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The map label for this gene is mrdA [H]

Identifier: 103487115

GI number: 103487115

Start: 1709897

End: 1711807

Strand: Direct

Name: mrdA [H]

Synonym: Sala_1630

Alternate gene names: 103487115

Gene position: 1709897-1711807 (Clockwise)

Preceding gene: 103487114

Following gene: 103487116

Centisome position: 51.12

GC content: 66.25

Gene sequence:

>1911_bases
ATGTTCAACAAGAAGCACCCGCCGATCACCGAAGCGTGGAGGGGTCTCACCTTCACCCGCCGCGCGCTCGTCGTCGGCGG
CGCGCAAGCGGCGGTGGGTGTCGCGCTGGCGGCGCGCATGGCTTATATCTCGGTGATCGACAACGACCGCTATGTGCTTG
AATCGGAAAGCAACCGCGTCAATCTGACGCTCATCCCGCCGCGCCGCGGCTGGATCGTCGACCGCAATGGCAAGGCGCTC
GCGAACAACCGCGTCAGCCTGCGCATCGACATCATTCCCGACCGTCTGCACAATCGCGAGATGGTGCTGGGTCAGCTCCG
GACGCTGTTGCGGCTCGACGGCGACACGATGGAACGCATCAACCGCGACCTCAAGGCCGCATCGGGGTTCCAGCCCGTCG
CGATCAAGGAGAATATGACCGAGGCCGAATATAGTTCGATCCTCGTCCGCCTGCCCGAACTGCCCGGCGTCGCGCCGCAG
CGCGGCTTTGCCCGCAACTATCCGACCGGCGCCGCGGTGGGCCATCTGATCGGCTATGTTGGGGCGCCCAATGCCGAAGA
ATATGAGAAAGCGAAAGATCCGCTCTACATCACGCCCGGCTACAAGATCGGCAAGGACGGGCTCGAAAAATATTTCCAGG
AAGTGCTGAAGGGCAAACCCGGCGCGCGGCGCGTCGAGGTGACTGCGCGCGGCAAGGTGGTGCGCGACCTCGACACCCAG
CCCGACGTGCAGGGCAAGACGGTGCATCTGACGATCGACGCCGACCTGCAGGAATATGTCGCACGGCGCATGGGGCGCGA
ATCGGGTGCGGCGGTCGTCATCGACTGCCGCAACGGCGACATCCTCGCCTTCGTGTCGATGCCGAGTTTCGACCCCAACA
GCTTTTCCGACGGGATCAGCAGTTCGGAATATGCCTGGCTGCGCGCCGACGATCACCAGCCGCTGATCAACAAGGCGACG
CGCGGGCTCTATCCGCCCGGATCGACGCTGAAACCGATGGCGGCGATCGCGGCGATCGACCATGGCGTCGACCCCGGCGA
GCGCCATACCTGCATCGGCGGCTATCGGCTCGGCAGCCGCTTTTTCCGCTGTCTCGGCACGCACGGCAGCATCGACATGC
CGACCGCGATCGAAAAAAGCTGCAACAGCTATTTCTACTGGCTGGCGCACCGGCTGGGTTACGACGCGATGGCGCCGACC
GCGCGGCTGCTGGGGCTGGGCGAGGAGTTCCGGCTTGCGGGCAGCAATCAGCGGTACGGCACCATCCCCGACAGCGCATG
GAAACGGCGCAAATATGATCAGGAGTGGACCGCGTCGGATTCGCTGAACGCGGTGATCGGCCAGGGCTATGTCAGCGTCA
ATCCGCTCCAGCTTGCCGTGATGACCGCGCGCATCGCGTCGGGCCGGCGCCTGTATCCGCGTCTCGTCAACCGGCAGTTC
ACCAACGAACCCCTGCCCTTCTCCGCCGAAGCGCTGGCGGTGGCGCGCGCGGGCATGGACCGCGTCGTCAACGGCGCGGG
CACCGCGGTGCGCAGCCGCCTGCCGCTCGACGGCATCACCATGGCGGGCAAGACCGGCACCGCACAGGTGCGCGGGCTGG
CGTCGGGTTCGCGCGGACAGGGCGGCGCGTGGAAATATCGCGACCACGGCCTGTTCGTCGGGTTCGCGCCGGTCGACAAT
CCGCGCTACGCCACGGGCATCGTCATCGAGCATGGCATGGGCGGCAGCCGTGCCGCGGCGCCGGTTGCGCGCGATTTCAT
GACCTTCCTCTTCGACCGCGAAAAGGGAATGGAGGCGCTCGAAACGCTCGAGGCCGGTTGGGGCGGCACGATCGGCGAGC
GCATGGAACGCGACTATGCGGCGTGGAAAGCGGGGGCGTCGAGCGATCCCGATCCGGGCGTTCCGCAATGA

Upstream 100 bases:

>100_bases
GTGCCGCAGATCGTCATTTCGGTGTTGCTGGTGCCGCTGATCATGCGCCTGACCGGCAAGTTTGACAACTTCCGGCTGAA
ACGCCGATAAAACTGCGCAC

Downstream 100 bases:

>100_bases
TCCCCGTCCCGCCCGCGATCCGGCGCGTTCCGTGGAAGCTGATCGCCATCCTGTGCGGTATTACCGGGTTCGGCCTGCTC
GTCCTCTATTCGGCCGCGGG

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 636; Mature: 636

Protein sequence:

>636_residues
MFNKKHPPITEAWRGLTFTRRALVVGGAQAAVGVALAARMAYISVIDNDRYVLESESNRVNLTLIPPRRGWIVDRNGKAL
ANNRVSLRIDIIPDRLHNREMVLGQLRTLLRLDGDTMERINRDLKAASGFQPVAIKENMTEAEYSSILVRLPELPGVAPQ
RGFARNYPTGAAVGHLIGYVGAPNAEEYEKAKDPLYITPGYKIGKDGLEKYFQEVLKGKPGARRVEVTARGKVVRDLDTQ
PDVQGKTVHLTIDADLQEYVARRMGRESGAAVVIDCRNGDILAFVSMPSFDPNSFSDGISSSEYAWLRADDHQPLINKAT
RGLYPPGSTLKPMAAIAAIDHGVDPGERHTCIGGYRLGSRFFRCLGTHGSIDMPTAIEKSCNSYFYWLAHRLGYDAMAPT
ARLLGLGEEFRLAGSNQRYGTIPDSAWKRRKYDQEWTASDSLNAVIGQGYVSVNPLQLAVMTARIASGRRLYPRLVNRQF
TNEPLPFSAEALAVARAGMDRVVNGAGTAVRSRLPLDGITMAGKTGTAQVRGLASGSRGQGGAWKYRDHGLFVGFAPVDN
PRYATGIVIEHGMGGSRAAAPVARDFMTFLFDREKGMEALETLEAGWGGTIGERMERDYAAWKAGASSDPDPGVPQ

Sequences:

>Translated_636_residues
MFNKKHPPITEAWRGLTFTRRALVVGGAQAAVGVALAARMAYISVIDNDRYVLESESNRVNLTLIPPRRGWIVDRNGKAL
ANNRVSLRIDIIPDRLHNREMVLGQLRTLLRLDGDTMERINRDLKAASGFQPVAIKENMTEAEYSSILVRLPELPGVAPQ
RGFARNYPTGAAVGHLIGYVGAPNAEEYEKAKDPLYITPGYKIGKDGLEKYFQEVLKGKPGARRVEVTARGKVVRDLDTQ
PDVQGKTVHLTIDADLQEYVARRMGRESGAAVVIDCRNGDILAFVSMPSFDPNSFSDGISSSEYAWLRADDHQPLINKAT
RGLYPPGSTLKPMAAIAAIDHGVDPGERHTCIGGYRLGSRFFRCLGTHGSIDMPTAIEKSCNSYFYWLAHRLGYDAMAPT
ARLLGLGEEFRLAGSNQRYGTIPDSAWKRRKYDQEWTASDSLNAVIGQGYVSVNPLQLAVMTARIASGRRLYPRLVNRQF
TNEPLPFSAEALAVARAGMDRVVNGAGTAVRSRLPLDGITMAGKTGTAQVRGLASGSRGQGGAWKYRDHGLFVGFAPVDN
PRYATGIVIEHGMGGSRAAAPVARDFMTFLFDREKGMEALETLEAGWGGTIGERMERDYAAWKAGASSDPDPGVPQ
>Mature_636_residues
MFNKKHPPITEAWRGLTFTRRALVVGGAQAAVGVALAARMAYISVIDNDRYVLESESNRVNLTLIPPRRGWIVDRNGKAL
ANNRVSLRIDIIPDRLHNREMVLGQLRTLLRLDGDTMERINRDLKAASGFQPVAIKENMTEAEYSSILVRLPELPGVAPQ
RGFARNYPTGAAVGHLIGYVGAPNAEEYEKAKDPLYITPGYKIGKDGLEKYFQEVLKGKPGARRVEVTARGKVVRDLDTQ
PDVQGKTVHLTIDADLQEYVARRMGRESGAAVVIDCRNGDILAFVSMPSFDPNSFSDGISSSEYAWLRADDHQPLINKAT
RGLYPPGSTLKPMAAIAAIDHGVDPGERHTCIGGYRLGSRFFRCLGTHGSIDMPTAIEKSCNSYFYWLAHRLGYDAMAPT
ARLLGLGEEFRLAGSNQRYGTIPDSAWKRRKYDQEWTASDSLNAVIGQGYVSVNPLQLAVMTARIASGRRLYPRLVNRQF
TNEPLPFSAEALAVARAGMDRVVNGAGTAVRSRLPLDGITMAGKTGTAQVRGLASGSRGQGGAWKYRDHGLFVGFAPVDN
PRYATGIVIEHGMGGSRAAAPVARDFMTFLFDREKGMEALETLEAGWGGTIGERMERDYAAWKAGASSDPDPGVPQ

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=584, Percent_Identity=31.8493150684932, Blast_Score=299, Evalue=3e-82,
Organism=Escherichia coli, GI1786272, Length=577, Percent_Identity=26.5164644714038, Blast_Score=143, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 69524; Mature: 69524

Theoretical pI: Translated: 9.63; Mature: 9.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNKKHPPITEAWRGLTFTRRALVVGGAQAAVGVALAARMAYISVIDNDRYVLESESNRV
CCCCCCCCHHHHHCCCCEEEEEEEECCHHHHHHHHHHHHHHEEEEECCCEEEEECCCCEE
NLTLIPPRRGWIVDRNGKALANNRVSLRIDIIPDRLHNREMVLGQLRTLLRLDGDTMERI
EEEEECCCCCEEEECCCCEEECCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHH
NRDLKAASGFQPVAIKENMTEAEYSSILVRLPELPGVAPQRGFARNYPTGAAVGHLIGYV
HHHHHHHCCCCCEEECCCCCHHHHHHHHEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHC
GAPNAEEYEKAKDPLYITPGYKIGKDGLEKYFQEVLKGKPGARRVEVTARGKVVRDLDTQ
CCCCHHHHHHCCCCEEECCCCEECHHHHHHHHHHHHCCCCCCEEEEEEECCCEEECCCCC
PDVQGKTVHLTIDADLQEYVARRMGRESGAAVVIDCRNGDILAFVSMPSFDPNSFSDGIS
CCCCCCEEEEEECCCHHHHHHHHCCCCCCCEEEEECCCCCEEEEEECCCCCCCCCCCCCC
SSEYAWLRADDHQPLINKATRGLYPPGSTLKPMAAIAAIDHGVDPGERHTCIGGYRLGSR
CCCEEEEEECCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEECHHHHHHH
FFRCLGTHGSIDMPTAIEKSCNSYFYWLAHRLGYDAMAPTARLLGLGEEFRLAGSNQRYG
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHCCCHHHEECCCCCCCC
TIPDSAWKRRKYDQEWTASDSLNAVIGQGYVSVNPLQLAVMTARIASGRRLYPRLVNRQF
CCCCHHHHHHCCCCCCCCCCCCHHHHCCCEEEECHHHEEHHHHHHHCCCHHHHHHHHHHC
TNEPLPFSAEALAVARAGMDRVVNGAGTAVRSRLPLDGITMAGKTGTAQVRGLASGSRGQ
CCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCEEECCCCCCCEEEEECCCCCCC
GGAWKYRDHGLFVGFAPVDNPRYATGIVIEHGMGGSRAAAPVARDFMTFLFDREKGMEAL
CCCEEEECCCEEEEEECCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ETLEAGWGGTIGERMERDYAAWKAGASSDPDPGVPQ
HHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MFNKKHPPITEAWRGLTFTRRALVVGGAQAAVGVALAARMAYISVIDNDRYVLESESNRV
CCCCCCCCHHHHHCCCCEEEEEEEECCHHHHHHHHHHHHHHEEEEECCCEEEEECCCCEE
NLTLIPPRRGWIVDRNGKALANNRVSLRIDIIPDRLHNREMVLGQLRTLLRLDGDTMERI
EEEEECCCCCEEEECCCCEEECCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHH
NRDLKAASGFQPVAIKENMTEAEYSSILVRLPELPGVAPQRGFARNYPTGAAVGHLIGYV
HHHHHHHCCCCCEEECCCCCHHHHHHHHEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHC
GAPNAEEYEKAKDPLYITPGYKIGKDGLEKYFQEVLKGKPGARRVEVTARGKVVRDLDTQ
CCCCHHHHHHCCCCEEECCCCEECHHHHHHHHHHHHCCCCCCEEEEEEECCCEEECCCCC
PDVQGKTVHLTIDADLQEYVARRMGRESGAAVVIDCRNGDILAFVSMPSFDPNSFSDGIS
CCCCCCEEEEEECCCHHHHHHHHCCCCCCCEEEEECCCCCEEEEEECCCCCCCCCCCCCC
SSEYAWLRADDHQPLINKATRGLYPPGSTLKPMAAIAAIDHGVDPGERHTCIGGYRLGSR
CCCEEEEEECCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEECHHHHHHH
FFRCLGTHGSIDMPTAIEKSCNSYFYWLAHRLGYDAMAPTARLLGLGEEFRLAGSNQRYG
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHCCCHHHEECCCCCCCC
TIPDSAWKRRKYDQEWTASDSLNAVIGQGYVSVNPLQLAVMTARIASGRRLYPRLVNRQF
CCCCHHHHHHCCCCCCCCCCCCHHHHCCCEEEECHHHEEHHHHHHHCCCHHHHHHHHHHC
TNEPLPFSAEALAVARAGMDRVVNGAGTAVRSRLPLDGITMAGKTGTAQVRGLASGSRGQ
CCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCEEECCCCCCCEEEEECCCCCCC
GGAWKYRDHGLFVGFAPVDNPRYATGIVIEHGMGGSRAAAPVARDFMTFLFDREKGMEAL
CCCEEEECCCEEEEEECCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ETLEAGWGGTIGERMERDYAAWKAGASSDPDPGVPQ
HHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]