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The map label for this gene is hemB [H]

Identifier: 103488214

GI number: 103488214

Start: 2883892

End: 2884890

Strand: Reverse

Name: hemB [H]

Synonym: Sala_2737

Alternate gene names: 103488214

Gene position: 2884890-2883892 (Counterclockwise)

Preceding gene: 103488215

Following gene: 103488213

Centisome position: 86.24

GC content: 67.97

Gene sequence:

>999_bases
ATGACCCACGCCGCTTTCCCCGACCTGCGTCTGCGCCGCACGCGCCGCACCCGTTGGAGCCGCGCGATGGTGCGCGAAAC
GCAGCTGTCGCCCGCGAATCTCATCTGGCCGCTGTTCGTCTGCGACGGATCGGAAACCGAGGAATCCATTGCCAGCCTGC
CCGGCGTGTCGCGCTGGTCGGTCGACCGCCTTGTCGATCGCGCCCGCGACGCCGTCGCCGCGGGCATCCCGTGCCTGGCC
CTCTTTCCTTATACGCCGGCGGAGCGGCGCAGCGCGGACGGCGGCGAGGCGCTCAATCCGGACAATCTCATGTGCCGCGC
CACCGCCGCGATCAAGCAGGCGCTCGGCGACGACATCGGCGTTCTCACCGATGTGGCGCTCGATCCCTATACCAGCCACG
GACAGGACGGACTCGTTGATGACAGCGGCTATGTGCTCAACGACGAAACGGTCGAGGTGCTGGTCGGGCAGGCGCTCAAC
CAGGCGCGCGCAGGTGCCGACATCATTGCGCCCAGCGACATGATGGACGGCCGCATCGGCGCGATCCGGCGGGCGCTCGA
AGCCGAAGGCTTCGGCCATGTCCAGATCATGAGCTACGCCGCCAAATATGCCTCGGCCTTTTACGGTCCCTTCCGCGACG
CGGTCGGATCGCGCGGGCTATTGCAGGGCGACAAGAAGACCTATCAGATGGACCCCGCGAACAGCGCGGAGGCCTTGCGC
GAGGTCGCGCAGGATCTGGCCGAGGGCGCCGACAGCGTGATGGTCAAGCCCGGCCTGCCCTATCTCGACATCGTCCGCGC
GGTGAAGGACAATTTCGCGGTCCCCGTCTACGCCTATCAGGTGTCGGGCGAATATGCGATGATCGAGGCTGCGGCGGTCG
CGGGTGCGGGCGACCGCGATGCGATCCTCCTCGAAACCCTGCTCGCTTTTCGCCGCGCGGGGGCGTCGGGGGTGCTCAGT
TACCACGCGCTCCACGCGGCGCGGCTGCTTGGCGCCTGA

Upstream 100 bases:

>100_bases
CGGGCGGGCGAGGGCATCTGAAGGGACATGCCCTCCGCTGAAGGGGAAGGGCTTTAGAAGAACCATTTGCCCCGCGCGGC
TGGGCCGCTATGCAGCGCGC

Downstream 100 bases:

>100_bases
CGCGATGATCGCAACATCTCCGCCGCGCCGCTGGCTGTTCGTGCTGACGATCCTTGTCGGCAGCTTCCTCCTCTTCATGG
TGCAGCCGATGGTCGCGCGC

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MTHAAFPDLRLRRTRRTRWSRAMVRETQLSPANLIWPLFVCDGSETEESIASLPGVSRWSVDRLVDRARDAVAAGIPCLA
LFPYTPAERRSADGGEALNPDNLMCRATAAIKQALGDDIGVLTDVALDPYTSHGQDGLVDDSGYVLNDETVEVLVGQALN
QARAGADIIAPSDMMDGRIGAIRRALEAEGFGHVQIMSYAAKYASAFYGPFRDAVGSRGLLQGDKKTYQMDPANSAEALR
EVAQDLAEGADSVMVKPGLPYLDIVRAVKDNFAVPVYAYQVSGEYAMIEAAAVAGAGDRDAILLETLLAFRRAGASGVLS
YHALHAARLLGA

Sequences:

>Translated_332_residues
MTHAAFPDLRLRRTRRTRWSRAMVRETQLSPANLIWPLFVCDGSETEESIASLPGVSRWSVDRLVDRARDAVAAGIPCLA
LFPYTPAERRSADGGEALNPDNLMCRATAAIKQALGDDIGVLTDVALDPYTSHGQDGLVDDSGYVLNDETVEVLVGQALN
QARAGADIIAPSDMMDGRIGAIRRALEAEGFGHVQIMSYAAKYASAFYGPFRDAVGSRGLLQGDKKTYQMDPANSAEALR
EVAQDLAEGADSVMVKPGLPYLDIVRAVKDNFAVPVYAYQVSGEYAMIEAAAVAGAGDRDAILLETLLAFRRAGASGVLS
YHALHAARLLGA
>Mature_331_residues
THAAFPDLRLRRTRRTRWSRAMVRETQLSPANLIWPLFVCDGSETEESIASLPGVSRWSVDRLVDRARDAVAAGIPCLAL
FPYTPAERRSADGGEALNPDNLMCRATAAIKQALGDDIGVLTDVALDPYTSHGQDGLVDDSGYVLNDETVEVLVGQALNQ
ARAGADIIAPSDMMDGRIGAIRRALEAEGFGHVQIMSYAAKYASAFYGPFRDAVGSRGLLQGDKKTYQMDPANSAEALRE
VAQDLAEGADSVMVKPGLPYLDIVRAVKDNFAVPVYAYQVSGEYAMIEAAAVAGAGDRDAILLETLLAFRRAGASGVLSY
HALHAARLLGA

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen. Required for nodule development [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=298, Percent_Identity=44.6308724832215, Blast_Score=236, Evalue=2e-62,
Organism=Escherichia coli, GI87081728, Length=318, Percent_Identity=44.9685534591195, Blast_Score=235, Evalue=4e-63,
Organism=Saccharomyces cerevisiae, GI6321398, Length=307, Percent_Identity=39.413680781759, Blast_Score=196, Evalue=3e-51,
Organism=Drosophila melanogaster, GI21358291, Length=327, Percent_Identity=36.3914373088685, Blast_Score=217, Evalue=8e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 35572; Mature: 35440

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHAAFPDLRLRRTRRTRWSRAMVRETQLSPANLIWPLFVCDGSETEESIASLPGVSRWS
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHHHCCCCCHHH
VDRLVDRARDAVAAGIPCLALFPYTPAERRSADGGEALNPDNLMCRATAAIKQALGDDIG
HHHHHHHHHHHHHHCCCEEEECCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHH
VLTDVALDPYTSHGQDGLVDDSGYVLNDETVEVLVGQALNQARAGADIIAPSDMMDGRIG
HHHHHHCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHCCCCCCCCCHHCCCHHH
AIRRALEAEGFGHVQIMSYAAKYASAFYGPFRDAVGSRGLLQGDKKTYQMDPANSAEALR
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHHH
EVAQDLAEGADSVMVKPGLPYLDIVRAVKDNFAVPVYAYQVSGEYAMIEAAAVAGAGDRD
HHHHHHHCCCCCEEECCCCCHHHHHHHHHCCCCCEEEEEEECCCEEEEEHHHHCCCCCCH
AILLETLLAFRRAGASGVLSYHALHAARLLGA
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
THAAFPDLRLRRTRRTRWSRAMVRETQLSPANLIWPLFVCDGSETEESIASLPGVSRWS
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHHHCCCCCHHH
VDRLVDRARDAVAAGIPCLALFPYTPAERRSADGGEALNPDNLMCRATAAIKQALGDDIG
HHHHHHHHHHHHHHCCCEEEECCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHH
VLTDVALDPYTSHGQDGLVDDSGYVLNDETVEVLVGQALNQARAGADIIAPSDMMDGRIG
HHHHHHCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHCCCCCCCCCHHCCCHHH
AIRRALEAEGFGHVQIMSYAAKYASAFYGPFRDAVGSRGLLQGDKKTYQMDPANSAEALR
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHHH
EVAQDLAEGADSVMVKPGLPYLDIVRAVKDNFAVPVYAYQVSGEYAMIEAAAVAGAGDRD
HHHHHHHCCCCCEEECCCCCHHHHHHHHHCCCCCEEEEEEECCCEEEEEHHHHCCCCCCH
AILLETLLAFRRAGASGVLSYHALHAARLLGA
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8226669; 12597275 [H]