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The map label for this gene is lpxB [H]

Identifier: 15888712

GI number: 15888712

Start: 1380109

End: 1381293

Strand: Direct

Name: lpxB [H]

Synonym: Atu1386

Alternate gene names: 15888712

Gene position: 1380109-1381293 (Clockwise)

Preceding gene: 159184741

Following gene: 15888713

Centisome position: 48.57

GC content: 60.84

Gene sequence:

>1185_bases
ATGACGGCGGCATTAAAAGTGGCGGTAATCGCCGGGGAAGTATCCGGCGATCTCTTGGGCGCGGATCTAATCCGATCGCT
CAAAGTCCGATATGCGGGTTCCGTTGAACTGGTGGGCGTTGGCGGCGAAGCGCTGGAGGCGCAGGGGCTCACCTCGCTGT
TCGACTATTCCGAACTCTCCATCATGGGCTTCACGCAGGTTCTCAAGAAGCTGCCGAAACTCATTGCGCGGATCAACCAG
ACCGCCGCAGCCATCGTGGCCGCAAAGCCGGACATTCTGCTGATCATCGACAGCCCGGATTTTACCCATCGCGTCGCGAA
AAAAGTCCGCAAACAATTGCCGCAGCTGCCGGTCGTCAATTATGTCTGCCCGAGCGTGTGGGCGTGGAAGGAATATCGCG
CCACGGCGATGTTGTCCTATGTCGACCACGTTCTGGCCCTGCTACCCTTCGAACCGGAGGCTATGCGGCGCCTTGGCGGC
CCGCCGACGACATTCGTCGGCCACCGGCTCAGCGTCGATCCTGAAGTGCTGGCGGCACGGCAGAAGCGGGCCGACCGGCC
TCTTCCGGAACAGGGCCAGCCGAGGACCATCCTTCTCCTGCCGGGATCGCGTTCCACTGAGACGACGCGGTTGATGGAGC
CGTTTCAGGACGCGGCGAAAGCTTTCGTGGAACGCAACGGCCCCACCCGGTTCCTGCTTCCCACCGTACCACGGCAGGAA
CATCGCATTCGCGAAATGGCAGCGATGTGGCCGGACGACATCAGGCCCGAGATCGGTATCGACTCTGCCTTCAAGTGGAA
GGCGTTTGCCGAGGCCGATGCGGCCATTGCCGCTTCCGGCACCGTCATTCTCGAACTGGCGCTGGCCGGTGTGCCGACCA
TCTCTGTCTACAAGACCGACTGGATTTTCACCATGCTGAGCAAACGGGTGAAGACATGGACGGGCGCCTTGCCGAACCTG
ATTGCCGATTACGCCATCATACCGGAATACTTCAACGAGGTGGTACGATCAGGCTCGATGCTGCGCTGGGCCGAGCGCCT
GTCTTCCGATACCACCGAACGGCGGGCGATGCTGGAAGGTTATGCACTGGTGCAGCAGCGTCTGCATACCGACGTCCCTC
CAGGCGAAACCGGTGCAGCCATTCTTCTCGATGTCCTGAAGACCAAAAATAGCCGCTCAGCCTGA

Upstream 100 bases:

>100_bases
ATCGTGAGGCGATGTTGAAAGCCGCCGATGAGGCGGGCATATTCGTCTGCGGCATCGATACATCACTGGGTGGCGACATG
GTGGGCGGAGACATGATCGG

Downstream 100 bases:

>100_bases
TCATATTTGTCCGGTCTGAGCGCCGGAATTGTGGTTCGTGGGCAGGTAACGCTCAGTTCCACCTGCCCCCGATCAAGGCA
GTCGAAGGCTCTGTTTTAGC

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MTAALKVAVIAGEVSGDLLGADLIRSLKVRYAGSVELVGVGGEALEAQGLTSLFDYSELSIMGFTQVLKKLPKLIARINQ
TAAAIVAAKPDILLIIDSPDFTHRVAKKVRKQLPQLPVVNYVCPSVWAWKEYRATAMLSYVDHVLALLPFEPEAMRRLGG
PPTTFVGHRLSVDPEVLAARQKRADRPLPEQGQPRTILLLPGSRSTETTRLMEPFQDAAKAFVERNGPTRFLLPTVPRQE
HRIREMAAMWPDDIRPEIGIDSAFKWKAFAEADAAIAASGTVILELALAGVPTISVYKTDWIFTMLSKRVKTWTGALPNL
IADYAIIPEYFNEVVRSGSMLRWAERLSSDTTERRAMLEGYALVQQRLHTDVPPGETGAAILLDVLKTKNSRSA

Sequences:

>Translated_394_residues
MTAALKVAVIAGEVSGDLLGADLIRSLKVRYAGSVELVGVGGEALEAQGLTSLFDYSELSIMGFTQVLKKLPKLIARINQ
TAAAIVAAKPDILLIIDSPDFTHRVAKKVRKQLPQLPVVNYVCPSVWAWKEYRATAMLSYVDHVLALLPFEPEAMRRLGG
PPTTFVGHRLSVDPEVLAARQKRADRPLPEQGQPRTILLLPGSRSTETTRLMEPFQDAAKAFVERNGPTRFLLPTVPRQE
HRIREMAAMWPDDIRPEIGIDSAFKWKAFAEADAAIAASGTVILELALAGVPTISVYKTDWIFTMLSKRVKTWTGALPNL
IADYAIIPEYFNEVVRSGSMLRWAERLSSDTTERRAMLEGYALVQQRLHTDVPPGETGAAILLDVLKTKNSRSA
>Mature_393_residues
TAALKVAVIAGEVSGDLLGADLIRSLKVRYAGSVELVGVGGEALEAQGLTSLFDYSELSIMGFTQVLKKLPKLIARINQT
AAAIVAAKPDILLIIDSPDFTHRVAKKVRKQLPQLPVVNYVCPSVWAWKEYRATAMLSYVDHVLALLPFEPEAMRRLGGP
PTTFVGHRLSVDPEVLAARQKRADRPLPEQGQPRTILLLPGSRSTETTRLMEPFQDAAKAFVERNGPTRFLLPTVPRQEH
RIREMAAMWPDDIRPEIGIDSAFKWKAFAEADAAIAASGTVILELALAGVPTISVYKTDWIFTMLSKRVKTWTGALPNLI
ADYAIIPEYFNEVVRSGSMLRWAERLSSDTTERRAMLEGYALVQQRLHTDVPPGETGAAILLDVLKTKNSRSA

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=374, Percent_Identity=31.283422459893, Blast_Score=156, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 43406; Mature: 43275

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAALKVAVIAGEVSGDLLGADLIRSLKVRYAGSVELVGVGGEALEAQGLTSLFDYSELS
CCCEEEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCHHHHHCCHHHHHCCHHHH
IMGFTQVLKKLPKLIARINQTAAAIVAAKPDILLIIDSPDFTHRVAKKVRKQLPQLPVVN
HHHHHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEECCCCHHHHHHHHHHHHCCCCCCHH
YVCPSVWAWKEYRATAMLSYVDHVLALLPFEPEAMRRLGGPPTTFVGHRLSVDPEVLAAR
HHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCHHCCCCCCCCHHHHHHH
QKRADRPLPEQGQPRTILLLPGSRSTETTRLMEPFQDAAKAFVERNGPTRFLLPTVPRQE
HHHCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHH
HRIREMAAMWPDDIRPEIGIDSAFKWKAFAEADAAIAASGTVILELALAGVPTISVYKTD
HHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCHHHHCCCHHEEHHHHHCCCEEEEEEHH
WIFTMLSKRVKTWTGALPNLIADYAIIPEYFNEVVRSGSMLRWAERLSSDTTERRAMLEG
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHH
YALVQQRLHTDVPPGETGAAILLDVLKTKNSRSA
HHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TAALKVAVIAGEVSGDLLGADLIRSLKVRYAGSVELVGVGGEALEAQGLTSLFDYSELS
CCEEEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCHHHHHCCHHHHHCCHHHH
IMGFTQVLKKLPKLIARINQTAAAIVAAKPDILLIIDSPDFTHRVAKKVRKQLPQLPVVN
HHHHHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEECCCCHHHHHHHHHHHHCCCCCCHH
YVCPSVWAWKEYRATAMLSYVDHVLALLPFEPEAMRRLGGPPTTFVGHRLSVDPEVLAAR
HHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCHHCCCCCCCCHHHHHHH
QKRADRPLPEQGQPRTILLLPGSRSTETTRLMEPFQDAAKAFVERNGPTRFLLPTVPRQE
HHHCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHH
HRIREMAAMWPDDIRPEIGIDSAFKWKAFAEADAAIAASGTVILELALAGVPTISVYKTD
HHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCHHHHCCCHHEEHHHHHCCCEEEEEEHH
WIFTMLSKRVKTWTGALPNLIADYAIIPEYFNEVVRSGSMLRWAERLSSDTTERRAMLEG
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHH
YALVQQRLHTDVPPGETGAAILLDVLKTKNSRSA
HHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA