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The map label for this gene is mmuM [H]

Identifier: 159185173

GI number: 159185173

Start: 2337514

End: 2338428

Strand: Reverse

Name: mmuM [H]

Synonym: Atu2362

Alternate gene names: 159185173

Gene position: 2338428-2337514 (Counterclockwise)

Preceding gene: 15889637

Following gene: 15889635

Centisome position: 82.29

GC content: 64.59

Gene sequence:

>915_bases
ATGGGCACTATCCGTATCCTCGACGGCGGCATGAGCCGCGAATTGCAGCGGCTCGGCGCCGAGCTGAAACAGCCGGAATG
GTCGGCACTGGCGCTGATCAATGCGCCTGACATCGTGCGGCAGGTGCATGCGGAATTCATCGAGGCCGGCGCCGATGTCG
TCACCACCAATTCCTATGCGCTGGTGCCGTTCCACATCGGCGAGGAGCGCTTTCAGAAGGATGGCGCGTCGCTGATCGCC
CTTTCCGGCCAGCTGGCGCGTGAGGCGGCGGATGCTTCCGGCCGCAAGGTGCAGGTGGCCGGCTCGCTGCCGCCGATCTT
CGGCTCCTACGAGCCGCAGAATTTCGATGCCACCCGGGTGCAGGACTATCTCAAGGTACTGGTCGACAATCTCGCGCCTT
CTGTCGATGTCTGGCTCGGCGAAACGCTGAGCCTGATCGCCGAGGGCGAAGCGGTGCGCCAGGCCGTTGCCGCAACGGAT
AAGCCGTTCTGGATCTCCTTCACGCTGAACGACGACGCCGCTGCGGTCGCCGGTGGCGAACCCGCGCTACGGTCAGGTGA
AACGGTGAAGGCTGCCGCCGAATGGGCGGCGCAATCGGGCGCTGCCGCCCTGCTGTTCAATTGCAGCAAGCCGGAAATCA
TGAAAGCCGCCGTCGAAACCGCCTCCGCCGTGTTCGCAGACAAGGGCGTATCGCTGGAAATCGGCGTTTATGCCAATGCC
TTCGAAGGCGAACAGGGCGATTCCGCCGCCAATGAAGGCCTGCACGGCACCCGCACCGACCTGACTGACGATGTTTATTC
GCGTTTCGCCTGCTCCTGGGCGGATGCCGGCGCAACCATGATCGGCGGCTGCTGCGGTATCGGTGCTGCCCATATCCACA
CGGTAGCGACGGCATTGCGGCGCGCGGCCGCCTGA

Upstream 100 bases:

>100_bases
CGTCTTTTATCTCATTCTCACCGCCATCATTGCCCGCTGTTTCGGCCTTGTCGAACGGCAGGTGCCGGTCCGGCGGTAAA
ACCGTTCAAGGAGTATGAAC

Downstream 100 bases:

>100_bases
CGCGGCCGGCATGTTGACGCCACTATTGGAAATGAATGCGACAGGCTGAAAGGCCTGCCGCTTTTTTGTCCGCGGCTATT
GACCTCAACTATGGTTGAGG

Product: S-methyltransferase

Products: NA

Alternate protein names: S-methylmethionine:homocysteine methyltransferase [H]

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MGTIRILDGGMSRELQRLGAELKQPEWSALALINAPDIVRQVHAEFIEAGADVVTTNSYALVPFHIGEERFQKDGASLIA
LSGQLAREAADASGRKVQVAGSLPPIFGSYEPQNFDATRVQDYLKVLVDNLAPSVDVWLGETLSLIAEGEAVRQAVAATD
KPFWISFTLNDDAAAVAGGEPALRSGETVKAAAEWAAQSGAAALLFNCSKPEIMKAAVETASAVFADKGVSLEIGVYANA
FEGEQGDSAANEGLHGTRTDLTDDVYSRFACSWADAGATMIGGCCGIGAAHIHTVATALRRAAA

Sequences:

>Translated_304_residues
MGTIRILDGGMSRELQRLGAELKQPEWSALALINAPDIVRQVHAEFIEAGADVVTTNSYALVPFHIGEERFQKDGASLIA
LSGQLAREAADASGRKVQVAGSLPPIFGSYEPQNFDATRVQDYLKVLVDNLAPSVDVWLGETLSLIAEGEAVRQAVAATD
KPFWISFTLNDDAAAVAGGEPALRSGETVKAAAEWAAQSGAAALLFNCSKPEIMKAAVETASAVFADKGVSLEIGVYANA
FEGEQGDSAANEGLHGTRTDLTDDVYSRFACSWADAGATMIGGCCGIGAAHIHTVATALRRAAA
>Mature_303_residues
GTIRILDGGMSRELQRLGAELKQPEWSALALINAPDIVRQVHAEFIEAGADVVTTNSYALVPFHIGEERFQKDGASLIAL
SGQLAREAADASGRKVQVAGSLPPIFGSYEPQNFDATRVQDYLKVLVDNLAPSVDVWLGETLSLIAEGEAVRQAVAATDK
PFWISFTLNDDAAAVAGGEPALRSGETVKAAAEWAAQSGAAALLFNCSKPEIMKAAVETASAVFADKGVSLEIGVYANAF
EGEQGDSAANEGLHGTRTDLTDDVYSRFACSWADAGATMIGGCCGIGAAHIHTVATALRRAAA

Specific function: Catalyzes methyl transfer from S-methylmethionine or S- adenosylmethionine (less efficient) to homocysteine, selenohomocysteine and less efficiently selenocysteine [H]

COG id: COG2040

COG function: function code E; Homocysteine/selenocysteine methylase (S-methylmethionine-dependent)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Hcy-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786456, Length=314, Percent_Identity=29.9363057324841, Blast_Score=81, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24585077, Length=319, Percent_Identity=25.3918495297806, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003726 [H]

Pfam domain/function: PF02574 S-methyl_trans [H]

EC number: =2.1.1.10 [H]

Molecular weight: Translated: 31809; Mature: 31678

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: PS50970 HCY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTIRILDGGMSRELQRLGAELKQPEWSALALINAPDIVRQVHAEFIEAGADVVTTNSYA
CCEEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHCCCCEEECCCEE
LVPFHIGEERFQKDGASLIALSGQLAREAADASGRKVQVAGSLPPIFGSYEPQNFDATRV
EEEEECCHHHHHHCCCEEEEECHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCHHHH
QDYLKVLVDNLAPSVDVWLGETLSLIAEGEAVRQAVAATDKPFWISFTLNDDAAAVAGGE
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEEECCCCEEECCCC
PALRSGETVKAAAEWAAQSGAAALLFNCSKPEIMKAAVETASAVFADKGVSLEIGVYANA
CCCCCCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEEC
FEGEQGDSAANEGLHGTRTDLTDDVYSRFACSWADAGATMIGGCCGIGAAHIHTVATALR
CCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHH
RAAA
HHCC
>Mature Secondary Structure 
GTIRILDGGMSRELQRLGAELKQPEWSALALINAPDIVRQVHAEFIEAGADVVTTNSYA
CEEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHCCCCEEECCCEE
LVPFHIGEERFQKDGASLIALSGQLAREAADASGRKVQVAGSLPPIFGSYEPQNFDATRV
EEEEECCHHHHHHCCCEEEEECHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCHHHH
QDYLKVLVDNLAPSVDVWLGETLSLIAEGEAVRQAVAATDKPFWISFTLNDDAAAVAGGE
HHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEEEECCCCEEECCCC
PALRSGETVKAAAEWAAQSGAAALLFNCSKPEIMKAAVETASAVFADKGVSLEIGVYANA
CCCCCCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEEC
FEGEQGDSAANEGLHGTRTDLTDDVYSRFACSWADAGATMIGGCCGIGAAHIHTVATALR
CCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHH
RAAA
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503; 9882684; 10026151 [H]