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The map label for this gene is add

Identifier: 103487492

GI number: 103487492

Start: 2119380

End: 2120405

Strand: Direct

Name: add

Synonym: Sala_2009

Alternate gene names: 103487492

Gene position: 2119380-2120405 (Clockwise)

Preceding gene: 103487491

Following gene: 103487499

Centisome position: 63.36

GC content: 64.23

Gene sequence:

>1026_bases
GTGCCTGACGGCTTCGCCTCGCACGAAGAGCGCGCCGCCTTCATCGCCGGTCTGCCGAAGGCCGAACTGCACCTCCATAT
CGAAGGCTCGCTCGAACCCGAACTGCTGTTCGAGTTCGCCCGGCGCAACCGTGTCGCCATCCCCTTCGCCAGCATCGACG
ACGTGCGCGCCGCCTACGCCTTCACAAACCTCCAGGATTTCCTCGATATTTATTATCAGGGCATGGGCGTCCTCCACACC
GAGCAGGACTTCTTCGACCTGACCGCCGCCTATTGTGCCCGTGCGAACGCCGACAGCGTCCGTCACATCGAAATCTTCTT
CGATCCGCAAGGCCACACGGCGCGCGGCGTCGCCTTTGAAACCGTCATCACCGGCATCACCCGCGCGCTGGATGATGCCG
AGGCGCGGTACGGGATCACGTCAAAGCTCATCCTCTGCTTCCTGCGCCACCTCAGCGAAGCCGAGGCCGAAGCGACACTC
GACGAAGCGCTGCCCTTCTTGGGTCGCATTGCCGGCGTCGGCCTCGATTCATCCGAAGTCGGCCATCCGCCGGCCAAGTT
CGAGCGCGTGTTCGCCCGCGCCCGCAGCCTCGGCCTCAAAACCGTTGCCCATGCGGGCGAGGAAGGTCCACCCGAATATG
TCCGCGAAGCGCTCGACCTCTTGAAAGTCGACCGCATCGACCATGGCAATCGCAGCCTCGAAGACCCCGCGCTCGTCGCG
CGCCTCGCCGCGTCGGACATGACGCTCACCGTCTGTCCGCTCTCCAACCTCAAGCTGTGCGTCGTGGACGACATCGCCGA
TCACCCGCTGAAAATCATGCTCGATGCGGACCTCAAGGCTACCGTCAACAGCGACGATCCCAGCTATTTCGGCGGCTATG
TGAACGCCAATTACCAGGCCGTCGCCGACGCGCTCGACCTGTCGCGCGACGACCTCGTCACCCTCGCGCGCAACAGCTTC
ACCGGCTCCTTCCTGAGTGATGCGGAAAAGGCGCGCCACCTCGCGGCGATCGACGCCTACGCCTGA

Upstream 100 bases:

>100_bases
TGGCTGATCTTCCCGCACGAGATCGACGGGCTGACGGTCGACGAGATCCGCCGCCACAAACCCGAAGCGGCGATCATCCT
TGGCGAAGTGGAGGCGCCGG

Downstream 100 bases:

>100_bases
CGCGCGCGCCCGCGATGTCCGCCAGAGCGGCGTGCTGTGACCGAAAACGACTGCCCGCTGCCCACCCCATTCGGGCCAGC
ACAGAATCTCACGCCGCGAT

Product: adenosine deaminase

Products: NA

Alternate protein names: Adenosine aminohydrolase

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MPDGFASHEERAAFIAGLPKAELHLHIEGSLEPELLFEFARRNRVAIPFASIDDVRAAYAFTNLQDFLDIYYQGMGVLHT
EQDFFDLTAAYCARANADSVRHIEIFFDPQGHTARGVAFETVITGITRALDDAEARYGITSKLILCFLRHLSEAEAEATL
DEALPFLGRIAGVGLDSSEVGHPPAKFERVFARARSLGLKTVAHAGEEGPPEYVREALDLLKVDRIDHGNRSLEDPALVA
RLAASDMTLTVCPLSNLKLCVVDDIADHPLKIMLDADLKATVNSDDPSYFGGYVNANYQAVADALDLSRDDLVTLARNSF
TGSFLSDAEKARHLAAIDAYA

Sequences:

>Translated_341_residues
MPDGFASHEERAAFIAGLPKAELHLHIEGSLEPELLFEFARRNRVAIPFASIDDVRAAYAFTNLQDFLDIYYQGMGVLHT
EQDFFDLTAAYCARANADSVRHIEIFFDPQGHTARGVAFETVITGITRALDDAEARYGITSKLILCFLRHLSEAEAEATL
DEALPFLGRIAGVGLDSSEVGHPPAKFERVFARARSLGLKTVAHAGEEGPPEYVREALDLLKVDRIDHGNRSLEDPALVA
RLAASDMTLTVCPLSNLKLCVVDDIADHPLKIMLDADLKATVNSDDPSYFGGYVNANYQAVADALDLSRDDLVTLARNSF
TGSFLSDAEKARHLAAIDAYA
>Mature_340_residues
PDGFASHEERAAFIAGLPKAELHLHIEGSLEPELLFEFARRNRVAIPFASIDDVRAAYAFTNLQDFLDIYYQGMGVLHTE
QDFFDLTAAYCARANADSVRHIEIFFDPQGHTARGVAFETVITGITRALDDAEARYGITSKLILCFLRHLSEAEAEATLD
EALPFLGRIAGVGLDSSEVGHPPAKFERVFARARSLGLKTVAHAGEEGPPEYVREALDLLKVDRIDHGNRSLEDPALVAR
LAASDMTLTVCPLSNLKLCVVDDIADHPLKIMLDADLKATVNSDDPSYFGGYVNANYQAVADALDLSRDDLVTLARNSFT
GSFLSDAEKARHLAAIDAYA

Specific function: Unknown

COG id: COG1816

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosine and AMP deaminases family

Homologues:

Organism=Homo sapiens, GI47078295, Length=345, Percent_Identity=24.3478260869565, Blast_Score=113, Evalue=3e-25,
Organism=Escherichia coli, GI1787910, Length=325, Percent_Identity=29.5384615384615, Blast_Score=135, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17538512, Length=356, Percent_Identity=24.1573033707865, Blast_Score=85, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI32565969, Length=340, Percent_Identity=24.1176470588235, Blast_Score=84, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6324188, Length=334, Percent_Identity=46.4071856287425, Blast_Score=298, Evalue=9e-82,
Organism=Drosophila melanogaster, GI24645260, Length=339, Percent_Identity=25.0737463126844, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ADD_SPHAL (Q1GRK2)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_617053.1
- ProteinModelPortal:   Q1GRK2
- SMR:   Q1GRK2
- GeneID:   4079946
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_2009
- NMPDR:   fig|317655.9.peg.1940
- HOGENOM:   HBG630382
- OMA:   YFGGYLN
- ProtClustDB:   PRK09358
- BioCyc:   SALA317655:SALA_2009-MONOMER
- BRENDA:   3.5.4.4
- HAMAP:   MF_00540
- InterPro:   IPR001365
- InterPro:   IPR006330
- PANTHER:   PTHR11409
- TIGRFAMs:   TIGR01430

Pfam domain/function: PF00962 A_deaminase

EC number: =3.5.4.4

Molecular weight: Translated: 37282; Mature: 37151

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00485 A_DEAMINASE

Important sites: ACT_SITE 207-207 BINDING 26-26 BINDING 28-28 BINDING 286-286

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDGFASHEERAAFIAGLPKAELHLHIEGSLEPELLFEFARRNRVAIPFASIDDVRAAYA
CCCCCCCCHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEECCHHHHHHHHH
FTNLQDFLDIYYQGMGVLHTEQDFFDLTAAYCARANADSVRHIEIFFDPQGHTARGVAFE
HHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCHHHH
TVITGITRALDDAEARYGITSKLILCFLRHLSEAEAEATLDEALPFLGRIAGVGLDSSEV
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GHPPAKFERVFARARSLGLKTVAHAGEEGPPEYVREALDLLKVDRIDHGNRSLEDPALVA
CCCHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
RLAASDMTLTVCPLSNLKLCVVDDIADHPLKIMLDADLKATVNSDDPSYFGGYVNANYQA
HHHHCCCEEEEECCCCCEEEEECCCCCCCEEEEEECCCEEEECCCCCCCCCCEECCCHHH
VADALDLSRDDLVTLARNSFTGSFLSDAEKARHLAAIDAYA
HHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PDGFASHEERAAFIAGLPKAELHLHIEGSLEPELLFEFARRNRVAIPFASIDDVRAAYA
CCCCCCCHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCEEEEECCHHHHHHHHH
FTNLQDFLDIYYQGMGVLHTEQDFFDLTAAYCARANADSVRHIEIFFDPQGHTARGVAFE
HHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCHHHH
TVITGITRALDDAEARYGITSKLILCFLRHLSEAEAEATLDEALPFLGRIAGVGLDSSEV
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GHPPAKFERVFARARSLGLKTVAHAGEEGPPEYVREALDLLKVDRIDHGNRSLEDPALVA
CCCHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
RLAASDMTLTVCPLSNLKLCVVDDIADHPLKIMLDADLKATVNSDDPSYFGGYVNANYQA
HHHHCCCEEEEECCCCCEEEEECCCCCCCEEEEEECCCEEEECCCCCCCCCCEECCCHHH
VADALDLSRDDLVTLARNSFTGSFLSDAEKARHLAAIDAYA
HHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA