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The map label for this gene is adk

Identifier: 103488274

GI number: 103488274

Start: 2961165

End: 2961824

Strand: Reverse

Name: adk

Synonym: Sala_2797

Alternate gene names: 103488274

Gene position: 2961824-2961165 (Counterclockwise)

Preceding gene: 103488275

Following gene: 103488273

Centisome position: 88.54

GC content: 65.15

Gene sequence:

>660_bases
ATGACGCTCAATATCATTCTGCTCGGCCCGCCGGGGGCAGGCAAGGGAACGCAGGCATCGCGGCTCGAGGATGAGCATGG
CATGGTCCAGCTGTCGACCGGCGACATGTTGCGCGCCGCGGTCAAGGCGGGAACCCCCATCGGGCTTCAGGCCAAGGCGG
TGATGGACGCGGGCGAGCTGGTCTCGGACGCGATCGTGTCGGGGCTGATCGGCGAGCGGCTCGACGAACTCGGTCCCGAT
GTTTCGGTGATCTTCGATGGCTATCCGCGCACCGCGGCACAGGCCGACGCGCTCGACGGCATTTTGTCGGCACGCGGGCG
CACGCTCGACCATGTCATCGAACTCGTCGTCGATGAGGATGCGCTCGTCGATCGCATCACCGGCCGTTTCAGTTGCGCCC
GGTGCGGCGAGGGCTATCACGACCGCTACAAGCTGCCCAAGGTCGCCGACATCTGCGATGTTTGCGGGTCGAAAGAGTTC
AAACGCCGTCCCGACGACAATGAGGACACCGTGCGCACACGCATGGTCGAATATCGGGCGAAGACCGCGCCGATCCTGCC
GATCTATGAAGCGCGGGGCATCGTCACCCGGGTCGATGGCATGGCGCCGATCGACCGGGTCAACGACGCGATCGAAACGA
TCCTCGGCACCGCTGGCTAG

Upstream 100 bases:

>100_bases
ATGGCGACCTGATCAAGAAGGCGAAATTGAAGGGTGGCGTTGCGCGGCGCTGACGGCTTCGTTAGGGCAGGCGGCAACAC
GCAGGGGACAGGGGCCTTTC

Downstream 100 bases:

>100_bases
CCAGCCCTGCCGCTGCCCGTTATTGAGGGGGCAAGGGGGGAAATGCTTGATGGCAATTTCGGGATATTTTGCAGGTGTCG
CCGCATTGGCCGCGCTTGCG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 219; Mature: 218

Protein sequence:

>219_residues
MTLNIILLGPPGAGKGTQASRLEDEHGMVQLSTGDMLRAAVKAGTPIGLQAKAVMDAGELVSDAIVSGLIGERLDELGPD
VSVIFDGYPRTAAQADALDGILSARGRTLDHVIELVVDEDALVDRITGRFSCARCGEGYHDRYKLPKVADICDVCGSKEF
KRRPDDNEDTVRTRMVEYRAKTAPILPIYEARGIVTRVDGMAPIDRVNDAIETILGTAG

Sequences:

>Translated_219_residues
MTLNIILLGPPGAGKGTQASRLEDEHGMVQLSTGDMLRAAVKAGTPIGLQAKAVMDAGELVSDAIVSGLIGERLDELGPD
VSVIFDGYPRTAAQADALDGILSARGRTLDHVIELVVDEDALVDRITGRFSCARCGEGYHDRYKLPKVADICDVCGSKEF
KRRPDDNEDTVRTRMVEYRAKTAPILPIYEARGIVTRVDGMAPIDRVNDAIETILGTAG
>Mature_218_residues
TLNIILLGPPGAGKGTQASRLEDEHGMVQLSTGDMLRAAVKAGTPIGLQAKAVMDAGELVSDAIVSGLIGERLDELGPDV
SVIFDGYPRTAAQADALDGILSARGRTLDHVIELVVDEDALVDRITGRFSCARCGEGYHDRYKLPKVADICDVCGSKEFK
RRPDDNEDTVRTRMVEYRAKTAPILPIYEARGIVTRVDGMAPIDRVNDAIETILGTAG

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=206, Percent_Identity=41.747572815534, Blast_Score=159, Evalue=1e-39,
Organism=Homo sapiens, GI4502013, Length=206, Percent_Identity=41.747572815534, Blast_Score=159, Evalue=2e-39,
Organism=Homo sapiens, GI19923437, Length=198, Percent_Identity=35.3535353535354, Blast_Score=119, Evalue=1e-27,
Organism=Homo sapiens, GI310110345, Length=198, Percent_Identity=32.8282828282828, Blast_Score=111, Evalue=6e-25,
Organism=Homo sapiens, GI53832003, Length=198, Percent_Identity=32.8282828282828, Blast_Score=111, Evalue=6e-25,
Organism=Homo sapiens, GI8051579, Length=198, Percent_Identity=32.8282828282828, Blast_Score=111, Evalue=6e-25,
Organism=Homo sapiens, GI53832001, Length=198, Percent_Identity=32.8282828282828, Blast_Score=111, Evalue=6e-25,
Organism=Homo sapiens, GI4502011, Length=214, Percent_Identity=27.5700934579439, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI22749187, Length=190, Percent_Identity=27.3684210526316, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI28144899, Length=197, Percent_Identity=26.3959390862944, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI28144897, Length=197, Percent_Identity=26.3959390862944, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1786680, Length=219, Percent_Identity=46.1187214611872, Blast_Score=170, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI17552384, Length=214, Percent_Identity=41.588785046729, Blast_Score=168, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17567503, Length=206, Percent_Identity=29.126213592233, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17537943, Length=199, Percent_Identity=29.1457286432161, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17550688, Length=217, Percent_Identity=25.8064516129032, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6320432, Length=203, Percent_Identity=41.871921182266, Blast_Score=158, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6321018, Length=196, Percent_Identity=35.7142857142857, Blast_Score=124, Evalue=2e-29,
Organism=Drosophila melanogaster, GI22026816, Length=213, Percent_Identity=41.7840375586854, Blast_Score=164, Evalue=5e-41,
Organism=Drosophila melanogaster, GI17737899, Length=195, Percent_Identity=37.4358974358974, Blast_Score=117, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24645822, Length=195, Percent_Identity=37.4358974358974, Blast_Score=117, Evalue=5e-27,
Organism=Drosophila melanogaster, GI17647141, Length=197, Percent_Identity=30.9644670050761, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24663208, Length=197, Percent_Identity=30.9644670050761, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI221459597, Length=218, Percent_Identity=28.8990825688073, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21356893, Length=218, Percent_Identity=28.8990825688073, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_SPHAL (Q1GPC0)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_617835.1
- ProteinModelPortal:   Q1GPC0
- SMR:   Q1GPC0
- GeneID:   4080378
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_2797
- NMPDR:   fig|317655.9.peg.2662
- HOGENOM:   HBG630208
- OMA:   CGEGYHD
- ProtClustDB:   PRK00279
- BioCyc:   SALA317655:SALA_2797-MONOMER
- BRENDA:   2.7.4.3
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid; SSF57774 Adenylate_kinase_Znf_lid

EC number: =2.7.4.3

Molecular weight: Translated: 23463; Mature: 23332

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLNIILLGPPGAGKGTQASRLEDEHGMVQLSTGDMLRAAVKAGTPIGLQAKAVMDAGEL
CEEEEEEECCCCCCCCCCHHHCCCCCCEEEECCCHHHHHHHHCCCCCCCCHHHHHHHHHH
VSDAIVSGLIGERLDELGPDVSVIFDGYPRTAAQADALDGILSARGRTLDHVIELVVDED
HHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCH
ALVDRITGRFSCARCGEGYHDRYKLPKVADICDVCGSKEFKRRPDDNEDTVRTRMVEYRA
HHHHHHHCCHHHHHCCCCCCHHCCCCHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHH
KTAPILPIYEARGIVTRVDGMAPIDRVNDAIETILGTAG
CCCCCCEEHHCCCCEEECCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TLNIILLGPPGAGKGTQASRLEDEHGMVQLSTGDMLRAAVKAGTPIGLQAKAVMDAGEL
EEEEEEECCCCCCCCCCHHHCCCCCCEEEECCCHHHHHHHHCCCCCCCCHHHHHHHHHH
VSDAIVSGLIGERLDELGPDVSVIFDGYPRTAAQADALDGILSARGRTLDHVIELVVDED
HHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCH
ALVDRITGRFSCARCGEGYHDRYKLPKVADICDVCGSKEFKRRPDDNEDTVRTRMVEYRA
HHHHHHHCCHHHHHCCCCCCHHCCCCHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHH
KTAPILPIYEARGIVTRVDGMAPIDRVNDAIETILGTAG
CCCCCCEEHHCCCCEEECCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA