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The map label for this gene is sthA [H]

Identifier: 159184862

GI number: 159184862

Start: 1646893

End: 1648296

Strand: Direct

Name: sthA [H]

Synonym: Atu1661

Alternate gene names: 159184862

Gene position: 1646893-1648296 (Clockwise)

Preceding gene: 17935555

Following gene: 15888970

Centisome position: 57.96

GC content: 61.11

Gene sequence:

>1404_bases
ATGTACCAGTTCGATCTGATTGTTGTCGGCAGCGGTCCGGCGGGAAGACGGGCCGCCATCCAGGCCGCCAAGCTCGAAAA
GAAGGTTCTGGTCATCGAGAAAGGCAGCCGTGTCGGCGGTGTTTCCGTGCATACCGGCACCATCCCGTCCAAGACCCTGC
GCGAAACCGCGCTCAATCTCACCGGCTGGCGCGAGCGCGGTTTTTACGGCCGTGCCTATCGCGTCAAGCAGGAGATCGAC
GCCGACGATCTGCGCCGCCGTCTGCTCATCACGCTCGATCATGAAGTCGAGGTGCTGGAGCATCAGTTCGCCCGCAACCG
CGTGCAGCACATTCGCGGCACGGCAAGCTTCATCGACGCCAACACGATGAAAGTCGTGAAGAGCGACGGTGAAGTCATGA
CCGTCACTGCCACCTCCATTCTGCTCACCATCGGCACCCGGCCCTACCGGCCGCCGCATATTCCCTTCGATGGCCAGGCG
GTGCTCGATTCGGATGAGATTCTCGAGATCAAGGAATTGCCGCGCTCCATGGTCGTCGTCGGTGCCGGCGTCATCGGCAT
CGAATATGCGACGATCTTCAGCGCACTCGACACACAGGTAACGGTGGTGGAACCACGCGAGACCATGCTGGAATTCATCG
ATAAGGAAATCGTCGAGGATTTCACCTATCAGCTGCGCGACCGCAACATGAAGCTGATCTTCGGCCAGAAGGCGGAAAAG
GTGGAGCGCGACGAAAGCGGCAAATGCCTCGTTTCGCTCAGCAACGGCCGCGTCCTGAAAGCCGAGACCGTACTCTTCGC
CGCCGGCCGCGTCGGCGCCACCGATACGCTCAATCTTTCCGCCTGCGGGCTGGAGGCCGACAGCCGTGGCCGCCTGAAGG
TCGATCCCGAGACCTTCCAGACCTCGGTGCCGAACATCTATGCCGCCGGCGACATCATCGGTTTCCCGAGCCTTGCCTCC
ACGTCAATGGAACAGGGCCGCATCGCCGCCCGCCATGCCGTCGGCGCACCGGCCGGCGAGCCGCCGCAATTCTTCCCCTA
CGGCATCTATGCCGTGCCTGAGATCTCCACCTGCGGCCTGACGGAAGAGGAAGTTGTTGAACGCGGCATTCCCTATGAAT
GCGGCATCGCCCATTTCCGCGAAACCTCGCGCGGCCACATCATGGGCCTCGACAGCGGTCTGTTGAAGATGATCTTCTCG
CTGAAAACCCGCCGCCTGCTCGGCGTCCACATCGTCGGCGAAGGCGCGACAGAACTGGTGCATATCGGCCAGGCGGTGCT
AAACCTCAAAGGCACGGTGGAATATTTCGTGGAGAATACGTTCAACTATCCGACGCTGGCAGAAGCCTACAAGATCGCCG
GGCTGGATGCGTGGAACCGCATGGGTGAGTTGAAGAAGGATTGA

Upstream 100 bases:

>100_bases
ATCACTCCCCATCGTCCAAATGGCATCACGACCATTTCGCGACGACGCCACGCCGGATGCGACATCCGGTATCGAAATAT
ATTCTGTTCCGGGGTTTTTC

Downstream 100 bases:

>100_bases
GGCTTTGTTGCAGGTAAGAGATCATCTGCGATGTGCAAAAACTCTCCTGCCCATCACGCTCGGGCCTGTCCCGAGCATCT
GCAACGTTTCGCTTTATGCG

Product: soluble pyridine nucleotide transhydrogenase

Products: NA

Alternate protein names: STH; NAD(P)(+) transhydrogenase [B-specific] [H]

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MYQFDLIVVGSGPAGRRAAIQAAKLEKKVLVIEKGSRVGGVSVHTGTIPSKTLRETALNLTGWRERGFYGRAYRVKQEID
ADDLRRRLLITLDHEVEVLEHQFARNRVQHIRGTASFIDANTMKVVKSDGEVMTVTATSILLTIGTRPYRPPHIPFDGQA
VLDSDEILEIKELPRSMVVVGAGVIGIEYATIFSALDTQVTVVEPRETMLEFIDKEIVEDFTYQLRDRNMKLIFGQKAEK
VERDESGKCLVSLSNGRVLKAETVLFAAGRVGATDTLNLSACGLEADSRGRLKVDPETFQTSVPNIYAAGDIIGFPSLAS
TSMEQGRIAARHAVGAPAGEPPQFFPYGIYAVPEISTCGLTEEEVVERGIPYECGIAHFRETSRGHIMGLDSGLLKMIFS
LKTRRLLGVHIVGEGATELVHIGQAVLNLKGTVEYFVENTFNYPTLAEAYKIAGLDAWNRMGELKKD

Sequences:

>Translated_467_residues
MYQFDLIVVGSGPAGRRAAIQAAKLEKKVLVIEKGSRVGGVSVHTGTIPSKTLRETALNLTGWRERGFYGRAYRVKQEID
ADDLRRRLLITLDHEVEVLEHQFARNRVQHIRGTASFIDANTMKVVKSDGEVMTVTATSILLTIGTRPYRPPHIPFDGQA
VLDSDEILEIKELPRSMVVVGAGVIGIEYATIFSALDTQVTVVEPRETMLEFIDKEIVEDFTYQLRDRNMKLIFGQKAEK
VERDESGKCLVSLSNGRVLKAETVLFAAGRVGATDTLNLSACGLEADSRGRLKVDPETFQTSVPNIYAAGDIIGFPSLAS
TSMEQGRIAARHAVGAPAGEPPQFFPYGIYAVPEISTCGLTEEEVVERGIPYECGIAHFRETSRGHIMGLDSGLLKMIFS
LKTRRLLGVHIVGEGATELVHIGQAVLNLKGTVEYFVENTFNYPTLAEAYKIAGLDAWNRMGELKKD
>Mature_467_residues
MYQFDLIVVGSGPAGRRAAIQAAKLEKKVLVIEKGSRVGGVSVHTGTIPSKTLRETALNLTGWRERGFYGRAYRVKQEID
ADDLRRRLLITLDHEVEVLEHQFARNRVQHIRGTASFIDANTMKVVKSDGEVMTVTATSILLTIGTRPYRPPHIPFDGQA
VLDSDEILEIKELPRSMVVVGAGVIGIEYATIFSALDTQVTVVEPRETMLEFIDKEIVEDFTYQLRDRNMKLIFGQKAEK
VERDESGKCLVSLSNGRVLKAETVLFAAGRVGATDTLNLSACGLEADSRGRLKVDPETFQTSVPNIYAAGDIIGFPSLAS
TSMEQGRIAARHAVGAPAGEPPQFFPYGIYAVPEISTCGLTEEEVVERGIPYECGIAHFRETSRGHIMGLDSGLLKMIFS
LKTRRLLGVHIVGEGATELVHIGQAVLNLKGTVEYFVENTFNYPTLAEAYKIAGLDAWNRMGELKKD

Specific function: Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=460, Percent_Identity=31.7391304347826, Blast_Score=220, Evalue=3e-57,
Organism=Homo sapiens, GI50301238, Length=472, Percent_Identity=26.271186440678, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI22035672, Length=428, Percent_Identity=27.1028037383178, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI148277065, Length=480, Percent_Identity=25.8333333333333, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI33519430, Length=476, Percent_Identity=26.0504201680672, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI33519428, Length=476, Percent_Identity=26.0504201680672, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI33519426, Length=476, Percent_Identity=26.0504201680672, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI148277071, Length=476, Percent_Identity=26.0504201680672, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI291045266, Length=492, Percent_Identity=25.4065040650407, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI291045268, Length=358, Percent_Identity=25.9776536312849, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI226437568, Length=346, Percent_Identity=26.878612716763, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI21389617, Length=346, Percent_Identity=26.878612716763, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI65787454, Length=346, Percent_Identity=26.878612716763, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI87082354, Length=471, Percent_Identity=40.1273885350318, Blast_Score=366, Evalue=1e-102,
Organism=Escherichia coli, GI1786307, Length=454, Percent_Identity=31.057268722467, Blast_Score=207, Evalue=2e-54,
Organism=Escherichia coli, GI87081717, Length=455, Percent_Identity=26.3736263736264, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1789915, Length=440, Percent_Identity=25.6818181818182, Blast_Score=119, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI32565766, Length=460, Percent_Identity=30.2173913043478, Blast_Score=217, Evalue=8e-57,
Organism=Caenorhabditis elegans, GI17557007, Length=470, Percent_Identity=25.3191489361702, Blast_Score=123, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI71983419, Length=373, Percent_Identity=26.5415549597855, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71983429, Length=373, Percent_Identity=26.5415549597855, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71982272, Length=491, Percent_Identity=25.4582484725051, Blast_Score=93, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6321091, Length=471, Percent_Identity=28.4501061571125, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6325240, Length=467, Percent_Identity=25.0535331905782, Blast_Score=153, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6325166, Length=464, Percent_Identity=23.9224137931034, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21358499, Length=467, Percent_Identity=30.406852248394, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24640549, Length=489, Percent_Identity=28.0163599182004, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24640553, Length=489, Percent_Identity=28.0163599182004, Blast_Score=141, Evalue=8e-34,
Organism=Drosophila melanogaster, GI24640551, Length=489, Percent_Identity=28.0163599182004, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI17737741, Length=486, Percent_Identity=27.7777777777778, Blast_Score=134, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327
- InterPro:   IPR022962 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.1.1 [H]

Molecular weight: Translated: 51370; Mature: 51370

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQFDLIVVGSGPAGRRAAIQAAKLEKKVLVIEKGSRVGGVSVHTGTIPSKTLRETALNL
CEEEEEEEECCCCCCCHHHHHHHHCCCEEEEEECCCCCCCEEEECCCCCHHHHHHHHCCC
TGWRERGFYGRAYRVKQEIDADDLRRRLLITLDHEVEVLEHQFARNRVQHIRGTASFIDA
CCCHHCCCCCCEEEEHHHCCHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHCCCHHHCCC
NTMKVVKSDGEVMTVTATSILLTIGTRPYRPPHIPFDGQAVLDSDEILEIKELPRSMVVV
CEEEEEECCCCEEEEEEEEEEEEECCCCCCCCCCCCCCCEEECCCHHHHHHHCCCEEEEE
GAGVIGIEYATIFSALDTQVTVVEPRETMLEFIDKEIVEDFTYQLRDRNMKLIFGQKAEK
ECCCHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHH
VERDESGKCLVSLSNGRVLKAETVLFAAGRVGATDTLNLSACGLEADSRGRLKVDPETFQ
HCCCCCCCEEEEECCCCEEEEEEEEEECCCCCCCCEEEEEEECCCCCCCCCEEECHHHHH
TSVPNIYAAGDIIGFPSLASTSMEQGRIAARHAVGAPAGEPPQFFPYGIYAVPEISTCGL
CCCCCEEECCCCCCCCCHHHCCHHHCCHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCC
TEEEVVERGIPYECGIAHFRETSRGHIMGLDSGLLKMIFSLKTRRLLGVHIVGEGATELV
CHHHHHHCCCCCCCCHHHHHCCCCCEEEECCHHHHHHHHHHHHCEEEEEEEECCCHHHHH
HIGQAVLNLKGTVEYFVENTFNYPTLAEAYKIAGLDAWNRMGELKKD
HHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHCCCHHHHHHCCCCCC
>Mature Secondary Structure
MYQFDLIVVGSGPAGRRAAIQAAKLEKKVLVIEKGSRVGGVSVHTGTIPSKTLRETALNL
CEEEEEEEECCCCCCCHHHHHHHHCCCEEEEEECCCCCCCEEEECCCCCHHHHHHHHCCC
TGWRERGFYGRAYRVKQEIDADDLRRRLLITLDHEVEVLEHQFARNRVQHIRGTASFIDA
CCCHHCCCCCCEEEEHHHCCHHHHCCEEEEEECCHHHHHHHHHHHHHHHHHCCCHHHCCC
NTMKVVKSDGEVMTVTATSILLTIGTRPYRPPHIPFDGQAVLDSDEILEIKELPRSMVVV
CEEEEEECCCCEEEEEEEEEEEEECCCCCCCCCCCCCCCEEECCCHHHHHHHCCCEEEEE
GAGVIGIEYATIFSALDTQVTVVEPRETMLEFIDKEIVEDFTYQLRDRNMKLIFGQKAEK
ECCCHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHH
VERDESGKCLVSLSNGRVLKAETVLFAAGRVGATDTLNLSACGLEADSRGRLKVDPETFQ
HCCCCCCCEEEEECCCCEEEEEEEEEECCCCCCCCEEEEEEECCCCCCCCCEEECHHHHH
TSVPNIYAAGDIIGFPSLASTSMEQGRIAARHAVGAPAGEPPQFFPYGIYAVPEISTCGL
CCCCCEEECCCCCCCCCHHHCCHHHCCHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCC
TEEEVVERGIPYECGIAHFRETSRGHIMGLDSGLLKMIFSLKTRRLLGVHIVGEGATELV
CHHHHHHCCCCCCCCHHHHHCCCCCEEEECCHHHHHHHHHHHHCEEEEEEEECCCHHHHH
HIGQAVLNLKGTVEYFVENTFNYPTLAEAYKIAGLDAWNRMGELKKD
HHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHCCCHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]