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The map label for this gene is mtrB [H]

Identifier: 15889800

GI number: 15889800

Start: 2507162

End: 2508598

Strand: Reverse

Name: mtrB [H]

Synonym: Atu2535

Alternate gene names: 15889800

Gene position: 2508598-2507162 (Counterclockwise)

Preceding gene: 159185258

Following gene: 159185257

Centisome position: 88.28

GC content: 59.43

Gene sequence:

>1437_bases
ATGAAGAAGACACATGATCGATCCCTGCGATGGGGGCTGATGAAGCGTCTTTTCGCCTTGCAGGCCTTCCTGCTTCTCCT
CTTCGTCATCCTTCTCATCGGCTGGATATGGATCATTGATCCGCGCCTCGAAGGCGCGAATGAAGAGGCTGCCCGCATCG
TCGCGGAGAGCGTGACAAAAGATGCACAGGGCAGGCCGCAACTGTCGCTGACGCCGGAACTGGCGGAGTTGAAACGGCGC
TATCCGAATCTCTGGTTTGTGGTGCGGGACACCGATGACATCGTGTTGCAATATGGTGTTGTTCCGGCGTCTGCCCTGTC
GGCGGCCTTTCCCTGGAGTTTTGACCGCGCGCGCCTGGAGGCGGCCGGTACAGTGCGCGCCACCGTGGAAAACCGCGATA
CATCCGCTGGGCGGCTTCAGTTCATTGCCGGAACAGAAGAGGGAATCCTCAATGAAGGCCTGAGTATCTGGATCAATGTT
CAACTCGATCTGGAAAAGGATGCCAAGGGCGCCATTCGCTGGTTGACCGTGCTGCCGGCGCTGGGCCTCATCATCCTTAT
CGCCGTCGTGCCGATGCTGATCCTGACGGGCATCGCGACGCTGCTCGTGACCCCACGGGCGGTCGGGCGATCCCTAAGCG
GACTGATGGAGACGGTGAAGCAGGCGCAGTCCATCGATTTTGATAACCGTTCCGCCCGCATCGACCGTTCGAAAGTCCCC
CTTGAAATCATCCCGCTGGTGGATGCCTTCAATGTTGCGCTTTCGAAGCTCGATGACGGGTATAATCGCCGTAACCGCTT
TCTCGCCGATGCGGCGCATGAACTGAGGACGCCGATCGCAATCGTGCGGACCAGAGCCGATCTTTTGCCCGATGACGCAC
TGAGCCGTCAAATCCGGGCGGATATCGATCGCCTCACCCGTGTTGCGCACCAGCTGCTGGAAATGCAGGCGGTGGGCGCA
GTGGAACTGCCGGCGGAGCCGTGCGATCTCAATAAGCTTGTCGAGCACATCGCGACCGATCTCGCCCCGATTGCGATGGA
TGCGGGTTACGAGTTCGATTTCGAGCCAAGCGTGGGTGCCGCCATCTTCACTGTGCAGGCGTCGATCATCGAGATGGCGG
TCGTCAACCTCGTTCGCAATGCGATCGATCATGCCGGCGGCAGGGGCGCAATCACGATCCGGATTGACGCGGCAGGCGCC
ATCGAGGTCTGCGATGAAGGACCGGGCATACCTGTTCCTGAGCGCGGGCAGGTATTCGAGCCATTTCATCGCATCAACAC
GAATTCGCCGGGCGCTGGCCTTGGGTTAAATCTGGTCCAGAAGGCCGCCGAGCTTCATCGTGGCCGTGTTCTGTTCCTTG
ATCTCAATCCCGGCTTCTGCGTTCGGCTGGAAATCCGTTCGGTCGTTTCGAAAGCAGTCGCGCCCGGTAATACTTAA

Upstream 100 bases:

>100_bases
ATGCGCATATTTCCCGTATCCGCAAGAAGCTGGCGCAGGCGGAAGCGACGGTGGAGATAAGAGCCGTGCGCAATATTGGT
TACCTCGTCCGGTTGAAGAC

Downstream 100 bases:

>100_bases
AATATAGTTAAAGAAAATCGTCTAATTATATTAAATAAATCAGATATTTATAGTCAAACTCGTTGCGTGCAATGCAGGCG
TAATTCTCGCGCGGAAAATG

Product: two component sensor kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MKKTHDRSLRWGLMKRLFALQAFLLLLFVILLIGWIWIIDPRLEGANEEAARIVAESVTKDAQGRPQLSLTPELAELKRR
YPNLWFVVRDTDDIVLQYGVVPASALSAAFPWSFDRARLEAAGTVRATVENRDTSAGRLQFIAGTEEGILNEGLSIWINV
QLDLEKDAKGAIRWLTVLPALGLIILIAVVPMLILTGIATLLVTPRAVGRSLSGLMETVKQAQSIDFDNRSARIDRSKVP
LEIIPLVDAFNVALSKLDDGYNRRNRFLADAAHELRTPIAIVRTRADLLPDDALSRQIRADIDRLTRVAHQLLEMQAVGA
VELPAEPCDLNKLVEHIATDLAPIAMDAGYEFDFEPSVGAAIFTVQASIIEMAVVNLVRNAIDHAGGRGAITIRIDAAGA
IEVCDEGPGIPVPERGQVFEPFHRINTNSPGAGLGLNLVQKAAELHRGRVLFLDLNPGFCVRLEIRSVVSKAVAPGNT

Sequences:

>Translated_478_residues
MKKTHDRSLRWGLMKRLFALQAFLLLLFVILLIGWIWIIDPRLEGANEEAARIVAESVTKDAQGRPQLSLTPELAELKRR
YPNLWFVVRDTDDIVLQYGVVPASALSAAFPWSFDRARLEAAGTVRATVENRDTSAGRLQFIAGTEEGILNEGLSIWINV
QLDLEKDAKGAIRWLTVLPALGLIILIAVVPMLILTGIATLLVTPRAVGRSLSGLMETVKQAQSIDFDNRSARIDRSKVP
LEIIPLVDAFNVALSKLDDGYNRRNRFLADAAHELRTPIAIVRTRADLLPDDALSRQIRADIDRLTRVAHQLLEMQAVGA
VELPAEPCDLNKLVEHIATDLAPIAMDAGYEFDFEPSVGAAIFTVQASIIEMAVVNLVRNAIDHAGGRGAITIRIDAAGA
IEVCDEGPGIPVPERGQVFEPFHRINTNSPGAGLGLNLVQKAAELHRGRVLFLDLNPGFCVRLEIRSVVSKAVAPGNT
>Mature_478_residues
MKKTHDRSLRWGLMKRLFALQAFLLLLFVILLIGWIWIIDPRLEGANEEAARIVAESVTKDAQGRPQLSLTPELAELKRR
YPNLWFVVRDTDDIVLQYGVVPASALSAAFPWSFDRARLEAAGTVRATVENRDTSAGRLQFIAGTEEGILNEGLSIWINV
QLDLEKDAKGAIRWLTVLPALGLIILIAVVPMLILTGIATLLVTPRAVGRSLSGLMETVKQAQSIDFDNRSARIDRSKVP
LEIIPLVDAFNVALSKLDDGYNRRNRFLADAAHELRTPIAIVRTRADLLPDDALSRQIRADIDRLTRVAHQLLEMQAVGA
VELPAEPCDLNKLVEHIATDLAPIAMDAGYEFDFEPSVGAAIFTVQASIIEMAVVNLVRNAIDHAGGRGAITIRIDAAGA
IEVCDEGPGIPVPERGQVFEPFHRINTNSPGAGLGLNLVQKAAELHRGRVLFLDLNPGFCVRLEIRSVVSKAVAPGNT

Specific function: Member of the two-component regulatory system mtrA/mtrB. Seems to function as a membrane-associated protein kinase that phosphorylates mtrA in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790551, Length=276, Percent_Identity=30.4347826086957, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1789808, Length=239, Percent_Identity=26.3598326359833, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786783, Length=286, Percent_Identity=26.2237762237762, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1789403, Length=298, Percent_Identity=27.1812080536913, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790346, Length=226, Percent_Identity=30.0884955752212, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788279, Length=298, Percent_Identity=26.1744966442953, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1786912, Length=220, Percent_Identity=28.1818181818182, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI87082128, Length=229, Percent_Identity=28.82096069869, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788393, Length=225, Percent_Identity=26.2222222222222, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790436, Length=214, Percent_Identity=28.5046728971963, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI145693157, Length=234, Percent_Identity=26.4957264957265, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1788549, Length=204, Percent_Identity=26.4705882352941, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787374, Length=217, Percent_Identity=23.963133640553, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52323; Mature: 52323

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKTHDRSLRWGLMKRLFALQAFLLLLFVILLIGWIWIIDPRLEGANEEAARIVAESVTK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHH
DAQGRPQLSLTPELAELKRRYPNLWFVVRDTDDIVLQYGVVPASALSAAFPWSFDRARLE
CCCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCEEEEECCCCHHHHHHCCCCCCCHHHHH
AAGTVRATVENRDTSAGRLQFIAGTEEGILNEGLSIWINVQLDLEKDAKGAIRWLTVLPA
HCCEEEEEECCCCCCCCEEEEEECCCHHHHCCCCEEEEEEEEECCCCCHHHHHHHHHHHH
LGLIILIAVVPMLILTGIATLLVTPRAVGRSLSGLMETVKQAQSIDFDNRSARIDRSKVP
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
LEIIPLVDAFNVALSKLDDGYNRRNRFLADAAHELRTPIAIVRTRADLLPDDALSRQIRA
EEEECHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHH
DIDRLTRVAHQLLEMQAVGAVELPAEPCDLNKLVEHIATDLAPIAMDAGYEFDFEPSVGA
HHHHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
AIFTVQASIIEMAVVNLVRNAIDHAGGRGAITIRIDAAGAIEVCDEGPGIPVPERGQVFE
EEEHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEECCCCCCCCCCCCCCCHH
PFHRINTNSPGAGLGLNLVQKAAELHRGRVLFLDLNPGFCVRLEIRSVVSKAVAPGNT
HHHHCCCCCCCCCCHHHHHHHHHHHHCCEEEEEECCCCCEEEEEHHHHHHHHCCCCCC
>Mature Secondary Structure
MKKTHDRSLRWGLMKRLFALQAFLLLLFVILLIGWIWIIDPRLEGANEEAARIVAESVTK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHH
DAQGRPQLSLTPELAELKRRYPNLWFVVRDTDDIVLQYGVVPASALSAAFPWSFDRARLE
CCCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCEEEEECCCCHHHHHHCCCCCCCHHHHH
AAGTVRATVENRDTSAGRLQFIAGTEEGILNEGLSIWINVQLDLEKDAKGAIRWLTVLPA
HCCEEEEEECCCCCCCCEEEEEECCCHHHHCCCCEEEEEEEEECCCCCHHHHHHHHHHHH
LGLIILIAVVPMLILTGIATLLVTPRAVGRSLSGLMETVKQAQSIDFDNRSARIDRSKVP
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
LEIIPLVDAFNVALSKLDDGYNRRNRFLADAAHELRTPIAIVRTRADLLPDDALSRQIRA
EEEECHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHH
DIDRLTRVAHQLLEMQAVGAVELPAEPCDLNKLVEHIATDLAPIAMDAGYEFDFEPSVGA
HHHHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
AIFTVQASIIEMAVVNLVRNAIDHAGGRGAITIRIDAAGAIEVCDEGPGIPVPERGQVFE
EEEHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEECCCCCCCCCCCCCCCHH
PFHRINTNSPGAGLGLNLVQKAAELHRGRVLFLDLNPGFCVRLEIRSVVSKAVAPGNT
HHHHCCCCCCCCCCHHHHHHHHHHHHCCEEEEEECCCCCEEEEEHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA