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The map label for this gene is blaA [H]

Identifier: 159184732

GI number: 159184732

Start: 1362044

End: 1362910

Strand: Reverse

Name: blaA [H]

Synonym: Atu1367

Alternate gene names: 159184732

Gene position: 1362910-1362044 (Counterclockwise)

Preceding gene: 15888695

Following gene: 15888687

Centisome position: 47.96

GC content: 60.9

Gene sequence:

>867_bases
ATGACACTGCCACCACTCGCCACCCTTCGTGCTTTCGAATCCGCCGCCAGAAAGGCTAGTTTTGCCCTGGCCGCGCAGGA
ACTTGGCATGACAGCCACTGCGGTGAGCCAGCATGTGCGCAATCTGGAAGCATGGCTTGGGGTCGCTCTTTTCGAGCGCC
ACGCGCGCGGCGTCAGGCTTACCCCCGCCGGAATGGAATTTGGCAACACGGTCTCGGGCAGCCTGCGGCAGATCGCTTCT
GGCGCGGAGCGCATCCGCCGGGGTCACGACCGCATGACCGTGCGCCTTGCCAGCCTGCCTTCGGTAGTGGCGCATTTTCT
CACGCCCCGGCTGCCCCGCTTCCGGGCCTCGCATCCAGACATACAGGTGTCGATCAGCTATTCCGGCGCGCAGCATACAA
GCGCAGCCGATCTCACCATCGGGCATGGGATATCCTTCGGGGAAAATGCCGTGGCCCTGTTCAGCGCAGAAACACGTCCA
ACCTGCGCGCCCAGCTATATCGCCAGTGCTGGTCCCTTCAATGACGAGGCCAGCCTGTTACGCGCGGAACTGCTGCATGA
TGATACCGAGACGGCATGGAGAGACTGGTTTGCGGTTGGTGACATGTCGCTACCTTACGGTGCAGGTCCGATTTTCGCGG
ATTTTAATCTACTGGTTACAGCCTTGAAAGCGGGACAGGGTATCGGCCTCTGCCCGACGGCACTTCTTCGTAAAGAGATC
GCCGAGGGCCAGTTGACAGTGCTTTTCGACCGGGCCGTCGATACGGATAAATATTACTGGCTCATCCGACCGGAAGAGAT
GACCGCATCGGCGCGCCTTCTCGCTGACTGGTTGGTGGCGGAAGCACGCGGGAGCGACCTGAAGTAG

Upstream 100 bases:

>100_bases
GAGAAAGACGTAATCGACGTGATAATTGCGCCATGTCCACCCCGCTGACAAGACAGGTTTTTCTTGCGCTCAGCCCAAGC
CTCACTTAGCCTCATCGATC

Downstream 100 bases:

>100_bases
AACAAGCAGGCATTAAAAACCGCGCAAAAACAGCCCAGCCGCTAGAAGCACAATTGGAACCGCCACGCCAACGATGACGC
GCTGGCCGGCAACTAGAAAT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Beta-lactamase regulatory protein BlaA [H]

Number of amino acids: Translated: 288; Mature: 287

Protein sequence:

>288_residues
MTLPPLATLRAFESAARKASFALAAQELGMTATAVSQHVRNLEAWLGVALFERHARGVRLTPAGMEFGNTVSGSLRQIAS
GAERIRRGHDRMTVRLASLPSVVAHFLTPRLPRFRASHPDIQVSISYSGAQHTSAADLTIGHGISFGENAVALFSAETRP
TCAPSYIASAGPFNDEASLLRAELLHDDTETAWRDWFAVGDMSLPYGAGPIFADFNLLVTALKAGQGIGLCPTALLRKEI
AEGQLTVLFDRAVDTDKYYWLIRPEEMTASARLLADWLVAEARGSDLK

Sequences:

>Translated_288_residues
MTLPPLATLRAFESAARKASFALAAQELGMTATAVSQHVRNLEAWLGVALFERHARGVRLTPAGMEFGNTVSGSLRQIAS
GAERIRRGHDRMTVRLASLPSVVAHFLTPRLPRFRASHPDIQVSISYSGAQHTSAADLTIGHGISFGENAVALFSAETRP
TCAPSYIASAGPFNDEASLLRAELLHDDTETAWRDWFAVGDMSLPYGAGPIFADFNLLVTALKAGQGIGLCPTALLRKEI
AEGQLTVLFDRAVDTDKYYWLIRPEEMTASARLLADWLVAEARGSDLK
>Mature_287_residues
TLPPLATLRAFESAARKASFALAAQELGMTATAVSQHVRNLEAWLGVALFERHARGVRLTPAGMEFGNTVSGSLRQIASG
AERIRRGHDRMTVRLASLPSVVAHFLTPRLPRFRASHPDIQVSISYSGAQHTSAADLTIGHGISFGENAVALFSAETRPT
CAPSYIASAGPFNDEASLLRAELLHDDTETAWRDWFAVGDMSLPYGAGPIFADFNLLVTALKAGQGIGLCPTALLRKEIA
EGQLTVLFDRAVDTDKYYWLIRPEEMTASARLLADWLVAEARGSDLK

Specific function: Positive regulator of the expression of the gene (blaB) for beta-lactamase [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789173, Length=288, Percent_Identity=28.4722222222222, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1788706, Length=270, Percent_Identity=30, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1786448, Length=287, Percent_Identity=28.2229965156794, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI1786401, Length=287, Percent_Identity=28.2229965156794, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI157672245, Length=117, Percent_Identity=34.1880341880342, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1787589, Length=264, Percent_Identity=24.2424242424242, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 31161; Mature: 31030

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLPPLATLRAFESAARKASFALAAQELGMTATAVSQHVRNLEAWLGVALFERHARGVRL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
TPAGMEFGNTVSGSLRQIASGAERIRRGHDRMTVRLASLPSVVAHFLTPRLPRFRASHPD
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHEEEEHHHHHHHHHHHHCCCCCCCCCCCCC
IQVSISYSGAQHTSAADLTIGHGISFGENAVALFSAETRPTCAPSYIASAGPFNDEASLL
EEEEEEECCCCCCCCCCEEECCCCCCCCCEEEEEECCCCCCCCHHHHHCCCCCCCHHHHH
RAELLHDDTETAWRDWFAVGDMSLPYGAGPIFADFNLLVTALKAGQGIGLCPTALLRKEI
HHHHHCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
AEGQLTVLFDRAVDTDKYYWLIRPEEMTASARLLADWLVAEARGSDLK
CCCCEEEEEECCCCCCCEEEEEECHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TLPPLATLRAFESAARKASFALAAQELGMTATAVSQHVRNLEAWLGVALFERHARGVRL
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
TPAGMEFGNTVSGSLRQIASGAERIRRGHDRMTVRLASLPSVVAHFLTPRLPRFRASHPD
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHEEEEHHHHHHHHHHHHCCCCCCCCCCCCC
IQVSISYSGAQHTSAADLTIGHGISFGENAVALFSAETRPTCAPSYIASAGPFNDEASLL
EEEEEEECCCCCCCCCCEEECCCCCCCCCEEEEEECCCCCCCCHHHHHCCCCCCCHHHHH
RAELLHDDTETAWRDWFAVGDMSLPYGAGPIFADFNLLVTALKAGQGIGLCPTALLRKEI
HHHHHCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
AEGQLTVLFDRAVDTDKYYWLIRPEEMTASARLLADWLVAEARGSDLK
CCCCEEEEEECCCCCCCEEEEEECHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7957242 [H]