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The map label for this gene is purM

Identifier: 103487242

GI number: 103487242

Start: 1852025

End: 1853131

Strand: Direct

Name: purM

Synonym: Sala_1757

Alternate gene names: 103487242

Gene position: 1852025-1853131 (Clockwise)

Preceding gene: 103487237

Following gene: 103487243

Centisome position: 55.36

GC content: 66.49

Gene sequence:

>1107_bases
ATGGATTCCAAGCACAACTCACCCGCCTCCTACACTTATGCGCAGGCCGGGGTGTCGATCGAAACCGGCAACGCGCTGGT
CCGGGCCATCGCCCCGCTCGCCCGCGCGACGCGGCGGCCCGGCGCCGACGCCGACCTTGGCGGCTTTGGCGGTTTCTTTG
ACCTCAGGGCGGCGGGCTTCGCCGATCCGCTGCTCGTCGCCGCGAACGACGGTGTGGGAACCAAGCTCAAGCTCGCGATC
GAATCGGGCCGCCACGACGGGGTGGGTATCGACCTGGTCGCGATGTGCGCCAACGACCTGATCGTGCAGGGCGCCGAGCC
GCTGTTTTTCCTCGATTATTATGCGACGGGCAAACTCGACAACGACGTCGCGACCGCCGTGGTCGCAAGCATCGCCGAAG
GGTGCAAGCAGGCGGGTTGCGCGCTGATCGGCGGCGAGACGGCCGAAATGCCGGGCATGTATTCGGACGGCGATTATGAC
CTTGCGGGCTTTTGCGTCGGCGCGGTCGAGCGCGATCGGGTGCTGACCAGCGACAAGGTTGCCGCGGGCGACGTGATTCT
GGGCCTCGCCTCATCGGGGGTGCATTCGAACGGCTTTTCGCTCGTGCGGCGGCTGGCGGCGGACAAGGGCTGGAAGCTCG
ACCGTCCCGCGCTGTTCGACCAGACCGTCCTGCTGATCGACGCGCTGATGGCGCCGACGCGCATCTATGTGAAAAGCCTG
CTGCCGCTGGTGAAGACGGGCAAGATCCACGCGCTCGCGCACATCACCGGCGGCGGGCTGCTCGAAAACATCCCGCGCGT
GCTGCCGAAGACGCTGCACGCCCATGTTGACGCCGATAGCTGGGAGCAGCCGCGGCTGATGGCGTTTTTGCAGGCGCAGG
GCAATATCGAGCCCGAAGAAATGGCGCGCACCTTCAACTGCGGGATCGGCATGGCGGTCGTCGTGGCGGAAGCCGATGTC
GCAGACGTGACTGCGGCGCTCGAAGCAGTGGGCGAAACGGTGTTTCGGATCGGGCATATCGCCGAAGGTGAAAGGGGCTG
CACGGTGACGGGCAGCGCCGAAACGTGGAGCGCGCGCGCCGACTGGAGCGCGAGGCATAATGCGTAG

Upstream 100 bases:

>100_bases
GGCGGCCGAAATCATATCTTCTCTATGCTCTGCCCAAAAGCTTGGCCCCGGACAAGGAAATCATGGCATTTCGTGGCGAG
AGTCGTTAGTCGCGCTGGCC

Downstream 100 bases:

>100_bases
GTTCCTCCCCGGAACGGGGAGGGGGACCATCCGCAGGATGGTGGAGGGGTACGCGCAGATCTGTGCGGCCTTTCAAGATC
AGCCGGTCCAGCCTGCGCCC

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MDSKHNSPASYTYAQAGVSIETGNALVRAIAPLARATRRPGADADLGGFGGFFDLRAAGFADPLLVAANDGVGTKLKLAI
ESGRHDGVGIDLVAMCANDLIVQGAEPLFFLDYYATGKLDNDVATAVVASIAEGCKQAGCALIGGETAEMPGMYSDGDYD
LAGFCVGAVERDRVLTSDKVAAGDVILGLASSGVHSNGFSLVRRLAADKGWKLDRPALFDQTVLLIDALMAPTRIYVKSL
LPLVKTGKIHALAHITGGGLLENIPRVLPKTLHAHVDADSWEQPRLMAFLQAQGNIEPEEMARTFNCGIGMAVVVAEADV
ADVTAALEAVGETVFRIGHIAEGERGCTVTGSAETWSARADWSARHNA

Sequences:

>Translated_368_residues
MDSKHNSPASYTYAQAGVSIETGNALVRAIAPLARATRRPGADADLGGFGGFFDLRAAGFADPLLVAANDGVGTKLKLAI
ESGRHDGVGIDLVAMCANDLIVQGAEPLFFLDYYATGKLDNDVATAVVASIAEGCKQAGCALIGGETAEMPGMYSDGDYD
LAGFCVGAVERDRVLTSDKVAAGDVILGLASSGVHSNGFSLVRRLAADKGWKLDRPALFDQTVLLIDALMAPTRIYVKSL
LPLVKTGKIHALAHITGGGLLENIPRVLPKTLHAHVDADSWEQPRLMAFLQAQGNIEPEEMARTFNCGIGMAVVVAEADV
ADVTAALEAVGETVFRIGHIAEGERGCTVTGSAETWSARADWSARHNA
>Mature_368_residues
MDSKHNSPASYTYAQAGVSIETGNALVRAIAPLARATRRPGADADLGGFGGFFDLRAAGFADPLLVAANDGVGTKLKLAI
ESGRHDGVGIDLVAMCANDLIVQGAEPLFFLDYYATGKLDNDVATAVVASIAEGCKQAGCALIGGETAEMPGMYSDGDYD
LAGFCVGAVERDRVLTSDKVAAGDVILGLASSGVHSNGFSLVRRLAADKGWKLDRPALFDQTVLLIDALMAPTRIYVKSL
LPLVKTGKIHALAHITGGGLLENIPRVLPKTLHAHVDADSWEQPRLMAFLQAQGNIEPEEMARTFNCGIGMAVVVAEADV
ADVTAALEAVGETVFRIGHIAEGERGCTVTGSAETWSARADWSARHNA

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=339, Percent_Identity=55.1622418879056, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI209869995, Length=339, Percent_Identity=55.1622418879056, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI209869993, Length=339, Percent_Identity=55.1622418879056, Blast_Score=382, Evalue=1e-106,
Organism=Escherichia coli, GI1788845, Length=331, Percent_Identity=54.380664652568, Blast_Score=359, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17567511, Length=342, Percent_Identity=45.0292397660819, Blast_Score=285, Evalue=3e-77,
Organism=Saccharomyces cerevisiae, GI6321203, Length=363, Percent_Identity=50.6887052341598, Blast_Score=365, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24582400, Length=287, Percent_Identity=47.3867595818815, Blast_Score=243, Evalue=1e-64,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_SPHAL (Q1GSA2)

Other databases:

- EMBL:   CP000356
- RefSeq:   YP_616803.1
- ProteinModelPortal:   Q1GSA2
- SMR:   Q1GSA2
- GeneID:   4081992
- GenomeReviews:   CP000356_GR
- KEGG:   sal:Sala_1757
- NMPDR:   fig|317655.9.peg.1690
- HOGENOM:   HBG531222
- OMA:   HYDLAGF
- ProtClustDB:   PRK05385
- BioCyc:   SALA317655:SALA_1757-MONOMER
- BRENDA:   6.3.3.1
- GO:   GO:0005737
- HAMAP:   MF_00741_B
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 38518; Mature: 38518

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSKHNSPASYTYAQAGVSIETGNALVRAIAPLARATRRPGADADLGGFGGFFDLRAAGF
CCCCCCCCCCEEEHHCCCEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCC
ADPLLVAANDGVGTKLKLAIESGRHDGVGIDLVAMCANDLIVQGAEPLFFLDYYATGKLD
CCCEEEEECCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCC
NDVATAVVASIAEGCKQAGCALIGGETAEMPGMYSDGDYDLAGFCVGAVERDRVLTSDKV
HHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHEEHHHHHCCEECCCCC
AAGDVILGLASSGVHSNGFSLVRRLAADKGWKLDRPALFDQTVLLIDALMAPTRIYVKSL
CCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHH
LPLVKTGKIHALAHITGGGLLENIPRVLPKTLHAHVDADSWEQPRLMAFLQAQGNIEPEE
HHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCHHH
MARTFNCGIGMAVVVAEADVADVTAALEAVGETVFRIGHIAEGERGCTVTGSAETWSARA
HHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCC
DWSARHNA
CCCCCCCC
>Mature Secondary Structure
MDSKHNSPASYTYAQAGVSIETGNALVRAIAPLARATRRPGADADLGGFGGFFDLRAAGF
CCCCCCCCCCEEEHHCCCEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCC
ADPLLVAANDGVGTKLKLAIESGRHDGVGIDLVAMCANDLIVQGAEPLFFLDYYATGKLD
CCCEEEEECCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCC
NDVATAVVASIAEGCKQAGCALIGGETAEMPGMYSDGDYDLAGFCVGAVERDRVLTSDKV
HHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHEEHHHHHCCEECCCCC
AAGDVILGLASSGVHSNGFSLVRRLAADKGWKLDRPALFDQTVLLIDALMAPTRIYVKSL
CCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHH
LPLVKTGKIHALAHITGGGLLENIPRVLPKTLHAHVDADSWEQPRLMAFLQAQGNIEPEE
HHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCHHH
MARTFNCGIGMAVVVAEADVADVTAALEAVGETVFRIGHIAEGERGCTVTGSAETWSARA
HHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCC
DWSARHNA
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA