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The map label for this gene is ribBA [H]

Identifier: 239617612

GI number: 239617612

Start: 1310323

End: 1311495

Strand: Direct

Name: ribBA [H]

Synonym: Kole_1233

Alternate gene names: 239617612

Gene position: 1310323-1311495 (Clockwise)

Preceding gene: 239617611

Following gene: 239617613

Centisome position: 56.92

GC content: 42.37

Gene sequence:

>1173_bases
ATGGAGATATCGAAAATTAGAAAGGCATTTTTGGACAGAAAACCAATTGTGCTCATAGATGATAAACGCGAGATGGAGGC
AGATCTCATCTTTCCAGCCGAACTTGTAAACACTTATATTATAAACACGATGATAGAGAACAAAGGAATGTTGTGTGTCG
CGATGGATGAATATGTACTTTTTGAAAGGGGATTTTTCAAACTTCCTTCACGAAATAGTGAAACGAACTTCTTCGTCCCT
GTTGATCATTTGGATGCAGGGACCGGGATTTCTGCAAGTGATCGCGCGAAGACGATTCGGGCACTTGCGAAAGGGGAAAA
CATAAATGCTTTTCGATACCCCGGCCATATACATCTTCTTGGAAGCATTGGGCTCAATAAAAGACAAGGGCACACAGAGT
TGTCGCTCGAAATTATGGAACTGTGTGGATTCTCAAGATCAGCGGTCATAATCGAAATACTCGACAAACATGGAAATTCG
CACAATATAGACTTTGCCAAACAACGCGCGAAAGAGAATGGTTTCCCCATCGTCACACGCGATCAAGTTATTCAGGAATA
CACAAAAAACAAACAGCTGGTTAAAGTAGTGTCAATCGCCTCGCTGCCGACGAAGTTCGGAACTTTCCAGATCGTTTCCT
TCGAAAACAATTACGACTTTCTGGAACATACAGCAATCATATATGGAGACATATCCAAAGAACCGGTGCCTGTGAGGATC
CATTCTGAGTGCCTTACAGGTGATGCACTGGGGTCACTGAGATGTGATTGCGGCTCACAGCTTCAAAATGCAATGCGTTA
TATAAAGTCCCAGGGAAGAGGTATCGTGTTGTATCTCAGACAGGAGGGACGTGGAATAGGGCTTCACAACAAAATAAAAG
CATACCATCTTCAGGATAACGGCATGGATACGGTTGATGCGAACATCGCTCTCGGATTTCCTGAAGACATGAGAGATTAC
GGTGTTGCAGCACAGATGTTGAGAGCACTTGGAGTAAAAAAGATTATACTGCTATCAAATAACCCGGATAAACTCAGACA
ATTAAAGCATTACCAGATCATCGTTGATGAAACAAGGAACATCTTCGGCGAGATAACACCATACAACCACTTCTATCTAA
AGACAAAAATGGAAAGAATGGGTCACACATTTGAGGAGGTGCTTAAAAAATGA

Upstream 100 bases:

>100_bases
GAAAACACAAACCTTAGAACGCTTCATCCAGGTGACATAGTGAATTACGAGATAGACGTTATCGCGCGCTACTTGAAAGG
AATTTATAAGGGGTGAGTAT

Downstream 100 bases:

>100_bases
GGGTTTTCGAAGGAAGATATTACGGAGAAGGGCTGAAGATCGCCATCGTGATTTCGAGATTTAATTCCGCTGTTACGAAG
GAACTTTTAGACGGAGCTCT

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MEISKIRKAFLDRKPIVLIDDKREMEADLIFPAELVNTYIINTMIENKGMLCVAMDEYVLFERGFFKLPSRNSETNFFVP
VDHLDAGTGISASDRAKTIRALAKGENINAFRYPGHIHLLGSIGLNKRQGHTELSLEIMELCGFSRSAVIIEILDKHGNS
HNIDFAKQRAKENGFPIVTRDQVIQEYTKNKQLVKVVSIASLPTKFGTFQIVSFENNYDFLEHTAIIYGDISKEPVPVRI
HSECLTGDALGSLRCDCGSQLQNAMRYIKSQGRGIVLYLRQEGRGIGLHNKIKAYHLQDNGMDTVDANIALGFPEDMRDY
GVAAQMLRALGVKKIILLSNNPDKLRQLKHYQIIVDETRNIFGEITPYNHFYLKTKMERMGHTFEEVLKK

Sequences:

>Translated_390_residues
MEISKIRKAFLDRKPIVLIDDKREMEADLIFPAELVNTYIINTMIENKGMLCVAMDEYVLFERGFFKLPSRNSETNFFVP
VDHLDAGTGISASDRAKTIRALAKGENINAFRYPGHIHLLGSIGLNKRQGHTELSLEIMELCGFSRSAVIIEILDKHGNS
HNIDFAKQRAKENGFPIVTRDQVIQEYTKNKQLVKVVSIASLPTKFGTFQIVSFENNYDFLEHTAIIYGDISKEPVPVRI
HSECLTGDALGSLRCDCGSQLQNAMRYIKSQGRGIVLYLRQEGRGIGLHNKIKAYHLQDNGMDTVDANIALGFPEDMRDY
GVAAQMLRALGVKKIILLSNNPDKLRQLKHYQIIVDETRNIFGEITPYNHFYLKTKMERMGHTFEEVLKK
>Mature_390_residues
MEISKIRKAFLDRKPIVLIDDKREMEADLIFPAELVNTYIINTMIENKGMLCVAMDEYVLFERGFFKLPSRNSETNFFVP
VDHLDAGTGISASDRAKTIRALAKGENINAFRYPGHIHLLGSIGLNKRQGHTELSLEIMELCGFSRSAVIIEILDKHGNS
HNIDFAKQRAKENGFPIVTRDQVIQEYTKNKQLVKVVSIASLPTKFGTFQIVSFENNYDFLEHTAIIYGDISKEPVPVRI
HSECLTGDALGSLRCDCGSQLQNAMRYIKSQGRGIVLYLRQEGRGIGLHNKIKAYHLQDNGMDTVDANIALGFPEDMRDY
GVAAQMLRALGVKKIILLSNNPDKLRQLKHYQIIVDETRNIFGEITPYNHFYLKTKMERMGHTFEEVLKK

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=191, Percent_Identity=53.9267015706806, Blast_Score=190, Evalue=1e-49,
Organism=Escherichia coli, GI1789420, Length=180, Percent_Identity=28.8888888888889, Blast_Score=72, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6319438, Length=173, Percent_Identity=43.3526011560694, Blast_Score=135, Evalue=8e-33,
Organism=Saccharomyces cerevisiae, GI6320695, Length=190, Percent_Identity=31.5789473684211, Blast_Score=74, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 44297; Mature: 44297

Theoretical pI: Translated: 8.44; Mature: 8.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEISKIRKAFLDRKPIVLIDDKREMEADLIFPAELVNTYIINTMIENKGMLCVAMDEYVL
CCHHHHHHHHHCCCCEEEEECCCCCCCCEECHHHHHHHHHHHHHCCCCCEEEEEECCEEE
FERGFFKLPSRNSETNFFVPVDHLDAGTGISASDRAKTIRALAKGENINAFRYPGHIHLL
ECCCCEECCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCEEECCCEEEEE
GSIGLNKRQGHTELSLEIMELCGFSRSAVIIEILDKHGNSHNIDFAKQRAKENGFPIVTR
EECCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCCEEEH
DQVIQEYTKNKQLVKVVSIASLPTKFGTFQIVSFENNYDFLEHTAIIYGDISKEPVPVRI
HHHHHHHHCCHHEEEHHHHHHCCCCCCEEEEEEECCCCCHHHCEEEEEECCCCCCEEEEE
HSECLTGDALGSLRCDCGSQLQNAMRYIKSQGRGIVLYLRQEGRGIGLHNKIKAYHLQDN
ECCCCCCCCCCCEECCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCEEEEEECCC
GMDTVDANIALGFPEDMRDYGVAAQMLRALGVKKIILLSNNPDKLRQLKHYQIIVDETRN
CCCEEECEEEECCCHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHEEEEECCHH
IFGEITPYNHFYLKTKMERMGHTFEEVLKK
HHCCCCCCCEEEEEEHHHHHCCHHHHHHCC
>Mature Secondary Structure
MEISKIRKAFLDRKPIVLIDDKREMEADLIFPAELVNTYIINTMIENKGMLCVAMDEYVL
CCHHHHHHHHHCCCCEEEEECCCCCCCCEECHHHHHHHHHHHHHCCCCCEEEEEECCEEE
FERGFFKLPSRNSETNFFVPVDHLDAGTGISASDRAKTIRALAKGENINAFRYPGHIHLL
ECCCCEECCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCEEECCCEEEEE
GSIGLNKRQGHTELSLEIMELCGFSRSAVIIEILDKHGNSHNIDFAKQRAKENGFPIVTR
EECCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCCEEEH
DQVIQEYTKNKQLVKVVSIASLPTKFGTFQIVSFENNYDFLEHTAIIYGDISKEPVPVRI
HHHHHHHHCCHHEEEHHHHHHCCCCCCEEEEEEECCCCCHHHCEEEEEECCCCCCEEEEE
HSECLTGDALGSLRCDCGSQLQNAMRYIKSQGRGIVLYLRQEGRGIGLHNKIKAYHLQDN
ECCCCCCCCCCCEECCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCEEEEEECCC
GMDTVDANIALGFPEDMRDYGVAAQMLRALGVKKIILLSNNPDKLRQLKHYQIIVDETRN
CCCEEECEEEECCCHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHEEEEECCHH
IFGEITPYNHFYLKTKMERMGHTFEEVLKK
HHCCCCCCCEEEEEEHHHHHCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]