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The map label for this gene is sucD [H]

Identifier: 238920746

GI number: 238920746

Start: 2753210

End: 2754082

Strand: Reverse

Name: sucD [H]

Synonym: NT01EI_2865

Alternate gene names: 238920746

Gene position: 2754082-2753210 (Counterclockwise)

Preceding gene: 238920747

Following gene: 238920745

Centisome position: 72.24

GC content: 61.28

Gene sequence:

>873_bases
ATGTCAATACTGATCAATCACGAAACCCGGGTCATCTGTCAGGGCTTTACCGGCAGTCAGGGGACATTCCACTCCGAGCA
GGCACTGGCCTACGGTACCCGTCTGGTGGGCGGGGTAACGCCGGGCAAAGGGGGCAGTGAGCATCTCGGTCTGCCGGTAT
TCAACACCGTGCGCGAGGCGGTATCGGCGACCGGCGCCAACGCCAGTGTGATCTACGTACCGGCGCCGTTCTGTAAAGAC
TCCATTCTGGAGGCGATAGACGGTGGTATTTCGCTGATTATTTGTATCACTGAAGGGATACCTACGCTGGATATGCTGGT
GATCCGGGCCAAGCTGGATCAGAGCCCCGGGGTACGGATGATCGGCCCGAACTGCCCGGGAGTAATCACGCCGGGCGCCT
GTAAGATCGGTATCATGCCGGGCCATATTCACCGCCCGGGACGCATCGGCATCGTTTCGCGATCCGGCACCCTGACCTAC
GAGGCGGTGAAGCAGACCAGCGACGTCGGGTTAGGGCAGTCCACCTGCGTCGGTATCGGCGGCGATCCGATCCCTGGTGC
CAGTTTTATCGATATTCTGGCGCTGTTTCAGGCCGATCCGCAGACTGAGGCCATCGTGATGATCGGAGAGATTGGCGGGA
ACGCGGAAGAGGAGGCGGCAGCCTATATCAAGGCATACGTTACCAAACCCGTGATCGGATATATCGCCGGGGTGACGGCG
CCTAAGGGTAAGCGGATGGGACACGCCGGGGCGATTATCGCCGGCGGTAAGGGCACCGCGGATGAGAAGTTTGCCGCCCT
GGAGGCTGCCGGGGTTGTGACGGTGCGTAGCCTGGCAGATATCGGCCAGGCGGCGCTGCAGGCCCTGACCTGA

Upstream 100 bases:

>100_bases
TGGGCACCCGAATACTGGCCGACAGCGGCCTGAATATCATTGCGGCCACCAGTCTGACGGATGCCGCGCGCCAGGTGGTT
AGCGCCGTGGAGGGGAAATA

Downstream 100 bases:

>100_bases
CGTATCGAGTTACTTAAATTTTGGCCACCGGTGAGTGGCCTTTTTTTATTGTCTCAATAGATGATAAATGAAATATTCAC
TGCGGTGAAAATAGGGAATT

Product: succinyl-CoA synthetase, alpha subunit

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha [H]

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MSILINHETRVICQGFTGSQGTFHSEQALAYGTRLVGGVTPGKGGSEHLGLPVFNTVREAVSATGANASVIYVPAPFCKD
SILEAIDGGISLIICITEGIPTLDMLVIRAKLDQSPGVRMIGPNCPGVITPGACKIGIMPGHIHRPGRIGIVSRSGTLTY
EAVKQTSDVGLGQSTCVGIGGDPIPGASFIDILALFQADPQTEAIVMIGEIGGNAEEEAAAYIKAYVTKPVIGYIAGVTA
PKGKRMGHAGAIIAGGKGTADEKFAALEAAGVVTVRSLADIGQAALQALT

Sequences:

>Translated_290_residues
MSILINHETRVICQGFTGSQGTFHSEQALAYGTRLVGGVTPGKGGSEHLGLPVFNTVREAVSATGANASVIYVPAPFCKD
SILEAIDGGISLIICITEGIPTLDMLVIRAKLDQSPGVRMIGPNCPGVITPGACKIGIMPGHIHRPGRIGIVSRSGTLTY
EAVKQTSDVGLGQSTCVGIGGDPIPGASFIDILALFQADPQTEAIVMIGEIGGNAEEEAAAYIKAYVTKPVIGYIAGVTA
PKGKRMGHAGAIIAGGKGTADEKFAALEAAGVVTVRSLADIGQAALQALT
>Mature_289_residues
SILINHETRVICQGFTGSQGTFHSEQALAYGTRLVGGVTPGKGGSEHLGLPVFNTVREAVSATGANASVIYVPAPFCKDS
ILEAIDGGISLIICITEGIPTLDMLVIRAKLDQSPGVRMIGPNCPGVITPGACKIGIMPGHIHRPGRIGIVSRSGTLTYE
AVKQTSDVGLGQSTCVGIGGDPIPGASFIDILALFQADPQTEAIVMIGEIGGNAEEEAAAYIKAYVTKPVIGYIAGVTAP
KGKRMGHAGAIIAGGKGTADEKFAALEAAGVVTVRSLADIGQAALQALT

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=284, Percent_Identity=65.4929577464789, Blast_Score=325, Evalue=4e-89,
Organism=Homo sapiens, GI38569423, Length=253, Percent_Identity=33.201581027668, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI38569421, Length=253, Percent_Identity=33.201581027668, Blast_Score=104, Evalue=1e-22,
Organism=Escherichia coli, GI1786949, Length=289, Percent_Identity=84.4290657439446, Blast_Score=497, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI17550194, Length=292, Percent_Identity=59.5890410958904, Blast_Score=334, Evalue=3e-92,
Organism=Caenorhabditis elegans, GI17553126, Length=292, Percent_Identity=59.9315068493151, Blast_Score=327, Evalue=4e-90,
Organism=Caenorhabditis elegans, GI17557344, Length=260, Percent_Identity=31.5384615384615, Blast_Score=100, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17551266, Length=261, Percent_Identity=31.8007662835249, Blast_Score=100, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6324716, Length=296, Percent_Identity=50.3378378378378, Blast_Score=278, Evalue=5e-76,
Organism=Drosophila melanogaster, GI21356559, Length=292, Percent_Identity=56.5068493150685, Blast_Score=331, Evalue=4e-91,
Organism=Drosophila melanogaster, GI28574296, Length=292, Percent_Identity=59.2465753424658, Blast_Score=328, Evalue=2e-90,
Organism=Drosophila melanogaster, GI281363477, Length=255, Percent_Identity=30.9803921568627, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI281363475, Length=255, Percent_Identity=30.9803921568627, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI281363473, Length=255, Percent_Identity=30.9803921568627, Blast_Score=103, Evalue=1e-22,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 29573; Mature: 29441

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS01216 SUCCINYL_COA_LIG_1 ; PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSILINHETRVICQGFTGSQGTFHSEQALAYGTRLVGGVTPGKGGSEHLGLPVFNTVREA
CEEEEECCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHH
VSATGANASVIYVPAPFCKDSILEAIDGGISLIICITEGIPTLDMLVIRAKLDQSPGVRM
HHHCCCCCEEEEEECCCCHHHHHHHHCCCEEEEEEEECCCCHHHHHEEEHHCCCCCCEEE
IGPNCPGVITPGACKIGIMPGHIHRPGRIGIVSRSGTLTYEAVKQTSDVGLGQSTCVGIG
ECCCCCCEECCCCEEEEECCCCCCCCCEEEEEECCCCEEHHHHHHHHCCCCCCCEEEECC
GDPIPGASFIDILALFQADPQTEAIVMIGEIGGNAEEEAAAYIKAYVTKPVIGYIAGVTA
CCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
PKGKRMGHAGAIIAGGKGTADEKFAALEAAGVVTVRSLADIGQAALQALT
CCCCCCCCCCEEEECCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SILINHETRVICQGFTGSQGTFHSEQALAYGTRLVGGVTPGKGGSEHLGLPVFNTVREA
EEEEECCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHH
VSATGANASVIYVPAPFCKDSILEAIDGGISLIICITEGIPTLDMLVIRAKLDQSPGVRM
HHHCCCCCEEEEEECCCCHHHHHHHHCCCEEEEEEEECCCCHHHHHEEEHHCCCCCCEEE
IGPNCPGVITPGACKIGIMPGHIHRPGRIGIVSRSGTLTYEAVKQTSDVGLGQSTCVGIG
ECCCCCCEECCCCEEEEECCCCCCCCCEEEEEECCCCEEHHHHHHHHCCCCCCCEEEECC
GDPIPGASFIDILALFQADPQTEAIVMIGEIGGNAEEEAAAYIKAYVTKPVIGYIAGVTA
CCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
PKGKRMGHAGAIIAGGKGTADEKFAALEAAGVVTVRSLADIGQAALQALT
CCCCCCCCCCEEEECCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]