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The map label for this gene is upp [H]

Identifier: 238919121

GI number: 238919121

Start: 1185863

End: 1186489

Strand: Direct

Name: upp [H]

Synonym: NT01EI_1192

Alternate gene names: 238919121

Gene position: 1185863-1186489 (Clockwise)

Preceding gene: 238919115

Following gene: 238919122

Centisome position: 31.11

GC content: 55.82

Gene sequence:

>627_bases
ATGAAGATCGTTGAAGTGAAACACCCGCTTGTGAAACACAAACTGGGTTTGATGCGTGAAAATGACATCAGCACCAAACG
ATTCCGTGAACTGGCCTCTGAAGTGGGCAGTTTGCTGACCTATGAAGCGACCGCAGACCTCGAAACAGAAAAAGTAACCA
TTGATGGTTGGTGCGGCCCGGTCGAAGTTGAACAGATTAAAGGGAAAAAGATCACCGTGGTGCCGATCCTGCGCGCGGGG
CTGGGCATGATGGAAGGGGTGCTGGAGCATGTGCCGAGCGCCCGTATCAGCGTGGTGGGGATCTACCGTAACGAAGAGAC
GCTGGAGCCGGTTCCCTATTTCCAGAAGCTGGTATCCCATATCGATGAGCGTATGGCGCTGGTCGTTGATCCAATGCTGG
CCACGGGCGGCTCCATGATCGCCACTATCGATCTGCTGAAGAATGCCGGCTGTCGCGCGATCAAGGTGCTGGTGCTGGTG
GCGGCACCGGAGGGTATCGCCGCGCTGGAGAAGGCGCACCCGGACGTGGAGCTGTACACCGCCTCCATCGATCAGGGCCT
AAACGATAAGGGTTACATTATTCCGGGTCTGGGCGACGCCGGCGATAAAATATTTGGTACCAAGTAA

Upstream 100 bases:

>100_bases
TATTGATAGAGATCATGATTTTTCCTCTGAAAAGCGAGTGAAAGGGAGGTATAATCTCGCGATTTTTTTGGGCGCAGAAC
AGCTACATGGGAGAGAAAAA

Downstream 100 bases:

>100_bases
CCCATGAGCCGACTCGTTAGTCGGCTTTTTTTTGGCGTGACGCCGGGTGCGCCGCGCCCCTTTCAAACCCTAACACTATC
GATTAACGAGAGAGGAAATA

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MKIVEVKHPLVKHKLGLMRENDISTKRFRELASEVGSLLTYEATADLETEKVTIDGWCGPVEVEQIKGKKITVVPILRAG
LGMMEGVLEHVPSARISVVGIYRNEETLEPVPYFQKLVSHIDERMALVVDPMLATGGSMIATIDLLKNAGCRAIKVLVLV
AAPEGIAALEKAHPDVELYTASIDQGLNDKGYIIPGLGDAGDKIFGTK

Sequences:

>Translated_208_residues
MKIVEVKHPLVKHKLGLMRENDISTKRFRELASEVGSLLTYEATADLETEKVTIDGWCGPVEVEQIKGKKITVVPILRAG
LGMMEGVLEHVPSARISVVGIYRNEETLEPVPYFQKLVSHIDERMALVVDPMLATGGSMIATIDLLKNAGCRAIKVLVLV
AAPEGIAALEKAHPDVELYTASIDQGLNDKGYIIPGLGDAGDKIFGTK
>Mature_208_residues
MKIVEVKHPLVKHKLGLMRENDISTKRFRELASEVGSLLTYEATADLETEKVTIDGWCGPVEVEQIKGKKITVVPILRAG
LGMMEGVLEHVPSARISVVGIYRNEETLEPVPYFQKLVSHIDERMALVVDPMLATGGSMIATIDLLKNAGCRAIKVLVLV
AAPEGIAALEKAHPDVELYTASIDQGLNDKGYIIPGLGDAGDKIFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=27.7227722772277, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI57863312, Length=142, Percent_Identity=32.3943661971831, Blast_Score=72, Evalue=3e-13,
Organism=Escherichia coli, GI87082118, Length=208, Percent_Identity=92.3076923076923, Blast_Score=389, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17539892, Length=201, Percent_Identity=26.3681592039801, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17539894, Length=201, Percent_Identity=26.3681592039801, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6321920, Length=138, Percent_Identity=40.5797101449275, Blast_Score=104, Evalue=1e-23,
Organism=Drosophila melanogaster, GI45550449, Length=203, Percent_Identity=28.0788177339901, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28573516, Length=203, Percent_Identity=28.0788177339901, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28573514, Length=203, Percent_Identity=28.0788177339901, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28573512, Length=203, Percent_Identity=28.0788177339901, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 22571; Mature: 22571

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVEVKHPLVKHKLGLMRENDISTKRFRELASEVGSLLTYEATADLETEKVTIDGWCGP
CEEEECCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHEEEECCCCCCCCEEEECCCCCC
VEVEQIKGKKITVVPILRAGLGMMEGVLEHVPSARISVVGIYRNEETLEPVPYFQKLVSH
CCHHHHCCCEEEEEHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHHH
IDERMALVVDPMLATGGSMIATIDLLKNAGCRAIKVLVLVAAPEGIAALEKAHPDVELYT
HHHHHHHHCCHHHHCCCCCEEHHHHHHCCCCCEEEEEEEEECCCCHHHHHHCCCCEEEEE
ASIDQGLNDKGYIIPGLGDAGDKIFGTK
ECHHCCCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MKIVEVKHPLVKHKLGLMRENDISTKRFRELASEVGSLLTYEATADLETEKVTIDGWCGP
CEEEECCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHEEEECCCCCCCCEEEECCCCCC
VEVEQIKGKKITVVPILRAGLGMMEGVLEHVPSARISVVGIYRNEETLEPVPYFQKLVSH
CCHHHHCCCEEEEEHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHHH
IDERMALVVDPMLATGGSMIATIDLLKNAGCRAIKVLVLVAAPEGIAALEKAHPDVELYT
HHHHHHHHCCHHHHCCCCCEEHHHHHHCCCCCEEEEEEEEECCCCHHHHHHCCCCEEEEE
ASIDQGLNDKGYIIPGLGDAGDKIFGTK
ECHHCCCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA