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The map label for this gene is fadD [H]

Identifier: 15888978

GI number: 15888978

Start: 1658392

End: 1659924

Strand: Direct

Name: fadD [H]

Synonym: Atu1672

Alternate gene names: 15888978

Gene position: 1658392-1659924 (Clockwise)

Preceding gene: 15888977

Following gene: 159184868

Centisome position: 58.36

GC content: 61.97

Gene sequence:

>1533_bases
ATGACACCGCATTTCCTGCTGCACCATCTTCTGGCTGCCCGTGCGGCTAGCGAGGATCAGGCGCTTGTGCATAAGGAACA
ATCGCTGACTTATCGCGAATTCGCGGAGGCAGCAGCACATTGTGCAGCGGCATTGCATGAAGCAGGCACAGAGCGCGGCG
ATCGCGTCGTCATCTACCTGCCGCGCGGCTTCGAGGAATGCTGGTCGATCTTCGGCGTCAGCATGGCATCCGGCGTTTTC
GTGCCGGTCAATGCGCTGCTGAAGGCACAGCAGATTCGCCATATCGTTACCGACTGCGGCGCGAAGATCGTCATCAGCAG
CATGGCAATGATGGATGAGCTGAAGGCAGCATTGACTGACCTTCCTGATATCACGATCCTGCTGGCGGAAGAGATCACGG
CACGCAAAAGCGCGCCCGCCCGCCCTTCGGCGGCGATCGGCGAAGACCTCGCGGCCATCCTTTATACATCCGGCTCCACC
GGCTCGCCCAAGGGTGTGATGCTGTCGCACCGCAATCTTCTGGCCGGTGCGCGGATCGTGCGTACCTATCTCGATATTAC
CGGCAAGGACCGCATTCTCTCCCTCCTGCCCTTCAGCTTCGATTATGGTCTCAACCAGCTGCTGACGGCGGTGGAACAGG
GCGCGACCACTATTATCTCCACCTTCCGGCTGGGCGACGAGATCGTCCGCGACCTGCGCGACCAGGCCATCACCGGCCTT
GCCGGCGTGCCGACCATCTGGGCGATCCTGACGCGGGCAGCCCCTTTGCTCGCGAAAACGCCCCTACCGCATCTGCGCTA
CCTCACCAATTCCGGCGGGCGTGTGCCGCAGGAGACCGTGAAGGCGCTGCGCGAAAAGCTGCCGGACACGAAAATCTACC
TGATGTATGGCCTGACCGAGGCCTTCCGCTCCACCTTCCTGCCGCCGGACGAAATCGACCGCCGCCCGACCTCCATCGGC
AAGGCCATTCCCGAATGTGAAATCTTCATCGTCACCGACAAGGGACAAAGGGCAAAACCGGGCGAGCCCGGCATTCTCGT
GCATCGCGGCCCAACCGTCTCTCTCGGCTATTGGAACCGGCCGGAAGACACCGCCAAGGTCCTGCGCCCTCACCCTTTCA
TTCCGGCTGCGCGCGGCGGCGAGACCGTGTGTTACTCCGGCGATCTTGCGGTGGAAGACGAGGACGGCTTCTTCAGCTTT
GTTGCCCGCAACGATGCCATGATCAAATCCTCGGGCTATCGCATCAGCCCGACTGAGGTCGAGGAAAGCCTGATGTCGAC
GGGGCTTTTCCGTGAGGTTGCCGTCATCGGCCTGCCGGACCCGTTTGCCGGTGAAAAGGTGCATGCCGTGGCAACCGCGG
CCAGTGAGACTATCGATGTTTCGGCAGCGCTGAAGAAGGCCGCCGAAATGCTCGCCCCCTTCATGATCCCGCGCGCCATC
GAACTGGTCGAGCGGCTGCCGATCACCGCCAATGGCAAGGTGGATTACCGCGCGTTGGTGCGCGAACGGACGGACAATGG
CGCCCACGGATAA

Upstream 100 bases:

>100_bases
GCGAAAGTTTCGGCATCATTCTGAATGACGAGCATTTCACCCCTGACAATCTCGGCACGCCCGCCGATCTCATCACCTTC
GTTCTGAGGGAACGGAGGAA

Downstream 100 bases:

>100_bases
ATCCCAGAACCACGGCCCGGCCCTTGCCGCCGGACTATTCGATATCAGCGAAAACGATCTATTGATCGGCGGACTTTCGG
TGCGCGATATCGTTGCAGAA

Product: long-chain fatty acid-CoA ligase

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase [H]

Number of amino acids: Translated: 510; Mature: 509

Protein sequence:

>510_residues
MTPHFLLHHLLAARAASEDQALVHKEQSLTYREFAEAAAHCAAALHEAGTERGDRVVIYLPRGFEECWSIFGVSMASGVF
VPVNALLKAQQIRHIVTDCGAKIVISSMAMMDELKAALTDLPDITILLAEEITARKSAPARPSAAIGEDLAAILYTSGST
GSPKGVMLSHRNLLAGARIVRTYLDITGKDRILSLLPFSFDYGLNQLLTAVEQGATTIISTFRLGDEIVRDLRDQAITGL
AGVPTIWAILTRAAPLLAKTPLPHLRYLTNSGGRVPQETVKALREKLPDTKIYLMYGLTEAFRSTFLPPDEIDRRPTSIG
KAIPECEIFIVTDKGQRAKPGEPGILVHRGPTVSLGYWNRPEDTAKVLRPHPFIPAARGGETVCYSGDLAVEDEDGFFSF
VARNDAMIKSSGYRISPTEVEESLMSTGLFREVAVIGLPDPFAGEKVHAVATAASETIDVSAALKKAAEMLAPFMIPRAI
ELVERLPITANGKVDYRALVRERTDNGAHG

Sequences:

>Translated_510_residues
MTPHFLLHHLLAARAASEDQALVHKEQSLTYREFAEAAAHCAAALHEAGTERGDRVVIYLPRGFEECWSIFGVSMASGVF
VPVNALLKAQQIRHIVTDCGAKIVISSMAMMDELKAALTDLPDITILLAEEITARKSAPARPSAAIGEDLAAILYTSGST
GSPKGVMLSHRNLLAGARIVRTYLDITGKDRILSLLPFSFDYGLNQLLTAVEQGATTIISTFRLGDEIVRDLRDQAITGL
AGVPTIWAILTRAAPLLAKTPLPHLRYLTNSGGRVPQETVKALREKLPDTKIYLMYGLTEAFRSTFLPPDEIDRRPTSIG
KAIPECEIFIVTDKGQRAKPGEPGILVHRGPTVSLGYWNRPEDTAKVLRPHPFIPAARGGETVCYSGDLAVEDEDGFFSF
VARNDAMIKSSGYRISPTEVEESLMSTGLFREVAVIGLPDPFAGEKVHAVATAASETIDVSAALKKAAEMLAPFMIPRAI
ELVERLPITANGKVDYRALVRERTDNGAHG
>Mature_509_residues
TPHFLLHHLLAARAASEDQALVHKEQSLTYREFAEAAAHCAAALHEAGTERGDRVVIYLPRGFEECWSIFGVSMASGVFV
PVNALLKAQQIRHIVTDCGAKIVISSMAMMDELKAALTDLPDITILLAEEITARKSAPARPSAAIGEDLAAILYTSGSTG
SPKGVMLSHRNLLAGARIVRTYLDITGKDRILSLLPFSFDYGLNQLLTAVEQGATTIISTFRLGDEIVRDLRDQAITGLA
GVPTIWAILTRAAPLLAKTPLPHLRYLTNSGGRVPQETVKALREKLPDTKIYLMYGLTEAFRSTFLPPDEIDRRPTSIGK
AIPECEIFIVTDKGQRAKPGEPGILVHRGPTVSLGYWNRPEDTAKVLRPHPFIPAARGGETVCYSGDLAVEDEDGFFSFV
ARNDAMIKSSGYRISPTEVEESLMSTGLFREVAVIGLPDPFAGEKVHAVATAASETIDVSAALKKAAEMLAPFMIPRAIE
LVERLPITANGKVDYRALVRERTDNGAHG

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI58082049, Length=508, Percent_Identity=28.3464566929134, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI157311624, Length=506, Percent_Identity=27.8656126482213, Blast_Score=155, Evalue=7e-38,
Organism=Homo sapiens, GI157311622, Length=506, Percent_Identity=27.8656126482213, Blast_Score=155, Evalue=7e-38,
Organism=Homo sapiens, GI156151445, Length=544, Percent_Identity=25.7352941176471, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI187761345, Length=529, Percent_Identity=26.4650283553875, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI187761343, Length=529, Percent_Identity=26.4650283553875, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI38505220, Length=504, Percent_Identity=28.3730158730159, Blast_Score=139, Evalue=8e-33,
Organism=Homo sapiens, GI122937307, Length=525, Percent_Identity=26.2857142857143, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI42544132, Length=513, Percent_Identity=25.5360623781676, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI115511026, Length=517, Percent_Identity=27.0793036750484, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI195947378, Length=414, Percent_Identity=24.8792270531401, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI13236579, Length=505, Percent_Identity=23.5643564356436, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1788107, Length=547, Percent_Identity=28.3363802559415, Blast_Score=190, Evalue=2e-49,
Organism=Escherichia coli, GI145693145, Length=510, Percent_Identity=27.0588235294118, Blast_Score=141, Evalue=9e-35,
Organism=Escherichia coli, GI1786801, Length=527, Percent_Identity=25.0474383301708, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI221142682, Length=499, Percent_Identity=24.0480961923848, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI1786810, Length=525, Percent_Identity=22.6666666666667, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI1789201, Length=504, Percent_Identity=25.9920634920635, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17559526, Length=510, Percent_Identity=25.6862745098039, Blast_Score=149, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17557194, Length=527, Percent_Identity=23.719165085389, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI71994703, Length=540, Percent_Identity=24.2592592592593, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71994694, Length=540, Percent_Identity=24.2592592592593, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17531443, Length=514, Percent_Identity=23.1517509727626, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71994690, Length=540, Percent_Identity=24.2592592592593, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI32563687, Length=490, Percent_Identity=24.4897959183673, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17560308, Length=516, Percent_Identity=24.8062015503876, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI71996755, Length=526, Percent_Identity=25.0950570342205, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17538037, Length=516, Percent_Identity=22.6744186046512, Blast_Score=118, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17558820, Length=478, Percent_Identity=25.7322175732218, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71985884, Length=370, Percent_Identity=25.4054054054054, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI115534440, Length=518, Percent_Identity=23.5521235521236, Blast_Score=79, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6319699, Length=535, Percent_Identity=24.1121495327103, Blast_Score=126, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6323182, Length=536, Percent_Identity=25, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6319264, Length=533, Percent_Identity=24.577861163227, Blast_Score=98, Evalue=4e-21,
Organism=Drosophila melanogaster, GI18859661, Length=517, Percent_Identity=26.8858800773694, Blast_Score=132, Evalue=6e-31,
Organism=Drosophila melanogaster, GI24581924, Length=547, Percent_Identity=24.3144424131627, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24656500, Length=422, Percent_Identity=26.5402843601896, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21356441, Length=310, Percent_Identity=27.741935483871, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21355181, Length=493, Percent_Identity=22.7180527383367, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24648260, Length=353, Percent_Identity=26.0623229461756, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21356947, Length=433, Percent_Identity=24.4803695150115, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI281365686, Length=312, Percent_Identity=24.0384615384615, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21358303, Length=304, Percent_Identity=24.0131578947368, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24648257, Length=365, Percent_Identity=28.4931506849315, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI19922652, Length=509, Percent_Identity=22.3968565815324, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI20130357, Length=363, Percent_Identity=26.1707988980716, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24653035, Length=355, Percent_Identity=26.4788732394366, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24648253, Length=356, Percent_Identity=23.5955056179775, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24648255, Length=370, Percent_Identity=24.0540540540541, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI62471681, Length=516, Percent_Identity=21.8992248062016, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI62471687, Length=516, Percent_Identity=21.8992248062016, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24586634, Length=516, Percent_Identity=21.8992248062016, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI22026970, Length=516, Percent_Identity=21.8992248062016, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI62471679, Length=516, Percent_Identity=21.8992248062016, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI62471683, Length=516, Percent_Identity=21.8992248062016, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI62471685, Length=516, Percent_Identity=21.8992248062016, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24586636, Length=516, Percent_Identity=21.8992248062016, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI62471689, Length=516, Percent_Identity=21.8992248062016, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI161076582, Length=371, Percent_Identity=25.6064690026954, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020459
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 55327; Mature: 55196

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPHFLLHHLLAARAASEDQALVHKEQSLTYREFAEAAAHCAAALHEAGTERGDRVVIYL
CCHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEC
PRGFEECWSIFGVSMASGVFVPVNALLKAQQIRHIVTDCGAKIVISSMAMMDELKAALTD
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHC
LPDITILLAEEITARKSAPARPSAAIGEDLAAILYTSGSTGSPKGVMLSHRNLLAGARIV
CCCEEEEEHHHHHHHCCCCCCCCHHHHHHHEEEEEECCCCCCCCCEEEECCHHHHHHHHH
RTYLDITGKDRILSLLPFSFDYGLNQLLTAVEQGATTIISTFRLGDEIVRDLRDQAITGL
HHHHHCCCCHHHHHHCCCHHHCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCC
AGVPTIWAILTRAAPLLAKTPLPHLRYLTNSGGRVPQETVKALREKLPDTKIYLMYGLTE
CCHHHHHHHHHHHCHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEECHHH
AFRSTFLPPDEIDRRPTSIGKAIPECEIFIVTDKGQRAKPGEPGILVHRGPTVSLGYWNR
HHHHHCCCHHHHCCCCHHHHCCCCCCEEEEEECCCCCCCCCCCCEEEECCCEEEECCCCC
PEDTAKVLRPHPFIPAARGGETVCYSGDLAVEDEDGFFSFVARNDAMIKSSGYRISPTEV
CHHHHHHCCCCCCCCCCCCCCEEEECCCEEEECCCCEEEEEECCCCEEECCCCCCCHHHH
EESLMSTGLFREVAVIGLPDPFAGEKVHAVATAASETIDVSAALKKAAEMLAPFMIPRAI
HHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELVERLPITANGKVDYRALVRERTDNGAHG
HHHHHCCCCCCCCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TPHFLLHHLLAARAASEDQALVHKEQSLTYREFAEAAAHCAAALHEAGTERGDRVVIYL
CHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEC
PRGFEECWSIFGVSMASGVFVPVNALLKAQQIRHIVTDCGAKIVISSMAMMDELKAALTD
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHC
LPDITILLAEEITARKSAPARPSAAIGEDLAAILYTSGSTGSPKGVMLSHRNLLAGARIV
CCCEEEEEHHHHHHHCCCCCCCCHHHHHHHEEEEEECCCCCCCCCEEEECCHHHHHHHHH
RTYLDITGKDRILSLLPFSFDYGLNQLLTAVEQGATTIISTFRLGDEIVRDLRDQAITGL
HHHHHCCCCHHHHHHCCCHHHCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCC
AGVPTIWAILTRAAPLLAKTPLPHLRYLTNSGGRVPQETVKALREKLPDTKIYLMYGLTE
CCHHHHHHHHHHHCHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEECHHH
AFRSTFLPPDEIDRRPTSIGKAIPECEIFIVTDKGQRAKPGEPGILVHRGPTVSLGYWNR
HHHHHCCCHHHHCCCCHHHHCCCCCCEEEEEECCCCCCCCCCCCEEEECCCEEEECCCCC
PEDTAKVLRPHPFIPAARGGETVCYSGDLAVEDEDGFFSFVARNDAMIKSSGYRISPTEV
CHHHHHHCCCCCCCCCCCCCCEEEECCCEEEECCCCEEEEEECCCCEEECCCCCCCHHHH
EESLMSTGLFREVAVIGLPDPFAGEKVHAVATAASETIDVSAALKKAAEMLAPFMIPRAI
HHHHHHHHHHHHHEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELVERLPITANGKVDYRALVRERTDNGAHG
HHHHHCCCCCCCCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]