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The map label for this gene is garS [H]

Identifier: 159184635

GI number: 159184635

Start: 1129627

End: 1130700

Strand: Reverse

Name: garS [H]

Synonym: Atu1141

Alternate gene names: 159184635

Gene position: 1130700-1129627 (Counterclockwise)

Preceding gene: 15888483

Following gene: 159184634

Centisome position: 39.79

GC content: 63.5

Gene sequence:

>1074_bases
ATGAGCCAGTCGGGCAAGAACGGTCTTACCTATAGCGATGCGGGTGTGGATATCGACGCCGGCAACCTGATGGTCGAGAA
GATCAAACCGGCGGTGCGCTCCACGCGGCGTCCCGGCGCGGATGGCGAAATCGGCGGCTTCGGCGGCCTGTTCGATCTGA
AGGCCGCAGGTTTCACCGATCCGGTTCTGGTCGCCGCCAATGACGGCGTCGGCACCAAGCTGAAGATCGCCATCGACGCT
GACTATCACGACACCGTCGGCATCGACCTCGTCGCCATGTGCGTCAACGATCTCGTCGTCCAGGGCGCAGAGCCGCTATT
CTTCCTCGATTATTTCGCCACCGGTAAGCTCGATCCCGATCAGGGTGCTGCCATCGTTTCCGGCATCGCCGCCGGTTGCC
GCGAATCCGGCTGTGCGCTGATCGGCGGCGAAACCGCTGAAATGCCCGGCATGTATTCCGATGGCGACTACGACCTCGCC
GGCTTTGCCGTGGGCGCGGCCGAACGCGGCCAGCTTCTGCCGGCCGGCGATATTGCCGAAGGCGACGTCATTCTCGGCCT
CTCCTCCTCCGGCGTGCACTCCAACGGCTTTTCGCTGGTGCGCAAGATCGTATCGCTCTCCGGTCTGGAATGGAGCGCTC
CCGCACCCTTTGCCGATGGTAAGAAGCTCGGCGAAGCGCTGCTGACCCCGACCCGCATCTATGTGAAGCCGCTTCTGAAG
GCGATCCGCGAGACCGGCGCGCTGAAGGCGCTGGCACATATTACCGGCGGCGGTTTTCCGGAGAATATTCCGCGCGTTCT
GCCCAAGCATCTCGCCGCCGAGATCGATCTTGCAGCCATCAAGGTTCCGGCCGTCTTCTCCTGGCTCGCCAAGACCGGCG
GCGTCGAAGCCCATGAAATGCTACGCACCTTCAATTGCGGCGTCGGCATGATCGTCGTCGTTTCGGCTGAAAATGCCACC
AAGGTCACCGAGGCGCTCACGGCGGAAGGCGAGACCGTCTTCCCGCTCGGCCGCATGGTCGCCCGCGAAGACGGCGCGCA
CGGCACGATCTACAAGGGCACTCTCGGCCTATGA

Upstream 100 bases:

>100_bases
CAAAGCCGTTAAAAACCGGAGCTTTTGCCACGCAAACCCTTGCATCAGGCCCCGTCCCGTGCGAATGGCGACGCCAAAGG
AACCAGCGGAGACGAGAGCC

Downstream 100 bases:

>100_bases
TGAGCGCCGCCTTGTCGTCCGGTCGCAAGCGTGTCGTCGTTTTCATCTCCGGCGGCGGCTCCAACATGGTGTCGCTGGCC
AAGGCTTGTCAGGCCGCGGA

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MSQSGKNGLTYSDAGVDIDAGNLMVEKIKPAVRSTRRPGADGEIGGFGGLFDLKAAGFTDPVLVAANDGVGTKLKIAIDA
DYHDTVGIDLVAMCVNDLVVQGAEPLFFLDYFATGKLDPDQGAAIVSGIAAGCRESGCALIGGETAEMPGMYSDGDYDLA
GFAVGAAERGQLLPAGDIAEGDVILGLSSSGVHSNGFSLVRKIVSLSGLEWSAPAPFADGKKLGEALLTPTRIYVKPLLK
AIRETGALKALAHITGGGFPENIPRVLPKHLAAEIDLAAIKVPAVFSWLAKTGGVEAHEMLRTFNCGVGMIVVVSAENAT
KVTEALTAEGETVFPLGRMVAREDGAHGTIYKGTLGL

Sequences:

>Translated_357_residues
MSQSGKNGLTYSDAGVDIDAGNLMVEKIKPAVRSTRRPGADGEIGGFGGLFDLKAAGFTDPVLVAANDGVGTKLKIAIDA
DYHDTVGIDLVAMCVNDLVVQGAEPLFFLDYFATGKLDPDQGAAIVSGIAAGCRESGCALIGGETAEMPGMYSDGDYDLA
GFAVGAAERGQLLPAGDIAEGDVILGLSSSGVHSNGFSLVRKIVSLSGLEWSAPAPFADGKKLGEALLTPTRIYVKPLLK
AIRETGALKALAHITGGGFPENIPRVLPKHLAAEIDLAAIKVPAVFSWLAKTGGVEAHEMLRTFNCGVGMIVVVSAENAT
KVTEALTAEGETVFPLGRMVAREDGAHGTIYKGTLGL
>Mature_356_residues
SQSGKNGLTYSDAGVDIDAGNLMVEKIKPAVRSTRRPGADGEIGGFGGLFDLKAAGFTDPVLVAANDGVGTKLKIAIDAD
YHDTVGIDLVAMCVNDLVVQGAEPLFFLDYFATGKLDPDQGAAIVSGIAAGCRESGCALIGGETAEMPGMYSDGDYDLAG
FAVGAAERGQLLPAGDIAEGDVILGLSSSGVHSNGFSLVRKIVSLSGLEWSAPAPFADGKKLGEALLTPTRIYVKPLLKA
IRETGALKALAHITGGGFPENIPRVLPKHLAAEIDLAAIKVPAVFSWLAKTGGVEAHEMLRTFNCGVGMIVVVSAENATK
VTEALTAEGETVFPLGRMVAREDGAHGTIYKGTLGL

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=342, Percent_Identity=57.3099415204678, Blast_Score=394, Evalue=1e-110,
Organism=Homo sapiens, GI209869995, Length=342, Percent_Identity=57.3099415204678, Blast_Score=394, Evalue=1e-110,
Organism=Homo sapiens, GI209869993, Length=342, Percent_Identity=57.3099415204678, Blast_Score=394, Evalue=1e-110,
Organism=Escherichia coli, GI1788845, Length=338, Percent_Identity=55.9171597633136, Blast_Score=375, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17567511, Length=346, Percent_Identity=46.5317919075145, Blast_Score=302, Evalue=2e-82,
Organism=Saccharomyces cerevisiae, GI6321203, Length=356, Percent_Identity=57.8651685393258, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24582400, Length=289, Percent_Identity=47.4048442906574, Blast_Score=254, Evalue=5e-68,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 36800; Mature: 36668

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQSGKNGLTYSDAGVDIDAGNLMVEKIKPAVRSTRRPGADGEIGGFGGLFDLKAAGFTD
CCCCCCCCCEECCCCCEECCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCC
PVLVAANDGVGTKLKIAIDADYHDTVGIDLVAMCVNDLVVQGAEPLFFLDYFATGKLDPD
CEEEEECCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEHHCCCCCCC
QGAAIVSGIAAGCRESGCALIGGETAEMPGMYSDGDYDLAGFAVGAAERGQLLPAGDIAE
CCHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCC
GDVILGLSSSGVHSNGFSLVRKIVSLSGLEWSAPAPFADGKKLGEALLTPTRIYVKPLLK
CCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHH
AIRETGALKALAHITGGGFPENIPRVLPKHLAAEIDLAAIKVPAVFSWLAKTGGVEAHEM
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHEEEHHHHHHHHHHHCCCCHHHH
LRTFNCGVGMIVVVSAENATKVTEALTAEGETVFPLGRMVAREDGAHGTIYKGTLGL
HHHHCCCCEEEEEEECCCCHHHHHHHHCCCCEECHHHHHHHHCCCCCCEEECCCCCC
>Mature Secondary Structure 
SQSGKNGLTYSDAGVDIDAGNLMVEKIKPAVRSTRRPGADGEIGGFGGLFDLKAAGFTD
CCCCCCCCEECCCCCEECCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCC
PVLVAANDGVGTKLKIAIDADYHDTVGIDLVAMCVNDLVVQGAEPLFFLDYFATGKLDPD
CEEEEECCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEHHCCCCCCC
QGAAIVSGIAAGCRESGCALIGGETAEMPGMYSDGDYDLAGFAVGAAERGQLLPAGDIAE
CCHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCC
GDVILGLSSSGVHSNGFSLVRKIVSLSGLEWSAPAPFADGKKLGEALLTPTRIYVKPLLK
CCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHH
AIRETGALKALAHITGGGFPENIPRVLPKHLAAEIDLAAIKVPAVFSWLAKTGGVEAHEM
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHEEEHHHHHHHHHHHCCCCHHHH
LRTFNCGVGMIVVVSAENATKVTEALTAEGETVFPLGRMVAREDGAHGTIYKGTLGL
HHHHCCCCEEEEEEECCCCHHHHHHHHCCCCEECHHHHHHHHCCCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA