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The map label for this gene is glpK [H]

Identifier: 103487432

GI number: 103487432

Start: 2054275

End: 2055747

Strand: Direct

Name: glpK [H]

Synonym: Sala_1948

Alternate gene names: 103487432

Gene position: 2054275-2055747 (Clockwise)

Preceding gene: 103487428

Following gene: 103487445

Centisome position: 61.41

GC content: 67.14

Gene sequence:

>1473_bases
ATGGCCGAAATGATCATTGTCATCGACGAAGGCACGACCTCCACCCGCACCATGCTGTTTGCCGCCGACGGGACGCCGCT
CGGCAGCGCGCAGCGCGAGATAAGGCAGCACTATCCGGGTCCCGGCCTCGTCGAGCATGACGCCGCCGAGATCTGGGAAG
CGACGCTTGCCTGCACGCGCGAAATGGTGGCGCGCGCCGGTGGCGCGGATCATGTGGCGGCGATCGGCATCACCAACCAG
CGTGAAACGATCGTCTTCTGGGATCGCGCAACCAACGAACCGCTTGCGCCTGCGATCGTGTGGCAGGACCGGCGCACCTC
GGCCGACTGTGCCGCGCTGAAGGAGGCGGGGCATGAGACTGCGGTGCAGGCGACCAGCGGATTGCTGCTCGACCCCTATT
TTTCGGGAAGCAAGATCGGCTGGGCGCTTCGGCACTGGCCGCAACTGAAGGACGCGGGAGCGCGGCTCGCCGTGGGAACG
ATCGAATCATGGCTCGTTTATCGCCTGACCGGCGGCGTGCATGTCACCGACGCGACCAATGCGTCGCGCACGGCATTGAT
GGCCATCGAGGGCGAGGGAGGCTGGAACGCCGGGCTTTGCGACCTGTTTGGCGTACCGATGCGGCTGCTGCCCGAAATCA
CCGGCTGTACCACGGTCGTCGGCACGACCGACCCGGCGCTGTTCGGCGGCGCGATCGCGATCGCCGGCATCGCGGGCGAC
CAGCAGGCCGCAACGATCGGCCAGGCGTGCCTTTCACCGGGGCAGACCAAGGCTACCTTCGGCACTGGCGCCTTCATCCT
GTCGGCGAGCGGCGCGACGCGACGGCATTCGTCGAATCGCCTGCTCGCGACGGTGCTGGTGCAGGAAGGCGACGCCCGCG
TCTATGCGCTCGAAGGGTCGGTCTTCGTTGCCGGCAGCCTGATCAAATGGCTGCGCGACGGATTGGGCCTGCTCGCAAGC
GCGAGCGAAAGCGAGGGACTGGCACGGGCGGTACCCGATAATGGCGGCGTCTACCTGGTCCCCGCCCTGTCGGGACTGGG
AGCGCCGCACTGGCGGCCTGACGCGCTCGCGGCGCTTTCGGGCCTCAGTTTTGCCAGCACGAAGGCGCATGTCGCGCGCG
CTGCGCTGGAGGCGCAGTCCTATCAGGCGCATGATCTTAAATCGGCCTTCGCCGCCGACGGGGTCGACTGGGCCGAATTG
CGTATCGATGGCGGCATGGCGGCGAATGACTGGATGGCGCAGGACCTGGCCGACATGCTGGATCTGACCGTCGAGCGACC
CGATTTCGTCGAAAGCACCGCGCTTGGCGCCGCAATGCTCGCTGCAACCGGCGCAGGGATTTACCCCGACCTCAAGACCG
CGGCGCAGGCGATGCGCGGCACCGCGACCCGCTTCACGCCGGCGCTGGATGCCACGCAACGCAAAACGCGCCTTGCCGGG
TGGCAAAGCGCGCTTGCAAAGGTTCTGGGATAA

Upstream 100 bases:

>100_bases
CTGGGGCGAGAGCTGGCGGCACCCTGGCGCAACGTCGCTTGACGCCGACAGCCACCTCCGTCTTCGCGGGGGCGACGCGG
GAAAGACAGGTGGAGGATAT

Downstream 100 bases:

>100_bases
ACCGATCCTCCCCATGGCTTCGCCACGGGAGATCACAAGAATCAACGCTTGAGCGTCAGCCCGCCGAAACGCTTGTTGAA
CTTGGCCACCTGCCCGCCCG

Product: carbohydrate kinase, FGGY

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK [H]

Number of amino acids: Translated: 490; Mature: 489

Protein sequence:

>490_residues
MAEMIIVIDEGTTSTRTMLFAADGTPLGSAQREIRQHYPGPGLVEHDAAEIWEATLACTREMVARAGGADHVAAIGITNQ
RETIVFWDRATNEPLAPAIVWQDRRTSADCAALKEAGHETAVQATSGLLLDPYFSGSKIGWALRHWPQLKDAGARLAVGT
IESWLVYRLTGGVHVTDATNASRTALMAIEGEGGWNAGLCDLFGVPMRLLPEITGCTTVVGTTDPALFGGAIAIAGIAGD
QQAATIGQACLSPGQTKATFGTGAFILSASGATRRHSSNRLLATVLVQEGDARVYALEGSVFVAGSLIKWLRDGLGLLAS
ASESEGLARAVPDNGGVYLVPALSGLGAPHWRPDALAALSGLSFASTKAHVARAALEAQSYQAHDLKSAFAADGVDWAEL
RIDGGMAANDWMAQDLADMLDLTVERPDFVESTALGAAMLAATGAGIYPDLKTAAQAMRGTATRFTPALDATQRKTRLAG
WQSALAKVLG

Sequences:

>Translated_490_residues
MAEMIIVIDEGTTSTRTMLFAADGTPLGSAQREIRQHYPGPGLVEHDAAEIWEATLACTREMVARAGGADHVAAIGITNQ
RETIVFWDRATNEPLAPAIVWQDRRTSADCAALKEAGHETAVQATSGLLLDPYFSGSKIGWALRHWPQLKDAGARLAVGT
IESWLVYRLTGGVHVTDATNASRTALMAIEGEGGWNAGLCDLFGVPMRLLPEITGCTTVVGTTDPALFGGAIAIAGIAGD
QQAATIGQACLSPGQTKATFGTGAFILSASGATRRHSSNRLLATVLVQEGDARVYALEGSVFVAGSLIKWLRDGLGLLAS
ASESEGLARAVPDNGGVYLVPALSGLGAPHWRPDALAALSGLSFASTKAHVARAALEAQSYQAHDLKSAFAADGVDWAEL
RIDGGMAANDWMAQDLADMLDLTVERPDFVESTALGAAMLAATGAGIYPDLKTAAQAMRGTATRFTPALDATQRKTRLAG
WQSALAKVLG
>Mature_489_residues
AEMIIVIDEGTTSTRTMLFAADGTPLGSAQREIRQHYPGPGLVEHDAAEIWEATLACTREMVARAGGADHVAAIGITNQR
ETIVFWDRATNEPLAPAIVWQDRRTSADCAALKEAGHETAVQATSGLLLDPYFSGSKIGWALRHWPQLKDAGARLAVGTI
ESWLVYRLTGGVHVTDATNASRTALMAIEGEGGWNAGLCDLFGVPMRLLPEITGCTTVVGTTDPALFGGAIAIAGIAGDQ
QAATIGQACLSPGQTKATFGTGAFILSASGATRRHSSNRLLATVLVQEGDARVYALEGSVFVAGSLIKWLRDGLGLLASA
SESEGLARAVPDNGGVYLVPALSGLGAPHWRPDALAALSGLSFASTKAHVARAALEAQSYQAHDLKSAFAADGVDWAELR
IDGGMAANDWMAQDLADMLDLTVERPDFVESTALGAAMLAATGAGIYPDLKTAAQAMRGTATRFTPALDATQRKTRLAGW
QSALAKVLG

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI189409120, Length=504, Percent_Identity=39.0873015873016, Blast_Score=332, Evalue=4e-91,
Organism=Homo sapiens, GI4504007, Length=504, Percent_Identity=39.0873015873016, Blast_Score=332, Evalue=4e-91,
Organism=Homo sapiens, GI42794763, Length=509, Percent_Identity=38.8998035363458, Blast_Score=329, Evalue=3e-90,
Organism=Homo sapiens, GI41393575, Length=501, Percent_Identity=38.3233532934132, Blast_Score=318, Evalue=9e-87,
Organism=Homo sapiens, GI88196792, Length=508, Percent_Identity=26.9685039370079, Blast_Score=213, Evalue=5e-55,
Organism=Escherichia coli, GI1790361, Length=493, Percent_Identity=42.393509127789, Blast_Score=390, Evalue=1e-109,
Organism=Escherichia coli, GI1790005, Length=500, Percent_Identity=23.2, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1787789, Length=499, Percent_Identity=25.8517034068136, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1789987, Length=474, Percent_Identity=25.3164556962025, Blast_Score=83, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17535599, Length=505, Percent_Identity=36.4356435643564, Blast_Score=308, Evalue=5e-84,
Organism=Caenorhabditis elegans, GI71986140, Length=523, Percent_Identity=24.0917782026769, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71986147, Length=272, Percent_Identity=27.2058823529412, Blast_Score=96, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6321755, Length=480, Percent_Identity=33.125, Blast_Score=210, Evalue=4e-55,
Organism=Drosophila melanogaster, GI17864214, Length=503, Percent_Identity=39.1650099403579, Blast_Score=322, Evalue=3e-88,
Organism=Drosophila melanogaster, GI24654573, Length=448, Percent_Identity=40.1785714285714, Blast_Score=307, Evalue=1e-83,
Organism=Drosophila melanogaster, GI24655555, Length=509, Percent_Identity=34.5776031434185, Blast_Score=285, Evalue=6e-77,
Organism=Drosophila melanogaster, GI24655560, Length=509, Percent_Identity=34.5776031434185, Blast_Score=285, Evalue=6e-77,
Organism=Drosophila melanogaster, GI24655570, Length=509, Percent_Identity=34.5776031434185, Blast_Score=285, Evalue=6e-77,
Organism=Drosophila melanogaster, GI24655574, Length=509, Percent_Identity=34.5776031434185, Blast_Score=285, Evalue=6e-77,
Organism=Drosophila melanogaster, GI24655565, Length=509, Percent_Identity=34.5776031434185, Blast_Score=285, Evalue=6e-77,
Organism=Drosophila melanogaster, GI19922058, Length=525, Percent_Identity=29.1428571428571, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24652871, Length=492, Percent_Identity=29.8780487804878, Blast_Score=211, Evalue=8e-55,
Organism=Drosophila melanogaster, GI24656367, Length=510, Percent_Identity=26.6666666666667, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI21357867, Length=523, Percent_Identity=26.0038240917782, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24656372, Length=350, Percent_Identity=29.1428571428571, Blast_Score=132, Evalue=5e-31,
Organism=Drosophila melanogaster, GI45552909, Length=250, Percent_Identity=28.8, Blast_Score=92, Evalue=9e-19,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 51174; Mature: 51043

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEMIIVIDEGTTSTRTMLFAADGTPLGSAQREIRQHYPGPGLVEHDAAEIWEATLACTR
CCEEEEEEECCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
EMVARAGGADHVAAIGITNQRETIVFWDRATNEPLAPAIVWQDRRTSADCAALKEAGHET
HHHHHCCCCCCEEEEEECCCCCEEEEEECCCCCCCCCEEEECCCCCCHHHHHHHHCCCHH
AVQATSGLLLDPYFSGSKIGWALRHWPQLKDAGARLAVGTIESWLVYRLTGGVHVTDATN
HHHHCCCCEECCCCCCCCCCHHHHHCCCHHHCCCEEEEHHHHHEEEEEEECCEEEEECCC
ASRTALMAIEGEGGWNAGLCDLFGVPMRLLPEITGCTTVVGTTDPALFGGAIAIAGIAGD
CCCEEEEEEECCCCCCCCHHHHHCCCHHHHCCCCCCEEEECCCCCHHHCCEEEEEEECCC
QQAATIGQACLSPGQTKATFGTGAFILSASGATRRHSSNRLLATVLVQEGDARVYALEGS
HHHHHHHHHHCCCCCCEEEECCCEEEEECCCCCCCCCCCCEEEEEEEECCCEEEEEECCC
VFVAGSLIKWLRDGLGLLASASESEGLARAVPDNGGVYLVPALSGLGAPHWRPDALAALS
EEEHHHHHHHHHHCHHHEECCCCCCCCEEECCCCCCEEEEEECCCCCCCCCCCHHHHHHH
GLSFASTKAHVARAALEAQSYQAHDLKSAFAADGVDWAELRIDGGMAANDWMAQDLADML
CCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHH
DLTVERPDFVESTALGAAMLAATGAGIYPDLKTAAQAMRGTATRFTPALDATQRKTRLAG
HHCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHCCCCCCHHHHHHHHHH
WQSALAKVLG
HHHHHHHHCC
>Mature Secondary Structure 
AEMIIVIDEGTTSTRTMLFAADGTPLGSAQREIRQHYPGPGLVEHDAAEIWEATLACTR
CEEEEEEECCCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
EMVARAGGADHVAAIGITNQRETIVFWDRATNEPLAPAIVWQDRRTSADCAALKEAGHET
HHHHHCCCCCCEEEEEECCCCCEEEEEECCCCCCCCCEEEECCCCCCHHHHHHHHCCCHH
AVQATSGLLLDPYFSGSKIGWALRHWPQLKDAGARLAVGTIESWLVYRLTGGVHVTDATN
HHHHCCCCEECCCCCCCCCCHHHHHCCCHHHCCCEEEEHHHHHEEEEEEECCEEEEECCC
ASRTALMAIEGEGGWNAGLCDLFGVPMRLLPEITGCTTVVGTTDPALFGGAIAIAGIAGD
CCCEEEEEEECCCCCCCCHHHHHCCCHHHHCCCCCCEEEECCCCCHHHCCEEEEEEECCC
QQAATIGQACLSPGQTKATFGTGAFILSASGATRRHSSNRLLATVLVQEGDARVYALEGS
HHHHHHHHHHCCCCCCEEEECCCEEEEECCCCCCCCCCCCEEEEEEEECCCEEEEEECCC
VFVAGSLIKWLRDGLGLLASASESEGLARAVPDNGGVYLVPALSGLGAPHWRPDALAALS
EEEHHHHHHHHHHCHHHEECCCCCCCCEEECCCCCCEEEEEECCCCCCCCCCCHHHHHHH
GLSFASTKAHVARAALEAQSYQAHDLKSAFAADGVDWAELRIDGGMAANDWMAQDLADML
CCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHH
DLTVERPDFVESTALGAAMLAATGAGIYPDLKTAAQAMRGTATRFTPALDATQRKTRLAG
HHCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHCCCCCCHHHHHHHHHH
WQSALAKVLG
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA