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The map label for this gene is tyrR [H]

Identifier: 238919735

GI number: 238919735

Start: 1776431

End: 1778017

Strand: Direct

Name: tyrR [H]

Synonym: NT01EI_1839

Alternate gene names: 238919735

Gene position: 1776431-1778017 (Clockwise)

Preceding gene: 238919733

Following gene: 238919737

Centisome position: 46.6

GC content: 61.12

Gene sequence:

>1587_bases
ATGCGTCTGGAAGTTTTTTGTGAAGATCGTATCGGTCTAACGCGTGAACTGCTGGATCTTCTCGCTGCCCGTAATATCGA
TCTGCGCGGCATTGAGATTGATACCATTGGGCGAATTTATCTGAACTTTAATGAGCTGGATTTTGAGGTGTTCCGTCAGC
TGATGGCGGAGATCCGTCGCATCAGCGGGGTAACCGACGTCCGGACCGTGCCGTTTATGCCCTCCGAGCGTGAGCACAGG
GCCATGTGGGCGCTGCTGGAGTCGCTGCCGGAGCCGGTCTTCTCCATCGACATGAAGGGCAAGGTTGAGCTGGCCAACCA
GGCGGCGCTATCCCTGTTTGCCACCAGCGAGGAGAAAATCTGCCAGCAGACCGCGGCGACGCTGATCGGCGGCTACAACT
TTATGCGCTGGCTGGAGGACGATGACGTCGCGCCGCACAGCGAGAAAGTGGTGATCCGTGGTCAGGATTACCTGATGGAT
ATCATGCCCATCTATCTGGACGACAGTAAACAGACGCACCGCACCCCGGTTGGCGCGGTGGTGGTGCTGAAGTCAGCGGT
GCGCATGGGGCGCCAGCTGCAGAATCTGGCGGTTAACGACAACAGCGAGTTTGACCATATCATCGGCGTCAGCCCCAAGA
TGCGTCAGCTGCTGGAGCAGGCGCGTAAGCTGGCGATGCTGGATGCGCCGCTGCTGCTGGTCGGCGAGACAGGTACCGGC
AAGGATGTGCTGGCCCGCGCTTGCCATCTGCGCAGCCCGCGCGGCAAAAAGCCATTCCTGGCCCTGAACTGCGCCGCGCT
GCCCGACGAGGTGGCAGAGAGCGAACTGTTCGGCCATGCGCCGGGGGCTTATCCCAACGCGCTGGAAGGCAAGAAGGGCT
TCTTTGAGCAGGCCACCGGCGGCACTGTGCTGCTGGATGAGATCGGCGAGATGTCGCCGCGCATGCAGGCCAAGCTGCTG
CGCTTCCTCAATGATGGCACCTTCCGCCGTGTCGGTGAGGAGCACGAGGTGCGCGTCGATGTACGGGTGATCTGCGCGAC
CCAGAAGAACCTGATCGACCTGGTGCAGCGGGGGCTGTTCCGCGAGGATCTCTACTATCGCCTCAACGTATTAACCCTCA
ACCTGCCGCCGCTGCGCGAACGCACACAGGATATCATGCCGCTGACGGAGCTGTTTGTCGCGCGCTTTGCCGACGAGCAG
GGGATGCCGCGGCCTAAGCTGGCGTTGGAGCTGAGCGCGTTTCTCAGCCAGTATGGCTGGCCGGGCAACGTGCGTCAGCT
GAAGAATGCCGTATACCGCGCTCTGACGCAGCTCCAGGGCTACGAGCTGCGCCCGCAGGACATTGTGCTGCCGGAGTTTG
AGGCCGAGATGGCGCTGGGGGATGAGGTGCTGGATGGTTCGCTGGATGAGATTTGCAAACGCTTTGAGCGTTCGGTGCTG
ACCCGCCTGTACCGTAACTACCCGAGCACCCGTAAGCTGGCCAAACGACTGGGCGTTTCCCATACCGCCATCGCCAACAA
GCTGCGCGAATACGGACTGAGCAGCCGCCGTCATCAGGAGGCCGATCCCCACCATCAGGGAGAATAA

Upstream 100 bases:

>100_bases
GGTGACAGGCAATAGCTTCAGCCGCTGTGCTGGTGGTTTGGGCAAACAACGGCTGTTTTTCGCGTACACACGCAGCATAA
GCAGAGTAAGGTCAAAACTA

Downstream 100 bases:

>100_bases
GGGAGTCTTGACGCCGTACCGCAAGGCGAGTCGCCTGCGGTACGGTGCCTGCCTGAGTGTTACTTCAGCGCGGCCAGGGC
GGCCTCGTAGTCTGGCTCGT

Product: DNA-binding transcriptional regulator TyrR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 528; Mature: 528

Protein sequence:

>528_residues
MRLEVFCEDRIGLTRELLDLLAARNIDLRGIEIDTIGRIYLNFNELDFEVFRQLMAEIRRISGVTDVRTVPFMPSEREHR
AMWALLESLPEPVFSIDMKGKVELANQAALSLFATSEEKICQQTAATLIGGYNFMRWLEDDDVAPHSEKVVIRGQDYLMD
IMPIYLDDSKQTHRTPVGAVVVLKSAVRMGRQLQNLAVNDNSEFDHIIGVSPKMRQLLEQARKLAMLDAPLLLVGETGTG
KDVLARACHLRSPRGKKPFLALNCAALPDEVAESELFGHAPGAYPNALEGKKGFFEQATGGTVLLDEIGEMSPRMQAKLL
RFLNDGTFRRVGEEHEVRVDVRVICATQKNLIDLVQRGLFREDLYYRLNVLTLNLPPLRERTQDIMPLTELFVARFADEQ
GMPRPKLALELSAFLSQYGWPGNVRQLKNAVYRALTQLQGYELRPQDIVLPEFEAEMALGDEVLDGSLDEICKRFERSVL
TRLYRNYPSTRKLAKRLGVSHTAIANKLREYGLSSRRHQEADPHHQGE

Sequences:

>Translated_528_residues
MRLEVFCEDRIGLTRELLDLLAARNIDLRGIEIDTIGRIYLNFNELDFEVFRQLMAEIRRISGVTDVRTVPFMPSEREHR
AMWALLESLPEPVFSIDMKGKVELANQAALSLFATSEEKICQQTAATLIGGYNFMRWLEDDDVAPHSEKVVIRGQDYLMD
IMPIYLDDSKQTHRTPVGAVVVLKSAVRMGRQLQNLAVNDNSEFDHIIGVSPKMRQLLEQARKLAMLDAPLLLVGETGTG
KDVLARACHLRSPRGKKPFLALNCAALPDEVAESELFGHAPGAYPNALEGKKGFFEQATGGTVLLDEIGEMSPRMQAKLL
RFLNDGTFRRVGEEHEVRVDVRVICATQKNLIDLVQRGLFREDLYYRLNVLTLNLPPLRERTQDIMPLTELFVARFADEQ
GMPRPKLALELSAFLSQYGWPGNVRQLKNAVYRALTQLQGYELRPQDIVLPEFEAEMALGDEVLDGSLDEICKRFERSVL
TRLYRNYPSTRKLAKRLGVSHTAIANKLREYGLSSRRHQEADPHHQGE
>Mature_528_residues
MRLEVFCEDRIGLTRELLDLLAARNIDLRGIEIDTIGRIYLNFNELDFEVFRQLMAEIRRISGVTDVRTVPFMPSEREHR
AMWALLESLPEPVFSIDMKGKVELANQAALSLFATSEEKICQQTAATLIGGYNFMRWLEDDDVAPHSEKVVIRGQDYLMD
IMPIYLDDSKQTHRTPVGAVVVLKSAVRMGRQLQNLAVNDNSEFDHIIGVSPKMRQLLEQARKLAMLDAPLLLVGETGTG
KDVLARACHLRSPRGKKPFLALNCAALPDEVAESELFGHAPGAYPNALEGKKGFFEQATGGTVLLDEIGEMSPRMQAKLL
RFLNDGTFRRVGEEHEVRVDVRVICATQKNLIDLVQRGLFREDLYYRLNVLTLNLPPLRERTQDIMPLTELFVARFADEQ
GMPRPKLALELSAFLSQYGWPGNVRQLKNAVYRALTQLQGYELRPQDIVLPEFEAEMALGDEVLDGSLDEICKRFERSVL
TRLYRNYPSTRKLAKRLGVSHTAIANKLREYGLSSRRHQEADPHHQGE

Specific function: Involved in transcriptional regulation of aromatic amino acid biosynthesis and transport. Modulates the expression of at least 8 unlinked operons. Seven of these operons are regulated in response to changes in the concentration of the three aromatic amino

COG id: COG3283

COG function: function code KE; Transcriptional regulator of aromatic amino acids metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1787583, Length=521, Percent_Identity=71.5930902111324, Blast_Score=761, Evalue=0.0,
Organism=Escherichia coli, GI1788550, Length=332, Percent_Identity=39.7590361445783, Blast_Score=239, Evalue=3e-64,
Organism=Escherichia coli, GI1790299, Length=358, Percent_Identity=39.9441340782123, Blast_Score=224, Evalue=8e-60,
Organism=Escherichia coli, GI87082152, Length=335, Percent_Identity=39.7014925373134, Blast_Score=217, Evalue=1e-57,
Organism=Escherichia coli, GI1790437, Length=302, Percent_Identity=39.0728476821192, Blast_Score=212, Evalue=6e-56,
Organism=Escherichia coli, GI1788905, Length=239, Percent_Identity=45.6066945606695, Blast_Score=209, Evalue=4e-55,
Organism=Escherichia coli, GI1789233, Length=458, Percent_Identity=30.1310043668122, Blast_Score=208, Evalue=7e-55,
Organism=Escherichia coli, GI87082117, Length=336, Percent_Identity=38.3928571428571, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI1789087, Length=327, Percent_Identity=39.4495412844037, Blast_Score=205, Evalue=5e-54,
Organism=Escherichia coli, GI87081872, Length=251, Percent_Identity=40.6374501992032, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1786524, Length=270, Percent_Identity=41.4814814814815, Blast_Score=179, Evalue=4e-46,
Organism=Escherichia coli, GI1789828, Length=238, Percent_Identity=39.0756302521008, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI87081858, Length=440, Percent_Identity=27.0454545454545, Blast_Score=117, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR003593
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR000014
- InterPro:   IPR002078 [H]

Pfam domain/function: PF01842 ACT; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 59898; Mature: 59898

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS50112 PAS ; PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLEVFCEDRIGLTRELLDLLAARNIDLRGIEIDTIGRIYLNFNELDFEVFRQLMAEIRR
CCEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEECCEEEEEECCCCCHHHHHHHHHHHHH
ISGVTDVRTVPFMPSEREHRAMWALLESLPEPVFSIDMKGKVELANQAALSLFATSEEKI
HCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEECCCCCEEHHHHHHHHHHCCCHHHH
CQQTAATLIGGYNFMRWLEDDDVAPHSEKVVIRGQDYLMDIMPIYLDDSKQTHRTPVGAV
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCHHHHHHHHEEECCCCCCCCCCHHHH
VVLKSAVRMGRQLQNLAVNDNSEFDHIIGVSPKMRQLLEQARKLAMLDAPLLLVGETGTG
HHHHHHHHHHHHHHHCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHCCCEEEEECCCCC
KDVLARACHLRSPRGKKPFLALNCAALPDEVAESELFGHAPGAYPNALEGKKGFFEQATG
HHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCC
GTVLLDEIGEMSPRMQAKLLRFLNDGTFRRVGEEHEVRVDVRVICATQKNLIDLVQRGLF
CEEEHHHHHCCCHHHHHHHHHHHCCCHHHHCCCCCCEEEEEEEEECCHHHHHHHHHHHHH
REDLYYRLNVLTLNLPPLRERTQDIMPLTELFVARFADEQGMPRPKLALELSAFLSQYGW
HHHHHEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCC
PGNVRQLKNAVYRALTQLQGYELRPQDIVLPEFEAEMALGDEVLDGSLDEICKRFERSVL
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCHHHHCCCHHHHHHHHHHHHH
TRLYRNYPSTRKLAKRLGVSHTAIANKLREYGLSSRRHQEADPHHQGE
HHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRLEVFCEDRIGLTRELLDLLAARNIDLRGIEIDTIGRIYLNFNELDFEVFRQLMAEIRR
CCEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEECCEEEEEECCCCCHHHHHHHHHHHHH
ISGVTDVRTVPFMPSEREHRAMWALLESLPEPVFSIDMKGKVELANQAALSLFATSEEKI
HCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEECCCCCEEHHHHHHHHHHCCCHHHH
CQQTAATLIGGYNFMRWLEDDDVAPHSEKVVIRGQDYLMDIMPIYLDDSKQTHRTPVGAV
HHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCHHHHHHHHEEECCCCCCCCCCHHHH
VVLKSAVRMGRQLQNLAVNDNSEFDHIIGVSPKMRQLLEQARKLAMLDAPLLLVGETGTG
HHHHHHHHHHHHHHHCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHCCCEEEEECCCCC
KDVLARACHLRSPRGKKPFLALNCAALPDEVAESELFGHAPGAYPNALEGKKGFFEQATG
HHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCC
GTVLLDEIGEMSPRMQAKLLRFLNDGTFRRVGEEHEVRVDVRVICATQKNLIDLVQRGLF
CEEEHHHHHCCCHHHHHHHHHHHCCCHHHHCCCCCCEEEEEEEEECCHHHHHHHHHHHHH
REDLYYRLNVLTLNLPPLRERTQDIMPLTELFVARFADEQGMPRPKLALELSAFLSQYGW
HHHHHEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCC
PGNVRQLKNAVYRALTQLQGYELRPQDIVLPEFEAEMALGDEVLDGSLDEICKRFERSVL
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCHHHHCCCHHHHHHHHHHHHH
TRLYRNYPSTRKLAKRLGVSHTAIANKLREYGLSSRRHQEADPHHQGE
HHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11055921 [H]