Click here to switch to the map view.

The map label for this gene is ftsJ

Identifier: 159184390

GI number: 159184390

Start: 608838

End: 609578

Strand: Direct

Name: ftsJ

Synonym: Atu0620

Alternate gene names: 159184390

Gene position: 608838-609578 (Clockwise)

Preceding gene: 15887961

Following gene: 159184392

Centisome position: 21.43

GC content: 60.19

Gene sequence:

>741_bases
ATGAGCAAGGCGCCGACAAGCACCAATCGCACCGGCCGCAAGATCGGCCAGAAGGTCAAGAAGACCAAGCTCAAGGCCTC
GTCGCGCCGCTGGCTGGAGCGTCATATCAATGACCCCTATGTGCAGCGCGCCAAGCTGGAAGGCTATCGCGCCCGCGCCG
CCTTCAAGCTGCTGGAAATCAACGACAAGCACCAGATTTTGAAGGGTGCGACCCGCATCATCGACCTTGGTGCCGCACCC
GGAAGCTGGTCGCAGATCGCCTCCAAGGTGACGGATTCCACGGAGGATGATATCCGCGTCGCTGCCATCGATTTCCTCGA
AATCGATCCGATCCCCGGCGTGAAGATCCTGCAACTCGACTTCCTCGACCCGACCGCACCCGACCAGCTGATGGAAGCCG
TTGGCGGCACGCCCGATCTGGTCTTGTCGGATATGGCCGCGCCCACCACGGGCCACCAGAAGACCGACCACATCCGCACC
ATGCATCTGTGCGAAGTCGCAGCCGATTTCGCGGTTCAGGTGCTGGCGGAAGGCGGCCATTTCCTTGCCAAGACCTTCCA
GGGCGGCACGGAAAAGGCATTGCTTGATATGCTGAAGAAGAACTTCAAGCAGGTTCTGCATATCAAGCCGGCGTCGTCAC
GCTCGGAATCGGTCGAAATGTTCCTGCTTGCCAAGCACTTCAAGGGTCGCAGACACGAACCGGCCATCGATGCCGACGCC
GAAGAGTCGACTGAGGACTGA

Upstream 100 bases:

>100_bases
AAGGCCTCTTGACGGATATGATGGCCGATGACGGCGCATGGCGGCGCAACCGCATAAGGCGCATGCAGATGGTACGGCAG
GACAGAACGGAAGGTTTGAC

Downstream 100 bases:

>100_bases
TCACTCCGCCGGTTGCGAAACCTTGCCGCGGTGGCCGGAAACGGCCGCCCCGGCCTGCGCGTCCATGCGGATGATCGGCA
CGATCGCGAACAACGATACC

Product: cell division protein

Products: NA

Alternate protein names: 23S rRNA Um2552 methyltransferase; rRNA (uridine-2'-O-)-methyltransferase

Number of amino acids: Translated: 246; Mature: 245

Protein sequence:

>246_residues
MSKAPTSTNRTGRKIGQKVKKTKLKASSRRWLERHINDPYVQRAKLEGYRARAAFKLLEINDKHQILKGATRIIDLGAAP
GSWSQIASKVTDSTEDDIRVAAIDFLEIDPIPGVKILQLDFLDPTAPDQLMEAVGGTPDLVLSDMAAPTTGHQKTDHIRT
MHLCEVAADFAVQVLAEGGHFLAKTFQGGTEKALLDMLKKNFKQVLHIKPASSRSESVEMFLLAKHFKGRRHEPAIDADA
EESTED

Sequences:

>Translated_246_residues
MSKAPTSTNRTGRKIGQKVKKTKLKASSRRWLERHINDPYVQRAKLEGYRARAAFKLLEINDKHQILKGATRIIDLGAAP
GSWSQIASKVTDSTEDDIRVAAIDFLEIDPIPGVKILQLDFLDPTAPDQLMEAVGGTPDLVLSDMAAPTTGHQKTDHIRT
MHLCEVAADFAVQVLAEGGHFLAKTFQGGTEKALLDMLKKNFKQVLHIKPASSRSESVEMFLLAKHFKGRRHEPAIDADA
EESTED
>Mature_245_residues
SKAPTSTNRTGRKIGQKVKKTKLKASSRRWLERHINDPYVQRAKLEGYRARAAFKLLEINDKHQILKGATRIIDLGAAPG
SWSQIASKVTDSTEDDIRVAAIDFLEIDPIPGVKILQLDFLDPTAPDQLMEAVGGTPDLVLSDMAAPTTGHQKTDHIRTM
HLCEVAADFAVQVLAEGGHFLAKTFQGGTEKALLDMLKKNFKQVLHIKPASSRSESVEMFLLAKHFKGRRHEPAIDADAE
ESTED

Specific function: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit

COG id: COG0293

COG function: function code J; 23S rRNA methylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. RlmE family

Homologues:

Organism=Homo sapiens, GI7019377, Length=208, Percent_Identity=40.8653846153846, Blast_Score=164, Evalue=5e-41,
Organism=Homo sapiens, GI29029591, Length=191, Percent_Identity=37.696335078534, Blast_Score=124, Evalue=6e-29,
Organism=Homo sapiens, GI29029589, Length=191, Percent_Identity=37.696335078534, Blast_Score=124, Evalue=6e-29,
Organism=Homo sapiens, GI7110661, Length=191, Percent_Identity=37.696335078534, Blast_Score=124, Evalue=7e-29,
Organism=Homo sapiens, GI194097365, Length=192, Percent_Identity=34.8958333333333, Blast_Score=108, Evalue=3e-24,
Organism=Escherichia coli, GI1789569, Length=203, Percent_Identity=41.871921182266, Blast_Score=145, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17554650, Length=195, Percent_Identity=40.5128205128205, Blast_Score=137, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17553474, Length=205, Percent_Identity=34.6341463414634, Blast_Score=124, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71987550, Length=193, Percent_Identity=34.1968911917098, Blast_Score=100, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI71987561, Length=193, Percent_Identity=34.1968911917098, Blast_Score=100, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17553860, Length=193, Percent_Identity=34.1968911917098, Blast_Score=100, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6319535, Length=195, Percent_Identity=36.9230769230769, Blast_Score=118, Evalue=9e-28,
Organism=Saccharomyces cerevisiae, GI6319796, Length=203, Percent_Identity=33.0049261083744, Blast_Score=97, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6321302, Length=99, Percent_Identity=39.3939393939394, Blast_Score=82, Evalue=7e-17,
Organism=Drosophila melanogaster, GI21356387, Length=210, Percent_Identity=37.6190476190476, Blast_Score=141, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24648639, Length=196, Percent_Identity=35.7142857142857, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24647580, Length=198, Percent_Identity=37.3737373737374, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI18859957, Length=192, Percent_Identity=34.8958333333333, Blast_Score=97, Evalue=9e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RLME_AGRT5 (Q8UHR0)

Other databases:

- EMBL:   AE007869
- PIR:   AF2652
- PIR:   C97434
- RefSeq:   NP_353643.2
- ProteinModelPortal:   Q8UHR0
- SMR:   Q8UHR0
- STRING:   Q8UHR0
- GeneID:   1132658
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu0620
- eggNOG:   COG0293
- HOGENOM:   HBG398270
- OMA:   SDMAANT
- PhylomeDB:   Q8UHR0
- ProtClustDB:   CLSK800160
- BioCyc:   ATUM176299-1:ATU0620-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01547
- InterPro:   IPR015507
- InterPro:   IPR002877
- PANTHER:   PTHR10920
- PIRSF:   PIRSF005461

Pfam domain/function: PF01728 FtsJ

EC number: =2.1.1.166

Molecular weight: Translated: 27203; Mature: 27072

Theoretical pI: Translated: 9.03; Mature: 9.03

Prosite motif: NA

Important sites: ACT_SITE 184-184 BINDING 81-81 BINDING 83-83 BINDING 104-104 BINDING 120-120 BINDING 144-144

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKAPTSTNRTGRKIGQKVKKTKLKASSRRWLERHINDPYVQRAKLEGYRARAAFKLLEI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHEEEE
NDKHQILKGATRIIDLGAAPGSWSQIASKVTDSTEDDIRVAAIDFLEIDPIPGVKILQLD
CCHHHHHHHHHHHEECCCCCCCHHHHHHHHCCCCCCCEEEEEEEEEEECCCCCCEEEEEE
FLDPTAPDQLMEAVGGTPDLVLSDMAAPTTGHQKTDHIRTMHLCEVAADFAVQVLAEGGH
CCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCH
FLAKTFQGGTEKALLDMLKKNFKQVLHIKPASSRSESVEMFLLAKHFKGRRHEPAIDADA
HHHHHHCCCHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC
EESTED
CCCCCC
>Mature Secondary Structure 
SKAPTSTNRTGRKIGQKVKKTKLKASSRRWLERHINDPYVQRAKLEGYRARAAFKLLEI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHEEEE
NDKHQILKGATRIIDLGAAPGSWSQIASKVTDSTEDDIRVAAIDFLEIDPIPGVKILQLD
CCHHHHHHHHHHHEECCCCCCCHHHHHHHHCCCCCCCEEEEEEEEEEECCCCCCEEEEEE
FLDPTAPDQLMEAVGGTPDLVLSDMAAPTTGHQKTDHIRTMHLCEVAADFAVQVLAEGGH
CCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCH
FLAKTFQGGTEKALLDMLKKNFKQVLHIKPASSRSESVEMFLLAKHFKGRRHEPAIDADA
HHHHHHCCCHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC
EESTED
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194