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The map label for this gene is uraA [H]

Identifier: 238919122

GI number: 238919122

Start: 1186594

End: 1187871

Strand: Direct

Name: uraA [H]

Synonym: NT01EI_1193

Alternate gene names: 238919122

Gene position: 1186594-1187871 (Clockwise)

Preceding gene: 238919121

Following gene: 238919123

Centisome position: 31.13

GC content: 59.23

Gene sequence:

>1278_bases
ATGACCCGTCGCGTCATCGGCGTCAGCGAGCGTCCATCGCTTCTGCAAACGATTCCGTTGAGCTTTCAGCACCTGTTCGC
CATGTTTGGTGCCACCGTGCTGGTTCCCATTCTGTTTAAGATTAACCCGGCGACGGTACTGCTGTTTAACGGCATCGGCA
CTCTGCTGTATCTGTTTATCTGTAAAGGCAAGATACCGGCCTATCTCGGCTCCAGCTTTGCCTTTATTTCACCGGTGATG
TTGCTGCTGCCGCTAGGCTATGAGCTGGCGCTGGGCGGCTTTATCGTCTGCGGTGCACTGTTCTGTCTGGTGGCGCTGAT
TGTCAAAAAAGCCGGTACCGGCTGGCTGAATGTGATCTTTCCTCCGGCGGCAATGGGGGCGATTGTGGCGGTGATCGGCC
TGGAGCTGGCTGGTGTGGCGGCCAATATGGCCGGTCTGCTGCCGGCCGACGGCACCCGGGCCGACGGCACCACCATCACC
ATCTCCATGGTGACGCTGGCGGTGACGGTACTGGGCTCGGTGCTGTTCCGTGGCTTTTTGGCTATCATCCCGATCCTGAT
CGGCGTACTGGTGGGCTACGGGCTCTCCTTCTTCATGGGCGTGGTGGATATTACGCCGATCAAAGAGGCCCACTGGTTTG
CGCTGCCGACCTTCTATACGCCGCGCTTTGAGTGGTTCGCCATTTTGACCATCCTGCCGGCGGCGCTGGTGGTGATTGCC
GAGCACGTCGGCCACCTGGTGGTGACCGCCAATATCGTGAAGAAGGATCTGATGCGCGATCCGGGGCTGCATCGCTCCAT
GTTTGCCAACGGCTTCTCCACCATGTTCTCCGGCTTTTTCGGCTCGACGCCGAATACCACCTACGGTGAAAATATCGGTG
TGTTGGCCATCACCAAGGTCTACAGCACCTGGGTGATCGGCGGGGCGGCGGTGCTGGCGATCCTGCTCTCCTGCGTCGGT
AAGCTGGCGGCGGCGATCCAGGTGATCCCGGTGCCGGTGATGGGGGGGGTCTCCCTGCTGCTGTATGGCGTGATTGGGGC
GTCCGGGATCCGGGTGCTGATCGACTCCAAGGTCGACTATAACAAGGCTCAGAATCTGATCCTGACTTCGGTTATCCTGA
TCATCGGCGTCAGCGGTGCCAAGGTGCATATCGGCGCCGCGGAGTTGAAGGGGATGGCGCTGGCGACCATCGTCGGTATC
GGGATGAGCCTGCTGTTCAAGCTGTTCAGCCTGATGCGCAAAGAAGAAGAGATTATCGAGCTACCGGAGGATATCTAA

Upstream 100 bases:

>100_bases
TGAGCCGACTCGTTAGTCGGCTTTTTTTTGGCGTGACGCCGGGTGCGCCGCGCCCCTTTCAAACCCTAACACTATCGATT
AACGAGAGAGGAAATACATC

Downstream 100 bases:

>100_bases
CGCCTCCGAGGGGAGCTGGGCGGTATCCGGCTCCCTTTTCCACCCCGTATTATCCCCTGTTCTCCTCTCCCTGTGGGGAT
GCTAACCGCATGAGGGTGTG

Product: uracil transporter

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MTRRVIGVSERPSLLQTIPLSFQHLFAMFGATVLVPILFKINPATVLLFNGIGTLLYLFICKGKIPAYLGSSFAFISPVM
LLLPLGYELALGGFIVCGALFCLVALIVKKAGTGWLNVIFPPAAMGAIVAVIGLELAGVAANMAGLLPADGTRADGTTIT
ISMVTLAVTVLGSVLFRGFLAIIPILIGVLVGYGLSFFMGVVDITPIKEAHWFALPTFYTPRFEWFAILTILPAALVVIA
EHVGHLVVTANIVKKDLMRDPGLHRSMFANGFSTMFSGFFGSTPNTTYGENIGVLAITKVYSTWVIGGAAVLAILLSCVG
KLAAAIQVIPVPVMGGVSLLLYGVIGASGIRVLIDSKVDYNKAQNLILTSVILIIGVSGAKVHIGAAELKGMALATIVGI
GMSLLFKLFSLMRKEEEIIELPEDI

Sequences:

>Translated_425_residues
MTRRVIGVSERPSLLQTIPLSFQHLFAMFGATVLVPILFKINPATVLLFNGIGTLLYLFICKGKIPAYLGSSFAFISPVM
LLLPLGYELALGGFIVCGALFCLVALIVKKAGTGWLNVIFPPAAMGAIVAVIGLELAGVAANMAGLLPADGTRADGTTIT
ISMVTLAVTVLGSVLFRGFLAIIPILIGVLVGYGLSFFMGVVDITPIKEAHWFALPTFYTPRFEWFAILTILPAALVVIA
EHVGHLVVTANIVKKDLMRDPGLHRSMFANGFSTMFSGFFGSTPNTTYGENIGVLAITKVYSTWVIGGAAVLAILLSCVG
KLAAAIQVIPVPVMGGVSLLLYGVIGASGIRVLIDSKVDYNKAQNLILTSVILIIGVSGAKVHIGAAELKGMALATIVGI
GMSLLFKLFSLMRKEEEIIELPEDI
>Mature_424_residues
TRRVIGVSERPSLLQTIPLSFQHLFAMFGATVLVPILFKINPATVLLFNGIGTLLYLFICKGKIPAYLGSSFAFISPVML
LLPLGYELALGGFIVCGALFCLVALIVKKAGTGWLNVIFPPAAMGAIVAVIGLELAGVAANMAGLLPADGTRADGTTITI
SMVTLAVTVLGSVLFRGFLAIIPILIGVLVGYGLSFFMGVVDITPIKEAHWFALPTFYTPRFEWFAILTILPAALVVIAE
HVGHLVVTANIVKKDLMRDPGLHRSMFANGFSTMFSGFFGSTPNTTYGENIGVLAITKVYSTWVIGGAAVLAILLSCVGK
LAAAIQVIPVPVMGGVSLLLYGVIGASGIRVLIDSKVDYNKAQNLILTSVILIIGVSGAKVHIGAAELKGMALATIVGIG
MSLLFKLFSLMRKEEEIIELPEDI

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=211, Percent_Identity=28.436018957346, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI40316845, Length=211, Percent_Identity=28.436018957346, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1788843, Length=424, Percent_Identity=87.2641509433962, Blast_Score=729, Evalue=0.0,
Organism=Escherichia coli, GI87081818, Length=432, Percent_Identity=37.5, Blast_Score=251, Evalue=9e-68,
Organism=Escherichia coli, GI87082181, Length=427, Percent_Identity=26.6978922716628, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1790087, Length=405, Percent_Identity=26.6666666666667, Blast_Score=92, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17541904, Length=233, Percent_Identity=25.7510729613734, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17558856, Length=135, Percent_Identity=31.8518518518519, Blast_Score=69, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17542262, Length=216, Percent_Identity=25.462962962963, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI21356175, Length=439, Percent_Identity=24.373576309795, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 44924; Mature: 44793

Theoretical pI: Translated: 9.08; Mature: 9.08

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRRVIGVSERPSLLQTIPLSFQHLFAMFGATVLVPILFKINPATVLLFNGIGTLLYLFI
CCCCEECCCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEHHHHHHHHHHH
CKGKIPAYLGSSFAFISPVMLLLPLGYELALGGFIVCGALFCLVALIVKKAGTGWLNVIF
HCCCCCHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
PPAAMGAIVAVIGLELAGVAANMAGLLPADGTRADGTTITISMVTLAVTVLGSVLFRGFL
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
AIIPILIGVLVGYGLSFFMGVVDITPIKEAHWFALPTFYTPRFEWFAILTILPAALVVIA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHH
EHVGHLVVTANIVKKDLMRDPGLHRSMFANGFSTMFSGFFGSTPNTTYGENIGVLAITKV
HHHCHHEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEHHHH
YSTWVIGGAAVLAILLSCVGKLAAAIQVIPVPVMGGVSLLLYGVIGASGIRVLIDSKVDY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCH
NKAQNLILTSVILIIGVSGAKVHIGAAELKGMALATIVGIGMSLLFKLFSLMRKEEEIIE
HHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHC
LPEDI
CCCCC
>Mature Secondary Structure 
TRRVIGVSERPSLLQTIPLSFQHLFAMFGATVLVPILFKINPATVLLFNGIGTLLYLFI
CCCEECCCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEHHHHHHHHHHH
CKGKIPAYLGSSFAFISPVMLLLPLGYELALGGFIVCGALFCLVALIVKKAGTGWLNVIF
HCCCCCHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
PPAAMGAIVAVIGLELAGVAANMAGLLPADGTRADGTTITISMVTLAVTVLGSVLFRGFL
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
AIIPILIGVLVGYGLSFFMGVVDITPIKEAHWFALPTFYTPRFEWFAILTILPAALVVIA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHH
EHVGHLVVTANIVKKDLMRDPGLHRSMFANGFSTMFSGFFGSTPNTTYGENIGVLAITKV
HHHCHHEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEHHHH
YSTWVIGGAAVLAILLSCVGKLAAAIQVIPVPVMGGVSLLLYGVIGASGIRVLIDSKVDY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCH
NKAQNLILTSVILIIGVSGAKVHIGAAELKGMALATIVGIGMSLLFKLFSLMRKEEEIIE
HHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHC
LPEDI
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]