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The map label for this gene is lysA [H]

Identifier: 159184868

GI number: 159184868

Start: 1660004

End: 1661185

Strand: Direct

Name: lysA [H]

Synonym: Atu1673

Alternate gene names: 159184868

Gene position: 1660004-1661185 (Clockwise)

Preceding gene: 15888978

Following gene: 15888981

Centisome position: 58.42

GC content: 61.25

Gene sequence:

>1182_bases
GTGCGCGATATCGTTGCAGAAACCGGGACCCCGTGTTTTCTCTATGATAACAGCGCCATGCGCCAAGCCTATCGCGATCT
CGAAACGGCGCTTTCCGGTTTTGCCGATATCTATTATTCGGTGAAGGCCAATCCCCTGCCCGCCATCATCTCACTTTTCC
GCGAAGAAGGCGCCGGCGCGGAAATCGCCTCCGTTGGCGAATATCGCGCCGCTGTAAAGGCCGGCGTCGCGCCTGATAAC
ATCATCTTCGCCGGCCCCGGCAAGAGCATGGCCGAATTGCGCGAAGTGATCGAGGGCGGTATCGGTGAAATCCACATCGA
GAGTGCGGAAGAAATCGCCCGTATCGAGGCGATCAACAGGCCGGTCAAGGCGTCGATCCGCATCAATCCGGTGCCGGATG
CGCAGGCGGGCGCCATGCGCATGGGCGGCAAGGCCACGGCCTTCGGTTTCGACGAGGAGGAACTGGAAAACGTCCTGAAG
CTCTTTGCGAACGTCAGACATATCGATCTCGTTGGTATCCATATTTACGGCGGCACGCAGATCCTCGATGCCGACATGCT
TGTCTCCCAATGGCGACACGCCATCGCTCTTGCAGGTCGCATGGCGCAAATGCTCGGCAAACCGCTCGAAACCATCGATC
TCGGCGGCGGCCTCGGCATTCCCTATTTCGCCGGGGAAACATCGCTCGATCTCGCCAAGGTGGCTGCCGCCATTCCCGAT
CTCAAGGCGCTTCTAAAGGCGCATCCGCTGATCGCCGATGCCCATGTCATAGTCGAACCCGGCCGCTTCCTCGCCGGCCC
TGGCGGCCTCTATGTGGTAGAGGTCAACTCGGTAAAGACCTCGCGCGGCACCACCTTCGTGGTCACGGATGGCGGCATGC
ACCACCACCTGGCAGCCTCCGGCAATCTCGGCCAGATCGTCAAACGCAACTACCCCATCGTCGCACCGGCCATGATGCAG
GCGGCACACGATGAGACAGCCACCATCGTCGGCCCGCTCTGCACCCCGCTCGATACGCTCGCCCGCAATGCGACCCTGCC
GAAACTGAACGCCGGCGATCTCCTCGCCATCCTGCAATCCGGTGCCTATGGCGCGAGCGCCAGCCCAGGCGGTTTTCTCA
GCCATACGGTAGCGAAGGAAGTGCTGGTGGAGGATGGTGCGTTTGAGGTGATCGGGCGCTGA

Upstream 100 bases:

>100_bases
GACAATGGCGCCCACGGATAAATCCCAGAACCACGGCCCGGCCCTTGCCGCCGGACTATTCGATATCAGCGAAAACGATC
TATTGATCGGCGGACTTTCG

Downstream 100 bases:

>100_bases
GAGAGTTGCGACAGCGAACCGGCGCAGTTTTTCTGGCAGACGGATGCAGTCATCGCATTTAACTCTGCATCTTCAACCCC
AACTATCCCCATACTGAGGA

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MRDIVAETGTPCFLYDNSAMRQAYRDLETALSGFADIYYSVKANPLPAIISLFREEGAGAEIASVGEYRAAVKAGVAPDN
IIFAGPGKSMAELREVIEGGIGEIHIESAEEIARIEAINRPVKASIRINPVPDAQAGAMRMGGKATAFGFDEEELENVLK
LFANVRHIDLVGIHIYGGTQILDADMLVSQWRHAIALAGRMAQMLGKPLETIDLGGGLGIPYFAGETSLDLAKVAAAIPD
LKALLKAHPLIADAHVIVEPGRFLAGPGGLYVVEVNSVKTSRGTTFVVTDGGMHHHLAASGNLGQIVKRNYPIVAPAMMQ
AAHDETATIVGPLCTPLDTLARNATLPKLNAGDLLAILQSGAYGASASPGGFLSHTVAKEVLVEDGAFEVIGR

Sequences:

>Translated_393_residues
MRDIVAETGTPCFLYDNSAMRQAYRDLETALSGFADIYYSVKANPLPAIISLFREEGAGAEIASVGEYRAAVKAGVAPDN
IIFAGPGKSMAELREVIEGGIGEIHIESAEEIARIEAINRPVKASIRINPVPDAQAGAMRMGGKATAFGFDEEELENVLK
LFANVRHIDLVGIHIYGGTQILDADMLVSQWRHAIALAGRMAQMLGKPLETIDLGGGLGIPYFAGETSLDLAKVAAAIPD
LKALLKAHPLIADAHVIVEPGRFLAGPGGLYVVEVNSVKTSRGTTFVVTDGGMHHHLAASGNLGQIVKRNYPIVAPAMMQ
AAHDETATIVGPLCTPLDTLARNATLPKLNAGDLLAILQSGAYGASASPGGFLSHTVAKEVLVEDGAFEVIGR
>Mature_393_residues
MRDIVAETGTPCFLYDNSAMRQAYRDLETALSGFADIYYSVKANPLPAIISLFREEGAGAEIASVGEYRAAVKAGVAPDN
IIFAGPGKSMAELREVIEGGIGEIHIESAEEIARIEAINRPVKASIRINPVPDAQAGAMRMGGKATAFGFDEEELENVLK
LFANVRHIDLVGIHIYGGTQILDADMLVSQWRHAIALAGRMAQMLGKPLETIDLGGGLGIPYFAGETSLDLAKVAAAIPD
LKALLKAHPLIADAHVIVEPGRFLAGPGGLYVVEVNSVKTSRGTTFVVTDGGMHHHLAASGNLGQIVKRNYPIVAPAMMQ
AAHDETATIVGPLCTPLDTLARNATLPKLNAGDLLAILQSGAYGASASPGGFLSHTVAKEVLVEDGAFEVIGR

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=362, Percent_Identity=24.0331491712707, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI22538418, Length=345, Percent_Identity=23.1884057971014, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI21361583, Length=345, Percent_Identity=23.1884057971014, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1789203, Length=417, Percent_Identity=27.0983213429257, Blast_Score=122, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17562780, Length=362, Percent_Identity=27.0718232044199, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6322664, Length=359, Percent_Identity=23.9554317548747, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24586472, Length=334, Percent_Identity=24.251497005988, Blast_Score=95, Evalue=9e-20,
Organism=Drosophila melanogaster, GI24586474, Length=348, Percent_Identity=25.2873563218391, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 41364; Mature: 41364

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00879 ODR_DC_2_2 ; PS00228 TUBULIN_B_AUTOREG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDIVAETGTPCFLYDNSAMRQAYRDLETALSGFADIYYSVKANPLPAIISLFREEGAGA
CCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHCCCCC
EIASVGEYRAAVKAGVAPDNIIFAGPGKSMAELREVIEGGIGEIHIESAEEIARIEAINR
CHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHCCCCEEEECCHHHHHHHHHHCC
PVKASIRINPVPDAQAGAMRMGGKATAFGFDEEELENVLKLFANVRHIDLVGIHIYGGTQ
CEEEEEEECCCCCCCCCHHHCCCCEEECCCCHHHHHHHHHHHHCCCEEEEEEEEEECCCE
ILDADMLVSQWRHAIALAGRMAQMLGKPLETIDLGGGLGIPYFAGETSLDLAKVAAAIPD
EECHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCEECCCCCHHHHHHHHHHHH
LKALLKAHPLIADAHVIVEPGRFLAGPGGLYVVEVNSVKTSRGTTFVVTDGGMHHHLAAS
HHHHHHHCCCEECCEEEECCCCEEECCCCEEEEEECCEECCCCCEEEEECCCCEEEEECC
GNLGQIVKRNYPIVAPAMMQAAHDETATIVGPLCTPLDTLARNATLPKLNAGDLLAILQS
CCHHHHHHCCCCEECHHHHHHHCCCCCEEECCCCCCHHHHHCCCCCCCCCCCHHHHHHHC
GAYGASASPGGFLSHTVAKEVLVEDGAFEVIGR
CCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCC
>Mature Secondary Structure
MRDIVAETGTPCFLYDNSAMRQAYRDLETALSGFADIYYSVKANPLPAIISLFREEGAGA
CCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHCCCCC
EIASVGEYRAAVKAGVAPDNIIFAGPGKSMAELREVIEGGIGEIHIESAEEIARIEAINR
CHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHCCCCEEEECCHHHHHHHHHHCC
PVKASIRINPVPDAQAGAMRMGGKATAFGFDEEELENVLKLFANVRHIDLVGIHIYGGTQ
CEEEEEEECCCCCCCCCHHHCCCCEEECCCCHHHHHHHHHHHHCCCEEEEEEEEEECCCE
ILDADMLVSQWRHAIALAGRMAQMLGKPLETIDLGGGLGIPYFAGETSLDLAKVAAAIPD
EECHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCEECCCCCHHHHHHHHHHHH
LKALLKAHPLIADAHVIVEPGRFLAGPGGLYVVEVNSVKTSRGTTFVVTDGGMHHHLAAS
HHHHHHHCCCEECCEEEECCCCEEECCCCEEEEEECCEECCCCCEEEEECCCCEEEEECC
GNLGQIVKRNYPIVAPAMMQAAHDETATIVGPLCTPLDTLARNATLPKLNAGDLLAILQS
CCHHHHHHCCCCEECHHHHHHHCCCCCEEECCCCCCHHHHHCCCCCCCCCCCHHHHHHHC
GAYGASASPGGFLSHTVAKEVLVEDGAFEVIGR
CCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA