Click here to switch to the map view.

The map label for this gene is gmk

Identifier: 15888441

GI number: 15888441

Start: 1090440

End: 1091102

Strand: Direct

Name: gmk

Synonym: Atu1101

Alternate gene names: 15888441

Gene position: 1090440-1091102 (Clockwise)

Preceding gene: 15888440

Following gene: 159184616

Centisome position: 38.37

GC content: 59.73

Gene sequence:

>663_bases
ATGGTCCCGGTGAATAATTCTCCCGTCACGATTGCCCGTAGAGGGCTGATGCTGGTGATTTCTTCGCCATCGGGCGCAGG
CAAATCCACGATCGCGCGTAACCTGCTCGAAAAAGACAAGAATATCAGCCTGTCCGTCAGTGTGACGACACGTCCGCGCC
GCCAGAGCGAGATCGAAGGCATCCACTACCACTTCATCTCCAAGCGTGATTTCGAGCGCATGCGCGATGGTGACGAACTG
CTGGAATGGGCAGAAGTTCATGGCAATTTCTACGGCACGCCGCGCGAACCGGTCGAAGCGGCGATGGCCGCCGGCCGCGA
CATGCTGTTCGATATCGACTGGCAGGGCGCCGAGCAGCTTCAGGACAAGATGAAGGCCGACGTCGTCTCGATCTTCATAC
TGCCGCCGACCATGACCGAGTTGCAGTCACGCCTGCACCGTCGCGCCGAAGATAGCGAAGAGGTCATCAAGACCCGCCTC
CTCAACTCCCGTGCAGAGATCGAACATTGGCGCGACTATGACTATGTCATCCTCAACGACGACCTGCAGGCCGCCTTCGA
GGGCATAGAGGCGATCGTCAAGGCCGAACGCGTCCGCCGCGACCGCCGCCACGGCATGTTCGACTTCGTGCGGTCATTGC
TCGAGGAAGAGCCGAAGCTCTGA

Upstream 100 bases:

>100_bases
GTTCCAAATCGAATGCCAGTGCGGTAACCGCAGCGGGCATAGAGTTGAAAGTGGTGATCGACCAGTTTCGCGAACAGGTC
CAAAATCTGGAGTAGACCCC

Downstream 100 bases:

>100_bases
TTTACGCGATAGGCAAGCGTGCCAGCCATTGACGTGACAATCTTTCGTCTGCCGCGTCTTCCGCCCAGCCATGGCCCGTA
TTGATCGTCTCCAGCACGGC

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MVPVNNSPVTIARRGLMLVISSPSGAGKSTIARNLLEKDKNISLSVSVTTRPRRQSEIEGIHYHFISKRDFERMRDGDEL
LEWAEVHGNFYGTPREPVEAAMAAGRDMLFDIDWQGAEQLQDKMKADVVSIFILPPTMTELQSRLHRRAEDSEEVIKTRL
LNSRAEIEHWRDYDYVILNDDLQAAFEGIEAIVKAERVRRDRRHGMFDFVRSLLEEEPKL

Sequences:

>Translated_220_residues
MVPVNNSPVTIARRGLMLVISSPSGAGKSTIARNLLEKDKNISLSVSVTTRPRRQSEIEGIHYHFISKRDFERMRDGDEL
LEWAEVHGNFYGTPREPVEAAMAAGRDMLFDIDWQGAEQLQDKMKADVVSIFILPPTMTELQSRLHRRAEDSEEVIKTRL
LNSRAEIEHWRDYDYVILNDDLQAAFEGIEAIVKAERVRRDRRHGMFDFVRSLLEEEPKL
>Mature_220_residues
MVPVNNSPVTIARRGLMLVISSPSGAGKSTIARNLLEKDKNISLSVSVTTRPRRQSEIEGIHYHFISKRDFERMRDGDEL
LEWAEVHGNFYGTPREPVEAAMAAGRDMLFDIDWQGAEQLQDKMKADVVSIFILPPTMTELQSRLHRRAEDSEEVIKTRL
LNSRAEIEHWRDYDYVILNDDLQAAFEGIEAIVKAERVRRDRRHGMFDFVRSLLEEEPKL

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874833, Length=194, Percent_Identity=34.020618556701, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI4504221, Length=194, Percent_Identity=34.020618556701, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI226874831, Length=194, Percent_Identity=34.020618556701, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI14780902, Length=192, Percent_Identity=28.6458333333333, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI38570142, Length=183, Percent_Identity=28.4153005464481, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI111154074, Length=173, Percent_Identity=30.635838150289, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI21536464, Length=173, Percent_Identity=28.9017341040462, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4505237, Length=178, Percent_Identity=28.6516853932584, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI262118259, Length=178, Percent_Identity=28.6516853932584, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI262118255, Length=178, Percent_Identity=28.6516853932584, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI262118263, Length=178, Percent_Identity=28.6516853932584, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI21361598, Length=193, Percent_Identity=25.3886010362694, Blast_Score=64, Evalue=7e-11,
Organism=Escherichia coli, GI1790080, Length=203, Percent_Identity=44.8275862068966, Blast_Score=177, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI193203132, Length=175, Percent_Identity=36.5714285714286, Blast_Score=101, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17508835, Length=175, Percent_Identity=36.5714285714286, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=36.0655737704918, Blast_Score=127, Evalue=2e-30,
Organism=Drosophila melanogaster, GI21356141, Length=193, Percent_Identity=33.6787564766839, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI161077626, Length=181, Percent_Identity=25.9668508287293, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI116007136, Length=181, Percent_Identity=25.9668508287293, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI85724806, Length=181, Percent_Identity=25.9668508287293, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI45554481, Length=172, Percent_Identity=26.7441860465116, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI45554489, Length=181, Percent_Identity=25.9668508287293, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24640542, Length=181, Percent_Identity=25.9668508287293, Blast_Score=70, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_AGRT5 (Q8UGD7)

Other databases:

- EMBL:   AE007869
- PIR:   AD2712
- PIR:   B97494
- RefSeq:   NP_354122.1
- ProteinModelPortal:   Q8UGD7
- SMR:   Q8UGD7
- STRING:   Q8UGD7
- GeneID:   1133139
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu1101
- eggNOG:   COG0194
- HOGENOM:   HBG671982
- OMA:   DIDWQGT
- PhylomeDB:   Q8UGD7
- ProtClustDB:   PRK00300
- BioCyc:   ATUM176299-1:ATU1101-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 25363; Mature: 25363

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVPVNNSPVTIARRGLMLVISSPSGAGKSTIARNLLEKDKNISLSVSVTTRPRRQSEIEG
CCCCCCCCEEEEECCEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHCC
IHYHFISKRDFERMRDGDELLEWAEVHGNFYGTPREPVEAAMAAGRDMLFDIDWQGAEQL
HHHHHHCHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCEEEECCCCCHHHH
QDKMKADVVSIFILPPTMTELQSRLHRRAEDSEEVIKTRLLNSRAEIEHWRDYDYVILND
HHHHHHHHEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECC
DLQAAFEGIEAIVKAERVRRDRRHGMFDFVRSLLEEEPKL
CHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVPVNNSPVTIARRGLMLVISSPSGAGKSTIARNLLEKDKNISLSVSVTTRPRRQSEIEG
CCCCCCCCEEEEECCEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHCC
IHYHFISKRDFERMRDGDELLEWAEVHGNFYGTPREPVEAAMAAGRDMLFDIDWQGAEQL
HHHHHHCHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCEEEECCCCCHHHH
QDKMKADVVSIFILPPTMTELQSRLHRRAEDSEEVIKTRLLNSRAEIEHWRDYDYVILND
HHHHHHHHEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECC
DLQAAFEGIEAIVKAERVRRDRRHGMFDFVRSLLEEEPKL
CHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194