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The map label for this gene is gppA [H]

Identifier: 15887961

GI number: 15887961

Start: 607141

End: 608841

Strand: Direct

Name: gppA [H]

Synonym: Atu0619

Alternate gene names: 15887961

Gene position: 607141-608841 (Clockwise)

Preceding gene: 15887957

Following gene: 159184390

Centisome position: 21.37

GC content: 63.79

Gene sequence:

>1701_bases
ATGTACAGCCTGCCAAAAACCATTTGGCTAAAATCGCCTGCGCTGGTATTGTCCACCCAACGAAACCTTATGAAAGCCAG
CAGCATAGCGTCTACGCTTGTGCGCGGCGAAATGGACAAGACAGTGATCGACCCCGGAAACGGCCCAAAGCCGTCGGAAC
AAGGGGCGTCGGTGGCGAACAAAGGGAAAGCGAAGCGATCCCGTCGTGGCAAGAAACACAAGCGTGACGGTAAGCCCCGT
GACGCTGTTGTGCTGTCGCATGATGTTGCCGCGGATGTTCCGGCCGGTTCCTCCTATGTATCGGCTCTCGAGCCGGATGC
GGAGCCGCGCAAGAGAAAGCGTCGCAGGCGTTCTCGCGGCAAAGGCACGTCTCAGCAGGCTGCTGCCGCTGTCAACGGAG
AAGTGCAGGCTCCAGCCGCACCCGATGGCGCAAATTCATCCTCCGTGCCGCCTATTGGCGCGCGAAAATCGCGTAACCGC
AAACGCGGCCACCGCGATCCGCGCGGTCGTGACCCGCAGGGCCGTCCACTGGTTCCCAGCCACGCACCCAAACATGGCGG
CAAGCAGAACGGTCGTGCCAATGGCTCTGCGCAGGAAGCGCACCGGTCGCAATCCGAAATCTCCGCCCGCCACGCAGGCC
GCCAGCATGAGCATGGTCAGGAGCCGCCGGCGGACATGTATGCGGCGCTCGATCTCGGCACCAATAATTGCCGCCTGCTG
ATCGCGCAGCCGACACGGCCGGGCCAGTTCCGCGTCGTCGATGCCTTTTCGCGCATCGTCCGGCTGGGCGAGGGACTGAT
ATCGAGCGGCCGGCTCTCCGATGATGCGATGGATCGCGCCGTGGAAGCGCTCAAGGTCTGCTCCTCGAAACTTGCCGGAC
GACCAATCAGGCGCATGCGGCTGATCGCCACCGAGGCCTGCCGTGCAGCCTCCAATGGCGAGGAATTTTTGGAGCGTGTC
ACGCGGGAAACGGGGCTGAAGCTCGAGATCATCAGCCGCGAGACGGAAGCCCGGCTTGCGGTCTCCGGCTGCGCGTCGCT
TGTCGGGCGCGAGGCACGCTCTGTCGTGCTGTTCGATATTGGCGGCGGATCGTCGGAAATCGCGGTCATCAAGGTCGGTG
AAAACCGCTCGAACCGGCTCGCCAACCACATCACCCACTGGACCTCGCTGCCGGTCGGCGTCGTCACGCTTTCGGAACGC
CATGGCGGCCGCGATGTGACGCCGGATGTCTTTGCGGCGATGGTGCGGGAGGTCGAAGGCCTGCTCGATGCCTTCCATTG
CCCGCCGCTCGCGCCGCAATTGCACCATGAGGATTTCCATCTGATCGGCACCTCGGGCACGGTCACGACGCTTGCGGGAG
TCCATCTCGATCTGCCGCGTTATGATCGCCGCAAGGTGGATGGCCTCTGGCTTTCCGATGTCGAGGTGACGGCCATGCAG
GACAAGTTGCTGGCCTGGGATTTCGCTGGCCGCGCCGCCAATGCCTGCATCGGGCCTGACCGGGCCGATCTGGTTCTGGC
CGGTTGCGCCATTCTCGAGGCCATTCGCCGCCGCTGGCCGGCACGCCGCATGCGGGTGGCAGATCGCGGCCTGCGCGAAG
GCCTCTTGACGGATATGATGGCCGATGACGGCGCATGGCGGCGCAACCGCATAAGGCGCATGCAGATGGTACGGCAGGAC
AGAACGGAAGGTTTGACATGA

Upstream 100 bases:

>100_bases
GCGCCGTGCATACCTGCCTGCCGGTTTCGAAAATCCACGGAAATCATTGCCGCGATCATGACGATCCGTATCCAGCCTCG
GCGCGGCATCAGACCATCCC

Downstream 100 bases:

>100_bases
GCAAGGCGCCGACAAGCACCAATCGCACCGGCCGCAAGATCGGCCAGAAGGTCAAGAAGACCAAGCTCAAGGCCTCGTCG
CGCCGCTGGCTGGAGCGTCA

Product: exopolyphosphatase

Products: NA

Alternate protein names: Guanosine pentaphosphate phosphohydrolase; pppGpp-5'-phosphohydrolase [H]

Number of amino acids: Translated: 566; Mature: 566

Protein sequence:

>566_residues
MYSLPKTIWLKSPALVLSTQRNLMKASSIASTLVRGEMDKTVIDPGNGPKPSEQGASVANKGKAKRSRRGKKHKRDGKPR
DAVVLSHDVAADVPAGSSYVSALEPDAEPRKRKRRRRSRGKGTSQQAAAAVNGEVQAPAAPDGANSSSVPPIGARKSRNR
KRGHRDPRGRDPQGRPLVPSHAPKHGGKQNGRANGSAQEAHRSQSEISARHAGRQHEHGQEPPADMYAALDLGTNNCRLL
IAQPTRPGQFRVVDAFSRIVRLGEGLISSGRLSDDAMDRAVEALKVCSSKLAGRPIRRMRLIATEACRAASNGEEFLERV
TRETGLKLEIISRETEARLAVSGCASLVGREARSVVLFDIGGGSSEIAVIKVGENRSNRLANHITHWTSLPVGVVTLSER
HGGRDVTPDVFAAMVREVEGLLDAFHCPPLAPQLHHEDFHLIGTSGTVTTLAGVHLDLPRYDRRKVDGLWLSDVEVTAMQ
DKLLAWDFAGRAANACIGPDRADLVLAGCAILEAIRRRWPARRMRVADRGLREGLLTDMMADDGAWRRNRIRRMQMVRQD
RTEGLT

Sequences:

>Translated_566_residues
MYSLPKTIWLKSPALVLSTQRNLMKASSIASTLVRGEMDKTVIDPGNGPKPSEQGASVANKGKAKRSRRGKKHKRDGKPR
DAVVLSHDVAADVPAGSSYVSALEPDAEPRKRKRRRRSRGKGTSQQAAAAVNGEVQAPAAPDGANSSSVPPIGARKSRNR
KRGHRDPRGRDPQGRPLVPSHAPKHGGKQNGRANGSAQEAHRSQSEISARHAGRQHEHGQEPPADMYAALDLGTNNCRLL
IAQPTRPGQFRVVDAFSRIVRLGEGLISSGRLSDDAMDRAVEALKVCSSKLAGRPIRRMRLIATEACRAASNGEEFLERV
TRETGLKLEIISRETEARLAVSGCASLVGREARSVVLFDIGGGSSEIAVIKVGENRSNRLANHITHWTSLPVGVVTLSER
HGGRDVTPDVFAAMVREVEGLLDAFHCPPLAPQLHHEDFHLIGTSGTVTTLAGVHLDLPRYDRRKVDGLWLSDVEVTAMQ
DKLLAWDFAGRAANACIGPDRADLVLAGCAILEAIRRRWPARRMRVADRGLREGLLTDMMADDGAWRRNRIRRMQMVRQD
RTEGLT
>Mature_566_residues
MYSLPKTIWLKSPALVLSTQRNLMKASSIASTLVRGEMDKTVIDPGNGPKPSEQGASVANKGKAKRSRRGKKHKRDGKPR
DAVVLSHDVAADVPAGSSYVSALEPDAEPRKRKRRRRSRGKGTSQQAAAAVNGEVQAPAAPDGANSSSVPPIGARKSRNR
KRGHRDPRGRDPQGRPLVPSHAPKHGGKQNGRANGSAQEAHRSQSEISARHAGRQHEHGQEPPADMYAALDLGTNNCRLL
IAQPTRPGQFRVVDAFSRIVRLGEGLISSGRLSDDAMDRAVEALKVCSSKLAGRPIRRMRLIATEACRAASNGEEFLERV
TRETGLKLEIISRETEARLAVSGCASLVGREARSVVLFDIGGGSSEIAVIKVGENRSNRLANHITHWTSLPVGVVTLSER
HGGRDVTPDVFAAMVREVEGLLDAFHCPPLAPQLHHEDFHLIGTSGTVTTLAGVHLDLPRYDRRKVDGLWLSDVEVTAMQ
DKLLAWDFAGRAANACIGPDRADLVLAGCAILEAIRRRWPARRMRVADRGLREGLLTDMMADDGAWRRNRIRRMQMVRQD
RTEGLT

Specific function: Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in th

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family. GppA subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994966, Length=330, Percent_Identity=27.5757575757576, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1788848, Length=340, Percent_Identity=25.8823529411765, Blast_Score=86, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.40 [H]

Molecular weight: Translated: 61680; Mature: 61680

Theoretical pI: Translated: 11.05; Mature: 11.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSLPKTIWLKSPALVLSTQRNLMKASSIASTLVRGEMDKTVIDPGNGPKPSEQGASVAN
CCCCCCEEEECCCCEEEHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCHHCCHHHH
KGKAKRSRRGKKHKRDGKPRDAVVLSHDVAADVPAGSSYVSALEPDAEPRKRKRRRRSRG
HHHHHHHHCCCHHHCCCCCCCEEEEECCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHCC
KGTSQQAAAAVNGEVQAPAAPDGANSSSVPPIGARKSRNRKRGHRDPRGRDPQGRPLVPS
CCCCHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCC
HAPKHGGKQNGRANGSAQEAHRSQSEISARHAGRQHEHGQEPPADMYAALDLGTNNCRLL
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHEEEEECCCCCCEEE
IAQPTRPGQFRVVDAFSRIVRLGEGLISSGRLSDDAMDRAVEALKVCSSKLAGRPIRRMR
EECCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHH
LIATEACRAASNGEEFLERVTRETGLKLEIISRETEARLAVSGCASLVGREARSVVLFDI
HHHHHHHHHCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEEEE
GGGSSEIAVIKVGENRSNRLANHITHWTSLPVGVVTLSERHGGRDVTPDVFAAMVREVEG
CCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHH
LLDAFHCPPLAPQLHHEDFHLIGTSGTVTTLAGVHLDLPRYDRRKVDGLWLSDVEVTAMQ
HHHHHCCCCCCCCCCCCCEEEEECCCCCHHHCCEEECCCCCCCCCCCCEEECCEEEEHHH
DKLLAWDFAGRAANACIGPDRADLVLAGCAILEAIRRRWPARRMRVADRGLREGLLTDMM
HHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
ADDGAWRRNRIRRMQMVRQDRTEGLT
HCCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MYSLPKTIWLKSPALVLSTQRNLMKASSIASTLVRGEMDKTVIDPGNGPKPSEQGASVAN
CCCCCCEEEECCCCEEEHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCHHCCHHHH
KGKAKRSRRGKKHKRDGKPRDAVVLSHDVAADVPAGSSYVSALEPDAEPRKRKRRRRSRG
HHHHHHHHCCCHHHCCCCCCCEEEEECCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHCC
KGTSQQAAAAVNGEVQAPAAPDGANSSSVPPIGARKSRNRKRGHRDPRGRDPQGRPLVPS
CCCCHHHHHHHCCCEECCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCC
HAPKHGGKQNGRANGSAQEAHRSQSEISARHAGRQHEHGQEPPADMYAALDLGTNNCRLL
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHEEEEECCCCCCEEE
IAQPTRPGQFRVVDAFSRIVRLGEGLISSGRLSDDAMDRAVEALKVCSSKLAGRPIRRMR
EECCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHH
LIATEACRAASNGEEFLERVTRETGLKLEIISRETEARLAVSGCASLVGREARSVVLFDI
HHHHHHHHHCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEEEE
GGGSSEIAVIKVGENRSNRLANHITHWTSLPVGVVTLSERHGGRDVTPDVFAAMVREVEG
CCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHH
LLDAFHCPPLAPQLHHEDFHLIGTSGTVTTLAGVHLDLPRYDRRKVDGLWLSDVEVTAMQ
HHHHHCCCCCCCCCCCCCEEEEECCCCCHHHCCEEECCCCCCCCCCCCEEECCEEEEHHH
DKLLAWDFAGRAANACIGPDRADLVLAGCAILEAIRRRWPARRMRVADRGLREGLLTDMM
HHHHHEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
ADDGAWRRNRIRRMQMVRQDRTEGLT
HCCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA