHGVGVSVVNALSKRLIMTIKKEGQIYRQEFEKGIPISELEIIGKTKS
AKESGTTIEFFPDESVMEVVEFQAGILQKRFKEMAYLNDGLKISFKEEKTQLQETYFYKDGLKQFVKDSAKKELLTPVIA
FKSMDEETRTSIEVALAYADDYNENTLSFVNNIKTSEGGTHEAGFKMGLSKAILQYIDNNIKTKESRPISEDIKEGLIAV
VSLKMSEPLFEGQTKSKLGSSYARALVSKLVYDKIHQFLEENPNEAKIIANKALLAAKAREASKKARELTRKKDNLSVGT
LPGKLADCQSKDPLESEIFLVEGDSAGGSAKQGRDRVFQAILPLKGKILNVEKSHLSKILKSEEIKNMITAFGCGIQESF
DIERLRYHKIIIMTDADVDGSHIQTLLMTFFYRYLRPLIEQGHVYIAQAPLYKYKKGKTEIYLKDSVALDHFLIEHGINS
VDIEGIGKNDLMNLLKVARHYRYALLELEKRYNLLEILRFLIETKDALSLDMKVLEKSILEKLEGLNYQILRSFATEESL
HLHAQTPKGLVEFNLDDNLFKEVLFEEAHYTYQKLMEYNLDFLENKDILAFLEEVENHAKKGANIQRYKGLGEMNPNDLW
ETTMHKENRSLIKLKIEDLEKTDAVFSLCMGDEVEPRRAFIQAHAKDVKQLDV

Sequences:

>Translated_773_residues
MQNYQSHSIKVLKGLEGVRKRPGMYIGDTNIGGLHHMVYEVVDNAVDESMAGFCDTINITLTSEGSCIVEDNGRGIPVDI
HPTEKIPACTVVLTILHAGGKFDNDTYKVSGGLHGVGVSVVNALSKRLIMTIKKEGQIYRQEFEKGIPISELEIIGKTKS
AKESGTTIEFFPDESVMEVVEFQAGILQKRFKEMAYLNDGLKISFKEEKTQLQETYFYKDGLKQFVKDSAKKELLTPVIA
FKSMDEETRTSIEVALAYADDYNENTLSFVNNIKTSEGGTHEAGFKMGLSKAILQYIDNNIKTKESRPISEDIKEGLIAV
VSLKMSEPLFEGQTKSKLGSSYARALVSKLVYDKIHQFLEENPNEAKIIANKALLAAKAREASKKARELTRKKDNLSVGT
LPGKLADCQSKDPLESEIFLVEGDSAGGSAKQGRDRVFQAILPLKGKILNVEKSHLSKILKSEEIKNMITAFGCGIQESF
DIERLRYHKIIIMTDADVDGSHIQTLLMTFFYRYLRPLIEQGHVYIAQAPLYKYKKGKTEIYLKDSVALDHFLIEHGINS
VDIEGIGKNDLMNLLKVARHYRYALLELEKRYNLLEILRFLIETKDALSLDMKVLEKSILEKLEGLNYQILRSFATEESL
HLHAQTPKGLVEFNLDDNLFKEVLFEEAHYTYQKLMEYNLDFLENKDILAFLEEVENHAKKGANIQRYKGLGEMNPNDLW
ETTMHKENRSLIKLKIEDLEKTDAVFSLCMGDEVEPRRAFIQAHAKDVKQLDV
>Mature_773_residues
MQNYQSHSIKVLKGLEGVRKRPGMYIGDTNIGGLHHMVYEVVDNAVDESMAGFCDTINITLTSEGSCIVEDNGRGIPVDI
HPTEKIPACTVVLTILHAGGKFDNDTYKVSGGLHGVGVSVVNALSKRLIMTIKKEGQIYRQEFEKGIPISELEIIGKTKS
AKESGTTIEFFPDESVMEVVEFQAGILQKRFKEMAYLNDGLKISFKEEKTQLQETYFYKDGLKQFVKDSAKKELLTPVIA
FKSMDEETRTSIEVALAYADDYNENTLSFVNNIKTSEGGTHEAGFKMGLSKAILQYIDNNIKTKESRPISEDIKEGLIAV
VSLKMSEPLFEGQTKSKLGSSYARALVSKLVYDKIHQFLEENPNEAKIIANKALLAAKAREASKKARELTRKKDNLSVGT
LPGKLADCQSKDPLESEIFLVEGDSAGGSAKQGRDRVFQAILPLKGKILNVEKSHLSKILKSEEIKNMITAFGCGIQESF
DIERLRYHKIIIMTDADVDGSHIQTLLMTFFYRYLRPLIEQGHVYIAQAPLYKYKKGKTEIYLKDSVALDHFLIEHGINS
VDIEGIGKNDLMNLLKVARHYRYALLELEKRYNLLEILRFLIETKDALSLDMKVLEKSILEKLEGLNYQILRSFATEESL
HLHAQTPKGLVEFNLDDNLFKEVLFEEAHYTYQKLMEYNLDFLENKDILAFLEEVENHAKKGANIQRYKGLGEMNPNDLW
ETTMHKENRSLIKLKIEDLEKTDAVFSLCMGDEVEPRRAFIQAHAKDVKQLDV

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Toprim domain [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=576, Percent_Identity=26.9097222222222, Blast_Score=147, Evalue=5e-35,
Organism=Homo sapiens, GI19913406, Length=585, Percent_Identity=24.4444444444444, Blast_Score=128, Evalue=2e-29,
Organism=Escherichia coli, GI48994957, Length=816, Percent_Identity=43.5049019607843, Blast_Score=628, Evalue=0.0,
Organism=Escherichia coli, GI1789408, Length=544, Percent_Identity=41.9117647058824, Blast_Score=419, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI212645845, Length=504, Percent_Identity=27.3809523809524, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17535065, Length=559, Percent_Identity=27.0125223613596, Blast_Score=133, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI212645657, Length=144, Percent_Identity=31.25, Blast_Score=73, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=558, Percent_Identity=27.4193548387097, Blast_Score=127, Evalue=7e-30,
Organism=Drosophila melanogaster, GI17136538, Length=500, Percent_Identity=25.8, Blast_Score=121, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011557
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR006171 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c; PF01751 Toprim [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 87387; Mature: 87387

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNYQSHSIKVLKGLEGVRKRPGMYIGDTNIGGLHHMVYEVVDNAVDESMAGFCDTINIT
CCCCCHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEE
LTSEGSCIVEDNGRGIPVDIHPTEKIPACTVVLTILHAGGKFDNDTYKVSGGLHGVGVSV
EECCCCEEEECCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHH
VNALSKRLIMTIKKEGQIYRQEFEKGIPISELEIIGKTKSAKESGTTIEFFPDESVMEVV
HHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHEECCCCCCCCCCCEEEECCCHHHHHHH
EFQAGILQKRFKEMAYLNDGLKISFKEEKTQLQETYFYKDGLKQFVKDSAKKELLTPVIA
HHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FKSMDEETRTSIEVALAYADDYNENTLSFVNNIKTSEGGTHEAGFKMGLSKAILQYIDNN
HHCCCHHHHHEEEEEEEECCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCC
IKTKESRPISEDIKEGLIAVVSLKMSEPLFEGQTKSKLGSSYARALVSKLVYDKIHQFLE
CCCCCCCCCHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ENPNEAKIIANKALLAAKAREASKKARELTRKKDNLSVGTLPGKLADCQSKDPLESEIFL
CCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCEEEE
VEGDSAGGSAKQGRDRVFQAILPLKGKILNVEKSHLSKILKSEEIKNMITAFGCGIQESF
EECCCCCCCCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DIERLRYHKIIIMTDADVDGSHIQTLLMTFFYRYLRPLIEQGHVYIAQAPLYKYKKGKTE
CHHHEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHCCCCEE
IYLKDSVALDHFLIEHGINSVDIEGIGKNDLMNLLKVARHYRYALLELEKRYNLLEILRF
EEEECCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
LIETKDALSLDMKVLEKSILEKLEGLNYQILRSFATEESLHLHAQTPKGLVEFNLDDNLF
HHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEECCCCCCEEECCCHHHH
KEVLFEEAHYTYQKLMEYNLDFLENKDILAFLEEVENHAKKGANIQRYKGLGEMNPNDLW
HHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCHHHH
ETTMHKENRSLIKLKIEDLEKTDAVFSLCMGDEVEPRRAFIQAHAKDVKQLDV
HHHHHCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQNYQSHSIKVLKGLEGVRKRPGMYIGDTNIGGLHHMVYEVVDNAVDESMAGFCDTINIT
CCCCCHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEE
LTSEGSCIVEDNGRGIPVDIHPTEKIPACTVVLTILHAGGKFDNDTYKVSGGLHGVGVSV
EECCCCEEEECCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHH
VNALSKRLIMTIKKEGQIYRQEFEKGIPISELEIIGKTKSAKESGTTIEFFPDESVMEVV
HHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHEECCCCCCCCCCCEEEECCCHHHHHHH
EFQAGILQKRFKEMAYLNDGLKISFKEEKTQLQETYFYKDGLKQFVKDSAKKELLTPVIA
HHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FKSMDEETRTSIEVALAYADDYNENTLSFVNNIKTSEGGTHEAGFKMGLSKAILQYIDNN
HHCCCHHHHHEEEEEEEECCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCC
IKTKESRPISEDIKEGLIAVVSLKMSEPLFEGQTKSKLGSSYARALVSKLVYDKIHQFLE
CCCCCCCCCHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ENPNEAKIIANKALLAAKAREASKKARELTRKKDNLSVGTLPGKLADCQSKDPLESEIFL
CCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCCEEEE
VEGDSAGGSAKQGRDRVFQAILPLKGKILNVEKSHLSKILKSEEIKNMITAFGCGIQESF
EECCCCCCCCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DIERLRYHKIIIMTDADVDGSHIQTLLMTFFYRYLRPLIEQGHVYIAQAPLYKYKKGKTE
CHHHEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHCCCCEE
IYLKDSVALDHFLIEHGINSVDIEGIGKNDLMNLLKVARHYRYALLELEKRYNLLEILRF
EEEECCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
LIETKDALSLDMKVLEKSILEKLEGLNYQILRSFATEESLHLHAQTPKGLVEFNLDDNLF
HHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEECCCCCCEEECCCHHHH
KEVLFEEAHYTYQKLMEYNLDFLENKDILAFLEEVENHAKKGANIQRYKGLGEMNPNDLW
HHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCHHHH
ETTMHKENRSLIKLKIEDLEKTDAVFSLCMGDEVEPRRAFIQAHAKDVKQLDV
HHHHHCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]