Click here to switch to the map view.

The map label for this gene is atoC [H]

Identifier: 238920098

GI number: 238920098

Start: 2124624

End: 2126000

Strand: Direct

Name: atoC [H]

Synonym: NT01EI_2205

Alternate gene names: 238920098

Gene position: 2124624-2126000 (Clockwise)

Preceding gene: 238920097

Following gene: 238920100

Centisome position: 55.73

GC content: 61.66

Gene sequence:

>1377_bases
ATGAAATCCCGCTACCGTATCCTCATCGTGGATGACGAAGAGAATGTGCGCCGCATGCTCACCACCGCGTTTGCGCTCCA
GGGGCATGAAACGTACGACGCCAGCAACGGTGAAGAGGCGCTGCAGTGCTTTGCCGACGCGCCGCCGGACGTGGTGCTGA
TGGATATCCGCATGCCAACAATGAGCGGGATCGACGCCCTGAAAATCATGCGCACCCGGCAGCCACGCACGCCCGTCATT
CTGATGACCGCCTACGCCGAGGTGGCAACCGCCGTCGAGGCGCTGCGCAGCGGCGCATTCGATTACGTGATCAAGCCCTT
CGATCTGGAGGAGCTGAACTTACTGATCCGGCGCGCGCTACAGCTGCAGGCGATGAAGCAGGAGATCCGCAGCCTGCATC
AGGCCCTGAGCAGCCGCTGGCAATGGGGGCATATCCTGACCAACAGCCCCCGCATGATCGATATCTGCAAAGACACCGCG
AAAATTGCCCTTTCGCAGGCTAACGTACTGATCAGCGGCGAGAGCGGAACCGGCAAGGAGCTGATTGCCCGCGCCATTCA
CTACAACTCGCGGCGTGCAAACGGCCCGTTTATCAAGGTCAACTGCGCCGCCCTGCCGGAGTCTCTGCTGGAAAGCGAGC
TGTTCGGCCATGAAAAGGGGGCATTTACCGGGGCGCAGGCCCTGCGCCAGGGCCTGTTTGAGCGTGCCCACCGGGGAACC
CTGCTGCTGGATGAAATCGGCGAAATGCCGCCGGTGCTGCAGGCCAAGCTGCTGCGGATCCTGCAGGAAAGGGAGTTCGA
GCGCGTGGGGGGGCATCAAACCATTCGGGTGGATATCCGCATCGTGGCCGCCACCAACCGGGATTTGCAGGCAATGGTGC
GCGAGGGCCGCTTCCGTAACGATCTCTTCTATCGCCTGAACGTCATTCATCTGCAGCTGCCGCCGCTGCGCGAGCGGCGA
CAGGACATCGCCCTGCTCGCCAACCATTTCTTACAGAAATTCAGCTCAGAGAATCAGCGCGACATGATTGAGATCGATCC
TGCCGCCCTGGCGCTGCTCTGCTCCTGGCCCTGGCCGGGTAACATCCGCGAGCTCTCCAATGTCATTGAGCGCGCGGTGG
TAATGAGCACCGGCGCGATCATTTTTGCTGACGATCTGCCAGCCCCGCTGCACCAGCCCATCAGCGGCGTCAAAAGTACC
CCCTCCGGCGAACGCAATCTGAAAGAGGAGATCAAGCGCGAGGAGCGGCGCATCATCAGCGAAGTGCTCGAGCAGCAGGA
GGGAAACCGCACCCGCACCGCCTTAATGCTGGGCATCAGCCGTCGCGCCCTGATGTACAAACTGCAGGAGTACGGTATCG
ATCCGGCGGGGTGCTAG

Upstream 100 bases:

>100_bases
TCAACGCCCACCGGGGGGATATTGACGTGGCCAGCACGCCGGGAGGCGGTACCGCCTTTACCCTCATGTTACCGACCCAT
CCGCCGGAGAGCCCGCCAGA

Downstream 100 bases:

>100_bases
GCGGTGCCGTACAGGGTGACGGTGCATCGCCTGCGGCCAGAATCTGCTGTGCAAAATGTTGCACAGTGTGCAAAGCGCTG
CACATCACCCCCGCTCACTG

Product: acetoacetate metabolism regulatory protein AtoC

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MKSRYRILIVDDEENVRRMLTTAFALQGHETYDASNGEEALQCFADAPPDVVLMDIRMPTMSGIDALKIMRTRQPRTPVI
LMTAYAEVATAVEALRSGAFDYVIKPFDLEELNLLIRRALQLQAMKQEIRSLHQALSSRWQWGHILTNSPRMIDICKDTA
KIALSQANVLISGESGTGKELIARAIHYNSRRANGPFIKVNCAALPESLLESELFGHEKGAFTGAQALRQGLFERAHRGT
LLLDEIGEMPPVLQAKLLRILQEREFERVGGHQTIRVDIRIVAATNRDLQAMVREGRFRNDLFYRLNVIHLQLPPLRERR
QDIALLANHFLQKFSSENQRDMIEIDPAALALLCSWPWPGNIRELSNVIERAVVMSTGAIIFADDLPAPLHQPISGVKST
PSGERNLKEEIKREERRIISEVLEQQEGNRTRTALMLGISRRALMYKLQEYGIDPAGC

Sequences:

>Translated_458_residues
MKSRYRILIVDDEENVRRMLTTAFALQGHETYDASNGEEALQCFADAPPDVVLMDIRMPTMSGIDALKIMRTRQPRTPVI
LMTAYAEVATAVEALRSGAFDYVIKPFDLEELNLLIRRALQLQAMKQEIRSLHQALSSRWQWGHILTNSPRMIDICKDTA
KIALSQANVLISGESGTGKELIARAIHYNSRRANGPFIKVNCAALPESLLESELFGHEKGAFTGAQALRQGLFERAHRGT
LLLDEIGEMPPVLQAKLLRILQEREFERVGGHQTIRVDIRIVAATNRDLQAMVREGRFRNDLFYRLNVIHLQLPPLRERR
QDIALLANHFLQKFSSENQRDMIEIDPAALALLCSWPWPGNIRELSNVIERAVVMSTGAIIFADDLPAPLHQPISGVKST
PSGERNLKEEIKREERRIISEVLEQQEGNRTRTALMLGISRRALMYKLQEYGIDPAGC
>Mature_458_residues
MKSRYRILIVDDEENVRRMLTTAFALQGHETYDASNGEEALQCFADAPPDVVLMDIRMPTMSGIDALKIMRTRQPRTPVI
LMTAYAEVATAVEALRSGAFDYVIKPFDLEELNLLIRRALQLQAMKQEIRSLHQALSSRWQWGHILTNSPRMIDICKDTA
KIALSQANVLISGESGTGKELIARAIHYNSRRANGPFIKVNCAALPESLLESELFGHEKGAFTGAQALRQGLFERAHRGT
LLLDEIGEMPPVLQAKLLRILQEREFERVGGHQTIRVDIRIVAATNRDLQAMVREGRFRNDLFYRLNVIHLQLPPLRERR
QDIALLANHFLQKFSSENQRDMIEIDPAALALLCSWPWPGNIRELSNVIERAVVMSTGAIIFADDLPAPLHQPISGVKST
PSGERNLKEEIKREERRIISEVLEQQEGNRTRTALMLGISRRALMYKLQEYGIDPAGC

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=459, Percent_Identity=82.1350762527233, Blast_Score=771, Evalue=0.0,
Organism=Escherichia coli, GI1790437, Length=443, Percent_Identity=47.1783295711061, Blast_Score=383, Evalue=1e-107,
Organism=Escherichia coli, GI1790299, Length=468, Percent_Identity=42.9487179487179, Blast_Score=367, Evalue=1e-103,
Organism=Escherichia coli, GI1788905, Length=449, Percent_Identity=38.9755011135858, Blast_Score=301, Evalue=8e-83,
Organism=Escherichia coli, GI87082117, Length=345, Percent_Identity=47.2463768115942, Blast_Score=281, Evalue=5e-77,
Organism=Escherichia coli, GI1789087, Length=324, Percent_Identity=46.2962962962963, Blast_Score=265, Evalue=3e-72,
Organism=Escherichia coli, GI87082152, Length=336, Percent_Identity=44.047619047619, Blast_Score=248, Evalue=5e-67,
Organism=Escherichia coli, GI1786524, Length=335, Percent_Identity=43.5820895522388, Blast_Score=239, Evalue=3e-64,
Organism=Escherichia coli, GI1789233, Length=302, Percent_Identity=46.0264900662252, Blast_Score=237, Evalue=9e-64,
Organism=Escherichia coli, GI87081872, Length=318, Percent_Identity=43.7106918238994, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI1787583, Length=312, Percent_Identity=38.7820512820513, Blast_Score=225, Evalue=6e-60,
Organism=Escherichia coli, GI87081858, Length=323, Percent_Identity=33.7461300309598, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI1789828, Length=249, Percent_Identity=37.3493975903614, Blast_Score=151, Evalue=1e-37,
Organism=Escherichia coli, GI1787487, Length=108, Percent_Identity=37.962962962963, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1786911, Length=115, Percent_Identity=34.7826086956522, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1789402, Length=118, Percent_Identity=34.7457627118644, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790863, Length=139, Percent_Identity=28.7769784172662, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1787375, Length=107, Percent_Identity=31.7757009345794, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI1786599, Length=119, Percent_Identity=32.7731092436975, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1786784, Length=116, Percent_Identity=30.1724137931034, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1789809, Length=124, Percent_Identity=29.8387096774194, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI87082012, Length=116, Percent_Identity=31.8965517241379, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51788; Mature: 51788

Theoretical pI: Translated: 7.95; Mature: 7.95

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSRYRILIVDDEENVRRMLTTAFALQGHETYDASNGEEALQCFADAPPDVVLMDIRMPT
CCCCEEEEEEECHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCEEEEEEECCC
MSGIDALKIMRTRQPRTPVILMTAYAEVATAVEALRSGAFDYVIKPFDLEELNLLIRRAL
CCCHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHCCCHHEEECCCCHHHHHHHHHHHH
QLQAMKQEIRSLHQALSSRWQWGHILTNSPRMIDICKDTAKIALSQANVLISGESGTGKE
HHHHHHHHHHHHHHHHHCCCCCCEEECCCCCEEEEHHHHHHHHHEECCEEEECCCCCHHH
LIARAIHYNSRRANGPFIKVNCAALPESLLESELFGHEKGAFTGAQALRQGLFERAHRGT
HHHHHHHCCCCCCCCCEEEEEHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCC
LLLDEIGEMPPVLQAKLLRILQEREFERVGGHQTIRVDIRIVAATNRDLQAMVREGRFRN
EEHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCHHHHHHHHCCCCCC
DLFYRLNVIHLQLPPLRERRQDIALLANHFLQKFSSENQRDMIEIDPAALALLCSWPWPG
CCEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECHHHEEEEECCCCCC
NIRELSNVIERAVVMSTGAIIFADDLPAPLHQPISGVKSTPSGERNLKEEIKREERRIIS
CHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
EVLEQQEGNRTRTALMLGISRRALMYKLQEYGIDPAGC
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKSRYRILIVDDEENVRRMLTTAFALQGHETYDASNGEEALQCFADAPPDVVLMDIRMPT
CCCCEEEEEEECHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCEEEEEEECCC
MSGIDALKIMRTRQPRTPVILMTAYAEVATAVEALRSGAFDYVIKPFDLEELNLLIRRAL
CCCHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHCCCHHEEECCCCHHHHHHHHHHHH
QLQAMKQEIRSLHQALSSRWQWGHILTNSPRMIDICKDTAKIALSQANVLISGESGTGKE
HHHHHHHHHHHHHHHHHCCCCCCEEECCCCCEEEEHHHHHHHHHEECCEEEECCCCCHHH
LIARAIHYNSRRANGPFIKVNCAALPESLLESELFGHEKGAFTGAQALRQGLFERAHRGT
HHHHHHHCCCCCCCCCEEEEEHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCC
LLLDEIGEMPPVLQAKLLRILQEREFERVGGHQTIRVDIRIVAATNRDLQAMVREGRFRN
EEHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCHHHHHHHHCCCCCC
DLFYRLNVIHLQLPPLRERRQDIALLANHFLQKFSSENQRDMIEIDPAALALLCSWPWPG
CCEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECHHHEEEEECCCCCC
NIRELSNVIERAVVMSTGAIIFADDLPAPLHQPISGVKSTPSGERNLKEEIKREERRIIS
CHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
EVLEQQEGNRTRTALMLGISRRALMYKLQEYGIDPAGC
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]