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The map label for this gene is malL [H]

Identifier: 238923281

GI number: 238923281

Start: 797643

End: 799268

Strand: Direct

Name: malL [H]

Synonym: EUBREC_0892

Alternate gene names: 238923281

Gene position: 797643-799268 (Clockwise)

Preceding gene: 238923280

Following gene: 238923282

Centisome position: 23.12

GC content: 44.59

Gene sequence:

>1626_bases
ATGAGCAAAAACAATAACGAAAAATGGTGGAAAAAGGCGGTAGTTTACCAGATTTATCCAAAGAGCTTCCAGGATTCTAA
CGGAGACGGCTTTGGTGATTTACAGGGTATCATCAAAAGACTTGATTATCTTGAGACGCTTGGAATCAATGCAATCTGGC
TTTCGCCGGTATTCAAATCACCGCAGGCGGACAACGGTTATGACATTTCGGATTACAGGGATATTGATCCGACGTTTGGC
AGTCTCGATGATATGGAAGAGCTCATAAACGAGGCAAAGAAGCACAATATAAGGATTATGATGGATCTTGTCTTAAATCA
TTCTTCAAACGAACACAGGTGGTTCAAGGAGGCTAAAAAGAGCAAGGACAATCCATACCATGACTACTATATTTGGAGAG
ACGGAGATGAAGGCGTGCCGCCAAGTGATATGAAGGCTTGTTTCGGTGGAAGCGCATGGGAATATGTGCCGGAAATCGGA
CAGTATTATTTCCATCAGTTTTTACCGGAGCAGCCGGATTTAAACTGGGAGAATCCAAAGGTCAGAAGAGCAATCTACGA
TATGATTCTCTGGTGGATGGATAAGGGAGTCGGCGGCTTCAGACTTGATGTAATCGACCAGATAGCAAAAGAGCCGGACA
AGAGAATCACCATAAACGGACCAAGGCTTCAGGAATATTTTAAGGAACTTAGCAGGGAGACCTTCCAGAAGGGCGACCTG
ATTACTGTAGGTGAGGCATGGGGCGCAGACACAGAGCGCGCAAAGCTTTACAGCAATCCGGATGGCAGCGAGTTTTCTAT
GGTGTTCCAGTTTGAGCACATAGGGCTTGACCAGAAGGAGGGCGGCGAGAAATGGGACCTTGCACCGCTTCCGTTTAAAA
AGCTCAAAAAGATAATGGCTCACTGGCAGAATGAGCTCTACAACTGTGGCTGGAACAGTCTGTTCTGGGACAATCATGAC
CTGCCGCGTATCGTGTCAAGATGGGGCAATGACAGGGAGTACAGAGTGGAATCTGCAAAGATGCTTGCTATATTGCTGCA
CGGCATGCAGGGTACACCATACATCTATCAGGGCGAGGAGCTGGGCATGACAAATGTACAGTATGATATCGAGGATTATA
AGGACTGTGAAATCATAAACATGTACCATGAGCGCCTTGAAAAAGGATACTCAAAGGATGAAATCATGAAGTCCATTTAC
GCAAAGGGCCGTGACAATGCAAGGACACCTATGCAGTGGGATGACTCGGCAAATGCCGGCTTCACCACAGGAACACCTTG
GATAAAGGTAAATGACAATTACGACAAAATAAATGCCAAATCACAGGTGAATGACCCTGATTCAATCTTTAGCTGCTACA
AGAAGCTTGTTCAGCTGAGAAAGGATTATCCGGTATTTGTTGATGGTAAATTTACACTTTTACTTGAGGATGATGAGAAT
ATTTTTGCATACAGCAGAAAGAATGAAGAAAAAACCATGATTGTTGTGTGCAATTTCTTTGACAAGGAGATACCAATGCC
GCTTGCAAAGGAGTGTGAGGGCATGGAGGTGCTGATTTCAAATTATAAGGATACCTCTGATATGTCAGTGCTCAGACCTT
ATGAGGCCAGGATGTATATACGATAG

Upstream 100 bases:

>100_bases
AGCATTAAAGAAACCAGGCTGAATTTTTACAAAAAGAAACAGCTATAAGAGATAACAAAAAGAGATAATGAAGAGACAAT
GAAGAGACAAGGAGGGCATA

Downstream 100 bases:

>100_bases
ATAAATTTGATACCGCTTGTTTTTATAAAGGTGTTTTATAAAAGCAGGCGGTATTATTGTATTTTTTAAGGATAATGTAT
ATAATAAGTTACCGAAAAAA

Product: glucan 1,6-alpha-glucosidase

Products: NA

Alternate protein names: Dextrin 6-alpha-D-glucanohydrolase; Oligosaccharide alpha-1,6-glucosidase; Sucrase-isomaltase; Isomaltase [H]

Number of amino acids: Translated: 541; Mature: 540

Protein sequence:

>541_residues
MSKNNNEKWWKKAVVYQIYPKSFQDSNGDGFGDLQGIIKRLDYLETLGINAIWLSPVFKSPQADNGYDISDYRDIDPTFG
SLDDMEELINEAKKHNIRIMMDLVLNHSSNEHRWFKEAKKSKDNPYHDYYIWRDGDEGVPPSDMKACFGGSAWEYVPEIG
QYYFHQFLPEQPDLNWENPKVRRAIYDMILWWMDKGVGGFRLDVIDQIAKEPDKRITINGPRLQEYFKELSRETFQKGDL
ITVGEAWGADTERAKLYSNPDGSEFSMVFQFEHIGLDQKEGGEKWDLAPLPFKKLKKIMAHWQNELYNCGWNSLFWDNHD
LPRIVSRWGNDREYRVESAKMLAILLHGMQGTPYIYQGEELGMTNVQYDIEDYKDCEIINMYHERLEKGYSKDEIMKSIY
AKGRDNARTPMQWDDSANAGFTTGTPWIKVNDNYDKINAKSQVNDPDSIFSCYKKLVQLRKDYPVFVDGKFTLLLEDDEN
IFAYSRKNEEKTMIVVCNFFDKEIPMPLAKECEGMEVLISNYKDTSDMSVLRPYEARMYIR

Sequences:

>Translated_541_residues
MSKNNNEKWWKKAVVYQIYPKSFQDSNGDGFGDLQGIIKRLDYLETLGINAIWLSPVFKSPQADNGYDISDYRDIDPTFG
SLDDMEELINEAKKHNIRIMMDLVLNHSSNEHRWFKEAKKSKDNPYHDYYIWRDGDEGVPPSDMKACFGGSAWEYVPEIG
QYYFHQFLPEQPDLNWENPKVRRAIYDMILWWMDKGVGGFRLDVIDQIAKEPDKRITINGPRLQEYFKELSRETFQKGDL
ITVGEAWGADTERAKLYSNPDGSEFSMVFQFEHIGLDQKEGGEKWDLAPLPFKKLKKIMAHWQNELYNCGWNSLFWDNHD
LPRIVSRWGNDREYRVESAKMLAILLHGMQGTPYIYQGEELGMTNVQYDIEDYKDCEIINMYHERLEKGYSKDEIMKSIY
AKGRDNARTPMQWDDSANAGFTTGTPWIKVNDNYDKINAKSQVNDPDSIFSCYKKLVQLRKDYPVFVDGKFTLLLEDDEN
IFAYSRKNEEKTMIVVCNFFDKEIPMPLAKECEGMEVLISNYKDTSDMSVLRPYEARMYIR
>Mature_540_residues
SKNNNEKWWKKAVVYQIYPKSFQDSNGDGFGDLQGIIKRLDYLETLGINAIWLSPVFKSPQADNGYDISDYRDIDPTFGS
LDDMEELINEAKKHNIRIMMDLVLNHSSNEHRWFKEAKKSKDNPYHDYYIWRDGDEGVPPSDMKACFGGSAWEYVPEIGQ
YYFHQFLPEQPDLNWENPKVRRAIYDMILWWMDKGVGGFRLDVIDQIAKEPDKRITINGPRLQEYFKELSRETFQKGDLI
TVGEAWGADTERAKLYSNPDGSEFSMVFQFEHIGLDQKEGGEKWDLAPLPFKKLKKIMAHWQNELYNCGWNSLFWDNHDL
PRIVSRWGNDREYRVESAKMLAILLHGMQGTPYIYQGEELGMTNVQYDIEDYKDCEIINMYHERLEKGYSKDEIMKSIYA
KGRDNARTPMQWDDSANAGFTTGTPWIKVNDNYDKINAKSQVNDPDSIFSCYKKLVQLRKDYPVFVDGKFTLLLEDDENI
FAYSRKNEEKTMIVVCNFFDKEIPMPLAKECEGMEVLISNYKDTSDMSVLRPYEARMYIR

Specific function: Unknown

COG id: COG0366

COG function: function code G; Glycosidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 13 family [H]

Homologues:

Organism=Homo sapiens, GI187423904, Length=528, Percent_Identity=28.7878787878788, Blast_Score=238, Evalue=1e-62,
Organism=Homo sapiens, GI61744477, Length=122, Percent_Identity=36.8852459016393, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI61744475, Length=122, Percent_Identity=36.8852459016393, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI65506891, Length=122, Percent_Identity=36.8852459016393, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI61744479, Length=122, Percent_Identity=36.8852459016393, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI61744481, Length=122, Percent_Identity=36.8852459016393, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI61744483, Length=122, Percent_Identity=36.8852459016393, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1790687, Length=546, Percent_Identity=46.5201465201465, Blast_Score=533, Evalue=1e-153,
Organism=Escherichia coli, GI1786604, Length=349, Percent_Identity=25.5014326647564, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1789995, Length=91, Percent_Identity=34.0659340659341, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI25147709, Length=530, Percent_Identity=26.4150943396226, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI32565753, Length=519, Percent_Identity=24.0847784200385, Blast_Score=119, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6322245, Length=581, Percent_Identity=37.0051635111876, Blast_Score=369, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6319776, Length=580, Percent_Identity=38.1034482758621, Blast_Score=366, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6321731, Length=580, Percent_Identity=37.9310344827586, Blast_Score=365, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6321726, Length=581, Percent_Identity=37.0051635111876, Blast_Score=364, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6324416, Length=581, Percent_Identity=36.4888123924269, Blast_Score=353, Evalue=4e-98,
Organism=Saccharomyces cerevisiae, GI6322241, Length=581, Percent_Identity=36.3166953528399, Blast_Score=352, Evalue=8e-98,
Organism=Saccharomyces cerevisiae, GI6322021, Length=581, Percent_Identity=36.3166953528399, Blast_Score=352, Evalue=8e-98,
Organism=Drosophila melanogaster, GI221330053, Length=593, Percent_Identity=35.2445193929174, Blast_Score=308, Evalue=8e-84,
Organism=Drosophila melanogaster, GI24583749, Length=539, Percent_Identity=35.4359925788497, Blast_Score=280, Evalue=1e-75,
Organism=Drosophila melanogaster, GI24583747, Length=539, Percent_Identity=35.4359925788497, Blast_Score=280, Evalue=1e-75,
Organism=Drosophila melanogaster, GI45549022, Length=541, Percent_Identity=33.826247689464, Blast_Score=278, Evalue=9e-75,
Organism=Drosophila melanogaster, GI24586593, Length=527, Percent_Identity=33.3965844402277, Blast_Score=276, Evalue=4e-74,
Organism=Drosophila melanogaster, GI24583745, Length=530, Percent_Identity=34.7169811320755, Blast_Score=275, Evalue=5e-74,
Organism=Drosophila melanogaster, GI24586599, Length=571, Percent_Identity=32.5744308231173, Blast_Score=270, Evalue=1e-72,
Organism=Drosophila melanogaster, GI24586597, Length=541, Percent_Identity=32.902033271719, Blast_Score=270, Evalue=2e-72,
Organism=Drosophila melanogaster, GI24586591, Length=491, Percent_Identity=35.030549898167, Blast_Score=263, Evalue=3e-70,
Organism=Drosophila melanogaster, GI24586589, Length=529, Percent_Identity=33.0812854442344, Blast_Score=259, Evalue=4e-69,
Organism=Drosophila melanogaster, GI24586587, Length=554, Percent_Identity=31.4079422382672, Blast_Score=256, Evalue=2e-68,
Organism=Drosophila melanogaster, GI281360393, Length=472, Percent_Identity=29.6610169491525, Blast_Score=196, Evalue=3e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013780
- InterPro:   IPR006047
- InterPro:   IPR006589
- InterPro:   IPR017853
- InterPro:   IPR013781 [H]

Pfam domain/function: PF00128 Alpha-amylase [H]

EC number: =3.2.1.10 [H]

Molecular weight: Translated: 63440; Mature: 63309

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKNNNEKWWKKAVVYQIYPKSFQDSNGDGFGDLQGIIKRLDYLETLGINAIWLSPVFKS
CCCCCCHHHHHHHHEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECHHHCC
PQADNGYDISDYRDIDPTFGSLDDMEELINEAKKHNIRIMMDLVLNHSSNEHRWFKEAKK
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEEEHHCCCCCHHHHHHHHHH
SKDNPYHDYYIWRDGDEGVPPSDMKACFGGSAWEYVPEIGQYYFHQFLPEQPDLNWENPK
CCCCCCCCEEEEECCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
VRRAIYDMILWWMDKGVGGFRLDVIDQIAKEPDKRITINGPRLQEYFKELSRETFQKGDL
HHHHHHHHHHHHHHCCCCCEEHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHCCCE
ITVGEAWGADTERAKLYSNPDGSEFSMVFQFEHIGLDQKEGGEKWDLAPLPFKKLKKIMA
EEECCCCCCCCCCHHCCCCCCCCCEEEEEEEHHCCCCCCCCCCCCCCCCCCHHHHHHHHH
HWQNELYNCGWNSLFWDNHDLPRIVSRWGNDREYRVESAKMLAILLHGMQGTPYIYQGEE
HHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCEEHHHHHHHHHHHHHCCCCCCEEEECCC
LGMTNVQYDIEDYKDCEIINMYHERLEKGYSKDEIMKSIYAKGRDNARTPMQWDDSANAG
CCCCCEEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
FTTGTPWIKVNDNYDKINAKSQVNDPDSIFSCYKKLVQLRKDYPVFVDGKFTLLLEDDEN
CCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCEEEEEEECCCC
IFAYSRKNEEKTMIVVCNFFDKEIPMPLAKECEGMEVLISNYKDTSDMSVLRPYEARMYI
EEEEECCCCCCEEEEEEECCCCCCCCCHHHHCCCHHHHHHCCCCCCCCHHCCCCCCEEEC
R
C
>Mature Secondary Structure 
SKNNNEKWWKKAVVYQIYPKSFQDSNGDGFGDLQGIIKRLDYLETLGINAIWLSPVFKS
CCCCCHHHHHHHHEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECHHHCC
PQADNGYDISDYRDIDPTFGSLDDMEELINEAKKHNIRIMMDLVLNHSSNEHRWFKEAKK
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEEEHHCCCCCHHHHHHHHHH
SKDNPYHDYYIWRDGDEGVPPSDMKACFGGSAWEYVPEIGQYYFHQFLPEQPDLNWENPK
CCCCCCCCEEEEECCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
VRRAIYDMILWWMDKGVGGFRLDVIDQIAKEPDKRITINGPRLQEYFKELSRETFQKGDL
HHHHHHHHHHHHHHCCCCCEEHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHCCCE
ITVGEAWGADTERAKLYSNPDGSEFSMVFQFEHIGLDQKEGGEKWDLAPLPFKKLKKIMA
EEECCCCCCCCCCHHCCCCCCCCCEEEEEEEHHCCCCCCCCCCCCCCCCCCHHHHHHHHH
HWQNELYNCGWNSLFWDNHDLPRIVSRWGNDREYRVESAKMLAILLHGMQGTPYIYQGEE
HHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCEEHHHHHHHHHHHHHCCCCCCEEEECCC
LGMTNVQYDIEDYKDCEIINMYHERLEKGYSKDEIMKSIYAKGRDNARTPMQWDDSANAG
CCCCCEEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
FTTGTPWIKVNDNYDKINAKSQVNDPDSIFSCYKKLVQLRKDYPVFVDGKFTLLLEDDEN
CCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCEEEEEEECCCC
IFAYSRKNEEKTMIVVCNFFDKEIPMPLAKECEGMEVLISNYKDTSDMSVLRPYEARMYI
EEEEECCCCCCEEEEEEECCCCCCCCCHHHHCCCHHHHHHCCCCCCCCHHCCCCCCEEEC
R
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1761534 [H]