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The map label for this gene is glyA [H]

Identifier: 159184645

GI number: 159184645

Start: 1160109

End: 1161398

Strand: Direct

Name: glyA [H]

Synonym: Atu1165

Alternate gene names: 159184645

Gene position: 1160109-1161398 (Clockwise)

Preceding gene: 15888502

Following gene: 15888504

Centisome position: 40.83

GC content: 60.62

Gene sequence:

>1290_bases
ATGTCGAACACAGATGCTTTCTTCTCCCGTCCGCTTGCCGAAGTCGATCCGGATATTTTCGGCGCGATCGAGAAGGAACT
GGGTCGCCAGCGCCACGAGATCGAACTGATCGCCTCGGAAAACATCGTTTCCCGCGCTGTGCTTGAAGCGCAGGGTTCGA
TCATGACCAACAAATATGCGGAAGGTTATCCGGGCAAGCGTTATTACGGCGGCTGCCAGTTCGTCGATATCGCTGAAGAG
CTTGCCATCGAGCGCGCCAAGAAGCTGTTCGGCGTCAACTTCGCCAACGTTCAGCCGAACTCCGGTTCGCAGATGAATCA
GGCCGTGTTCCTCGCGCTTTTGCAGCCGGGCGATACCTTCATGGGTCTCGATCTGAACTCGGGGGGCCACCTGACGCATG
GTTCGCCGGTCAACATGTCCGGTAAATGGTTCAACGTCGTGTCCTACGGCGTGCGTGAAGGCGACAACCTGCTCGACATG
GACGAAGTGGAGCGCAAGGCCAAGGAAACCCGGCCGAAGCTGATCCTTGCCGGCGGCACCGCCTATTCGCGCGTCTGGGA
CTGGAAGCGCTTCCGCGAGATCGCCGATGAAGTCGGCGCCTATCTGATGGTCGACATGGCCCACATCGCCGGTCTCGTTG
CCGGTGGCCAGCACCCGTCGCCGTTCCCGCATTGCCATGTTGCCACCACCACGACGCACAAGTCTCTGCGCGGCCCGCGT
GGCGGCATGATCCTCACCAATGACGAGGATCTGGCCAAGAAGTTCAACTCGGCCGTATTCCCCGGCCTGCAGGGTGGCCC
GCTGATGCATGTCATCGCCGCCAAGGCCGTTGCCTTCGGCGAAGCGCTGCAGCCGGAATTCAAGGACTATGCCGCGCAGG
TCGTGAAGAACGCCAAGGCGCTGGCCGAAACCCTGATCGAAGGCGGTCTCGATGTCGTCTCCGGCGGCACCGACAACCAC
CTGATGCTGGTCGATCTTCGCAAGAAGAACGCCACCGGCAAGCGCGCGGAAGCAGCCCTTGGCCGCGCTTACATCACCTG
CAACAAGAACGGCATTCCTTTCGACCCGGAAAAACCCTTCGTCACGTCGGGTGTCCGTCTCGGCACGCCGGCCGGCACGA
CGCGCGGTTTCAAGGAAGCGGAATTCCGCGAAATCGGCAAGCTGATCGTCGAGGTTCTCGACGGCCTGAAGGTTGCCAAT
TCGGATGAAGGTAATGCCTCCGTCGAGGCTGCCGTGCGCGAAAAGGTCGTCGGTTTGACCGACCGTTTCCCGATGTATCC
GTACATGTAA

Upstream 100 bases:

>100_bases
GCAACGTCGCAGTTTGACGGGCAAATCTCGCTGGCCGTATTGCTCTTGTTCGGGCAGGGCGCTAAGACGCCATCGCATTA
CTGTTTCAGGAGCCTTCACC

Downstream 100 bases:

>100_bases
GGAAAGAAAAAGATGCGCTGCCCATTTTGCGGTTCCGAAGACACACAGGTCAAGGACTCGCGTCCGGCGGAGGACAACAC
CTCCATCCGTCGGCGGCGCA

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MSNTDAFFSRPLAEVDPDIFGAIEKELGRQRHEIELIASENIVSRAVLEAQGSIMTNKYAEGYPGKRYYGGCQFVDIAEE
LAIERAKKLFGVNFANVQPNSGSQMNQAVFLALLQPGDTFMGLDLNSGGHLTHGSPVNMSGKWFNVVSYGVREGDNLLDM
DEVERKAKETRPKLILAGGTAYSRVWDWKRFREIADEVGAYLMVDMAHIAGLVAGGQHPSPFPHCHVATTTTHKSLRGPR
GGMILTNDEDLAKKFNSAVFPGLQGGPLMHVIAAKAVAFGEALQPEFKDYAAQVVKNAKALAETLIEGGLDVVSGGTDNH
LMLVDLRKKNATGKRAEAALGRAYITCNKNGIPFDPEKPFVTSGVRLGTPAGTTRGFKEAEFREIGKLIVEVLDGLKVAN
SDEGNASVEAAVREKVVGLTDRFPMYPYM

Sequences:

>Translated_429_residues
MSNTDAFFSRPLAEVDPDIFGAIEKELGRQRHEIELIASENIVSRAVLEAQGSIMTNKYAEGYPGKRYYGGCQFVDIAEE
LAIERAKKLFGVNFANVQPNSGSQMNQAVFLALLQPGDTFMGLDLNSGGHLTHGSPVNMSGKWFNVVSYGVREGDNLLDM
DEVERKAKETRPKLILAGGTAYSRVWDWKRFREIADEVGAYLMVDMAHIAGLVAGGQHPSPFPHCHVATTTTHKSLRGPR
GGMILTNDEDLAKKFNSAVFPGLQGGPLMHVIAAKAVAFGEALQPEFKDYAAQVVKNAKALAETLIEGGLDVVSGGTDNH
LMLVDLRKKNATGKRAEAALGRAYITCNKNGIPFDPEKPFVTSGVRLGTPAGTTRGFKEAEFREIGKLIVEVLDGLKVAN
SDEGNASVEAAVREKVVGLTDRFPMYPYM
>Mature_428_residues
SNTDAFFSRPLAEVDPDIFGAIEKELGRQRHEIELIASENIVSRAVLEAQGSIMTNKYAEGYPGKRYYGGCQFVDIAEEL
AIERAKKLFGVNFANVQPNSGSQMNQAVFLALLQPGDTFMGLDLNSGGHLTHGSPVNMSGKWFNVVSYGVREGDNLLDMD
EVERKAKETRPKLILAGGTAYSRVWDWKRFREIADEVGAYLMVDMAHIAGLVAGGQHPSPFPHCHVATTTTHKSLRGPRG
GMILTNDEDLAKKFNSAVFPGLQGGPLMHVIAAKAVAFGEALQPEFKDYAAQVVKNAKALAETLIEGGLDVVSGGTDNHL
MLVDLRKKNATGKRAEAALGRAYITCNKNGIPFDPEKPFVTSGVRLGTPAGTTRGFKEAEFREIGKLIVEVLDGLKVANS
DEGNASVEAAVREKVVGLTDRFPMYPYM

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=451, Percent_Identity=45.2328159645233, Blast_Score=357, Evalue=1e-98,
Organism=Homo sapiens, GI261862352, Length=451, Percent_Identity=45.2328159645233, Blast_Score=357, Evalue=1e-98,
Organism=Homo sapiens, GI261862350, Length=451, Percent_Identity=45.2328159645233, Blast_Score=357, Evalue=1e-98,
Organism=Homo sapiens, GI261862348, Length=451, Percent_Identity=45.2328159645233, Blast_Score=357, Evalue=1e-98,
Organism=Homo sapiens, GI22547186, Length=440, Percent_Identity=47.2727272727273, Blast_Score=356, Evalue=2e-98,
Organism=Homo sapiens, GI261862346, Length=451, Percent_Identity=44.7893569844789, Blast_Score=345, Evalue=4e-95,
Organism=Homo sapiens, GI22547189, Length=426, Percent_Identity=44.8356807511737, Blast_Score=322, Evalue=4e-88,
Organism=Escherichia coli, GI1788902, Length=417, Percent_Identity=60.431654676259, Blast_Score=490, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI25144729, Length=425, Percent_Identity=48.4705882352941, Blast_Score=369, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI25144732, Length=425, Percent_Identity=48.4705882352941, Blast_Score=369, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6319739, Length=423, Percent_Identity=46.0992907801418, Blast_Score=366, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6323087, Length=401, Percent_Identity=46.6334164588529, Blast_Score=339, Evalue=6e-94,
Organism=Drosophila melanogaster, GI24640005, Length=457, Percent_Identity=44.8577680525164, Blast_Score=364, Evalue=1e-101,
Organism=Drosophila melanogaster, GI221329721, Length=405, Percent_Identity=47.9012345679012, Blast_Score=363, Evalue=1e-100,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 46563; Mature: 46431

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNTDAFFSRPLAEVDPDIFGAIEKELGRQRHEIELIASENIVSRAVLEAQGSIMTNKYA
CCCCHHHHHCCHHHCCHHHHHHHHHHHCCCHHEEEEEECCCHHHHHHHHHCCCEEECCCC
EGYPGKRYYGGCQFVDIAEELAIERAKKLFGVNFANVQPNSGSQMNQAVFLALLQPGDTF
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEECCCCCCCCCHHHHEEEEEEECCCCEE
MGLDLNSGGHLTHGSPVNMSGKWFNVVSYGVREGDNLLDMDEVERKAKETRPKLILAGGT
EEEEECCCCCCCCCCCCCCCCCEEHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEECCC
AYSRVWDWKRFREIADEVGAYLMVDMAHIAGLVAGGQHPSPFPHCHVATTTTHKSLRGPR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHCCCC
GGMILTNDEDLAKKFNSAVFPGLQGGPLMHVIAAKAVAFGEALQPEFKDYAAQVVKNAKA
CCEEEECCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
LAETLIEGGLDVVSGGTDNHLMLVDLRKKNATGKRAEAALGRAYITCNKNGIPFDPEKPF
HHHHHHHCCCEEECCCCCCEEEEEEEECCCCCCCHHHHHHCCEEEEECCCCCCCCCCCCC
VTSGVRLGTPAGTTRGFKEAEFREIGKLIVEVLDGLKVANSDEGNASVEAAVREKVVGLT
CCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCEECCCCCCCHHHHHHHHHHHHCCC
DRFPMYPYM
CCCCCCCCC
>Mature Secondary Structure 
SNTDAFFSRPLAEVDPDIFGAIEKELGRQRHEIELIASENIVSRAVLEAQGSIMTNKYA
CCCHHHHHCCHHHCCHHHHHHHHHHHCCCHHEEEEEECCCHHHHHHHHHCCCEEECCCC
EGYPGKRYYGGCQFVDIAEELAIERAKKLFGVNFANVQPNSGSQMNQAVFLALLQPGDTF
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEECCCCCCCCCHHHHEEEEEEECCCCEE
MGLDLNSGGHLTHGSPVNMSGKWFNVVSYGVREGDNLLDMDEVERKAKETRPKLILAGGT
EEEEECCCCCCCCCCCCCCCCCEEHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEECCC
AYSRVWDWKRFREIADEVGAYLMVDMAHIAGLVAGGQHPSPFPHCHVATTTTHKSLRGPR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHCCCC
GGMILTNDEDLAKKFNSAVFPGLQGGPLMHVIAAKAVAFGEALQPEFKDYAAQVVKNAKA
CCEEEECCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
LAETLIEGGLDVVSGGTDNHLMLVDLRKKNATGKRAEAALGRAYITCNKNGIPFDPEKPF
HHHHHHHCCCEEECCCCCCEEEEEEEECCCCCCCHHHHHHCCEEEEECCCCCCCCCCCCC
VTSGVRLGTPAGTTRGFKEAEFREIGKLIVEVLDGLKVANSDEGNASVEAAVREKVVGLT
CCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCEECCCCCCCHHHHHHHHHHHHCCC
DRFPMYPYM
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA