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The map label for this gene is pntB [H]

Identifier: 15889760

GI number: 15889760

Start: 2464191

End: 2465636

Strand: Direct

Name: pntB [H]

Synonym: Atu2494

Alternate gene names: 15889760

Gene position: 2464191-2465636 (Clockwise)

Preceding gene: 15889759

Following gene: 15889768

Centisome position: 86.72

GC content: 62.1

Gene sequence:

>1446_bases
ATGACCATTGGTATCGTTTCCGCGGCCTATGTTGCCGCAGCCGTTCTTTTCATCCTTTCCCTCGGCGGCCTTTCCGGACA
GGAAAGCGCCAAACGCGCTGTCTGGTACGGCATAACAGGCATGGGTCTCGCCATCGTCGCCACTGTCTTCGGCCCCGAAA
TCAGCAAGGGTGTCGGGCAATGGCTCGTCGTGCTCCTGATGCTCGCCGGCGGCTCGGTTCTCGGCTACTTCGTCGCAAGC
CGCGTGCAGATGACCGAAATGCCGCAGCTTGTGGCAGCCCTTCACTCCTTCGTCGGTCTTGCCGCCGTCTTCATCGGCTT
CAACGCCCATATCGAGGAAGCGCATGTCGCCTCGCTCGATGAGACGGCACGGTCGTTGCTGACAGGCTTTTCCGCCATCC
TCGCCCACAAGACACCGGTGGAACTGGCGATCATGAAGGTCGAGGTCTTCCTCGGCGTCTTCATCGGCGCAGTCACCTTC
ACCGGCTCCGTCGTCGCCTTCGGCAAGCTTGCCGGCAAGGTGGACGGCAAGGCGAAGAAGCTGCCGGGCGGACACCTGCT
GAACGCCGGTGCTGCGATCCTGTCGCTCGTGCTGCTCATCATGTATTGCAACGGCGCCGGCGCATGGACCCTCGTCCTGA
TGACGCTTGCCGCCTTCTTCATCGGTTACCACCTGATCATGGGTATCGGCGGCGCTGACATGCCTGTCGTCGTTTCGATG
TTGAACAGCTATTCCGGCTGGGCGGCCGCCGCCATCGGCTTCACGCTCGGCAACGATCTCCTGATCGTGACGGGCGCGCT
GGTCGGCTCCTCGGGTGCGATCCTCTCCTACATCATGTGCAAGGCGATGAACCGCTCTTTCATCTCGGTCATCCTTGGCG
GCTTCGGCGGCACGACGGGCCCGGCAATGGAAATCGAGGGCGAGCAGGTGGCGATCGACGCCGAGGGCGTGGCCGCAGCA
CTCAACGACGCCGACAGCGTCATCATCGTGCCCGGTTATGGCATGGCGGTGGCGCAGGCCCAGAGCGCGGTATCCGAGCT
GACCCGCAAGCTGCGCGCCGACGGCAAGACCGTGCGTTTCGCCATCCACCCCGTTGCCGGCCGCCTTCCCGGCCACATGA
ACGTGCTGCTCGCCGAAGCCAAGGTGCCCTACGACATCGTGCTGGAAATGGACGAGATCAACGACGATTTCCCGAGCACC
GACGTCGTCATCGTCATCGGCTCCAACGATATCGTCAACCCGGCGGCACAGGACGATCCGAATTCACCCATCGCTGGCAT
GCCGGTTCTGGAAGTGTGGAAGTCGAAGCTCGTCATCGTCTCCAAGCGCGGCCAGGGCACGGGTTACTCCGGCATCGAGA
ACCCGCTGTTCTATAAGGACAATACGCGCATGTTCTATGGCGATGCGAAGAAGTCGATCAACGAGCTTCTGCCGCTGATC
AAGTAA

Upstream 100 bases:

>100_bases
CCGTCCTGATCGCGACGATCAACATCGTTGGCGGTTTCCTCGTGACACGGCGCATGCTCGCCATGTTCCAGAAGTCCTGA
GCGTGCGGGGATTTAAATAA

Downstream 100 bases:

>100_bases
TGAGAAAGGCGTTTCCGGGAAACCGGGAACGCCCTTTTTACTGACGTGAAAAGAAACCTCCACCGTCATCCTCGGGCTTG
TCCCGAGGATCTATCCACGT

Product: NAD(P)+ transhydrogenase beta chain

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit beta; Pyridine nucleotide transhydrogenase subunit beta [H]

Number of amino acids: Translated: 481; Mature: 480

Protein sequence:

>481_residues
MTIGIVSAAYVAAAVLFILSLGGLSGQESAKRAVWYGITGMGLAIVATVFGPEISKGVGQWLVVLLMLAGGSVLGYFVAS
RVQMTEMPQLVAALHSFVGLAAVFIGFNAHIEEAHVASLDETARSLLTGFSAILAHKTPVELAIMKVEVFLGVFIGAVTF
TGSVVAFGKLAGKVDGKAKKLPGGHLLNAGAAILSLVLLIMYCNGAGAWTLVLMTLAAFFIGYHLIMGIGGADMPVVVSM
LNSYSGWAAAAIGFTLGNDLLIVTGALVGSSGAILSYIMCKAMNRSFISVILGGFGGTTGPAMEIEGEQVAIDAEGVAAA
LNDADSVIIVPGYGMAVAQAQSAVSELTRKLRADGKTVRFAIHPVAGRLPGHMNVLLAEAKVPYDIVLEMDEINDDFPST
DVVIVIGSNDIVNPAAQDDPNSPIAGMPVLEVWKSKLVIVSKRGQGTGYSGIENPLFYKDNTRMFYGDAKKSINELLPLI
K

Sequences:

>Translated_481_residues
MTIGIVSAAYVAAAVLFILSLGGLSGQESAKRAVWYGITGMGLAIVATVFGPEISKGVGQWLVVLLMLAGGSVLGYFVAS
RVQMTEMPQLVAALHSFVGLAAVFIGFNAHIEEAHVASLDETARSLLTGFSAILAHKTPVELAIMKVEVFLGVFIGAVTF
TGSVVAFGKLAGKVDGKAKKLPGGHLLNAGAAILSLVLLIMYCNGAGAWTLVLMTLAAFFIGYHLIMGIGGADMPVVVSM
LNSYSGWAAAAIGFTLGNDLLIVTGALVGSSGAILSYIMCKAMNRSFISVILGGFGGTTGPAMEIEGEQVAIDAEGVAAA
LNDADSVIIVPGYGMAVAQAQSAVSELTRKLRADGKTVRFAIHPVAGRLPGHMNVLLAEAKVPYDIVLEMDEINDDFPST
DVVIVIGSNDIVNPAAQDDPNSPIAGMPVLEVWKSKLVIVSKRGQGTGYSGIENPLFYKDNTRMFYGDAKKSINELLPLI
K
>Mature_480_residues
TIGIVSAAYVAAAVLFILSLGGLSGQESAKRAVWYGITGMGLAIVATVFGPEISKGVGQWLVVLLMLAGGSVLGYFVASR
VQMTEMPQLVAALHSFVGLAAVFIGFNAHIEEAHVASLDETARSLLTGFSAILAHKTPVELAIMKVEVFLGVFIGAVTFT
GSVVAFGKLAGKVDGKAKKLPGGHLLNAGAAILSLVLLIMYCNGAGAWTLVLMTLAAFFIGYHLIMGIGGADMPVVVSML
NSYSGWAAAAIGFTLGNDLLIVTGALVGSSGAILSYIMCKAMNRSFISVILGGFGGTTGPAMEIEGEQVAIDAEGVAAAL
NDADSVIIVPGYGMAVAQAQSAVSELTRKLRADGKTVRFAIHPVAGRLPGHMNVLLAEAKVPYDIVLEMDEINDDFPSTD
VVIVIGSNDIVNPAAQDDPNSPIAGMPVLEVWKSKLVIVSKRGQGTGYSGIENPLFYKDNTRMFYGDAKKSINELLPLIK

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG1282

COG function: function code C; NAD/NADP transhydrogenase beta subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNT beta subunit family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=479, Percent_Identity=47.8079331941545, Blast_Score=404, Evalue=1e-112,
Organism=Homo sapiens, GI122939153, Length=479, Percent_Identity=47.8079331941545, Blast_Score=404, Evalue=1e-112,
Organism=Escherichia coli, GI1787886, Length=484, Percent_Identity=60.5371900826446, Blast_Score=549, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI17550456, Length=489, Percent_Identity=47.8527607361963, Blast_Score=383, Evalue=1e-106,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012136
- InterPro:   IPR004003 [H]

Pfam domain/function: PF02233 PNTB [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 50079; Mature: 49948

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIGIVSAAYVAAAVLFILSLGGLSGQESAKRAVWYGITGMGLAIVATVFGPEISKGVGQ
CEEEHHHHHHHHHHHHHHHHHCCCCCCHHHCCEEEECCCHHHHHHHHHHHCCHHHHHHHH
WLVVLLMLAGGSVLGYFVASRVQMTEMPQLVAALHSFVGLAAVFIGFNAHIEEAHVASLD
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
ETARSLLTGFSAILAHKTPVELAIMKVEVFLGVFIGAVTFTGSVVAFGKLAGKVDGKAKK
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCC
LPGGHLLNAGAAILSLVLLIMYCNGAGAWTLVLMTLAAFFIGYHLIMGIGGADMPVVVSM
CCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LNSYSGWAAAAIGFTLGNDLLIVTGALVGSSGAILSYIMCKAMNRSFISVILGGFGGTTG
HHCCCCHHHHHHHHHCCCCEEEEEEHHHCCCCHHHHHHHHHHHCHHHHHHHHHCCCCCCC
PAMEIEGEQVAIDAEGVAAALNDADSVIIVPGYGMAVAQAQSAVSELTRKLRADGKTVRF
CCEEECCCEEEEECCCHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEE
AIHPVAGRLPGHMNVLLAEAKVPYDIVLEMDEINDDFPSTDVVIVIGSNDIVNPAAQDDP
EEECCCCCCCCCCEEEEECCCCCEEEEEEEHHCCCCCCCCCEEEEECCCCCCCCCCCCCC
NSPIAGMPVLEVWKSKLVIVSKRGQGTGYSGIENPLFYKDNTRMFYGDAKKSINELLPLI
CCCCCCCHHHHHCCCCEEEEEECCCCCCCCCCCCCEEEECCCEEEECCHHHHHHHHHHCC
K
C
>Mature Secondary Structure 
TIGIVSAAYVAAAVLFILSLGGLSGQESAKRAVWYGITGMGLAIVATVFGPEISKGVGQ
EEEHHHHHHHHHHHHHHHHHCCCCCCHHHCCEEEECCCHHHHHHHHHHHCCHHHHHHHH
WLVVLLMLAGGSVLGYFVASRVQMTEMPQLVAALHSFVGLAAVFIGFNAHIEEAHVASLD
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
ETARSLLTGFSAILAHKTPVELAIMKVEVFLGVFIGAVTFTGSVVAFGKLAGKVDGKAKK
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCC
LPGGHLLNAGAAILSLVLLIMYCNGAGAWTLVLMTLAAFFIGYHLIMGIGGADMPVVVSM
CCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LNSYSGWAAAAIGFTLGNDLLIVTGALVGSSGAILSYIMCKAMNRSFISVILGGFGGTTG
HHCCCCHHHHHHHHHCCCCEEEEEEHHHCCCCHHHHHHHHHHHCHHHHHHHHHCCCCCCC
PAMEIEGEQVAIDAEGVAAALNDADSVIIVPGYGMAVAQAQSAVSELTRKLRADGKTVRF
CCEEECCCEEEEECCCHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEE
AIHPVAGRLPGHMNVLLAEAKVPYDIVLEMDEINDDFPSTDVVIVIGSNDIVNPAAQDDP
EEECCCCCCCCCCEEEEECCCCCEEEEEEEHHCCCCCCCCCEEEEECCCCCCCCCCCCCC
NSPIAGMPVLEVWKSKLVIVSKRGQGTGYSGIENPLFYKDNTRMFYGDAKKSINELLPLI
CCCCCCCHHHHHCCCCEEEEEECCCCCCCCCCCCCEEEECCCEEEECCHHHHHHHHHHCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]