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The map label for this gene is kefB [H]

Identifier: 15888999

GI number: 15888999

Start: 1677558

End: 1679366

Strand: Reverse

Name: kefB [H]

Synonym: Atu1693

Alternate gene names: 15888999

Gene position: 1679366-1677558 (Counterclockwise)

Preceding gene: 15889000

Following gene: 15888998

Centisome position: 59.1

GC content: 62.96

Gene sequence:

>1809_bases
GTGGCTGTAGAAGCGAACGGAAATGATCTGGCCCAGGTGGTCGTGCTTTTGGCGGCGGGCGTTATCGCCGCGCCGATCTT
CAAGCGCATCGGCCTCGGCTCGGTGCTGGGTTATCTGGCCGCCGGCCTCGTGATCGGGCCTTATGGTCTCGGTTTCTTTT
CCGATTCGCAGGCCATCCTGCATGTCGCCGAACTGGGCGTGGTGATGTTCCTGTTCATCATCGGCCTTGAAATGCAGCCC
TCGCGATTGTGGTCGATGCGGCAGGATATTTTCGGGCTCGGCGCATTGCAGGTGCTGGTCTGCATGGGTGGCCTGACGCT
GGTGGGTGTCAGCCTCGGTTTTCCCGTCATCATGTCCTTCGTTGCCGGTACCGGCTTTGTGCTGACCTCGACGGCGATCG
TCATGCAGATGCTGCAGGAACGCAACAGCATGTCGAGCCTGAAAGGGCAGCGCATCATCGCCATCCTGCTGTTCGAGGAC
CTCGCCATCGTGCCGCTCTTGGCGCTCGTCGCCTTTCTCGGTTCGGGTGGGGAGCATGTGACCGCCTCGGAGCGCTGGCT
TTCGATCGGGATTGCGCTTGCCGCCGTCGGTGCGCTTATCCTCGCCGGCCGTTATCTGCTCAACCCGTTCTTCCGCCTGC
TGGCGGCCTCCGGCGCGCGCGAGGTGATGACAGCCGCGGCGCTGCTGGTGGTGCTGGGGTCGGCGCTTTTGATGCAGGTC
AGCGGTCTTTCCATGGCCATGGGGGCGTTTCTGGCCGGCGTGCTTTTGTCAGAATCATCCTTCCGCCATCAGCTGGAGGC
GGATATCGAGCCGTTTCGCGGCATTCTGCTCGGCCTGTTCTTCCTCGGCGTCGGCATGGCTATCGACCTTGCCGTCATTG
CCTCGAACTGGCAGCTCGTGGTCGTCAGCGTCGCCGGCTACATGCTGCTGAAAGCCTTCCTGATCTATGGCGTGGCGCGG
GCGCTTGGCACTACGCGGCGTGAAAGCCTCGAGCGGGCGGTGCTGATGGCGCAGGGCGGCGAATTCGCCTTCGTACTTTA
TTCAGCCGCCGTCAGCGCCGGCATTCTCGACCGGGAGGCCAACGCCATTCTGACGGCGACGATCATCATCTCCATGGTGC
TGACGCCGCTGATGGTCATCCTGCATGACCGGCTGGTGCCGGCGGCGGTTCCCAATACCGACGATCTCGATGTGCCTGAG
AATGTCGAGGGCAGCATTCTGCTGATCGGTTTCGGACGTTTCGGCCAGATCGTCAGCCAGCCGCTTCTGGCGCGCGGTTA
TACGCTGTCGCTGATCGACAAGGATGCCGACTTCGTGCGCGACGCGGCGGAGTTCGGTTTCAAGGTCTATTATGGCGACG
GATCGCGGGCGGAAATCCTGCACGCGGCGGGCGCCAGCACGGCACGAGCGGTGTTGATCTGCGTTGACGACAAGGACGCG
GCCGTGCGGATCGCGGAAATCGTCAAGCATGAATTCCCGCTGGTTCCTGTTCTTGCCCGTGCCTATGATCGTGGCCACGC
AATCGATCTGCTGAAGGCTGGCGTCGATTATCAGATTCGCGAGACGCTGGAATCGGCGCTGAATTTCAGCGAGGAAGTGC
TGGGTGCCATGGGCGAGGAGCGGGAAGACGCCGCCCGCCTGGTGGAGGAATTCCGCGACCGCGACGAGGAGCGTTTCGCC
ATGGAAGTCGTCGGCGGCATCTATGCCGGCCGTTCGCTGATCCGTGGCAATGCCCAGCCTGCCGATCTCGTCGCTGCGCG
CACCGCGCGCGAGCGGGCGGAGCGGGAAAAGGCGGAAGCGGAAGAATAA

Upstream 100 bases:

>100_bases
GCTCTGTCCCCGACGAAAATCGTTTTCGCTTTTCACGCCGATGCGCTAGGAAGTGAGGGAGGGAGCACCCTCGTCTTATT
GATTTTCAGCGGGGTGGCGT

Downstream 100 bases:

>100_bases
GGGATTGCGCCTTTCGGCGGCGCAGGGTGATTTCGAGGGATTGGAACTGACATGACGATCATTCGCACGGTTGAGGAACT
GAAGGCCATTTATGACGGCA

Product: glutathione-regulated potassium-efflux system protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 602; Mature: 601

Protein sequence:

>602_residues
MAVEANGNDLAQVVVLLAAGVIAAPIFKRIGLGSVLGYLAAGLVIGPYGLGFFSDSQAILHVAELGVVMFLFIIGLEMQP
SRLWSMRQDIFGLGALQVLVCMGGLTLVGVSLGFPVIMSFVAGTGFVLTSTAIVMQMLQERNSMSSLKGQRIIAILLFED
LAIVPLLALVAFLGSGGEHVTASERWLSIGIALAAVGALILAGRYLLNPFFRLLAASGAREVMTAAALLVVLGSALLMQV
SGLSMAMGAFLAGVLLSESSFRHQLEADIEPFRGILLGLFFLGVGMAIDLAVIASNWQLVVVSVAGYMLLKAFLIYGVAR
ALGTTRRESLERAVLMAQGGEFAFVLYSAAVSAGILDREANAILTATIIISMVLTPLMVILHDRLVPAAVPNTDDLDVPE
NVEGSILLIGFGRFGQIVSQPLLARGYTLSLIDKDADFVRDAAEFGFKVYYGDGSRAEILHAAGASTARAVLICVDDKDA
AVRIAEIVKHEFPLVPVLARAYDRGHAIDLLKAGVDYQIRETLESALNFSEEVLGAMGEEREDAARLVEEFRDRDEERFA
MEVVGGIYAGRSLIRGNAQPADLVAARTARERAEREKAEAEE

Sequences:

>Translated_602_residues
MAVEANGNDLAQVVVLLAAGVIAAPIFKRIGLGSVLGYLAAGLVIGPYGLGFFSDSQAILHVAELGVVMFLFIIGLEMQP
SRLWSMRQDIFGLGALQVLVCMGGLTLVGVSLGFPVIMSFVAGTGFVLTSTAIVMQMLQERNSMSSLKGQRIIAILLFED
LAIVPLLALVAFLGSGGEHVTASERWLSIGIALAAVGALILAGRYLLNPFFRLLAASGAREVMTAAALLVVLGSALLMQV
SGLSMAMGAFLAGVLLSESSFRHQLEADIEPFRGILLGLFFLGVGMAIDLAVIASNWQLVVVSVAGYMLLKAFLIYGVAR
ALGTTRRESLERAVLMAQGGEFAFVLYSAAVSAGILDREANAILTATIIISMVLTPLMVILHDRLVPAAVPNTDDLDVPE
NVEGSILLIGFGRFGQIVSQPLLARGYTLSLIDKDADFVRDAAEFGFKVYYGDGSRAEILHAAGASTARAVLICVDDKDA
AVRIAEIVKHEFPLVPVLARAYDRGHAIDLLKAGVDYQIRETLESALNFSEEVLGAMGEEREDAARLVEEFRDRDEERFA
MEVVGGIYAGRSLIRGNAQPADLVAARTARERAEREKAEAEE
>Mature_601_residues
AVEANGNDLAQVVVLLAAGVIAAPIFKRIGLGSVLGYLAAGLVIGPYGLGFFSDSQAILHVAELGVVMFLFIIGLEMQPS
RLWSMRQDIFGLGALQVLVCMGGLTLVGVSLGFPVIMSFVAGTGFVLTSTAIVMQMLQERNSMSSLKGQRIIAILLFEDL
AIVPLLALVAFLGSGGEHVTASERWLSIGIALAAVGALILAGRYLLNPFFRLLAASGAREVMTAAALLVVLGSALLMQVS
GLSMAMGAFLAGVLLSESSFRHQLEADIEPFRGILLGLFFLGVGMAIDLAVIASNWQLVVVSVAGYMLLKAFLIYGVARA
LGTTRRESLERAVLMAQGGEFAFVLYSAAVSAGILDREANAILTATIIISMVLTPLMVILHDRLVPAAVPNTDDLDVPEN
VEGSILLIGFGRFGQIVSQPLLARGYTLSLIDKDADFVRDAAEFGFKVYYGDGSRAEILHAAGASTARAVLICVDDKDAA
VRIAEIVKHEFPLVPVLARAYDRGHAIDLLKAGVDYQIRETLESALNFSEEVLGAMGEEREDAARLVEEFRDRDEERFAM
EVVGGIYAGRSLIRGNAQPADLVAARTARERAEREKAEAEE

Specific function: Transport system that facilitate potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=362, Percent_Identity=27.9005524861878, Blast_Score=91, Evalue=4e-18,
Organism=Escherichia coli, GI1786232, Length=562, Percent_Identity=41.2811387900356, Blast_Score=422, Evalue=1e-119,
Organism=Escherichia coli, GI1789749, Length=585, Percent_Identity=41.1965811965812, Blast_Score=413, Evalue=1e-116,
Organism=Escherichia coli, GI1786685, Length=497, Percent_Identity=27.364185110664, Blast_Score=166, Evalue=3e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 64189; Mature: 64058

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVEANGNDLAQVVVLLAAGVIAAPIFKRIGLGSVLGYLAAGLVIGPYGLGFFSDSQAIL
CEECCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
HVAELGVVMFLFIIGLEMQPSRLWSMRQDIFGLGALQVLVCMGGLTLVGVSLGFPVIMSF
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
VAGTGFVLTSTAIVMQMLQERNSMSSLKGQRIIAILLFEDLAIVPLLALVAFLGSGGEHV
HHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCEE
TASERWLSIGIALAAVGALILAGRYLLNPFFRLLAASGAREVMTAAALLVVLGSALLMQV
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
SGLSMAMGAFLAGVLLSESSFRHQLEADIEPFRGILLGLFFLGVGMAIDLAVIASNWQLV
HHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
VVSVAGYMLLKAFLIYGVARALGTTRRESLERAVLMAQGGEFAFVLYSAAVSAGILDREA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHCCCC
NAILTATIIISMVLTPLMVILHDRLVPAAVPNTDDLDVPENVEGSILLIGFGRFGQIVSQ
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHCC
PLLARGYTLSLIDKDADFVRDAAEFGFKVYYGDGSRAEILHAAGASTARAVLICVDDKDA
HHHHCCCEEEEECCCHHHHHHHHHCCEEEEECCCCCHHHHHHCCCCCCCEEEEEECCCCH
AVRIAEIVKHEFPLVPVLARAYDRGHAIDLLKAGVDYQIRETLESALNFSEEVLGAMGEE
HHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHCCCC
REDAARLVEEFRDRDEERFAMEVVGGIYAGRSLIRGNAQPADLVAARTARERAEREKAEA
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC
EE
CC
>Mature Secondary Structure 
AVEANGNDLAQVVVLLAAGVIAAPIFKRIGLGSVLGYLAAGLVIGPYGLGFFSDSQAIL
EECCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
HVAELGVVMFLFIIGLEMQPSRLWSMRQDIFGLGALQVLVCMGGLTLVGVSLGFPVIMSF
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
VAGTGFVLTSTAIVMQMLQERNSMSSLKGQRIIAILLFEDLAIVPLLALVAFLGSGGEHV
HHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCEE
TASERWLSIGIALAAVGALILAGRYLLNPFFRLLAASGAREVMTAAALLVVLGSALLMQV
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
SGLSMAMGAFLAGVLLSESSFRHQLEADIEPFRGILLGLFFLGVGMAIDLAVIASNWQLV
HHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
VVSVAGYMLLKAFLIYGVARALGTTRRESLERAVLMAQGGEFAFVLYSAAVSAGILDREA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHCCCC
NAILTATIIISMVLTPLMVILHDRLVPAAVPNTDDLDVPENVEGSILLIGFGRFGQIVSQ
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHCC
PLLARGYTLSLIDKDADFVRDAAEFGFKVYYGDGSRAEILHAAGASTARAVLICVDDKDA
HHHHCCCEEEEECCCHHHHHHHHHCCEEEEECCCCCHHHHHHCCCCCCCEEEEEECCCCH
AVRIAEIVKHEFPLVPVLARAYDRGHAIDLLKAGVDYQIRETLESALNFSEEVLGAMGEE
HHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHCCCC
REDAARLVEEFRDRDEERFAMEVVGGIYAGRSLIRGNAQPADLVAARTARERAEREKAEA
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC
EE
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]