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The map label for this gene is thrS

Identifier: 15889049

GI number: 15889049

Start: 1732562

End: 1734565

Strand: Reverse

Name: thrS

Synonym: Atu1746

Alternate gene names: 15889049

Gene position: 1734565-1732562 (Counterclockwise)

Preceding gene: 159185421

Following gene: 159184896

Centisome position: 61.04

GC content: 59.03

Gene sequence:

>2004_bases
ATGTCTGAAGCCATTTCCCTTACATTTCCCGATGGATCCGTGCGCAGCTACCCCGCCGGTACGACCGGCCGCGAGGTCGC
CGAATCCATCTCCAAATCGCTTGCCAAGAAAGCCGTCGCCATTGCGCTTGACGGCACCGTGCGCGATTTGTCCGAGACCA
TCACCGATGGCAAAATAGAGATCGTCACGCGTGAAGACGGCCGTGCGCTGGAGCTCATCCGCCACGACGCTGCTCACGTC
ATGGCTGAAGCCGTGCAGGAACTGTGGCCCGGCACGCAGGTGACGATCGGTCCGGTCATCGAGAACGGTTTTTATTACGA
CTTCGCCAAGAACGAGCCTTTCACGCCGGAAGATCTGCCGAAGATCGAAAAGCGGATGAAGGAGATCATTCAGCGCAACA
AGCCGTTTACCCGCGAAATCTGGTCGCGCGAGAAGGCCAAGGAAGTTTTTGCCGCCAAGGGTGAGAACTACAAGGTCGAG
CTGGTCGATGCCATTCCTGAAGGTCAGGACCTTAAGATCTATTATCAGGGCGACTGGTTCGATCTCTGCCGTGGTCCGCA
TATGGCCTCGACGGGTCAGATCGGTACGGCCTTCAAGCTGATGAAGGTGGCGGGCGCCTATTGGCGTGGTGATAGCAACA
ATGCGATGCTGTCGCGCATCTACGGCACCGCTTGGGCGACGCAGGAAGAGCTGGACAATTATCTGCACGTGCTGGCCGAA
GCTGAAAAGCGCGACCACCGCCGCCTCGGCCGCGAAATGGACCTGTTCCATTTCCAGGAAGAAGGTCCGGGCGTGGTGTT
CTGGCACGGCAAGGGCTGGCGCATGTTCCAGACGCTGACGGCCTATATGCGCCGGCGTCTCGCCAATACCTATCAGGAAG
TCAATGCGCCGCAGGTGCTGGACAAATCGCTGTGGGAAACCTCCGGTCACTGGGGCTGGTATCAGGAAAACATGTTCGCG
GTGAAATCCGCCCATGCCTTTACCCATCCCGATGACAAGGAAGCCGATCAGCGCGTCTTTGCCTTGAAGCCGATGAACTG
CCCCGGTCACGTTCAGATCTTCAAGCATGGCTTGAAGTCTTACCGCGAAATGCCCGTGCGTCTTGCGGAATTCGGCAACG
TGCATCGTTATGAGGCGTCGGGTGCACTGCACGGCCTTATGCGCGTTCGCGGCTTTACGCAGGACGATGCGCATGTCTTC
TGCACGGAAGAGCAGATGGCAGCGGAATGCCTGCGCATCAACGACCTGATCCTCTCAGTCTATGAGGATTTCGGCTTTAG
CGAGATCGTCGTCAAGCTCTCGACCCGTCCGGAAAAGCGCGTCGGTTCCGACGATCTCTGGGATCGCGCCGAAAGCGTGA
TGCTGGAGGTTCTGAAAACCATCGAGGAGCAGTCCGGCGGCCGCATCAAGACCGGCATCCTGCCGGGCGAGGGTGCTTTC
TACGGGCCGAAATTCGAATATACGCTGAAGGACGCCATCGGCCGTGAATGGCAATGCGGCACGACGCAGGTGGACTTCAA
TCTGCCGGAACGTTTTGGCGCCTTCTACATCGACCAGAACTCGGAAAAGACGCAGCCGGTGATGATCCATCGCGCCATCT
GCGGCTCCATGGAGCGCTTCCTCGGTATCCTGATCGAGAACTTTGCCGGTCACATGCCGTTGTGGTTCGCACCGCTTCAG
GTCGTGGTCGCGACGATCACCTCGGATGCGGACGATTACGGCCGCGAGGTTGCCGAAGCGCTGCGGGAGGCGGGCATGGC
GGTGGAAACCGACTTCCGCAACGAGAAGATCAACTACAAGGTTCGCGAGCATTCGGTGACCAAGGTTCCGGTCATCATTG
TCTGCGGCCGCAAGGAAGCGGAAGAGCGCACCGTCAACATTCGCCGTCTCGGTTCGCAGAACCAGACGTCGATGTCGCTC
GAAGAGGCGATCACCAGCCTCGTGGACGAGGCGACGCCGCCGGATGTCAAGCGCAAGCTTGCGGCGAAGAAGCAGCTTGC
CTGA

Upstream 100 bases:

>100_bases
GCAAAAGCCTTTATCAGCCTGCCTGTTCGCTTATCGCGGGCAGATCATTATTCCAACACCACCCGCATTCGTTGGCGGGA
CTGGACAGGAGCACGAGACG

Downstream 100 bases:

>100_bases
TAAATGACGACGGCCCCTTCGGGGGCCGTTTTTTGTTTTCGATAACGTGCTGAAAGCTCTCTTCCGTCATGCTCTGGCCT
GTCCCGAGCATCTGCAACGT

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 667; Mature: 666

Protein sequence:

>667_residues
MSEAISLTFPDGSVRSYPAGTTGREVAESISKSLAKKAVAIALDGTVRDLSETITDGKIEIVTREDGRALELIRHDAAHV
MAEAVQELWPGTQVTIGPVIENGFYYDFAKNEPFTPEDLPKIEKRMKEIIQRNKPFTREIWSREKAKEVFAAKGENYKVE
LVDAIPEGQDLKIYYQGDWFDLCRGPHMASTGQIGTAFKLMKVAGAYWRGDSNNAMLSRIYGTAWATQEELDNYLHVLAE
AEKRDHRRLGREMDLFHFQEEGPGVVFWHGKGWRMFQTLTAYMRRRLANTYQEVNAPQVLDKSLWETSGHWGWYQENMFA
VKSAHAFTHPDDKEADQRVFALKPMNCPGHVQIFKHGLKSYREMPVRLAEFGNVHRYEASGALHGLMRVRGFTQDDAHVF
CTEEQMAAECLRINDLILSVYEDFGFSEIVVKLSTRPEKRVGSDDLWDRAESVMLEVLKTIEEQSGGRIKTGILPGEGAF
YGPKFEYTLKDAIGREWQCGTTQVDFNLPERFGAFYIDQNSEKTQPVMIHRAICGSMERFLGILIENFAGHMPLWFAPLQ
VVVATITSDADDYGREVAEALREAGMAVETDFRNEKINYKVREHSVTKVPVIIVCGRKEAEERTVNIRRLGSQNQTSMSL
EEAITSLVDEATPPDVKRKLAAKKQLA

Sequences:

>Translated_667_residues
MSEAISLTFPDGSVRSYPAGTTGREVAESISKSLAKKAVAIALDGTVRDLSETITDGKIEIVTREDGRALELIRHDAAHV
MAEAVQELWPGTQVTIGPVIENGFYYDFAKNEPFTPEDLPKIEKRMKEIIQRNKPFTREIWSREKAKEVFAAKGENYKVE
LVDAIPEGQDLKIYYQGDWFDLCRGPHMASTGQIGTAFKLMKVAGAYWRGDSNNAMLSRIYGTAWATQEELDNYLHVLAE
AEKRDHRRLGREMDLFHFQEEGPGVVFWHGKGWRMFQTLTAYMRRRLANTYQEVNAPQVLDKSLWETSGHWGWYQENMFA
VKSAHAFTHPDDKEADQRVFALKPMNCPGHVQIFKHGLKSYREMPVRLAEFGNVHRYEASGALHGLMRVRGFTQDDAHVF
CTEEQMAAECLRINDLILSVYEDFGFSEIVVKLSTRPEKRVGSDDLWDRAESVMLEVLKTIEEQSGGRIKTGILPGEGAF
YGPKFEYTLKDAIGREWQCGTTQVDFNLPERFGAFYIDQNSEKTQPVMIHRAICGSMERFLGILIENFAGHMPLWFAPLQ
VVVATITSDADDYGREVAEALREAGMAVETDFRNEKINYKVREHSVTKVPVIIVCGRKEAEERTVNIRRLGSQNQTSMSL
EEAITSLVDEATPPDVKRKLAAKKQLA
>Mature_666_residues
SEAISLTFPDGSVRSYPAGTTGREVAESISKSLAKKAVAIALDGTVRDLSETITDGKIEIVTREDGRALELIRHDAAHVM
AEAVQELWPGTQVTIGPVIENGFYYDFAKNEPFTPEDLPKIEKRMKEIIQRNKPFTREIWSREKAKEVFAAKGENYKVEL
VDAIPEGQDLKIYYQGDWFDLCRGPHMASTGQIGTAFKLMKVAGAYWRGDSNNAMLSRIYGTAWATQEELDNYLHVLAEA
EKRDHRRLGREMDLFHFQEEGPGVVFWHGKGWRMFQTLTAYMRRRLANTYQEVNAPQVLDKSLWETSGHWGWYQENMFAV
KSAHAFTHPDDKEADQRVFALKPMNCPGHVQIFKHGLKSYREMPVRLAEFGNVHRYEASGALHGLMRVRGFTQDDAHVFC
TEEQMAAECLRINDLILSVYEDFGFSEIVVKLSTRPEKRVGSDDLWDRAESVMLEVLKTIEEQSGGRIKTGILPGEGAFY
GPKFEYTLKDAIGREWQCGTTQVDFNLPERFGAFYIDQNSEKTQPVMIHRAICGSMERFLGILIENFAGHMPLWFAPLQV
VVATITSDADDYGREVAEALREAGMAVETDFRNEKINYKVREHSVTKVPVIIVCGRKEAEERTVNIRRLGSQNQTSMSLE
EAITSLVDEATPPDVKRKLAAKKQLA

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38202255, Length=652, Percent_Identity=37.7300613496933, Blast_Score=430, Evalue=1e-120,
Organism=Homo sapiens, GI38570111, Length=652, Percent_Identity=37.2699386503067, Blast_Score=428, Evalue=1e-120,
Organism=Homo sapiens, GI20070344, Length=656, Percent_Identity=37.6524390243902, Blast_Score=425, Evalue=1e-119,
Organism=Escherichia coli, GI1788013, Length=658, Percent_Identity=48.3282674772036, Blast_Score=654, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71984184, Length=652, Percent_Identity=38.0368098159509, Blast_Score=456, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI71984192, Length=652, Percent_Identity=38.0368098159509, Blast_Score=455, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6322112, Length=669, Percent_Identity=38.7144992526158, Blast_Score=442, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6322654, Length=460, Percent_Identity=33.9130434782609, Blast_Score=259, Evalue=1e-69,
Organism=Drosophila melanogaster, GI24583842, Length=650, Percent_Identity=38.7692307692308, Blast_Score=444, Evalue=1e-125,
Organism=Drosophila melanogaster, GI28574141, Length=650, Percent_Identity=38.7692307692308, Blast_Score=444, Evalue=1e-125,
Organism=Drosophila melanogaster, GI24583839, Length=650, Percent_Identity=38.7692307692308, Blast_Score=444, Evalue=1e-125,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_AGRT5 (Q8UEL1)

Other databases:

- EMBL:   AE007869
- PIR:   AC2791
- PIR:   B97570
- RefSeq:   NP_354730.1
- ProteinModelPortal:   Q8UEL1
- SMR:   Q8UEL1
- STRING:   Q8UEL1
- GeneID:   1133784
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu1746
- eggNOG:   COG0441
- HOGENOM:   HBG352811
- OMA:   GFEYEVE
- PhylomeDB:   Q8UEL1
- ProtClustDB:   PRK00413
- BioCyc:   ATUM176299-1:ATU1746-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- Gene3D:   G3DSA:3.10.20.30
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF81271 TGS-like; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 75630; Mature: 75498

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEAISLTFPDGSVRSYPAGTTGREVAESISKSLAKKAVAIALDGTVRDLSETITDGKIE
CCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEEECCHHHHHHHHHCCCEEE
IVTREDGRALELIRHDAAHVMAEAVQELWPGTQVTIGPVIENGFYYDFAKNEPFTPEDLP
EEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEECCCCCCCCCHHH
KIEKRMKEIIQRNKPFTREIWSREKAKEVFAAKGENYKVELVDAIPEGQDLKIYYQGDWF
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEEEECCCHH
DLCRGPHMASTGQIGTAFKLMKVAGAYWRGDSNNAMLSRIYGTAWATQEELDNYLHVLAE
HHHCCCCCCCCCCCHHHHHHHHHHHHHEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
AEKRDHRRLGREMDLFHFQEEGPGVVFWHGKGWRMFQTLTAYMRRRLANTYQEVNAPQVL
HHHHHHHHHCCCCCCEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHHH
DKSLWETSGHWGWYQENMFAVKSAHAFTHPDDKEADQRVFALKPMNCPGHVQIFKHGLKS
HHHHHHCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHH
YREMPVRLAEFGNVHRYEASGALHGLMRVRGFTQDDAHVFCTEEQMAAECLRINDLILSV
HHHCCHHHHHCCCCEEEEHHHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHH
YEDFGFSEIVVKLSTRPEKRVGSDDLWDRAESVMLEVLKTIEEQSGGRIKTGILPGEGAF
HHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCC
YGPKFEYTLKDAIGREWQCGTTQVDFNLPERFGAFYIDQNSEKTQPVMIHRAICGSMERF
CCCCEEEEHHHHCCCCCCCCCEEEECCCHHHHCEEEEECCCCCCCHHHHHHHHHHHHHHH
LGILIENFAGHMPLWFAPLQVVVATITSDADDYGREVAEALREAGMAVETDFRNEKINYK
HHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCEE
VREHSVTKVPVIIVCGRKEAEERTVNIRRLGSQNQTSMSLEEAITSLVDEATPPDVKRKL
EECCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
AAKKQLA
HHHHCCC
>Mature Secondary Structure 
SEAISLTFPDGSVRSYPAGTTGREVAESISKSLAKKAVAIALDGTVRDLSETITDGKIE
CCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEEECCHHHHHHHHHCCCEEE
IVTREDGRALELIRHDAAHVMAEAVQELWPGTQVTIGPVIENGFYYDFAKNEPFTPEDLP
EEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEECCCCCCCCCHHH
KIEKRMKEIIQRNKPFTREIWSREKAKEVFAAKGENYKVELVDAIPEGQDLKIYYQGDWF
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEEEECCCHH
DLCRGPHMASTGQIGTAFKLMKVAGAYWRGDSNNAMLSRIYGTAWATQEELDNYLHVLAE
HHHCCCCCCCCCCCHHHHHHHHHHHHHEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
AEKRDHRRLGREMDLFHFQEEGPGVVFWHGKGWRMFQTLTAYMRRRLANTYQEVNAPQVL
HHHHHHHHHCCCCCCEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHHH
DKSLWETSGHWGWYQENMFAVKSAHAFTHPDDKEADQRVFALKPMNCPGHVQIFKHGLKS
HHHHHHCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHH
YREMPVRLAEFGNVHRYEASGALHGLMRVRGFTQDDAHVFCTEEQMAAECLRINDLILSV
HHHCCHHHHHCCCCEEEEHHHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHH
YEDFGFSEIVVKLSTRPEKRVGSDDLWDRAESVMLEVLKTIEEQSGGRIKTGILPGEGAF
HHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCC
YGPKFEYTLKDAIGREWQCGTTQVDFNLPERFGAFYIDQNSEKTQPVMIHRAICGSMERF
CCCCEEEEHHHHCCCCCCCCCEEEECCCHHHHCEEEEECCCCCCCHHHHHHHHHHHHHHH
LGILIENFAGHMPLWFAPLQVVVATITSDADDYGREVAEALREAGMAVETDFRNEKINYK
HHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCEE
VREHSVTKVPVIIVCGRKEAEERTVNIRRLGSQNQTSMSLEEAITSLVDEATPPDVKRKL
EECCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
AAKKQLA
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194