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The map label for this gene is glmU

Identifier: 15889091

GI number: 15889091

Start: 1772777

End: 1774138

Strand: Reverse

Name: glmU

Synonym: Atu1787

Alternate gene names: 15889091

Gene position: 1774138-1772777 (Counterclockwise)

Preceding gene: 159184917

Following gene: 15889090

Centisome position: 62.43

GC content: 61.09

Gene sequence:

>1362_bases
ATGGAGCGTAGCTCTCTAGCCGTTATTCTCGCAGCGGGCGATAGCACGCGCATGAAGTCTTCGAAGTCCAAGGTACTGCA
TCCGGTCGCGGGACGTCCGATGATCGGGCACGTGGTGGAGGCGGTTGCTGGAGCGGGCGTCGGCGCGGTGGCGCTGGTCG
TCGGGCGCGATGCCGACAATGTCGCTGCCGCTGCAAGTCTCAAGGGCCTCCAGGTGGAGGCCTTCCTGCAGAAGGAACGC
AAGGGCACTGGCCATGCGGTTCTCGCCGCACGCGAAGCGATCAAACGCGGTTTTGACGACGTCATCGTTGCTTATGGCGA
TGTACCGCTCATCACCTCGGCCACGCTCGACAGGGCGCGCGAGGCGATTGCCGCCGGTGCCGATGTGGCTGTCATCGGTT
TTCATACCGATCGTCCCACGGGTTATGGTCGACTTCTGGTCGAGAATGGCGAGCTGGTCGCGATCCGCGAGGAGAAGGAC
GCCACCGACGAGGAACGCAAGGTCACCTGGTGCAACAGCGGATTGATGGCCATTAACGGCCGCAATGCGCTGGATCTGCT
GGACCGGATCGGCAATAGCAACGTGAAGGGCGAATATTATCTAACTGACGTCGTCGAGATCGCCCGTTCTCTCGGCCGCC
GCGCCATCGCCATCGATGCACCGGAAAAGGAACTGACCGGCTGCAACAACCGCGCTGAGCTCGCCTTTATCGAGAGGCTC
TGGCAGGAGCGGCGCCGTCACGAATTGATGGTCGACGGCGTTTCGATGATTGCGCCAGAGACCGTGTTCCTTTCCTTCGA
TACAAAGATCGGTCAGGATGTTCTGATCGAGCCTAACGTCGTGTTCGGTCCCGGCGTTACGATCGAGCCGGGCGCCATCG
TTCATGCGTTTTCGCATCTTGAAGGCGCTCACCTGGCCGAAGGTGCGGTTGTCGGTCCGTTTGCGCGGTTGCGTCCGGGT
GCAAACCTGCACGCCAATGCCAAGGTCGGCAATTTCTGCGAGGTCAAGAAGGCCGAGATCGGCGAGGGCGCCAAGGTCAA
CCATCTGACCTATATCGGCGATGCTTTCGTGGGTGCAGGCAGCAATATAGGCGCGGGTGCCATCACCTGTAATTATGATG
GTTACAACAAGTCCGAAACGCGGATCGGGGCCAACAGCTTCATCGGCTCGAATTCGTCGCTGGTCGCTCCCGTCACCATT
GGAGAGCGGGCCTATATCGCCTCCGGCAGCGTGATTACCGATGATGTGCCGGCCGATGCGCTTGCTTTCGGGCGCGCGCG
CCAGGAGGTGAAGCCGGGCAGGGCGGTCGCCTTGCGCGAGCGGGCGAAAGCGCAGAAGGAAGCGAAGAAAAAGTCCTCTT
GA

Upstream 100 bases:

>100_bases
GAAATCACCCATACGCCCGTCCGCGATACCGGCCGGCGTAAAGTCAAACATTGCCCCTGTCCGGGCCGCCTGTGGCCGGT
GACGGGGTGTTGGAGGTCTT

Downstream 100 bases:

>100_bases
GAGACGTTACCGAGCGATACTGAAAGTGACCGGCGGCATAATTGCCGATTTCAGAGAAACGGTTAAAGCATTTCCAGTAA
AAGTGCGCAGCGGTTTTACG

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MERSSLAVILAAGDSTRMKSSKSKVLHPVAGRPMIGHVVEAVAGAGVGAVALVVGRDADNVAAAASLKGLQVEAFLQKER
KGTGHAVLAAREAIKRGFDDVIVAYGDVPLITSATLDRAREAIAAGADVAVIGFHTDRPTGYGRLLVENGELVAIREEKD
ATDEERKVTWCNSGLMAINGRNALDLLDRIGNSNVKGEYYLTDVVEIARSLGRRAIAIDAPEKELTGCNNRAELAFIERL
WQERRRHELMVDGVSMIAPETVFLSFDTKIGQDVLIEPNVVFGPGVTIEPGAIVHAFSHLEGAHLAEGAVVGPFARLRPG
ANLHANAKVGNFCEVKKAEIGEGAKVNHLTYIGDAFVGAGSNIGAGAITCNYDGYNKSETRIGANSFIGSNSSLVAPVTI
GERAYIASGSVITDDVPADALAFGRARQEVKPGRAVALRERAKAQKEAKKKSS

Sequences:

>Translated_453_residues
MERSSLAVILAAGDSTRMKSSKSKVLHPVAGRPMIGHVVEAVAGAGVGAVALVVGRDADNVAAAASLKGLQVEAFLQKER
KGTGHAVLAAREAIKRGFDDVIVAYGDVPLITSATLDRAREAIAAGADVAVIGFHTDRPTGYGRLLVENGELVAIREEKD
ATDEERKVTWCNSGLMAINGRNALDLLDRIGNSNVKGEYYLTDVVEIARSLGRRAIAIDAPEKELTGCNNRAELAFIERL
WQERRRHELMVDGVSMIAPETVFLSFDTKIGQDVLIEPNVVFGPGVTIEPGAIVHAFSHLEGAHLAEGAVVGPFARLRPG
ANLHANAKVGNFCEVKKAEIGEGAKVNHLTYIGDAFVGAGSNIGAGAITCNYDGYNKSETRIGANSFIGSNSSLVAPVTI
GERAYIASGSVITDDVPADALAFGRARQEVKPGRAVALRERAKAQKEAKKKSS
>Mature_453_residues
MERSSLAVILAAGDSTRMKSSKSKVLHPVAGRPMIGHVVEAVAGAGVGAVALVVGRDADNVAAAASLKGLQVEAFLQKER
KGTGHAVLAAREAIKRGFDDVIVAYGDVPLITSATLDRAREAIAAGADVAVIGFHTDRPTGYGRLLVENGELVAIREEKD
ATDEERKVTWCNSGLMAINGRNALDLLDRIGNSNVKGEYYLTDVVEIARSLGRRAIAIDAPEKELTGCNNRAELAFIERL
WQERRRHELMVDGVSMIAPETVFLSFDTKIGQDVLIEPNVVFGPGVTIEPGAIVHAFSHLEGAHLAEGAVVGPFARLRPG
ANLHANAKVGNFCEVKKAEIGEGAKVNHLTYIGDAFVGAGSNIGAGAITCNYDGYNKSETRIGANSFIGSNSSLVAPVTI
GERAYIASGSVITDDVPADALAFGRARQEVKPGRAVALRERAKAQKEAKKKSS

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Escherichia coli, GI1790168, Length=445, Percent_Identity=42.4719101123596, Blast_Score=327, Evalue=7e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_AGRT5 (Q8UEH0)

Other databases:

- EMBL:   AE007869
- PIR:   AD2796
- PIR:   D97575
- RefSeq:   NP_354772.1
- ProteinModelPortal:   Q8UEH0
- SMR:   Q8UEH0
- STRING:   Q8UEH0
- GeneID:   1133825
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu1787
- eggNOG:   COG1207
- HOGENOM:   HBG688195
- OMA:   MERTCLA
- PhylomeDB:   Q8UEH0
- ProtClustDB:   PRK14353
- BioCyc:   ATUM176299-1:ATU1787-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 47878; Mature: 47878

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 348-348 BINDING 77-77 BINDING 143-143 BINDING 157-157 BINDING 172-172 BINDING 372-372 BINDING 390-390 BINDING 425-425

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERSSLAVILAAGDSTRMKSSKSKVLHPVAGRPMIGHVVEAVAGAGVGAVALVVGRDADN
CCCCCEEEEEECCCCHHHCCCHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCC
VAAAASLKGLQVEAFLQKERKGTGHAVLAAREAIKRGFDDVIVAYGDVPLITSATLDRAR
HHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEECCCCEEEHHHHHHHH
EAIAAGADVAVIGFHTDRPTGYGRLLVENGELVAIREEKDATDEERKVTWCNSGLMAING
HHHHCCCCEEEEEEECCCCCCCCEEEEECCCEEEEECCCCCCCCCCEEEEECCCEEEECC
RNALDLLDRIGNSNVKGEYYLTDVVEIARSLGRRAIAIDAPEKELTGCNNRAELAFIERL
CCHHHHHHHHCCCCCCCCEEHHHHHHHHHHCCCEEEEEECCHHHHCCCCCCHHHHHHHHH
WQERRRHELMVDGVSMIAPETVFLSFDTKIGQDVLIEPNVVFGPGVTIEPGAIVHAFSHL
HHHHHHHEEECCCHHHHCCCEEEEEECCCCCCCEEECCCEEECCCCEECCCHHHHHHHHC
EGAHLAEGAVVGPFARLRPGANLHANAKVGNFCEVKKAEIGEGAKVNHLTYIGDAFVGAG
CCCHHCCCCEECCHHHCCCCCCEEECCCCCCCEECHHHHCCCCCEEEEEEEECCHHCCCC
SNIGAGAITCNYDGYNKSETRIGANSFIGSNSSLVAPVTIGERAYIASGSVITDDVPADA
CCCCCCEEEEECCCCCCCCCCCCCHHCCCCCCCEEEEEEECCEEEEECCCEEECCCCHHH
LAFGRARQEVKPGRAVALRERAKAQKEAKKKSS
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MERSSLAVILAAGDSTRMKSSKSKVLHPVAGRPMIGHVVEAVAGAGVGAVALVVGRDADN
CCCCCEEEEEECCCCHHHCCCHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCC
VAAAASLKGLQVEAFLQKERKGTGHAVLAAREAIKRGFDDVIVAYGDVPLITSATLDRAR
HHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEECCCCEEEHHHHHHHH
EAIAAGADVAVIGFHTDRPTGYGRLLVENGELVAIREEKDATDEERKVTWCNSGLMAING
HHHHCCCCEEEEEEECCCCCCCCEEEEECCCEEEEECCCCCCCCCCEEEEECCCEEEECC
RNALDLLDRIGNSNVKGEYYLTDVVEIARSLGRRAIAIDAPEKELTGCNNRAELAFIERL
CCHHHHHHHHCCCCCCCCEEHHHHHHHHHHCCCEEEEEECCHHHHCCCCCCHHHHHHHHH
WQERRRHELMVDGVSMIAPETVFLSFDTKIGQDVLIEPNVVFGPGVTIEPGAIVHAFSHL
HHHHHHHEEECCCHHHHCCCEEEEEECCCCCCCEEECCCEEECCCCEECCCHHHHHHHHC
EGAHLAEGAVVGPFARLRPGANLHANAKVGNFCEVKKAEIGEGAKVNHLTYIGDAFVGAG
CCCHHCCCCEECCHHHCCCCCCEEECCCCCCCEECHHHHCCCCCEEEEEEEECCHHCCCC
SNIGAGAITCNYDGYNKSETRIGANSFIGSNSSLVAPVTIGERAYIASGSVITDDVPADA
CCCCCCEEEEECCCCCCCCCCCCCHHCCCCCCCEEEEEEECCEEEEECCCEEECCCCHHH
LAFGRARQEVKPGRAVALRERAKAQKEAKKKSS
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194