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The map label for this gene is pepA

Identifier: 159184616

GI number: 159184616

Start: 1099854

End: 1101347

Strand: Direct

Name: pepA

Synonym: Atu1110

Alternate gene names: 159184616

Gene position: 1099854-1101347 (Clockwise)

Preceding gene: 15888441

Following gene: 159184617

Centisome position: 38.71

GC content: 61.11

Gene sequence:

>1494_bases
ATGTCCGCTAAATTCGATATTTCTTTCGCCAATTCCGCCTCGCTGGAAAATGCCCTGGCCATCGTGCTGCAGGCCTCGGG
CGAGGCGCAGGCCGTTGCCGGTGCTTCCGAGGCTGATCCGGGTGGTGTGATCGAGAGGGCATCGAAGATTTCCGGCTTTT
CCGCAAAGTCGATGGCGACGCTCGACGTCATCGCGCCGCAGGGTTCGTCCGCCGACCGTCTGCTCGTCATCGGGCTCGGC
AAGCCGTCGAAGCTGGTCGCCCATGACTGGCTGCGCGCCGGCGGCACCGCGGCTGCCCATTTCAAGAAAGCGGACAAGGT
CGTTATCTACCTAGATGCCCCGGGCGTTGAGGTGAGCGCCGAAGCGGCTGCGGATTTCGCGCTTGGCCTCCTGCTGCGCG
CCTATAGTTTCGATGCCTATAAGACCAAGAAGAAATCCGACGATGAAAAGACACCGAAGAAAGTCGATGTCACCATCGTA
ACCGCCGCCCATAAGGACGCGGAAAAGGCCTCTGCCGTGTCGGAAGCCATTGCGGGCGGCGTGATTCTGGCGCGTGACCT
CGTCAACCTGCCGCCGAATGTGCTTGGCCCGGTCGAATTCGCCGAAAAGGCGGAGGAGCTGCGCAAGCTCGGCGTCGATG
TCGAAATCCTCGGCGAAAAGGAGCTGAAGAAGCTCGGCATGAATGCACTTCTCGGTGTTGCGCAGGGTTCGGCTCGCCCG
CCGCGGCTGGCAGTCATGCAGTGGAACGGTGGTTCCAAGAAAGATGAACCCATTGCCTTCGTCGGCAAGGGCGTCGTTTT
CGACACCGGCGGTATTTCGCTGAAGCCCGGCCTCGGCATGGAAGACATGAAGGGCGACATGGGCGGGGCTGCGGCGGTGA
CCGGCCTGATGCATGTGCTCGCAGCCCGCAAGGCCAAGGCAAACGTGATCGGCGTCATCGGCCTTGTGGAAAACATGCCT
GATGGCAATGCCCAGCGTCCCGGCGATATCGTCACCTCCATGTCCGGCCAGACCATCGAGATCATCAATACCGATGCCGA
GGGCCGGCTGGTTCTGGCCGATGCGCTCTGGTACACCAAGGATCGCTTCAACCCGAAATTCATGATCAACCTCGCCACAC
TGACCGGCGCGATTACCGTTGCGCTCGGCAATCTCCAGGCCGGTCTTTTCTCCAACGACGACGAACTGGCTACACGGCTT
GCGGAGGCGGGAGAGGCGACGGCCGAGAAGCTGTGGCGCATGCCGCTCGGCAAGGACTACGACAAGATCATCGATTCCAA
ATTCGCCGATATGAAGAACAGCTCCGGCCGACTGGCGGGTTCCGTCACCGCCGCGCAGTTCCTCAAGCGTTTCGTTGGCG
AAACGCCGTGGGCGCATCTTGATATCGCCGGTACTGCCATGGGCTCGCCGCTGACCGAGATCAACCAGTCCTGGGGATCG
GGCTACGGTGTGCGTCTGCTGAACGAACTCGTTCGTGCCCATTACGAAGATTGA

Upstream 100 bases:

>100_bases
TTTAACGACTGTAGGCCTTTAAAGAATGCGGGTTGCGCCCCGGGCCGAAAAGGCCATGATCACGCGCATCGTGCAAGTCG
TCCAAGAAGAGCAGGAAAAC

Downstream 100 bases:

>100_bases
AGCGAGCGGAGCGGCGCGTCTGCGAATGACTGAAATTCTGTTCTACCATCTGACGGAATCGAAGCTGGAGGATGCGCTGC
CGCCTTTGCTCGAGAAATCG

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 497; Mature: 496

Protein sequence:

>497_residues
MSAKFDISFANSASLENALAIVLQASGEAQAVAGASEADPGGVIERASKISGFSAKSMATLDVIAPQGSSADRLLVIGLG
KPSKLVAHDWLRAGGTAAAHFKKADKVVIYLDAPGVEVSAEAAADFALGLLLRAYSFDAYKTKKKSDDEKTPKKVDVTIV
TAAHKDAEKASAVSEAIAGGVILARDLVNLPPNVLGPVEFAEKAEELRKLGVDVEILGEKELKKLGMNALLGVAQGSARP
PRLAVMQWNGGSKKDEPIAFVGKGVVFDTGGISLKPGLGMEDMKGDMGGAAAVTGLMHVLAARKAKANVIGVIGLVENMP
DGNAQRPGDIVTSMSGQTIEIINTDAEGRLVLADALWYTKDRFNPKFMINLATLTGAITVALGNLQAGLFSNDDELATRL
AEAGEATAEKLWRMPLGKDYDKIIDSKFADMKNSSGRLAGSVTAAQFLKRFVGETPWAHLDIAGTAMGSPLTEINQSWGS
GYGVRLLNELVRAHYED

Sequences:

>Translated_497_residues
MSAKFDISFANSASLENALAIVLQASGEAQAVAGASEADPGGVIERASKISGFSAKSMATLDVIAPQGSSADRLLVIGLG
KPSKLVAHDWLRAGGTAAAHFKKADKVVIYLDAPGVEVSAEAAADFALGLLLRAYSFDAYKTKKKSDDEKTPKKVDVTIV
TAAHKDAEKASAVSEAIAGGVILARDLVNLPPNVLGPVEFAEKAEELRKLGVDVEILGEKELKKLGMNALLGVAQGSARP
PRLAVMQWNGGSKKDEPIAFVGKGVVFDTGGISLKPGLGMEDMKGDMGGAAAVTGLMHVLAARKAKANVIGVIGLVENMP
DGNAQRPGDIVTSMSGQTIEIINTDAEGRLVLADALWYTKDRFNPKFMINLATLTGAITVALGNLQAGLFSNDDELATRL
AEAGEATAEKLWRMPLGKDYDKIIDSKFADMKNSSGRLAGSVTAAQFLKRFVGETPWAHLDIAGTAMGSPLTEINQSWGS
GYGVRLLNELVRAHYED
>Mature_496_residues
SAKFDISFANSASLENALAIVLQASGEAQAVAGASEADPGGVIERASKISGFSAKSMATLDVIAPQGSSADRLLVIGLGK
PSKLVAHDWLRAGGTAAAHFKKADKVVIYLDAPGVEVSAEAAADFALGLLLRAYSFDAYKTKKKSDDEKTPKKVDVTIVT
AAHKDAEKASAVSEAIAGGVILARDLVNLPPNVLGPVEFAEKAEELRKLGVDVEILGEKELKKLGMNALLGVAQGSARPP
RLAVMQWNGGSKKDEPIAFVGKGVVFDTGGISLKPGLGMEDMKGDMGGAAAVTGLMHVLAARKAKANVIGVIGLVENMPD
GNAQRPGDIVTSMSGQTIEIINTDAEGRLVLADALWYTKDRFNPKFMINLATLTGAITVALGNLQAGLFSNDDELATRLA
EAGEATAEKLWRMPLGKDYDKIIDSKFADMKNSSGRLAGSVTAAQFLKRFVGETPWAHLDIAGTAMGSPLTEINQSWGSG
YGVRLLNELVRAHYED

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=403, Percent_Identity=38.4615384615385, Blast_Score=242, Evalue=5e-64,
Organism=Homo sapiens, GI47155554, Length=399, Percent_Identity=33.5839598997494, Blast_Score=159, Evalue=5e-39,
Organism=Escherichia coli, GI1790710, Length=337, Percent_Identity=46.2908011869436, Blast_Score=286, Evalue=1e-78,
Organism=Escherichia coli, GI87082123, Length=319, Percent_Identity=38.2445141065831, Blast_Score=190, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17556903, Length=347, Percent_Identity=33.7175792507205, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17565172, Length=218, Percent_Identity=30.7339449541284, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI20129969, Length=289, Percent_Identity=35.2941176470588, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24662227, Length=287, Percent_Identity=35.191637630662, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24661038, Length=282, Percent_Identity=37.9432624113475, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI21355725, Length=282, Percent_Identity=37.2340425531915, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI161077148, Length=295, Percent_Identity=34.9152542372881, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI20130057, Length=295, Percent_Identity=34.9152542372881, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI21355645, Length=287, Percent_Identity=32.404181184669, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24662223, Length=287, Percent_Identity=32.404181184669, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI19922386, Length=287, Percent_Identity=34.8432055749129, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI20129963, Length=379, Percent_Identity=30.6068601583113, Blast_Score=172, Evalue=5e-43,
Organism=Drosophila melanogaster, GI221379063, Length=315, Percent_Identity=35.2380952380952, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI221379062, Length=315, Percent_Identity=35.2380952380952, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI21357381, Length=315, Percent_Identity=35.2380952380952, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24646701, Length=257, Percent_Identity=28.4046692607004, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24646703, Length=257, Percent_Identity=28.4046692607004, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI21358201, Length=257, Percent_Identity=28.4046692607004, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_AGRT5 (Q8UGC8)

Other databases:

- EMBL:   AE007869
- PIR:   AE2713
- PIR:   B97495
- RefSeq:   NP_354130.2
- ProteinModelPortal:   Q8UGC8
- SMR:   Q8UGC8
- STRING:   Q8UGC8
- MEROPS:   M17.003
- GeneID:   1133148
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu1110
- eggNOG:   COG0260
- HOGENOM:   HBG742580
- OMA:   ELHKPCE
- PhylomeDB:   Q8UGC8
- ProtClustDB:   PRK00913
- BioCyc:   ATUM176299-1:ATU1110-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 52171; Mature: 52040

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 275-275 ACT_SITE 349-349

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAKFDISFANSASLENALAIVLQASGEAQAVAGASEADPGGVIERASKISGFSAKSMAT
CCCEEEEEECCCCCCCCEEEEEEECCCCCEEECCCCCCCCCHHHHHHHHCCCCCCCCEEE
LDVIAPQGSSADRLLVIGLGKPSKLVAHDWLRAGGTAAAHFKKADKVVIYLDAPGVEVSA
EEEECCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCHHHHHHCCCEEEEEEECCCCEEEH
EAAADFALGLLLRAYSFDAYKTKKKSDDEKTPKKVDVTIVTAAHKDAEKASAVSEAIAGG
HHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHCC
VILARDLVNLPPNVLGPVEFAEKAEELRKLGVDVEILGEKELKKLGMNALLGVAQGSARP
HHEEHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEECHHHHHHHCHHHHHHHCCCCCCC
PRLAVMQWNGGSKKDEPIAFVGKGVVFDTGGISLKPGLGMEDMKGDMGGAAAVTGLMHVL
CEEEEEEECCCCCCCCCEEEEECCEEEECCCEEECCCCCHHHHCCCCCHHHHHHHHHHHH
AARKAKANVIGVIGLVENMPDGNAQRPGDIVTSMSGQTIEIINTDAEGRLVLADALWYTK
HHHHHCCCEEEEEEHHHCCCCCCCCCCCHHHCCCCCCEEEEEECCCCCCEEEEEHHHHHH
DRFNPKFMINLATLTGAITVALGNLQAGLFSNDDELATRLAEAGEATAEKLWRMPLGKDY
CCCCCEEEEEEHHHHCEEEEEECCCCCCCCCCCHHHHHHHHHHCCHHHHHHHCCCCCCCH
DKIIDSKFADMKNSSGRLAGSVTAAQFLKRFVGETPWAHLDIAGTAMGSPLTEINQSWGS
HHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHCC
GYGVRLLNELVRAHYED
CCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SAKFDISFANSASLENALAIVLQASGEAQAVAGASEADPGGVIERASKISGFSAKSMAT
CCEEEEEECCCCCCCCEEEEEEECCCCCEEECCCCCCCCCHHHHHHHHCCCCCCCCEEE
LDVIAPQGSSADRLLVIGLGKPSKLVAHDWLRAGGTAAAHFKKADKVVIYLDAPGVEVSA
EEEECCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCHHHHHHCCCEEEEEEECCCCEEEH
EAAADFALGLLLRAYSFDAYKTKKKSDDEKTPKKVDVTIVTAAHKDAEKASAVSEAIAGG
HHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHCC
VILARDLVNLPPNVLGPVEFAEKAEELRKLGVDVEILGEKELKKLGMNALLGVAQGSARP
HHEEHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEECHHHHHHHCHHHHHHHCCCCCCC
PRLAVMQWNGGSKKDEPIAFVGKGVVFDTGGISLKPGLGMEDMKGDMGGAAAVTGLMHVL
CEEEEEEECCCCCCCCCEEEEECCEEEECCCEEECCCCCHHHHCCCCCHHHHHHHHHHHH
AARKAKANVIGVIGLVENMPDGNAQRPGDIVTSMSGQTIEIINTDAEGRLVLADALWYTK
HHHHHCCCEEEEEEHHHCCCCCCCCCCCHHHCCCCCCEEEEEECCCCCCEEEEEHHHHHH
DRFNPKFMINLATLTGAITVALGNLQAGLFSNDDELATRLAEAGEATAEKLWRMPLGKDY
CCCCCEEEEEEHHHHCEEEEEECCCCCCCCCCCHHHHHHHHHHCCHHHHHHHCCCCCCCH
DKIIDSKFADMKNSSGRLAGSVTAAQFLKRFVGETPWAHLDIAGTAMGSPLTEINQSWGS
HHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHCC
GYGVRLLNELVRAHYED
CCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194