Click here to switch to the map view.

The map label for this gene is glmS

Identifier: 15889090

GI number: 15889090

Start: 1770746

End: 1772572

Strand: Reverse

Name: glmS

Synonym: Atu1786

Alternate gene names: 15889090

Gene position: 1772572-1770746 (Counterclockwise)

Preceding gene: 15889091

Following gene: 15889089

Centisome position: 62.38

GC content: 60.32

Gene sequence:

>1827_bases
ATGTGCGGAATTGTCGGAATTGTCGGAACCCAGCCCGTTGCTGAACGGCTTGTCGATGCGCTGAAGCGCCTCGAATATCG
CGGTTACGATTCGGCGGGTGTCGCCACCATCGACAATGGCGCGATGGACCGGCGCCGGGCGGAAGGCAAGCTGTTCAATC
TGGAAAAGCTGGTTTCGGAAAAGCCGCTGCCGGGTGTCGTTGGCATTGCGCATACGCGCTGGGCGACCCACGGCGTTCCG
AACGAAATCAACGCCCACCCGCATTTCGTTGACGGCGTTGCCGTCGTGCATAACGGCATCATCGAAAACTTCTCCGAATT
GCGCGAGGAACTGAGCGCCGAGGGTGCAACCTTTACCACCCAGACCGATACCGAAGTGGTGGCGCAGCTTCTGGCGAAAT
ACACCCGCGAGGGGCTTGGCCATCGCGAAGCAATGTTGAAGATGCTGAACCACGTAACGGGCGCCTATGCGCTGGTCGTG
ATGTTTCAGGACGATCCCGGTACGCTGCTTTCGGCGCGCTCCGGCCCGCCGCTTGCGGTTGGTTACGGCAGGGGCGAAAT
GTTCCTGGGGTCCGACGCGATCGCGCTTTCGCCCTTCACCAACGAGATCACCTATCTGGTCGATGGCGACTGCGCCATCG
TGACCCGGGACGGCGCGGAAATCATCGATTTCTCCGGCAAGCCGGTGAAACGCGAGCGCCAGATTTCGCAGGCGACGGCT
TTTGTGGTCGACAAGGGCAATCACCGCCATTTCATGGAAAAGGAAATCTATGAGCAGCCGGAAGTCATTTCCCACGCGCT
CAGCCACTATGTGGATTTCGCCACCAGGACCGTGAAGGACGCCGATAAGGCGATTGATTTTGCCAGCCTTTCCGGCCTTG
CCATCTCCGCCTGCGGCACGGCCTATCTGTCAGGCCTGATCGGCAAATACTGGTTCGAGCGTTATGCCCGCCTGCCGGTG
GAAATCGATGTTGCCTCGGAGTTCCGTTACCGCGAAATCCCGCTTGTTCCCACGCAGGCGGCGCTGTTCATTTCGCAATC
TGGCGAAACCGCCGATACGCTGGCGGCCCTGCGTTATTGCCAGCAGGAGGGTCTGAAGATCGGCGCGGTGGTCAATACCC
GCGAATCGACCATGGCGCGCGAATCCGATGCGATCTTTCCGATCCTCGCCGGGCCGGAAATCGGCGTTGCCTCCACCAAG
GCCTTTACCTGCCAGCTTGCGGTGCTTGCTTCGCTGGCCGTTGCCGCCGGCAAGGCGCGCGGCACGCTGAAACCGGGTGA
AGAAAAGCAGCTGGTGCAGCAGCTGATCGAGATGCCGCGCATCATGAGCAAGGTGTTGAACGTCATCCAGCCGCAGATCG
AGGCGCTGTCGCGTGACCTGTCGCGCTTCAAGGATGTGCTTTATCTCGGCCGTGGCACCAGCTTCCCGCTGGCGCTGGAA
GGCGCGCTGAAGCTCAAGGAAATCTCCTATATCCACGCTGAAGGTTACGCCGCTGGCGAGCTGAAGCATGGGCCTATCGC
GCTGATCGACGAGAACATGCCGGTTATCGTCATTGCTCCGCACGACCGCTTCTTCGAAAAGACCGTGTCGAACATGCAGG
AAGTAGCCGCGCGCGGCGGCCGCATCATCTTCATCACTGATGAGAAGGGTGCTGCCGCTTCCAAGCTCGAAACCATGGCG
ACGATCACGCTGCCCAATGTCGATGAACTGATCGCGCCGATGGTCTTCTCGCTGCCGATCCAGCTGCTCGCCTATCACAC
CGCCGTCTTCATGGGCACGGATGTGGACCAGCCGCGCAATCTGGCGAAATCGGTGACCGTGGAATGA

Upstream 100 bases:

>100_bases
GAAATGCGTCAGAATAAAAAGGTGGAGTATTTTCGCATTTCACGGAAAGGCGGAAATACTCTGGAAGTTTCGGCGAAGAG
ATCGCCGTCTGGAGAAATAT

Downstream 100 bases:

>100_bases
TCATCCGGCCGGAGCGGCAGGGTGATGAAGAGGCGATCGCTCGCGTTACGGAAGATGCCTTCCGTAACGTCGAACACCGT
AGCGGGACAGAACAACTGAT

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase

Number of amino acids: Translated: 608; Mature: 608

Protein sequence:

>608_residues
MCGIVGIVGTQPVAERLVDALKRLEYRGYDSAGVATIDNGAMDRRRAEGKLFNLEKLVSEKPLPGVVGIAHTRWATHGVP
NEINAHPHFVDGVAVVHNGIIENFSELREELSAEGATFTTQTDTEVVAQLLAKYTREGLGHREAMLKMLNHVTGAYALVV
MFQDDPGTLLSARSGPPLAVGYGRGEMFLGSDAIALSPFTNEITYLVDGDCAIVTRDGAEIIDFSGKPVKRERQISQATA
FVVDKGNHRHFMEKEIYEQPEVISHALSHYVDFATRTVKDADKAIDFASLSGLAISACGTAYLSGLIGKYWFERYARLPV
EIDVASEFRYREIPLVPTQAALFISQSGETADTLAALRYCQQEGLKIGAVVNTRESTMARESDAIFPILAGPEIGVASTK
AFTCQLAVLASLAVAAGKARGTLKPGEEKQLVQQLIEMPRIMSKVLNVIQPQIEALSRDLSRFKDVLYLGRGTSFPLALE
GALKLKEISYIHAEGYAAGELKHGPIALIDENMPVIVIAPHDRFFEKTVSNMQEVAARGGRIIFITDEKGAAASKLETMA
TITLPNVDELIAPMVFSLPIQLLAYHTAVFMGTDVDQPRNLAKSVTVE

Sequences:

>Translated_608_residues
MCGIVGIVGTQPVAERLVDALKRLEYRGYDSAGVATIDNGAMDRRRAEGKLFNLEKLVSEKPLPGVVGIAHTRWATHGVP
NEINAHPHFVDGVAVVHNGIIENFSELREELSAEGATFTTQTDTEVVAQLLAKYTREGLGHREAMLKMLNHVTGAYALVV
MFQDDPGTLLSARSGPPLAVGYGRGEMFLGSDAIALSPFTNEITYLVDGDCAIVTRDGAEIIDFSGKPVKRERQISQATA
FVVDKGNHRHFMEKEIYEQPEVISHALSHYVDFATRTVKDADKAIDFASLSGLAISACGTAYLSGLIGKYWFERYARLPV
EIDVASEFRYREIPLVPTQAALFISQSGETADTLAALRYCQQEGLKIGAVVNTRESTMARESDAIFPILAGPEIGVASTK
AFTCQLAVLASLAVAAGKARGTLKPGEEKQLVQQLIEMPRIMSKVLNVIQPQIEALSRDLSRFKDVLYLGRGTSFPLALE
GALKLKEISYIHAEGYAAGELKHGPIALIDENMPVIVIAPHDRFFEKTVSNMQEVAARGGRIIFITDEKGAAASKLETMA
TITLPNVDELIAPMVFSLPIQLLAYHTAVFMGTDVDQPRNLAKSVTVE
>Mature_608_residues
MCGIVGIVGTQPVAERLVDALKRLEYRGYDSAGVATIDNGAMDRRRAEGKLFNLEKLVSEKPLPGVVGIAHTRWATHGVP
NEINAHPHFVDGVAVVHNGIIENFSELREELSAEGATFTTQTDTEVVAQLLAKYTREGLGHREAMLKMLNHVTGAYALVV
MFQDDPGTLLSARSGPPLAVGYGRGEMFLGSDAIALSPFTNEITYLVDGDCAIVTRDGAEIIDFSGKPVKRERQISQATA
FVVDKGNHRHFMEKEIYEQPEVISHALSHYVDFATRTVKDADKAIDFASLSGLAISACGTAYLSGLIGKYWFERYARLPV
EIDVASEFRYREIPLVPTQAALFISQSGETADTLAALRYCQQEGLKIGAVVNTRESTMARESDAIFPILAGPEIGVASTK
AFTCQLAVLASLAVAAGKARGTLKPGEEKQLVQQLIEMPRIMSKVLNVIQPQIEALSRDLSRFKDVLYLGRGTSFPLALE
GALKLKEISYIHAEGYAAGELKHGPIALIDENMPVIVIAPHDRFFEKTVSNMQEVAARGGRIIFITDEKGAAASKLETMA
TITLPNVDELIAPMVFSLPIQLLAYHTAVFMGTDVDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains

Homologues:

Organism=Homo sapiens, GI4826742, Length=690, Percent_Identity=37.2463768115942, Blast_Score=386, Evalue=1e-107,
Organism=Homo sapiens, GI205277386, Length=690, Percent_Identity=36.231884057971, Blast_Score=379, Evalue=1e-105,
Organism=Homo sapiens, GI29570798, Length=199, Percent_Identity=28.643216080402, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1790167, Length=612, Percent_Identity=49.1830065359477, Blast_Score=565, Evalue=1e-162,
Organism=Escherichia coli, GI1788651, Length=222, Percent_Identity=31.981981981982, Blast_Score=93, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17539970, Length=714, Percent_Identity=33.1932773109244, Blast_Score=360, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17532899, Length=716, Percent_Identity=32.4022346368715, Blast_Score=354, Evalue=8e-98,
Organism=Caenorhabditis elegans, GI17532897, Length=430, Percent_Identity=37.2093023255814, Blast_Score=273, Evalue=2e-73,
Organism=Saccharomyces cerevisiae, GI6322745, Length=436, Percent_Identity=39.6788990825688, Blast_Score=273, Evalue=6e-74,
Organism=Saccharomyces cerevisiae, GI6323731, Length=437, Percent_Identity=30.8924485125858, Blast_Score=189, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6323730, Length=214, Percent_Identity=33.1775700934579, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6323958, Length=167, Percent_Identity=29.3413173652695, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI21357745, Length=686, Percent_Identity=36.5889212827988, Blast_Score=394, Evalue=1e-110,
Organism=Drosophila melanogaster, GI28573187, Length=198, Percent_Identity=28.7878787878788, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24659598, Length=198, Percent_Identity=26.2626262626263, Blast_Score=66, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMS_AGRT5 (Q8UEH1)

Other databases:

- EMBL:   AE007869
- PIR:   AC2796
- PIR:   C97575
- RefSeq:   NP_354771.1
- ProteinModelPortal:   Q8UEH1
- SMR:   Q8UEH1
- STRING:   Q8UEH1
- MEROPS:   C44.971
- GeneID:   1133824
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu1786
- eggNOG:   COG0449
- HOGENOM:   HBG645312
- OMA:   VESANDD
- PhylomeDB:   Q8UEH1
- ProtClustDB:   PRK00331
- BioCyc:   ATUM176299-1:ATU1786-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00164
- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347
- TIGRFAMs:   TIGR01135

Pfam domain/function: PF00310 GATase_2; PF01380 SIS

EC number: =2.6.1.16

Molecular weight: Translated: 66114; Mature: 66114

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS51278 GATASE_TYPE_2; PS51464 SIS; PS00443 GATASE_TYPE_II

Important sites: ACT_SITE 2-2 ACT_SITE 603-603

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGIVGTQPVAERLVDALKRLEYRGYDSAGVATIDNGAMDRRRAEGKLFNLEKLVSE
CCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHCCCEECHHHHHCC
KPLPGVVGIAHTRWATHGVPNEINAHPHFVDGVAVVHNGIIENFSELREELSAEGATFTT
CCCCCEEEEHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEC
QTDTEVVAQLLAKYTREGLGHREAMLKMLNHVTGAYALVVMFQDDPGTLLSARSGPPLAV
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEEEEECCCCCEEECCCCCCEEE
GYGRGEMFLGSDAIALSPFTNEITYLVDGDCAIVTRDGAEIIDFSGKPVKRERQISQATA
ECCCCCEEECCCCEEECCCCCCEEEEEECCEEEEECCCCEEEECCCCCCHHHHHHHHHHE
FVVDKGNHRHFMEKEIYEQPEVISHALSHYVDFATRTVKDADKAIDFASLSGLAISACGT
EEEECCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
AYLSGLIGKYWFERYARLPVEIDVASEFRYREIPLVPTQAALFISQSGETADTLAALRYC
HHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHH
QQEGLKIGAVVNTRESTMARESDAIFPILAGPEIGVASTKAFTCQLAVLASLAVAAGKAR
HHCCCEEEEEEECHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
GTLKPGEEKQLVQQLIEMPRIMSKVLNVIQPQIEALSRDLSRFKDVLYLGRGTSFPLALE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEC
GALKLKEISYIHAEGYAAGELKHGPIALIDENMPVIVIAPHDRFFEKTVSNMQEVAARGG
CCEEEHHEEEEEECCCCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHCCC
RIIFITDEKGAAASKLETMATITLPNVDELIAPMVFSLPIQLLAYHTAVFMGTDVDQPRN
EEEEEECCCCCCHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHH
LAKSVTVE
HHHHCCCC
>Mature Secondary Structure
MCGIVGIVGTQPVAERLVDALKRLEYRGYDSAGVATIDNGAMDRRRAEGKLFNLEKLVSE
CCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHCCCEECHHHHHCC
KPLPGVVGIAHTRWATHGVPNEINAHPHFVDGVAVVHNGIIENFSELREELSAEGATFTT
CCCCCEEEEHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEC
QTDTEVVAQLLAKYTREGLGHREAMLKMLNHVTGAYALVVMFQDDPGTLLSARSGPPLAV
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEEEEECCCCCEEECCCCCCEEE
GYGRGEMFLGSDAIALSPFTNEITYLVDGDCAIVTRDGAEIIDFSGKPVKRERQISQATA
ECCCCCEEECCCCEEECCCCCCEEEEEECCEEEEECCCCEEEECCCCCCHHHHHHHHHHE
FVVDKGNHRHFMEKEIYEQPEVISHALSHYVDFATRTVKDADKAIDFASLSGLAISACGT
EEEECCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
AYLSGLIGKYWFERYARLPVEIDVASEFRYREIPLVPTQAALFISQSGETADTLAALRYC
HHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHH
QQEGLKIGAVVNTRESTMARESDAIFPILAGPEIGVASTKAFTCQLAVLASLAVAAGKAR
HHCCCEEEEEEECHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
GTLKPGEEKQLVQQLIEMPRIMSKVLNVIQPQIEALSRDLSRFKDVLYLGRGTSFPLALE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEC
GALKLKEISYIHAEGYAAGELKHGPIALIDENMPVIVIAPHDRFFEKTVSNMQEVAARGG
CCEEEHHEEEEEECCCCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHCCC
RIIFITDEKGAAASKLETMATITLPNVDELIAPMVFSLPIQLLAYHTAVFMGTDVDQPRN
EEEEEECCCCCCHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHH
LAKSVTVE
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194