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The map label for this gene is merR1 [H]

Identifier: 103488040

GI number: 103488040

Start: 2702209

End: 2702616

Strand: Reverse

Name: merR1 [H]

Synonym: Sala_2562

Alternate gene names: 103488040

Gene position: 2702616-2702209 (Counterclockwise)

Preceding gene: 103488042

Following gene: 103488036

Centisome position: 80.79

GC content: 62.5

Gene sequence:

>408_bases
GTGATCGGAGAGACGATCGCAATTGGCGAGCTGTCGCGCCAGACTGGCTGCAACATCGAGACGATTCGCTATTATGAGCG
GATCGGCCTTACGCCAAGGGCGAGCCGGCGGGGTCGCTATCGCAGCTATGATACGGCCGATATCAGGCGGCTGCGGTTCA
TCCGCCGTGCGCGCGAGCTCGGCTTTACGCTCGAAGAGATCAGCGCACTTATCGGGATTGCCGCTGCAGGCGAGGTATCA
TGCGCGAATGCGCGCGGTATCGCTGCCGCGCATCTCGCAAGCGTGCGCGCACGGCTCCTCGATCTGCGGCGGATGGAAGA
GGTTCTTCATGGAGTCGTGCGAGCGTGTGATGCGGGCGAGCATGCTGGATGCCCCTTGATCGAGACGCTTTCTGCGGACG
CTGGTTGA

Upstream 100 bases:

>100_bases
TGAACCGCTCCGCATCAACGACTCCTTGAATCTTCCATGAGGAGGTCATACCGTCTGTAGTAGCTACAGACTCAAGCTAT
TATTTTCGGAGGAGGCGCGC

Downstream 100 bases:

>100_bases
GCGACACGGTGCCATCACAAGATGCTTCTACTCAGCCGCGGCCGTGCCTGCTGCATGCCTTCGCCCGTTATACCAGAAGC
CAACACACAGGATCGCGAGC

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 135; Mature: 135

Protein sequence:

>135_residues
MIGETIAIGELSRQTGCNIETIRYYERIGLTPRASRRGRYRSYDTADIRRLRFIRRARELGFTLEEISALIGIAAAGEVS
CANARGIAAAHLASVRARLLDLRRMEEVLHGVVRACDAGEHAGCPLIETLSADAG

Sequences:

>Translated_135_residues
MIGETIAIGELSRQTGCNIETIRYYERIGLTPRASRRGRYRSYDTADIRRLRFIRRARELGFTLEEISALIGIAAAGEVS
CANARGIAAAHLASVRARLLDLRRMEEVLHGVVRACDAGEHAGCPLIETLSADAG
>Mature_135_residues
MIGETIAIGELSRQTGCNIETIRYYERIGLTPRASRRGRYRSYDTADIRRLRFIRRARELGFTLEEISALIGIAAAGEVS
CANARGIAAAHLASVRARLLDLRRMEEVLHGVVRACDAGEHAGCPLIETLSADAG

Specific function: Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury merR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a pote

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789687, Length=132, Percent_Identity=36.3636363636364, Blast_Score=80, Evalue=6e-17,
Organism=Escherichia coli, GI1786695, Length=127, Percent_Identity=29.9212598425197, Blast_Score=71, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR011794
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 14769; Mature: 14769

Theoretical pI: Translated: 8.65; Mature: 8.65

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGETIAIGELSRQTGCNIETIRYYERIGLTPRASRRGRYRSYDTADIRRLRFIRRAREL
CCCCCCCHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
GFTLEEISALIGIAAAGEVSCANARGIAAAHLASVRARLLDLRRMEEVLHGVVRACDAGE
CCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
HAGCPLIETLSADAG
CCCCCHHHHHCCCCC
>Mature Secondary Structure
MIGETIAIGELSRQTGCNIETIRYYERIGLTPRASRRGRYRSYDTADIRRLRFIRRAREL
CCCCCCCHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
GFTLEEISALIGIAAAGEVSCANARGIAAAHLASVRARLLDLRRMEEVLHGVVRACDAGE
CCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
HAGCPLIETLSADAG
CCCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2536669; 10559175; 2492496; 2305262 [H]