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The map label for this gene is murC [H]

Identifier: 239617752

GI number: 239617752

Start: 1463223

End: 1464560

Strand: Reverse

Name: murC [H]

Synonym: Kole_1377

Alternate gene names: 239617752

Gene position: 1464560-1463223 (Counterclockwise)

Preceding gene: 239617753

Following gene: 239617748

Centisome position: 63.62

GC content: 44.02

Gene sequence:

>1338_bases
TTGAAATATCATTTTATTGGTATTGGCGGGATCGGAATGAGTGGTCTCGCTCTTCATTTAGCGGCTGAGGGTAATGAGGT
TTATGGCTCAAATTTCGAAGAAAATGAGCGGGTTGAATACCTGAGGCGCGTTGGTATGCGCATTTATATTGGACATGCCC
GCGAGAACTGGGAAAACCCCGATGTGGTTGTCCATACAACCGCTGTCAGTAGAGGAAATCCCGAGCTTGAACGCAGTATT
TCCGAAGGTGTTCCCCTTCTTTATCGTATGGAACTTCTCAGAAAAGTAATAGCTTCCCGAAACTCACTCAGCGTTACCGG
TACGGATGGCAAAACAACGACAACCGCTATGCTTTCCAAAGTAATGATAGACGCAGGAAAAGACCCTGTTGTCTTTCTTG
GAGGAAAATCTCCACATCTGGAACATGGAAATTACAGAAATGGTGAAGGACCTATTGTCGCCGAGGTTGATGAAAGCGAT
GGTTTCTTTGCTTCATTTTCTTCACTTCACGCTATAGTGACTAACGTTCGCGGAGATCATTTAGAACACTACAACAATTC
TCTAAAAAACCTACAAGCTCATTTTCACTACTTCGCCAAAAGAATAACCGGCATCTTCATATACAACGCCGATGATGAGG
CTTCAAAAAGGCTCTTTGGCGGGATGGGAATCACCTTTGGTGAAAATGATGGTGATTACAGATTTACCAAAAGAACCTGT
GATAGGACAAAACAGAGTTTCGAAGTTTATCATGGTAAACATTCCCTCGGGCGTTTCACGCTGAACCTTCCCGGAATACA
CAACGTTTATAATGCAACAGCCGTAATCGCTATGGCTGCCGAACTTGGAATTCCAATGGACATTGTAAAAAACTCATTGG
CAACGTTCAAGAGCGTAGACAGGCGCTTCACTTTTAGAGGCTTTAGTGAAGAGAAAAATCTTTACTTCATAGACGATTAT
GCCCACACACCTGACGAAATAAGAAACACAATAAGGGGAGCAAAAGAAAGTTATCCAGATAGAAAGATCATTGTTGTATT
TCAACCCCACAGATACTCGAGGCTTGCCAGGGAAAATGGACGGTTTGCAGCATCCTTAAAAAGCGCCGACGCTGTGTGCG
TTTACAAGCTTTATGACGCCTACGAAAAAGGAAGATACGCTGTCAGCGAAGTTGAAGTTTTGGAAGGCCTGAAGAATTAC
GGCGTAGAATCCTACCACGCCGACGACTACAACGACATCCTCAACTGGCTGGACAGCAAACGTGACGCTGTGGTTCTCTT
TCTTGGAGCCGGCGATATAACAGAAGCTTCAAAACTCAGTGCTTTAAAATTCGGATAA

Upstream 100 bases:

>100_bases
ACTCGTTACAACCCTAAAAAGGATGAGCTTCAAAAACAATGAGGTTTTCAGAAATCCCGCAAGGGTTATAGTAGAACATG
TAGTTCGGGAGGAATAGAAG

Downstream 100 bases:

>100_bases
GTCTGTTAGCGACCTTCAAATCCGGGCATACTCCACAAAGACTGCAAATATCCCATCTGCAATCAGGGGTTGTTTCCCCC
CTAAGTGCTTTTTTATATTC

Product: UDP-N-acetylmuramate/alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MKYHFIGIGGIGMSGLALHLAAEGNEVYGSNFEENERVEYLRRVGMRIYIGHARENWENPDVVVHTTAVSRGNPELERSI
SEGVPLLYRMELLRKVIASRNSLSVTGTDGKTTTTAMLSKVMIDAGKDPVVFLGGKSPHLEHGNYRNGEGPIVAEVDESD
GFFASFSSLHAIVTNVRGDHLEHYNNSLKNLQAHFHYFAKRITGIFIYNADDEASKRLFGGMGITFGENDGDYRFTKRTC
DRTKQSFEVYHGKHSLGRFTLNLPGIHNVYNATAVIAMAAELGIPMDIVKNSLATFKSVDRRFTFRGFSEEKNLYFIDDY
AHTPDEIRNTIRGAKESYPDRKIIVVFQPHRYSRLARENGRFAASLKSADAVCVYKLYDAYEKGRYAVSEVEVLEGLKNY
GVESYHADDYNDILNWLDSKRDAVVLFLGAGDITEASKLSALKFG

Sequences:

>Translated_445_residues
MKYHFIGIGGIGMSGLALHLAAEGNEVYGSNFEENERVEYLRRVGMRIYIGHARENWENPDVVVHTTAVSRGNPELERSI
SEGVPLLYRMELLRKVIASRNSLSVTGTDGKTTTTAMLSKVMIDAGKDPVVFLGGKSPHLEHGNYRNGEGPIVAEVDESD
GFFASFSSLHAIVTNVRGDHLEHYNNSLKNLQAHFHYFAKRITGIFIYNADDEASKRLFGGMGITFGENDGDYRFTKRTC
DRTKQSFEVYHGKHSLGRFTLNLPGIHNVYNATAVIAMAAELGIPMDIVKNSLATFKSVDRRFTFRGFSEEKNLYFIDDY
AHTPDEIRNTIRGAKESYPDRKIIVVFQPHRYSRLARENGRFAASLKSADAVCVYKLYDAYEKGRYAVSEVEVLEGLKNY
GVESYHADDYNDILNWLDSKRDAVVLFLGAGDITEASKLSALKFG
>Mature_445_residues
MKYHFIGIGGIGMSGLALHLAAEGNEVYGSNFEENERVEYLRRVGMRIYIGHARENWENPDVVVHTTAVSRGNPELERSI
SEGVPLLYRMELLRKVIASRNSLSVTGTDGKTTTTAMLSKVMIDAGKDPVVFLGGKSPHLEHGNYRNGEGPIVAEVDESD
GFFASFSSLHAIVTNVRGDHLEHYNNSLKNLQAHFHYFAKRITGIFIYNADDEASKRLFGGMGITFGENDGDYRFTKRTC
DRTKQSFEVYHGKHSLGRFTLNLPGIHNVYNATAVIAMAAELGIPMDIVKNSLATFKSVDRRFTFRGFSEEKNLYFIDDY
AHTPDEIRNTIRGAKESYPDRKIIVVFQPHRYSRLARENGRFAASLKSADAVCVYKLYDAYEKGRYAVSEVEVLEGLKNY
GVESYHADDYNDILNWLDSKRDAVVLFLGAGDITEASKLSALKFG

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=382, Percent_Identity=33.2460732984293, Blast_Score=174, Evalue=7e-45,
Organism=Escherichia coli, GI1790680, Length=391, Percent_Identity=28.1329923273657, Blast_Score=124, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 49906; Mature: 49906

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYHFIGIGGIGMSGLALHLAAEGNEVYGSNFEENERVEYLRRVGMRIYIGHARENWENP
CEEEEEEECCCCCCCEEEEEEECCCEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCC
DVVVHTTAVSRGNPELERSISEGVPLLYRMELLRKVIASRNSLSVTGTDGKTTTTAMLSK
CEEEEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHH
VMIDAGKDPVVFLGGKSPHLEHGNYRNGEGPIVAEVDESDGFFASFSSLHAIVTNVRGDH
HHHCCCCCCEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCHH
LEHYNNSLKNLQAHFHYFAKRITGIFIYNADDEASKRLFGGMGITFGENDGDYRFTKRTC
HHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCHHHHHHHCCCCEEECCCCCCEEEHHHHH
DRTKQSFEVYHGKHSLGRFTLNLPGIHNVYNATAVIAMAAELGIPMDIVKNSLATFKSVD
HHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
RRFTFRGFSEEKNLYFIDDYAHTPDEIRNTIRGAKESYPDRKIIVVFQPHRYSRLARENG
HEEEECCCCCCCCEEEEECCCCCHHHHHHHHCCHHHCCCCCEEEEEECCCHHHHHHHCCC
RFAASLKSADAVCVYKLYDAYEKGRYAVSEVEVLEGLKNYGVESYHADDYNDILNWLDSK
CEEEEECCCCCEEEHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCC
RDAVVLFLGAGDITEASKLSALKFG
CCEEEEEEECCCCCCHHHHHHCCCC
>Mature Secondary Structure
MKYHFIGIGGIGMSGLALHLAAEGNEVYGSNFEENERVEYLRRVGMRIYIGHARENWENP
CEEEEEEECCCCCCCEEEEEEECCCEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCC
DVVVHTTAVSRGNPELERSISEGVPLLYRMELLRKVIASRNSLSVTGTDGKTTTTAMLSK
CEEEEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHH
VMIDAGKDPVVFLGGKSPHLEHGNYRNGEGPIVAEVDESDGFFASFSSLHAIVTNVRGDH
HHHCCCCCCEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCHH
LEHYNNSLKNLQAHFHYFAKRITGIFIYNADDEASKRLFGGMGITFGENDGDYRFTKRTC
HHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCHHHHHHHCCCCEEECCCCCCEEEHHHHH
DRTKQSFEVYHGKHSLGRFTLNLPGIHNVYNATAVIAMAAELGIPMDIVKNSLATFKSVD
HHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
RRFTFRGFSEEKNLYFIDDYAHTPDEIRNTIRGAKESYPDRKIIVVFQPHRYSRLARENG
HEEEECCCCCCCCEEEEECCCCCHHHHHHHHCCHHHCCCCCEEEEEECCCHHHHHHHCCC
RFAASLKSADAVCVYKLYDAYEKGRYAVSEVEVLEGLKNYGVESYHADDYNDILNWLDSK
CEEEEECCCCCEEEHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCC
RDAVVLFLGAGDITEASKLSALKFG
CCEEEEEEECCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA